Article
Cell Biology
Azusa Yoneshige, Man Hagiyama, Yasutoshi Takashima, Satoru Ueno, Takao Inoue, Ryuichiro Kimura, Yoshiki Koriyama, Akihiko Ito
Summary: The study shows that elevation of hydrostatic pressure directly upregulates the expression of Lcn2 in the retina, leading to neurotoxic effects on retinal cells. Modulating Lcn2 and iron levels could be a promising therapeutic approach for retinal degeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Karolina Rowinska, Piotr Baszuk, Emilia Rogoza-Janiszewska, Jakub Deptula, Wojciech Marciniak, Roza Derkacz, Marcin Lener, Cezary Cybulski, Magdalena Kiedrowicz, Magdalena Boer, Mariola Marchlewicz, Tadeusz Debniak, Jan Lubinski
Summary: Low serum iron concentration is associated with increased mortality in patients with malignant melanoma. Patients with low iron levels have significantly lower survival rates.
Article
Biochemistry & Molecular Biology
Bowen Lou, Jakob Morgenstern, Thomas Fleming, Carsten Sticht, Ingrid Hausser, Ruediger Hell, Hans-Peter Hammes, Julia Szendrodi, Jens Kroll, David Philipp Wohlfart, Chiara Simone Middel, Peter Paul Nawroth
Summary: Reactive carbonyl species (RCS) formed in metabolism can impair the function of DNA, proteins, and lipids, leading to organ complications. This study focuses on the regulation of glucose metabolism, hyperglycemia, and diabetic organ damage by RCS in zebrafish.
Article
Clinical Neurology
Elahe Amini, Mohammad Rohani, Alfonso Fasano, Zahra Azad, Shahnaz Miri, Seyed Amir Hassan Habibi, Maziar Emamikhah, Reza Mirshahi, Mohammad Taghi Joghataei, Zeinab Gholibeigian, Khalil Ghasemi Falavarjani
Summary: Observing pathological structural and functional neurovascular changes in NBIA patients may provide an opportunity to elucidate the underlying mechanisms and differential retinal biomarkers in NBIA subtypes.
MOVEMENT DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Miriam Ryl, Alexander Urbasik, Kaspar Gierke, Norbert Babai, Anneka Joachimsthaler, Andreas Feigenspan, Renato Frischknecht, Nina Stallwitz, Anna Fejtova, Jan Kremers, Julia von Wittgenstein, Johann Helmut Brandstaetter
Summary: The study investigated the impact of mutations in the Bassoon protein on the synaptic function and structure of photoreceptor cells in mice. Results showed that the synaptic defects were more severe in Bsn(gt/gt) mice, while expression of the Bsn(gt) allele led to cone photoreceptor death and neurite sprouting in the outer retina.
Article
Chemistry, Multidisciplinary
Qiwen Mo, Wei Song, Zheyong Xue, Jifeng Yuan
Summary: In this study, the researchers found that inactivating a subset of alcohol dehydrogenases and an aldehyde dehydrogenase in yeast allowed for the accumulation of retinal. By optimizing beta-carotene synthesis, they were able to produce retinal in yeast, providing a platform for the future industrial development of bio-based retinal.
Article
Developmental Biology
Jie Dong, Xiangyu Guo, Chenxi Qian, Jingjing Wang, Hui Lei, Shuqiang Chen, Xiaohong Wang
Summary: IVF leads to enlarged mouse placentas with excessive glycogen storage in late pregnancy. Multiple genes involved in glycogen generation and glycogenolysis had lower mRNA levels in IVF placentas. Moreover, the expression levels of glycogen synthase, phosphorylase, Glut1, and Glut3 were significantly decreased in IVF placentas. The phosphorylation activities of Akt Ser473 and Gsk3 beta Ser9 were inhibited in IVF placentas.
Article
Chemistry, Analytical
Minghui Wu, Hogi Hartanto, Siying Wu, Tianyi Jiang, Gaobo Wang, Ting-Hsuan Chen
Summary: This article introduces a portable method for visualizing alpha-fetoprotein (AFP) levels in serum, which can be used as a biomarker for various cancers and for screening congenital disorders. It utilizes magnetic microparticles and polystyrene microparticles to bind with AFP simultaneously, and a microfluidic chip with a magnetic separator to separate unconnected polystyrene microparticles, enabling the visualization of AFP levels. The device can be used in both sensitive mode (70 min incubation) and rapid mode (15 min incubation), with limits of detection of 15.8 ng/ml and 34.3 ng/ml, respectively, in undiluted serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Biochemistry & Molecular Biology
Debora Napoli, Martina Biagioni, Federico Billeri, Beatrice Di Marco, Noemi Orsini, Elena Novelli, Enrica Strettoi
Summary: The study reveals structural abnormalities in the RPE of RP patients, leading to dysfunction of the inner barrier. Findings also suggest a correlation between the extent of photoreceptor loss and interruption zones of ZO-1. Treatment with dexamethasone in RP mice not only rescues cones but also restores RPE structure, highlighting a potential feedback loop for simultaneous protection of cones and the RPE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Developmental Biology
Chang Cao, Mark D. Fleming
Summary: Fetal development relies on adequate iron supply by the placenta, and the iron transporter Fpn1 plays an essential role in this process. Using gene manipulation techniques, we created a specific Cre mouse model, which provides direct evidence for the essential role of Fpn1 in placental iron transport.
Article
Ophthalmology
Mark L. Derbyshire, Sruti Akula, Austin Wong, Karisa Rawlins, Evelyn B. Voura, William J. Brunken, Michael E. Zuber, Sabine Fuhrmann, Anne M. Moon, Andrea S. Viczian
Summary: This study investigated the role of T-box factor Tbx3 in retinal vasculature formation. Conditional removal of Tbx3 resulted in hypovascular retina, reduced retinal ganglion cells, and abnormal retinal vasculature formation. These findings demonstrate the importance of Tbx3 in normal eye formation and provide a potential genetic model for retinal hypovascular diseases.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Urology & Nephrology
Daniela Egli-Spichtig, Ahmad Kamal Hamid, Eva Maria Pastor Arroyo, Markus Ketteler, Andrzej Wiecek, Alexander R. Rosenkranz, Andreas Pasch, Horst Lorenz, Burkhard Hellmann, Michael Karus, Richard Ammer, Isabel Rubio-Aliaga, Carsten A. Wagner
Summary: This study aimed to assess the effects of combined treatment with nicotinamide modified release (NAMR) and phosphate binders (PB) on serum phosphate, FGF23, inflammation, and iron metabolism in ESKF patients. The results showed that iFGF23 was a better predictor of serum phosphate changes induced by NAMR and PB treatment. Furthermore, serum phosphate and iPTH were the best predictors of FGF23. These findings suggest that lowering serum phosphate in ESKF patients may highly depend on iFGF23.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Neurosciences
Katie K. N. Tran, Vickie H. Y. Wong, Anh Hoang, David I. Finkelstein, Bang V. Bui, Christine T. O. Nguyen
Summary: This study investigates the retinal changes in a PD model of alpha-SYN overexpression and their correlation with the presence of retinal alpha-SYN. The findings suggest that these retinal signatures may serve as useful in vivo endpoints for PD drug discovery.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Engineering, Aerospace
Xiao Wen Mao, Seta Stanbouly, Bella Chieu, Vijayalakshmi Sridharan, Antino R. Allen, Marjan Boerma
Summary: This study investigates the effects of simulated galactic cosmic rays on the retina of male and female mice. The results show that low-dose ionizing radiation can cause oxidative damage to the retina and alter blood-retinal barrier integrity, with differences observed between males and females. Further research is needed to understand the mechanisms of spaceflight-induced ocular findings.
Article
Radiology, Nuclear Medicine & Medical Imaging
Anthony Tessier, Anthony J. Ruze, Isabelle Varlet, Estelle M. H. Laib, Emilien Royer, Monique Bernard, Angele Viola, Teodora-Adriana Perles-Barbacaru
Summary: This study aims to validate a quantitative time-resolved MRI technique for mapping the kinetics of contrast agent in the brain upon intraperitoneal administration. It was a prospective study using mice as an animal model.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)