Targeting PI3K-p110α Suppresses Influenza Virus Infection in Chronic Obstructive Pulmonary Disease

Animal models of chronic obstructive pulmonary disease

(2014) Michael Fricker et al.   Expert Opinion on Drug Discovery

Importance of Mast Cell Prss31/Transmembrane Tryptase/Tryptase-γ in Lung Function and Experimental Chronic Obstructive Pulmonary Disease and Colitis

(2014) Philip M. Hansbro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis

(2013) Emma L. Beckett et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Components of Streptococcus pneumoniae Suppress Allergic Airways Disease and NKT Cells by Inducing Regulatory T Cells

(2012) A. N. Thorburn et al.   JOURNAL OF IMMUNOLOGY

Critical Role of Constitutive Type I Interferon Response in Bronchial Epithelial Cell to Influenza Infection

(2012) Alan C-Y. Hsu et al.   PLoS One

Innate immunity to influenza in chronic airways diseases

(2012) ALAN C.-Y. HSU et al.   RESPIROLOGY

CombinedHaemophilus influenzaerespiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma

(2012) Ama-Tawiah Essilfie et al.   THORAX

Total lung capacity by plethysmography and high-resolution computed tomography in COPD

(2012) Jamie Garfield et al.   International Journal of Chronic Obstructive Pulmonary Disease

Cigarette smoke extract suppresses the RIG-I-initiated innate immune response to influenza virus in the human lung

(2011) Wenxin Wu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pulmonary-intestinal cross-talk in mucosal inflammatory disease

(2011) S Keely et al.   Mucosal Immunology

Community Transmission of Oseltamivir-Resistant A(H1N1)pdm09 Influenza

(2011) Aeron C. Hurt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease

(2011) John E. McDonough et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting Phosphoinositide-3-Kinase-δ with Theophylline Reverses Corticosteroid Insensitivity in Chronic Obstructive Pulmonary Disease

(2010) Yasuo To et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Experimental Rhinovirus Infection as a Human Model of Chronic Obstructive Pulmonary Disease Exacerbation

(2010) Patrick Mallia et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human Influenza Is More Effective than Avian Influenza at Antiviral Suppression in Airway Cells

(2010) Alan Chen-Yu Hsu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Perivascular fluid cuffs decrease lung compliance by increasing tissue resistance*

(2010) Kevin Lowe et al.   CRITICAL CARE MEDICINE

A role for phosphoinositol 3–kinase δ in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease

(2010) John A. Marwick et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Phosphatidylinositol 3-kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo

(2010) Hanguo Jiang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Chlamydial Respiratory Infection during Allergen Sensitization Drives Neutrophilic Allergic Airways Disease

(2010) J. C. Horvat et al.   JOURNAL OF IMMUNOLOGY

Resurrected Pandemic Influenza Viruses

(2009) Terrence M. Tumpey et al.   Annual Review of Microbiology

Neutrophils Ameliorate Lung Injury and the Development of Severe Disease during Influenza Infection

(2009) M. D. Tate et al.   JOURNAL OF IMMUNOLOGY

Critical Role of IL-1 Receptor-Associated Kinase-M in Regulating Chemokine-Dependent Deleterious Inflammation in Murine Influenza Pneumonia

(2009) M. Seki et al.   JOURNAL OF IMMUNOLOGY

Akt Inhibitor Akt-IV Blocks Virus Replication through an Akt-Independent Mechanism

(2009) E. F. Dunn et al.   JOURNAL OF VIROLOGY

Comparative Efficacy of Inactivated and Live Attenuated Influenza Vaccines

(2009) Arnold S. Monto et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hydroquinone, a major component in cigarette smoke, reduces IFN-γ production in antigen-primed lymphocytes

(2008) Jin Myung Choi et al.   ARCHIVES OF PHARMACAL RESEARCH

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation

(2008) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophils Play an Essential Role in Cooperation with Antibody in both Protection against and Recovery from Pulmonary Infection with Influenza Virus in Mice

(2008) H. Fujisawa   JOURNAL OF VIROLOGY