Article
Oncology
Jara Palomero, Carla Panisello, Maria Lozano-Rabella, Ricky Tirtakasuma, Judit Diaz-Gomez, Daniela Grases, Helena Pasamar, Laura Arregui, Eduard Dorca Duch, Esther Guerra Fernandez, Ana Vivancos, Carlos E. de Andrea, Ignacio Melero, Jordi Ponce, August Vidal, Josep Maria Piulats, Xavier Matias-Guiu, Alena Gros
Summary: Our study investigates the prevalence, phenotype, specificity and prognostic value of tumor infiltrating lymphocytes (TILs) in endometrial cancer (EC). We found that CD8(+)TILs expressing high levels of PD-1 and CD39 were associated with tumor reactivity and improved patient survival. The co-expression of inhibitory and activation markers on PD-1(hi) CD4(+) T cells was also observed, which accumulated antitumor T cells and correlated with prolonged survival in EC patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Shuangshuang Zhao, Lingli Chen, Yuqin Zang, Wenlu Liu, Shiqi Liu, Fei Teng, Fengxia Xue, Yingmei Wang
Summary: Lynch syndrome (LS) is caused by germline pathogenic variants in mismatch repair (MMR) genes, leading to LS-associated endometrial cancer (LS-EC) which has specific clinicopathologic features. Screening, diagnosis, surveillance, prevention and treatment for LS-EC have significantly advanced, with recommendations for universal LS screening among EC patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Oncology
Hans Raskov, Adile Orhan, Jan Pravsgaard Christensen, Ismail Gogenur
Summary: The functions and interactions between the innate and adaptive immune systems play a crucial role in anticancer immunity. Cytotoxic T cells with CD8 as the most effective effectors in the anticancer immune response form the basis of successful cancer immunotherapies. Advancements in genetically modified or synthetic receptors on cytotoxic T cells are being developed for future cancer treatment. Combinatory regimens may optimize treatment effects and reduce adverse events in cancer therapy.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Marta Mendiola, Victoria Heredia-Soto, Ignacio Ruz-Caracuel, Amparo Baillo, Jorge Luis Ramon-Patino, Francisco Javier Escudero, Maria Miguel, Alberto Pelaez-Garcia, Alicia Hernandez, Jaime Feliu, David Hardisson, Andres Redondo
Summary: This study aimed to establish and compare different approaches for assessing the MMR status in endometrial carcinomas. A total of 126 early-stage EC samples were analyzed using immunohistochemistry, PCR-based MSI, methylation-specific multiplex ligation-dependent probe amplification, and targeted next-generation sequencing. The study found that approximately 53.2% of the samples were MMR deficient, while 46.8% were MMR proficient. Additionally, 44.3% of the samples showed genetic or epigenetic alterations, with MLH1 promoter methylation being the most common event.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Angela Castoldi, Jennifer Lee, Daniel de Siqueira Carvalho, Fabricio Oliveira Souto
Summary: Immunometabolism has advanced our understanding of how cellular environment and nutrient availability regulate immune cell fate. Dysregulation of immune cell metabolism plays an essential role in the progression of diseases including breast cancer. CD8(+) T cells are crucial in the tumor microenvironment and their metabolic changes are important for tumor progression. However, identifying specific CD8(+) T cell subtypes in breast cancer remains challenging.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Oncology
Byung-Seok Kim, Da-Sol Kuen, Choong-Hyun Koh, Hyung-Don Kim, Seon Hee Chang, Sehui Kim, Yoon Kyung Jeon, Young-Jun Park, Garam Choi, Jiyeon Kim, Keon Wook Kang, Hye Young Kim, Suk-Jo Kang, Shin Hwang, Eui-Cheol Shin, Chang-Yuil Kang, Chen Dong, Yeonseok Chung
Summary: IL-17-producing cells promote terminal exhaustion of CD8(+) T cells and tumor progression in vivo, which can be reversed by blockade of IL-17 or ROR gamma t pathway. Human TCGA analyses reveal a strong positive correlation between type 17 and CD8(+) T cell exhaustion signature gene sets in multiple cancers, suggesting type 17 immunity as a promising target for cancer immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Mickey V. Patel, Zheng Shen, Marta Rodriguez-Garcia, Edward J. Usherwood, Laura J. Tafe, Charles R. Wira
Summary: Endometrial cancer suppresses host immune function by regulating the cytotoxic capacity of CD8+ T cells. CD103-CD8+ T cells are primarily responsible for killing of allogeneic target cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Correction
Oncology
Holly Russell, Katarzyna Kedzierska, Daniel D. Buchanan, Rachael Thomas, Emma Tham, Miriam Mints, Anne Keranen, Graham G. Giles, Melissa C. Southey, Roger L. Milne, Ian Tomlinson, David Church, Amanda B. Spurdle, Tracy A. O'Mara, Annabelle Lewis
Summary: The paper has been amended and the revised version can be accessed through the original article.
CLINICAL EPIGENETICS
(2021)
Article
Oncology
Wei Shi, Mackenzie Fijardo, Jeff P. Bruce, Jie Su, Wei Xu, Rachel Bell, Pierre-Antoine Bissey, Angela B. Y. Hui, John Waldron, Trevor J. Pugh, Kenneth W. Yip, Fei-Fei Liu
Summary: This study reveals the prognostic significance of CD8+ tumor-infiltrating lymphocytes (TILs) in naso-pharyngeal cancer (NPC) and suggests the potential of utilizing CD8+ lymphocytes for immunotherapy.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Sofia Edin, Bjorn Gylling, Xingru Li, Asa Stenberg, Anna Lofgren-Burstrom, Carl Zingmark, Bethany van Guelpen, Ingrid Ljuslinder, Agnes Ling, Richard Palmqvist
Summary: This study investigates the tumor immune cell infiltration in relation to well-established molecular markers of colorectal cancer (CRC). The results show an association between higher immune cell infiltration and microsatellite instability, and opposite relationships of BRAF and KRAS mutations with tumor infiltration of cytotoxic T cells. The positive prognostic importance of cytotoxic T cells is found in wild-type as well as KRAS and BRAF-mutated CRCs in both cohorts.
BRITISH JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Olga Adamczyk-Gruszka, Agata Horecka-Lewitowicz, Agnieszka Strzelecka, Monika Wawszczak-Kasza, Jakub Gruszka, Piotr Lewitowicz
Summary: This study analyzed the potential genes involved in the development of endometrial cancer in the Polish population and confirmed the key role of TP53 mutation in high-grade endometrial cancer, as well as the significance of FGFR2 mutation. Additionally, the study presented a wide range of mutations and polymorphism in endometrial cancer.
Article
Medical Informatics
Mohsin Bilal, Shan E. Ahmed Raza, Ayesha Azam, Simon Graham, Mohammad Ilyas, Ian A. Cree, David Snead, Fayyaz Minhas, Nasir M. Rajpoot
Summary: This study developed a novel deep learning pipeline to predict the status of key molecular pathways and mutations in colorectal cancer from tissue slides, and the results showed better performance compared to previous methods.
LANCET DIGITAL HEALTH
(2021)
Article
Oncology
Carlos Casas-Arozamena, Cristian Pablo Moiola, Ana Vilar, Marta Bouso, Juan Cueva, Silvia Cabrera, Victoria Sampayo, Efigenia Arias, Alicia Abalo, Angel Garcia, Ramon Manuel Lago-Leston, Sara Oltra, Eva Diaz, Juan Ruiz-Banobre, Rafael Lopez-Lopez, Gema Moreno-Bueno, Antonio Gil-Moreno, Eva Colas, Miguel Abal, Laura Muinelo-Romay
Summary: The analysis of mismatch repair proteins in solid tissue is the standard of care (SoC) for the microsatellite instability (MSI) characterization in endometrial cancer (EC). Uterine aspirates (UAs) or circulating-DNA (cfDNA) samples capture the intratumor heterogeneity and provide a more comprehensive and dynamic molecular diagnosis. MSI analysis by droplet-digital PCR (ddPCR) in UAs and cfDNA can provide a reliable tool to characterize and follow-up the disease.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Oncology
Camille Evrard, Jerome Alexandre
Summary: Endometrial cancers are highly affected by microsatellite instability, showing sensitivity to immunotherapy and requiring molecular biology for better understanding. The phenotype is poorly understood in ovarian cancer but does exist. Examination of literature reveals the importance of deficient mismatch repair/microsatellite instability in gynecological cancers and the potential therapeutic and prognostic implications.
Article
Multidisciplinary Sciences
Graham S. Erwin, Gamze Gursoy, Rashid Al-Abri, Ashwini Suriyaprakash, Egor Dolzhenko, Kevin Zhu, Christian R. Hoerner, Shannon M. White, Lucia Ramirez, Ananya Vadlakonda, Alekhya Vadlakonda, Konor von Kraut, Julia Park, Charlotte M. Brannon, Daniel A. Sumano, Raushun A. Kirtikar, Alicia A. Erwin, Thomas J. Metzner, Ryan K. C. Yuen, Alice C. Fan, John T. Leppert, Michael A. Eberle, Mark Gerstein, Michael P. Snyder
Summary: In this study, repeat DNA sequence expansions were identified in 2,622 cancer genomes across 29 cancer types. Most of these expansions were specific to certain subtypes of cancer and were found to be distributed non-uniformly in the genome, showing enrichment near potential cis-regulatory elements. One specific expansion, a GAAA-repeat expansion, was detected in 34% of renal cell carcinoma samples and was shown to decrease cell proliferation in a dose-dependent manner when targeted with a GAAA-targeting molecule in preliminary experiments. Overall, this research suggests that repeat DNA sequence expansions may be an important and unexplored source of genetic variation in human cancer, providing a comprehensive catalogue for further study.
Article
Obstetrics & Gynecology
Kensuke Sakai, Wataru Yamagami, Hiroko Machida, Yasuhiko Ebina, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Satoru Nagase, Takayuki Enomoto, Daisuke Aoki, Mikio Mikami
Summary: Patients with endometrial cancer who received radiotherapy had a significantly poorer prognosis compared to those who underwent surgery, with age, advanced stage, histological type, lymphadenectomy, and adjuvant radiotherapy being independent prognostic factors. Significant differences in survival rates were observed among patients receiving adjuvant therapy, chemotherapy, and no adjuvant therapy for stage I or II, and adjuvant chemotherapy showed significant differences compared to no adjuvant therapy and adjuvant radiotherapy for stage III or IV patients.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Yoshifumi Kasuga, Satoru Ikenoue, Hiroshi Nishio, Wataru Yamagami, Daigo Ochiai, Kiyoo Tanabe, Yasuhiro Tashima, Nobumaru Hirao, Kei Miyakoshi, Kenji Kasai, Yoshio Suda, Taiko Nemoto, Satoru Shiraishi, Hiroyuki Yoshida, Takashi Kurahashi, Kiyoshi Takamatsu, Shinya Iwasaki, Hiroshi Yamashita, Yasuo Akiba, Toru Arase, Sumiko Hara, Sakura Nakada, Mamoru Tanaka, Daisuke Aoki
Summary: This study investigated the risk factors associated with preterm delivery after conization. The results showed a higher incidence of nulliparity and a history of preterm delivery in the preterm delivery group. Additionally, the proportion of women with adenocarcinoma in situ (AIS) and cervical cancer was higher in the preterm delivery group. Multiple regression models revealed that cervical cancer or AIS and a short cervix in the second trimester increased the risk of preterm delivery in nulliparous women. Similarly, a history of preterm delivery, cervical cancer or AIS, and a short cervix in the second trimester increased the risk of preterm delivery in primiparous women.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Yusuke Matoba, Wataru Yamagami, Tatsuyuki Chiyoda, Yusuke Kobayashi, Eiichiro Tominaga, Kouji Banno, Daisuke Aoki
Summary: This study analyzed the risk factors for ovarian metastasis in endometrial cancer patients and identified the appropriate patient population for ovarian preservation surgery.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Oncology
Tomoko Yoshihama, Yuka Kuroda, Tatsuyuki Chiyoda, Mio Takahashi, Takuma Yoshimura, Keiko Saotome, Yoshiko Nanki, Kensuke Sakai, Yusuke Kobayashi, Wataru Yamagami, Daisuke Aoki
Summary: This study retrospectively evaluated the efficacy and safety of olaparib maintenance therapy in patients with platinum-sensitive recurrent ovarian cancer. The results showed that olaparib maintenance therapy is safe and no less effective than previous studies in the Japanese population.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Reina Ooka, Yoshiko Nanki, Wataru Yamagami, Miho Kawaida, Shimpei Nagai, Takuro Hirano, Kensuke Sakai, Takeshi Makabe, Tatsuyuki Chiyoda, Yusuke Kobayashi, Fumio Kataoka, Daisuke Aoki
Summary: This study compares the accuracy of preoperative endometrial biopsy and MRI with intraoperative frozen section in diagnosing endometrial cancer. The results show that there is no significant difference between preoperative and intraoperative diagnoses for histologic type and grade, but intraoperative diagnosis is more accurate in determining myometrial invasion.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Hiroaki Komatsu, Satoshi Nakagawa, Wataru Yamagami, Hideto Yamada, Susumu Miyashita, Kiyoshi Yoshino, Kei Kawana, Hiroaki Shibahara, Toshio Hamatani, Daisuke Aoki
Summary: The number of surgeries for benign gynecological diseases decreased by 8.5% in Japan in 2020 compared to 2019. There was a notable decrease in the number of total hysterectomies, while the number of robotic surgeries increased.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Oncology
Manabu Seino, Satoru Nagase, Tsuyoshi Ohta, Wataru Yamagami, Yasuhiko Ebina, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Takayuki Enomoto, Mikio Mikami
Summary: This study reviewed the clinicopathological characteristics of small cell neuroendocrine cervical cancer (SCNEC) and identified the optimal treatment. The rates of lymph-node and distant metastasis were significantly higher in T1b2 cases than T1b1 cases. For IB2 and T1bN1M0 SCNEC, the 5-year survival rate with surgery followed by chemotherapy was significantly higher than that with surgery followed by radiation therapy/concurrent chemoradiation therapy.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Guanliang Chen, Takashi Iwata, Masaki Sugawara, Hiroshi Nishio, Yuki Katoh, Iwao Kukimoto, Daisuke Aoki
Summary: The study aimed to identify predictors for the prognosis of CIN2 lesions and assess the prognostic value of the local immune response. Immunohistochemical analysis was conducted to determine the presence of p16-, MCM2-, or APOBEC3G-positive cells. Tumor-infiltrating lymphocytes (TILs) were scored using an automated system. The progression and regression rates of CIN3 were estimated, and a case-control study was performed to screen prognostic factors. CD4+ TIL infiltration was found to be related to CIN2 regression, suggesting its potential use for triaging patients.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Kimio Ushijima, Naotake Tsuda, Wataru Yamagami, Akira Mitsuhashi, Mikio Mikami, Nobuo Yaegashi, Takayuki Enomoto
Summary: The objective of this study was to examine the current trends in fertility-sparing treatment for young patients with atypical endometrial hyperplasia and endometrial cancer in Japan. A nationwide, retrospective survey was conducted, and data from 413 patients were collected. The study found that the most common treatments used were medroxyprogesterone alone or in combination with metformin, and the success rate of initial treatment was 78.2%. Factors such as histology, body mass index, treatment period, time to complete remission, maintenance therapy, and pregnancy had an impact on recurrence risk and pregnancy outcomes.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Shoko Kitazawa, Tatsuyuki Chiyoda, Kohei Nakamura, Kensuke Sakai, Tomoko Yoshihama, Hiroshi Nishio, Yusuke Kobayashi, Takashi Iwata, Kouji Banno, Wataru Yamagami, Hiroshi Nishihara, Daisuke Aoki
Summary: This study aimed to determine the potential availability and utility of gene panel testing clinically in gynecologic oncology. The study found that many patients had druggable gene alterations, but only 10.8% of them received the recommended treatment. TMB-H was mainly observed in cervical/endometrial cancer, suggesting its potential as a therapeutic biomarker of immune checkpoint inhibitors.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Virology
Gota Kogure, Kohsei Tanaka, Tomoya Matsui, Mamiko Onuki, Koji Matsumoto, Takashi Iwata, Iwao Kukimoto
Summary: HPV31 variants are predominantly of lineage B in Japanese women with cervical lesions. Deletions in the viral genome occur in the E1 to L1 genes, but retain the E6/E7 genes. High-frequency nonsynonymous nucleotide variations are found in the E1, E2, and E7 genes in cervical cancer samples, indicating positive selection during cervical cancer/precancer development.
Article
Oncology
Takuro Hirano, Eri Arai, Mao Fujimoto, Yuji Nakayama, Ying Tian, Nanako Ito, Takeshi Makabe, Wataru Yamagami, Nobuyuki Susumu, Daisuke Aoki, Yae Kanai
Summary: This study identified genes associated with recurrence risk in endometrial cancer through genome-wide DNA methylation analysis, and established DNA methylation diagnostic criteria for predicting recurrence risk in patients aged 40 years or less.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Tomoko Akahane, Kenta Masuda, Akira Hirasawa, Yusuke Kobayashi, Arisa Ueki, Miho Kawaida, Kumiko Misu, Kohei Nakamura, Shimpei Nagai, Tatsuyuki Chiyoda, Wataru Yamagami, Shigenori Hayashi, Fumio Kataoka, Kouji Banno, Kokichi Sugano, Hajime Okita, Kenjiro Kosaki, Hiroshi Nishihara, Daisuke Aoki
Summary: This study revealed a higher detection rate of TP53 pathogenic variants in patients undergoing RRSO with BRCA1/2 pathogenic variants compared to the control group, while no difference was observed in the frequency of p53 signatures between the two groups. TP53 sequencing analysis in several patients showed two different types of p53 signatures.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Hiroko Machida, Koji Matsuo, Koji Oba, Daisuke Aoki, Takayuki Enomoto, Aikou Okamoto, Hidetaka Katabuchi, Satoru Nagase, Masaki Mandai, Nobuo Yaegashi, Wataru Yamagami, Mikio Mikami
Summary: This study examined the associations between hospital treatment volume and survival outcomes for women with gynecologic malignancies. The results showed that treatments at high-volume centers had a positive impact on survival, and the proportion of treatments at high-volume centers has been decreasing recently.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)