Article
Biochemistry & Molecular Biology
Andrila E. Collins, Tarek M. Saleh, Bettina E. Kalisch
Summary: This study aimed to assess the cytoprotective effects of the novel antioxidant compound VANL-100 in a cellular model of beta-amyloid (A beta)-induced toxicity. The results demonstrate that VANL-100 significantly attenuated A beta-induced cell death, indicating its cytoprotective effects against A beta-induced toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hironori Mizutani, Yoshifumi Sato, Masaya Yamazaki, Tatsuya Yoshizawa, Yukio Ando, Mitsuharu Ueda, Kazuya Yamagata
Summary: This study found that the expression of SIRT7 is increased in the brain of Alzheimer's disease patients. Treatment with A beta(42) increased the expression of NOX4, leading to the production of reactive oxygen species (ROS) and apoptosis. Knockdown of SIRT7 inhibited A beta(42)-induced ROS production and apoptosis by suppressing the upregulation of NOX4. These findings suggest that inhibiting SIRT7 may be beneficial in the pathogenesis of AD by regulating ROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Benita Wiatrak, Paulina Jawien, Agnieszka Matuszewska, Adam Szelag, Adriana Kubis-Kubiak
Summary: This study aimed to investigate the impact of amyloid fragments on oxidative stress and found that amyloid fragments have antioxidant properties, protecting neurons from neuroinflammation-induced damage. Among the tested fragments, the 1-40 fragment showed a stronger antioxidant effect.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Yujian Lin, Lei Zhang, Mengyue Gao, Zixin Tang, Xiang Cheng, Haoming Li, Jianbing Qin, Meiling Tian, Guohua Jin, Xinhua Zhang, Wen Li
Summary: This study found that miR-6076 attenuates A beta(1-42)-induced neuronal damage by targeting BCL6, providing a potential target for prevention and treatment of Alzheimer's disease.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Mohsen Sedighi, Tourandokht Baluchnejadmojarad, Siamak Afshin-Majd, Mona Amiri, Malihe Aminzade, Mehrdad Roghani
Summary: Klotho pretreatment at different concentrations effectively mitigated cell damage, reduced oxidative stress, and inflammation caused by A beta 1-42 toxicity. The beneficial effects of Klotho were achieved through modulation of Wnt1/pCREB/Nrf2/HO-1 signaling pathway, leading to improved cell viability and decreased cellular damage.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Ping Wang, Peipei Wang, Hengfei Luan, Yong Wu, Ying Chen
Summary: The study suggests that Midazolam has potential therapeutic effects in Alzheimer's disease (AD) by reducing oligomerized amyloid beta (A beta)-associated neuronal senescence and restoring telomerase activity and gene expressions associated with cellular senescence.
BRAIN AND BEHAVIOR
(2023)
Article
Cell Biology
Ching-Chia Huang, Kuo-Hsuan Chang, Ya-Jen Chiu, Yi-Ru Chen, Tsai-Hui Lung, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Ying-Chieh Sun, Chiung-Mei Chen, Wenwei Lin, Guey-Jen Lee-Chen
Summary: Alzheimer's disease is characterized by progressive memory and cognitive impairments due to the aggregation of misfolded amyloid beta. Novel synthetic coumarin derivatives ZN014 and ZN015 show potential as therapeutic candidates for AD by reducing A beta neurotoxicity through pleiotropic mechanisms and activating TRKB-mediated signaling pathways.
Article
Biochemistry & Molecular Biology
Keren Zohar, Elyad Lezmi, Tsiona Eliyahu, Michal Linial
Summary: The compound ladostigil has been shown to alleviate cell damage induced by oxidation, inhibit microglial activation, and improve learning deficits under conditions of chronic oxidative stress in the aging brain.
Article
Neurosciences
Petra Riegerova, Jindrich Brejcha, Dagmar Bezdekova, Tomas Chum, Eva Masinova, Nikola Cermakova, Saak Ovsepian, Marek Cebecauer, Martin Stefl
Summary: The neuroblastoma cell line SH-SY5Y is commonly used as an experimental model for studying Alzheimer's disease. In this study, it was found that the expression and localization of amyloid-beta protein precursor (A beta PP) in SH-SY5Y cells can be dramatically altered by inducing full differentiation with retinoic acid and BDNF. Failure to fully differentiate SH-SY5Y cells can lead to mislocalization of A beta PP.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Integrative & Complementary Medicine
Hyongjun Jeon, Hee-Young Kim, Chang-Hwan Bae, Yukyung Lee, Sungtae Koo, Seungtae Kim
Summary: The study shows that Korean red ginseng effectively prevents MPP+-induced SH-SY5Y cell death by regulating cytochrome c release from mitochondria and PINK1/parkin-mediated mitophagy, through the regulation of the Bcl-2 family.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Cell Biology
Ya-Jen Chiu, Te-Hsien Lin, Kuo-Hsuan Chang, Wenwei Lin, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Chiung-Mei Chen, Ying-Chieh Sun, Guey-Jen Lee-Chen
Summary: This study demonstrates that LMDS-1 and -2, analogs of the coumarin derivative LM-031, act as TRKB agonists to protect SH-SY5Y cells against A beta toxicity. These compounds enhance the CREB/BDNF/BCL2 pathway, exhibit anti-aggregation and neuroprotective efficacy, and activate downstream ERK, PI3K-AKT, and CREB signaling. LMDS-1 and -2 are shown to be capable of crossing the blood-brain barrier, making them potential candidates for therapeutic applications in Alzheimer's disease.
Article
Cell Biology
Hong-Hao Chan, Chee-Onn Leong, Chooi-Ling Lim, Rhun-Yian Koh
Summary: This study explored the role of RIPK1 in A beta-induced necroptosis. It was found that A beta can activate the RIPK1-MLKL-dependent necroptosis pathway, leading to neuronal cell death. Inhibition of RIPK1 expression rescued cells from A beta-induced cell death, while ectopic expression of RIPK1 enhanced the stability of endogenous APP.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Masanari Taniguchi, Mayu Saito, Takahisa Kuga, Nobuyuki Yamagishi
Summary: Cu2+ plays a key role in the conformational conversion and aggregate formation of Aβ 1-29, while Zn2+ does not confer resistance against MMP-7 cleavage. Cu2+ may play an important role in the aggregation mechanism of Aβ and the pathology of AD.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Zhuo-Min Ling, Qian Wang, Yu Ma, Peng Xue, Yun Gu, Mao-Hong Cao, Zhong-Ya Wei
Summary: Reactive astrocytes play a crucial role in the inflammatory response of brain injury, including Parkinson's disease. Pannexin 1 has been identified as a membrane channel involved in substance release in neurodegenerative diseases, and in this study, upregulation of Panx 1 was associated with inflammatory cytokine expression. Moreover, inhibiting Panx 1 could suppress pro-inflammatory cytokine expression induced by lipopolysaccharide, suggesting its potential as a key regulator in reactive astrocytes.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yunhui Cai, Ran Xiao, Yadan Zhang, Diya Xu, Ni Wang, Mengze Han, Yili Zhang, Lin Zhang, Wenhua Zhou
Summary: This study investigated the protective effect of 5-hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA) on A beta((1-42))/Cu2+/AA mixture-treated SH-SY5Y cells through in vitro and in silico studies. The results showed that DHPA could inhibit oxidative stress, cell apoptosis, and mitochondrial damage, as well as activate the Keap1/Nrf2/HO-1 signaling pathway.
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)