Aging increases CCN1 expression leading to muscle senescence

Cellular senescence controls fibrosis in wound healing

(2016) Joon-Il Jun et al.   Aging-US

Primary human muscle precursor cells obtained from young and old donors produce similar proliferative, differentiation and senescent profiles in culture

(2013) Mansour Alsharidah et al.   AGING CELL

Role of Reactive Oxygen Species-Mediated Signaling in Aging

(2012) Vyacheslav M. Labunskyy et al.   ANTIOXIDANTS & REDOX SIGNALING

Cyr61/CCN1 Is Regulated by Wnt/β-Catenin Signaling and Plays an Important Role in the Progression of Hepatocellular Carcinoma

(2012) Zhi-Qiang Li et al.   PLoS One

CCN1/CYR61: the very model of a modern matricellular protein

(2011) Lester F. Lau   CELLULAR AND MOLECULAR LIFE SCIENCES

Hormone Replacement Therapy in the Geriatric Patient: Current State of the Evidence and Questions for the Future. Estrogen, Progesterone, Testosterone, and Thyroid Hormone Augmentation in Geriatric Clinical Practice: Part 1

(2011) Erika Schwartz et al.   CLINICS IN GERIATRIC MEDICINE

Chronic low-grade inflammation and age-related sarcopenia

(2011) Ingo Beyer et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Tumor Suppressor and Aging Biomarker p16INK4aInduces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

(2011) Jean-Philippe Coppé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Reduction of myoblast differentiation following multiple population doublings in mouse C2C12 cells: A model to investigate ageing?

(2011) Adam P. Sharples et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Decreased miR-29 Suppresses Myogenesis in CKD

(2011) X. H. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

(2011) Joon-Il Jun et al.   NATURE REVIEWS DRUG DISCOVERY

CCN1 contributes to skin connective tissue aging by inducing age-associated secretory phenotype in human skin dermal fibroblasts

(2011) Taihao Quan et al.   Journal of Cell Communication and Signaling

Human muscle satellite cells show age-related differential expression of S100B protein and RAGE

(2010) Sara Beccafico et al.   AGE

Satellite Cell Dysfunction and Impaired IGF-1 Signaling Cause CKD-Induced Muscle Atrophy

(2010) L. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation

(2009) Tiziana Pietrangelo et al.   EXPERIMENTAL GERONTOLOGY

Replicative aging down-regulates the myogenic regulatory factors in human myoblasts

(2008) Anne Bigot et al.   BIOLOGY OF THE CELL

A Temporal Switch from Notch to Wnt Signaling in Muscle Stem Cells Is Necessary for Normal Adult Myogenesis

(2008) Andrew S. Brack et al.   Cell Stem Cell

The Wnt signaling pathway: Aging gracefully as a protectionist?

(2008) Kenneth Maiese et al.   PHARMACOLOGY & THERAPEUTICS

Transcriptional activation of CCN1 and CCN2, targets of canonical Wnt signal, by ascorbic acid 2-phosphate in human dermal papilla cells

(2007) Young Kwan Sung et al.   JOURNAL OF DERMATOLOGICAL SCIENCE