标题
ENaCs and ASICs as therapeutic targets
作者
关键词
-
出版物
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Volume 302, Issue 7, Pages C943-C965
出版商
American Physiological Society
发表日期
2012-01-27
DOI
10.1152/ajpcell.00019.2012
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Enhancement of alveolar epithelial sodium channel activity with decreased cystic fibrosis transmembrane conductance regulator expression in mouse lung
- (2011) Ahmed Lazrak et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Randomized, Placebo-controlled Clinical Trial of an Aerosolized β2-Agonist for Treatment of Acute Lung Injury
- (2011) AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Apico-basal polarity in polycystic kidney disease epithelia
- (2011) Patricia D. Wilson BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Enhanced expression of epithelial sodium channels in the renal medulla of Dahl S rats
- (2011) Md. Shahrier Amin et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- The R563Q mutation of the epithelial sodium channel beta-subunit is associated with hypertension : cardiovascular topics
- (2011) E.S.W. Jones et al. Cardiovascular Journal of Africa
- Common Variants in Epithelial Sodium Channel Genes Contribute to Salt Sensitivity of Blood Pressure
- (2011) Qi Zhao et al. Circulation-Cardiovascular Genetics
- Proteinuric diseases with sodium retention: is plasmin the link?
- (2011) Per Svenningsen et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Glucocorticoid receptor is indispensable for physiological responses to aldosterone in epithelial Na+ channel induction via the mineralocorticoid receptor in a human colonic cell line
- (2011) Theresa Bergann et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- Regulation of sodium transport in the inner ear
- (2011) Sung Huhn Kim et al. HEARING RESEARCH
- Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways
- (2011) Yehoshua Enuka et al. HISTOCHEMISTRY AND CELL BIOLOGY
- The central mechanism underlying hypertension: a review of the roles of sodium ions, epithelial sodium channels, the renin–angiotensin–aldosterone system, oxidative stress and endogenous digitalis in the brain
- (2011) Hakuo Takahashi et al. HYPERTENSION RESEARCH
- Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: An orally active anti-cancer drug waiting for its call-of-duty?
- (2011) Hayden Matthews et al. INTERNATIONAL JOURNAL OF CANCER
- Glioma-specific Cation Conductance Regulates Migration and Cell Cycle Progression
- (2011) Arun K. Rooj et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2011) Andrew P. Stewart et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Body Fluid Expansion in Acromegaly Is Related to Enhanced Epithelial Sodium Channel (ENaC) Activity
- (2011) Peter Kamenicky et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
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- (2011) Verónica Sánchez-Freire et al. JOURNAL OF UROLOGY
- A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
- (2011) Christopher J. Bohlen et al. NATURE
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- (2011) Roxanne Y. Walder et al. PAIN
- Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption
- (2011) Jiraporn Ousingsawat et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Human cystic fibrosis airway epithelia have reduced Cl- conductance but not increased Na+ conductance
- (2011) O. A. Itani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Expression of acid-sensing ion channels in intestinal epithelial cells and their role in the regulation of duodenal mucosal bicarbonate secretion
- (2010) X. Dong et al. Acta Physiologica
- Disruption of PICK1 attenuates the function of ASICs and PKC regulation of ASICs
- (2010) Zhuang-Li Hu et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Rac1-mediated NADPH oxidase release of O2− regulates epithelial sodium channel activity in the alveolar epithelium
- (2010) Yoshizumi Takemura et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Regulation of endogenous ENaC functional expression by CFTR and ΔF508-CFTR in airway epithelial cells
- (2010) Ronald C. Rubenstein et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Examining the Role of Mechanosensitive Ion Channels in Pressure Mechanotransduction in Rat Bladder Urothelial Cells
- (2010) Shawn M. Olsen et al. ANNALS OF BIOMEDICAL ENGINEERING
- The epithelial sodium channel and the control of sodium balance
- (2010) Laurent Schild BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Differential Localization of Acid-Sensing Ion Channels 1 and 2 in Human Cutaneus Pacinian Corpuscles
- (2010) M. G. Calavia et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Regulation of renal sodium handling through the interaction between serine proteases and serine protease inhibitors
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- Epigenetics and Hypertension
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- (2010) Edlira B. Clark et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of Epithelial Sodium Channels and Their Regulators in Hypertension
- (2010) Rama Soundararajan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2010) Jingjing Su et al. NEUROSCIENCE LETTERS
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- (2010) Emmanuel Deval et al. PHARMACOLOGY & THERAPEUTICS
- Respiratory syncytial virus induces airway insensitivity to β-agonists in BALB/c mice
- (2009) Zachary P. Traylor et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
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- (2009) Nadine Bangel-Ruland et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
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- (2009) Scott D. Kuduk et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2009) Adam E. Ziemann et al. CELL
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- (2009) Damien S.K. Samways et al. CELL CALCIUM
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- ASIC2a and ASIC3 Heteromultimerize to Form pH-Sensitive Channels in Mouse Cardiac Dorsal Root Ganglia Neurons
- (2009) Tomonori Hattori et al. CIRCULATION RESEARCH
- The physiological impact of the serum and glucocorticoid-inducible kinase SGK1
- (2009) Florian Lang et al. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
- Regulation of sodium transport by ENaC in the kidney
- (2009) L Lee Hamm et al. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
- New role for plasmin in sodium homeostasis
- (2009) Christopher J Passero et al. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
- Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species
- (2009) Ahmed Lazrak et al. FASEB JOURNAL
- Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease
- (2009) Abul Kalam Azad et al. HUMAN MUTATION
- Effect of Epithelial Sodium Channel Blockade on the Myogenic Response of Rat Juxtamedullary Afferent Arterioles
- (2009) Zhengrong Guan et al. HYPERTENSION
- ENaC at the Cutting Edge: Regulation of Epithelial Sodium Channels by Proteases
- (2009) Thomas R. Kleyman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Knockdown of ASIC1 and Epithelial Sodium Channel Subunits Inhibits Glioblastoma Whole Cell Current and Cell Migration
- (2009) Niren Kapoor et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mechanotransducers in Rat Pulpal Afferents
- (2009) T.O. Hermanstyne et al. JOURNAL OF DENTAL RESEARCH
- Cell Migration in BeWo Cells and the Role of Epithelial Sodium Channels
- (2009) Silvana M. del Mónaco et al. JOURNAL OF MEMBRANE BIOLOGY
- The pathogenic mechanisms of polyglutamine diseases and current therapeutic strategies
- (2009) Peter O. Bauer et al. JOURNAL OF NEUROCHEMISTRY
- Endolymphatic Sodium Homeostasis by Extramacular Epithelium of the Saccule
- (2009) S. H. Kim et al. JOURNAL OF NEUROSCIENCE
- Dynorphin Opioid Peptides Enhance Acid-Sensing Ion Channel 1a Activity and Acidosis-Induced Neuronal Death
- (2009) T. W. Sherwood et al. JOURNAL OF NEUROSCIENCE
- Acid-Sensing Ion Channel-1a in the Amygdala, a Novel Therapeutic Target in Depression-Related Behavior
- (2009) M. W. Coryell et al. JOURNAL OF NEUROSCIENCE
- Acid-Sensing Ion Channel 3 Expression in Mouse Knee Joint Afferents and Effects of Carrageenan-Induced Arthritis
- (2009) Masahiko Ikeuchi et al. JOURNAL OF PAIN
- Camostat Attenuates Airway Epithelial Sodium Channel Function in Vivo through the Inhibition of a Channel-Activating Protease
- (2009) K. Coote et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- The Aminoglycosides Modulate the Acid-Sensing Ionic Channel Currents in Dorsal Root Ganglion Neurons from the Rat
- (2009) A. Garza et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Localisation of the mechanotransducer channels in mammalian cochlear hair cells provides clues to their gating
- (2009) David N. Furness et al. JOURNAL OF PHYSIOLOGY-LONDON
- Amiloride-sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles
- (2009) Anna Simon et al. JOURNAL OF PHYSIOLOGY-LONDON
- Mutant Sodium Channel for Tumor Therapy
- (2009) Bakhos A Tannous et al. MOLECULAR THERAPY
- Pore architecture and ion sites in acid-sensing ion channels and P2X receptors
- (2009) Eric B. Gonzales et al. NATURE
- The Ion Channel ASIC2 Is Required for Baroreceptor and Autonomic Control of the Circulation
- (2009) Yongjun Lu et al. NEURON
- Distribution of acid-sensing ion channel 3 in the rat hypothalamus
- (2009) Q.-Y. Meng et al. NEUROSCIENCE
- Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APCMin/+ mice
- (2009) G E Koehl et al. ONCOGENE
- Febrile Seizures: Characterization of Double-Stranded RNA-Induced Gene Expression
- (2009) Kazuya Sasaki et al. PEDIATRIC NEUROLOGY
- α-ENaC is a functional element of the hypertonicity-induced cation channel in HepG2 cells and it mediates proliferation
- (2009) Maryna Bondarava et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Sour Ageusia in Two Individuals Implicates Ion Channels of the ASIC and PKD Families in Human Sour Taste Perception at the Anterior Tongue
- (2009) Taufiqul Huque et al. PLoS One
- Lack of association between the amiloride-sensitive cation channel 2 (ACCN2) gene and anxiety spectrum disorders
- (2009) John M. Hettema et al. PSYCHIATRIC GENETICS
- Impaired pressure-induced constriction in mouse middle cerebral arteries of ASIC2 knockout mice
- (2008) Kimberly P. Gannon et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- SARS-CoV proteins decrease levels and activity of human ENaC via activation of distinct PKC isoforms
- (2008) Hong-Long Ji et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Inhibition of Na+Transport in Lung Epithelial Cells by Respiratory Syncytial Virus Infection
- (2008) Lan Chen et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- The Contribution of Epithelial Sodium Channels to Alveolar Function in Health and Disease
- (2008) Douglas C. Eaton et al. Annual Review of Physiology
- Revealing a subclinical salt-losing phenotype in heterozygous carriers of the novel S562P mutation in the α subunit of the epithelial sodium channel
- (2008) Felix G. Riepe et al. CLINICAL ENDOCRINOLOGY
- ASIC3, a sensor of acidic and primary inflammatory pain
- (2008) Emmanuel Deval et al. EMBO JOURNAL
- Epithelial Sodium Channel Is a Key Mediator of Growth Hormone-Induced Sodium Retention in Acromegaly
- (2008) Peter Kamenicky et al. ENDOCRINOLOGY
- Epithelial Na+ channel δ subunit is an acid sensor in the human oesophagus
- (2008) Hisao Yamamura et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Altered ENaC Expression Leads to Impaired Sodium Absorption in the Noninflamed Intestine in Crohn's Disease
- (2008) Sebastian Zeissig et al. GASTROENTEROLOGY
- CO2 chemosensing in rat oesophagus
- (2008) Y Akiba et al. GUT
- Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism
- (2008) Hon Kit Wong et al. HUMAN MOLECULAR GENETICS
- Molecular bases of impaired water and ion movements in inflammatory bowel diseases
- (2008) Olga Martínez-Augustin et al. INFLAMMATORY BOWEL DISEASES
- Blockade of epithelial sodium channels improves sperm motility in asthenospermia patients
- (2008) Xiang-Bin Kong et al. INTERNATIONAL JOURNAL OF ANDROLOGY
- Two faces of nitric oxide: implications for cellular mechanisms of oxygen toxicity
- (2008) Barry W. Allen et al. JOURNAL OF APPLIED PHYSIOLOGY
- Small Molecule Activator of the Human Epithelial Sodium Channel
- (2008) Min Lu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Plasmin Activates Epithelial Na+Channels by Cleaving the γ Subunit
- (2008) Christopher J. Passero et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Proteolytic Processing of the Epithelial Sodium Channel γ Subunit Has a Dominant Role in Channel Activation
- (2008) Marcelo D. Carattino et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Redox Regulation of Epithelial Sodium Channels Examined in Alveolar Type 1 and 2 Cells Patch-clamped in Lung Slice Tissue
- (2008) My N. Helms et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Liddle??s syndrome caused by a novel missense mutation (P617L) of the epithelial sodium channel ?? subunit
- (2008) Ermanno Rossi et al. JOURNAL OF HYPERTENSION
- Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension
- (2008) Ai Maekawa et al. JOURNAL OF HYPERTENSION
- Epithelial Sodium Channel in a Human Trophoblast Cell Line (BeWo)
- (2008) Silvana del Mónaco et al. JOURNAL OF MEMBRANE BIOLOGY
- Amiloride enhances the anticonvulsant action of various antiepileptic drugs in the mouse maximal electroshock seizure model
- (2008) Jarogniew J. Luszczki et al. JOURNAL OF NEURAL TRANSMISSION
- Acid Sensing Ion Channels in Dorsal Spinal Cord Neurons
- (2008) A. Baron et al. JOURNAL OF NEUROSCIENCE
- Pharmacological Properties of N-(3,5-Diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine Methanesulfonate (552-02), a Novel Epithelial Sodium Channel Blocker with Potential Clinical Efficacy for Cystic Fibrosis Lung Disease
- (2008) A. J. Hirsh et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Mechanisms of ENaC Regulation and Clinical Implications
- (2008) V. Bhalla et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Plasmin in Nephrotic Urine Activates the Epithelial Sodium Channel
- (2008) P. Svenningsen et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Epigenetics and the control of epithelial sodium channel expression in collecting duct
- (2008) Dongyu Zhang et al. KIDNEY INTERNATIONAL
- Assessment of the CFTR and ENaC association
- (2008) Bakhrom K. Berdiev et al. Molecular BioSystems
- Seizure termination by acidosis depends on ASIC1a
- (2008) Adam E Ziemann et al. NATURE NEUROSCIENCE
- Amiloride is neuroprotective in an MPTP model of Parkinson's disease
- (2008) Robert L. Arias et al. NEUROBIOLOGY OF DISEASE
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- (2008) WR Thelin et al. ORAL DISEASES
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- (2008) M. Ikeuchi et al. PAIN
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- (2008) Jiraporn Ousingsawat et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- A New Trick for an Old Dogma: ENaC Proteins as Mechanotransducers in Vascular Smooth Muscle
- (2008) Heather A. Drummond et al. PHYSIOLOGY
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- (2008) Jason M. Dwyer et al. PSYCHOPHARMACOLOGY
- Amiloride-sensitive NaCl taste responses are associated with genetic variation of ENaC α-subunit in mice
- (2007) Noriatsu Shigemura et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
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- (2007) Hisao Yamamura et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2007) Z XIONG et al. CURRENT OPINION IN PHARMACOLOGY
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- (2007) Samira C. Grifoni et al. MICROVASCULAR RESEARCH
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- (2007) Hsiu-Ying T. Yang et al. NEUROPEPTIDES
- Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach–brainstem axis
- (2007) Thomas Wultsch et al. PAIN
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