Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and activation of SERCA2a

A Glucagon-Like Peptide-1 Analog Reverses the Molecular Pathology and Cardiac Dysfunction of a Mouse Model of Obesity

(2012) Mohammad Hossein Noyan-Ashraf et al.   CIRCULATION

Modulation of Cardiac Contractility by the Phopholamban/SERCA2a Regulatome

(2012) Evangelia G. Kranias et al.   CIRCULATION RESEARCH

Impaired MEK Signaling and SERCA Expression Promote ER Stress and Apoptosis in Insulin-Resistant Macrophages and Are Reversed by Exenatide Treatment

(2012) C.-P. Liang et al.   DIABETES

The ghrelin gene products and exendin-4 promote survival of human pancreatic islet endothelial cells in hyperglycaemic conditions, through phosphoinositide 3-kinase/Akt, extracellular signal-related kinase (ERK)1/2 and cAMP/protein kinase A (PKA) signalling pathways

(2012) E. Favaro et al.   DIABETOLOGIA

Glucagon-Like Peptide-1 Counteracts Oxidative Stress-Dependent Apoptosis of Human Cardiac Progenitor Cells by Inhibiting the Activation of the c-Jun N-terminal Protein Kinase Signaling Pathway

(2012) L. Laviola et al.   ENDOCRINOLOGY

Antiapoptotic effects of GLP-1 in murine HL-1 cardiomyocytes

(2011) Susana Ravassa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial dysfunction in diabetic cardiomyopathy

(2011) Jennifer G. Duncan   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Glucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathway

(2011) Yong-Fu Xiao et al.   Cardiovascular Diabetology

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

GLP-1 analogue, Liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic reticulum stress

(2011) Bruno Schisano et al.   REGULATORY PEPTIDES

The diabetic cardiomyopathy

(2010) Roberto Tarquini et al.   ACTA DIABETOLOGICA

Cardiac contractile dysfunction during acute hyperglycemia due to impairment of SERCA by polyol pathway-mediated oxidative stress

(2010) Wai Ho Tang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hyperglycaemia-induced cardiomyocyte death is mediated via MCP-1 production and induction of a novel zinc-finger protein MCPIP

(2010) Craig W. Younce et al.   CARDIOVASCULAR RESEARCH

The Cardiovascular Effects of GLP-1 Receptor Agonists

(2010) Theodore Okerson et al.   Cardiovascular Therapeutics

Biology of Endoplasmic Reticulum Stress in the Heart

(2010) Jody Groenendyk et al.   CIRCULATION RESEARCH

Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function

(2009) Ratnadeep Basu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Neonatal exendin-4 treatment reduces oxidative stress and prevents hepatic insulin resistance in intrauterine growth-retarded rats

(2009) Elisabeth L. Raab et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

MCP-1 causes cardiomyoblast death via autophagy resulting from ER stress caused by oxidative stress generated by inducing a novel zinc-finger protein, MCPIP

(2009) Craig W. Younce et al.   BIOCHEMICAL JOURNAL

Calpain activation contributes to hyperglycaemia-induced apoptosis in cardiomyocytes

(2009) Y. Li et al.   CARDIOVASCULAR RESEARCH

Rac1 Is Required for Cardiomyocyte Apoptosis During Hyperglycemia

(2009) E. Shen et al.   DIABETES

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

(2009) Daniel A. Cunha et al.   DIABETES

GLP-1R Agonist Liraglutide Activates Cytoprotective Pathways and Improves Outcomes After Experimental Myocardial Infarction in Mice

(2009) M. H. Noyan-Ashraf et al.   DIABETES

PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis

(2009) Nabil Djouder et al.   EMBO JOURNAL

GLP-1 Mediates Antiapoptotic Effect by Phosphorylating Bad through a β-Arrestin 1-mediated ERK1/2 Activation in Pancreatic β-Cells

(2009) Julie Quoyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exenatide Reduces Infarct Size and Improves Cardiac Function in a Porcine Model of Ischemia and Reperfusion Injury

(2009) Leo Timmers et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway

(2009) R. Kimura et al.   NEUROSCIENCE

Gene Remodeling in Type 2 Diabetic Cardiomyopathy and Its Phenotypic Rescue with SERCA2a

(2009) Ioannis Karakikes et al.   PLoS One

Cardioprotective and Vasodilatory Actions of Glucagon-Like Peptide 1 Receptor Are Mediated Through Both Glucagon-Like Peptide 1 Receptor–Dependent and –Independent Pathways

(2008) Kiwon Ban et al.   CIRCULATION

Anti-apoptotic Action of Exendin-4 in INS-1 Beta Cells: Comparative Protein Pattern Analysis of Isolated Mitochondria

(2008) D. Tews et al.   HORMONE AND METABOLIC RESEARCH

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Mutated recombinant human glucagon-like peptide-1 protects SH-SY5Y cells from apoptosis induced by amyloid-β peptide (1–42)

(2008) Zhenxia Qin et al.   NEUROSCIENCE LETTERS

Protective effects of GLP-1 analogues exendin-4 and GLP-1(9–36) amide against ischemia–reperfusion injury in rat heart

(2007) David P. Sonne et al.   REGULATORY PEPTIDES