Article
Endocrinology & Metabolism
Reshma A. Pillai, Mohammed O. Islam, Preben Selvam, Neha Sharma, Anne H. Y. Chu, Oliver C. Watkins, Keith M. Godfrey, Rohan M. Lewis, Shiao Y. Chan
Summary: Research revealed that placental inositol content was lower in gestational diabetes patients compared to non-diabetic mothers. Maternal mid-gestation glycemia was negatively associated with placental inositol content, while fasting glycemia levels were negatively correlated with the expression levels of inositol synthesis enzyme and transport proteins in the placenta.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Max T. Aung, Pahriya Ashrap, Deborah J. Watkins, Bhramar Mukherjee, Zaira Rosario, Carmen M. Velez-Vega, Akram N. Alshawabkeh, Jose F. Cordero, John D. Meeker
Summary: Maternal lipidomic signatures associated with preterm birth and neonatal anthropometric parameters were characterized, revealing potential biomarkers for pregnancy outcomes. Fine omics-scale analysis of the maternal lipidome may offer more informative insights compared to whole class level lipid analysis.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Emmanuel Cosson, Eric Vicaut, Sopio Tatulashvili, Jean -Jacques Portal, Charlotte Nachtergaele, Meriem Sal, Narimane Berkane, Sara Pinto, Amel Rezgani, Lionel Carbillon, Helene Bihana
Summary: This study aims to evaluate the risk of large-for-gestational-age (LGA) infants in women with gestational diabetes mellitus (GDM) and found no residual risk of LGA infants in women treated for GDM.
DIABETES & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Ulla Sovio, Neil Goulding, Nancy McBride, Emma Cook, Francesca Gaccioli, D. Stephen Charnock-Jones, Deborah A. Lawlor, Gordon C. S. Smith
Summary: The study found that a metabolite ratio originally developed for predicting FGR also accurately predicts LGA birth weight and is inversely associated with birth weight across the whole range.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Li-Rong He, Li Yu, Yong Guo
Summary: There has been a decrease in birth weight and prevalence of large for gestational age (LGA) among offspring of women with gestational diabetes mellitus (GDM) in southern China. However, the risk of LGA remains stable at a relatively high level for GDM women over the past 10 years.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Rong Huang, Yu Dong, Emile Levy, Pierre Julien, Isabelle Marc, Hua He, Ya-Jie Xu, Shu-Qin Wei, William D. Fraser, Zhong-Cheng Luo
Summary: The study found that in infancy, LGA was not associated with circulating leptin and adiponectin levels, but weight gain and current BMI may be related to adiponectin levels. Female sex was associated with lower total and HMW adiponectin concentrations.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Sandra Szlapinski, Brenda Strutt, Madeline Deane, Edith Arany, Jamie Bennett, David J. Hill
Summary: The study found that artemisinin and acetone both improve glucose tolerance, mainly due to acetone. In non-pregnant mice, acetone treatment can promote α-cell to β-cell conversion. However, there was no significant change in β-cell mass during pregnancy or post-partum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Imasha Upulini Jayasinghe, Iresha Sandamali Koralegedara, Suneth Buddhika Agampodi
Summary: This study aimed to determine the impact of early pregnancy hyperglycemia on having a large for gestational age neonate. The results showed that women with gestational diabetes mellitus and previously undiagnosed diabetes had a higher risk of giving birth to large for gestational age babies. The use of IADPSG criteria for risk assessment in early pregnancy in high-risk populations is recommended.
ACTA DIABETOLOGICA
(2022)
Article
Multidisciplinary Sciences
Penny Lam, Brendan J. Mein, Ronald J. Benzie, John T. Ormerod, Kristy P. Robledo, Emily J. Hibbert, Ralph K. Nanan
Summary: This study analyzed the effects of maternal diabetes mellitus and body mass index on central and peripheral fat accrual in large for gestational age offspring. The results showed that diabetes mellitus was associated with increased abdominal and mid-thigh fat accumulation in fetuses, independent of BMI.
Article
Developmental Biology
Cyrielle Titaux, Camille Ternynck, Myrtille Pauchet, Morgane Stichelbout, Gabriel Bizet, Patrice Maboudou, Brigitte Onraed, Guillaume Clement, Xavier Lenne, Guillaume Potier, Damien Subtil, Anastasia Chudzinski
Summary: In this study, a physiological development curve for total alkaline phosphatase (tALP) in low-risk pregnancies was established and factors influencing tALP values were evaluated. The results showed that tALP levels varied in different stages of pregnancy, and factors such as chronic histiocytic intervillositis, cholestasis, multiple pregnancies, liver disease, preeclampsia, smoking, and low weight for gestational age were associated with a significant increase in tALP, while gestational diabetes was associated with a discrete decrease in tALP.
Article
Public, Environmental & Occupational Health
Sanna Mustaniemi, Hilkka Nikkinen, Aini Bloigu, Anneli Pouta, Risto Kaaja, Johan G. Eriksson, Hannele Laivuori, Mika Gissler, Eero Kajantie, Marja Vaarasmaki
Summary: The study showed that normal gestational weight gain is associated with a lower risk of large-for-gestational-age infants and lower birth weight standard deviation scores in the presence of gestational diabetes and maternal obesity.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Endocrinology & Metabolism
Samuel Furse, Albert Koulman, Susan E. Ozanne, Lucilla Poston, Sara L. White, Claire L. Meek
Summary: Gestational diabetes in obese women is associated with elevated levels of specific lipids related to de novo lipogenesis, which are also correlated with measures of offspring adiposity. These findings suggest that the effects of GDM on neonatal body composition may not be solely due to hyperglycemia, but may involve other pathways.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Joseph Phillipos, Thao Vi Luong, Deborah Chang, Suresh Varadarajan, Paul Howat, Lauren Hodgson, Deb Colville, Judy Savige
Summary: The study compared the effects of gestational diabetes, pregnancy-associated hypertension, and small-for-gestational age babies on systemic small vessel calibre examined in the retina. Results showed that women with gestational diabetes, pregnancy-associated hypertension, or small-for-gestational age babies had reduced mean retinal arterial calibre, with the greatest reduction seen in pregnancy-associated hypertension and small-for-gestational age babies.
FRONTIERS IN MEDICINE
(2023)
Article
Environmental Sciences
Weili Yang, Joseph M. Braun, Ann M. Vuong, Zana Percy, Yingying Xu, Changchun Xie, Ranjan Deka, Antonia M. Calafat, Maria Ospina, Heather H. Burris, Kimberly Yolton, Kim M. Cecil, Bruce P. Lanphear, Aimin Chen
Summary: Organophosphate esters (OPEs) have been found to be developmental toxicants in animal studies, but limited evidence is available in humans. This study investigated the association between gestational exposure to OPEs and gestational age, preterm birth, and newborn anthropometric measures. The findings suggest that certain OPEs may be associated with these outcomes, with some associations being specific to certain time windows and infant sex.
ENVIRONMENTAL POLLUTION
(2023)
Article
Nutrition & Dietetics
Xinli Song, Jing Shu, Senmao Zhang, Letao Chen, Jingyi Diao, Jinqi Li, Yihuan Li, Jianhui Wei, Yiping Liu, Mengting Sun, Tingting Wang, Jiabi Qin
Summary: This study reveals the impact of maternal pre-pregnancy BMI status on the risk of macrosomia and LGA through the mediation of GDM. Being overweight or obese before pregnancy increases the risk of macrosomia and LGA independently as well as partially mediated by GDM.
Article
Endocrinology & Metabolism
William R. Boyer, James R. Churilla, Samantha F. Ehrlich, Scott E. Crouter, Lyndsey M. Hornbuckle, Eugene C. Fitzhugh
JOURNAL OF DIABETES
(2018)
Article
Oncology
Marie C. Bradley, Assiamira Ferrara, Ninah Achacoso, Samantha F. Ehrlich, Charles P. Quesenberry, Laurel A. Habel
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2018)
Article
Endocrinology & Metabolism
Monique M. Hedderson, Susan D. Brown, Samantha F. Ehrlich, Ai-Lin Tsai, Yeyi Zhu, Charles P. Quesenberry, Yvonne Crites, Assiamira Ferrara
Article
Multidisciplinary Sciences
Ai Kubo, Assiamira Ferrara, Susan D. Brown, Samantha F. Ehrlich, Ai-Lin Tsai, Charles P. Quesenberry, Yvonne Crites, Monique M. Hedderson
Article
Public, Environmental & Occupational Health
Meghana D. Gadgil, Samantha F. Ehrlich, Yeyi Zhu, Susan D. Brown, Monique M. Hedderson, Yvonne Crites, Assiamira Ferrara
JOURNAL OF WOMENS HEALTH
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
William Boyer, Samantha Ehrlich, Scott Crouter, James Churilla, Eugene Fitzhugh
Article
Obstetrics & Gynecology
Susan D. Brown, Monique M. Hedderson, Samantha F. Ehrlich, Maren N. Galarce, Ai-Lin Tsai, Charles P. Quesenberry, Assiamira Ferrara
BMC PREGNANCY AND CHILDBIRTH
(2019)
Meeting Abstract
Endocrinology & Metabolism
Samantha F. Ehrlich, Romain Neugebauer, Juanran Feng, Monique M. Hedderson, Assiamira Ferrara
Article
Multidisciplinary Sciences
Samantha F. Ehrlich, Monique M. Hedderson, Fei Xu, Assiamira Ferrara
Article
Public, Environmental & Occupational Health
Samantha F. Ehrlich, Romain S. Neugebauer, Juanran Feng, Monique M. Hedderson, Assiamira Ferrara
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2020)
Article
Endocrinology & Metabolism
Assiamira Ferrara, Monique M. Hedderson, Susan D. Brown, Samantha F. Ehrlich, Ai-Lin Tsai, Juanran Feng, Maren Galarce, Santica Marcovina, Patrick Catalano, Charles P. Quesenberry
LANCET DIABETES & ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Samantha F. Ehrlich, Assiamira Ferrara, Monique M. Hedderson, Juanran Feng, Romain Neugebauer
Summary: Exercise during the first trimester of pregnancy reduces the risks of abnormal screening and gestational diabetes mellitus (GDM). The study suggests that engaging in at least 38 minutes of moderate-intensity exercise per day may help prevent GDM.
Review
Endocrinology & Metabolism
Samantha F. Ehrlich
Summary: Research suggests that infants born to women with gestational diabetes are more likely to be male, while women with pregestational diabetes may have a preference for female offspring. Disease-related maternal stress in diabetic women could result in the selective termination of male fetuses, indicating a potential impact on the sex ratio. Further study of pregestational diabetes is crucial for a deeper understanding of the sex ratio phenomenon.
CURRENT DIABETES REPORTS
(2021)
Letter
Obstetrics & Gynecology
Samantha F. Ehrlich, Bethany Rand, Nikki B. Zite, Kimberly B. Fortner, Alissa Paudel, Christina Pet, Jill Maples
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Endocrinology & Metabolism
Sylvia E. Badon, Yeyi Zhu, Sneha B. Sridhar, Fei Xu, Catherine Lee, Samantha F. Ehrlich, Charles P. Quesenberry, Monique M. Hedderson
JOURNAL OF THE ENDOCRINE SOCIETY
(2018)