Article
Endocrinology & Metabolism
Louise Fritsche, Martin Heni, Sabine S. Eckstein, Julia Hummel, Anette Schurmann, Hans-Ulrich Haring, Hubert Preissl, Andreas L. Birkenfeld, Andreas Peter, Andreas Fritsche, Robert Wagner
Summary: This study aimed to investigate the incretin response during an oral glucose tolerance test (OGTT) in pregnant women. The results showed that insulin secretion was lower in women with gestational diabetes mellitus (GDM), but the increase in GLP-1 was only associated with insulin secretion in GDM women. Additionally, postprandial GLP-1 levels were negatively associated with birth weight.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Tina Linder, Anna Eder, Cecile Monod, Ingo Rosicky, Daniel Eppel, Katharina Redling, Franziska Geissler, Evelyn A. Huhn, Irene Hosli, Christian S. Gobl
Summary: This study aimed to evaluate the impact of prepregnancy overweight on treatment modalities and pregnancy outcomes in gestational diabetes mellitus (GDM). The results showed that an increased BMI in pregnant women was associated with a higher likelihood of needing glucose lowering medication and an increased risk of adverse pregnancy outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Penny Lam, Brendan J. Mein, Ronald J. Benzie, John T. Ormerod, Kristy P. Robledo, Emily J. Hibbert, Ralph K. Nanan
Summary: This study analyzed the effects of maternal diabetes mellitus and body mass index on central and peripheral fat accrual in large for gestational age offspring. The results showed that diabetes mellitus was associated with increased abdominal and mid-thigh fat accumulation in fetuses, independent of BMI.
Review
Medicine, General & Internal
Sudipta Sarker Mou, Clare Gillies, Jiamiao Hu, Marianna Danielli, Bassel Hamameeh Al Wattar, Kamlesh Khunti, Bee Kang Tan
Summary: Gestational diabetes mellitus (GDM) is a common metabolic disorder in pregnancy, and it is associated with maternal and fetal complications. The HbA1c level at 24-28 weeks of pregnancy may predict the development of fetal macrosomia or large for gestational age (LGA) in women with GDM. A systematic review and meta-analysis showed that women with high HbA1c values had a higher risk of giving birth to an LGA baby. Further research is needed to evaluate the utility of HbA1c levels in predicting the delivery of a baby with fetal macrosomia or LGA in pregnant women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Marilia Silva Paulo, Noor Motea Abdo, Rita Bettencourt-Silva, Rami H. Al-Rifai
Summary: Gestational Diabetes Mellitus (GDM) prevalence in Europe is around 11%, with the highest prevalence in pregnant women in Eastern European countries reaching 31.5%. Findings highlight the need for vigilant public health awareness campaigns about the risk factors associated with developing GDM.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Ermioni Tsarna, Anna Eleftheriades, Efthymia Tsomi, Georgia Ziogou, Panagiotis Vakas, Theodoros Panoskaltsis, Panagiotis Christopoulos
Summary: This study found that there was no association between certain food categories and gestational diabetes mellitus (GDM) diagnosis. However, intake of cereals and fruits and vegetables appeared to have a protective effect against GDM, while frequent tea consumption was linked to a higher risk. These results highlight the importance of changing dietary habits during pregnancy to adjust one's risk of metabolic pregnancy complications, such as GDM.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Nadia Abu Samra, Herbert F. Jelinek, Habiba Alsafar, Farah Asghar, Muhieddine Seoud, Shahad M. Hussein, Hisham M. Mubarak, Siddiq Anwar, Mashal Memon, Nariman Afify, Ridda Manzoor, Zahrah Al-Homedi, Wael Osman
Summary: Gestational diabetes mellitus is a common complication during pregnancy, caused by genetic, epigenetic, and environmental factors. However, its underlying mechanisms are still unclear, and molecular research in this field is lagging. Early detection of metabolic changes and related genetic and epigenetic factors is crucial for predicting adverse pregnancy outcomes and future pathologies in GDM women and their children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Xiao-guang Yin, Peng Wang, Mei-ting Zhou, De-qin Li, Rui-xue Tao, Fang-biao Tao, Yang Wang, Peng Zhu
Summary: The timing of gestational diabetes mellitus (GDM) diagnosis and gestational weight gains (GWG) during pregnancy are associated with the growth trajectory of children from perinatal to early childhood. GDM diagnosed before 26 weeks increases the risk of fetal overgrowth and higher birth weight, as well as higher BMI peak within 48 months. Maternal early GDM diagnosis and excessive gestational weight gains have additive impacts on offspring overgrowth, with higher levels of hsCRP observed in the early EGWG group.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Immunology
Svenja Schrader, Laura Unverdorben, Stefan Hutter, Julia Knabl, Elisa Schmoeckel, Sarah Meister, Alaleh Zati Zehni, Susanne Beyer, Theresa Vilsmaier, Sven Mahner, Udo Jeschke, Thomas Kolben, Christina Buschmann, Lucia Keilmann
Summary: This study provides evidence for the involvement of galectins in chronic inflammation during pregnancy with gestational diabetes mellitus.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Israel Yoles, Eyal Sheiner, Tamar Wainstock
Summary: First pregnancy without GDM complicated by hypertensive disorders, perinatal mortality, maternal obesity, and fetal macrosomia was associated with an increased risk for GDM in the subsequent pregnancy. Women with these complications may benefit from early detection of GDM in their subsequent pregnancy.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Review
Nutrition & Dietetics
Jinhao Mu, Xian Guo, Yanbing Zhou, Guoxia Cao
Summary: Gut dysbiosis is associated with gestational diabetes mellitus (GDM), and probiotics can reduce blood sugar levels and regulate glucose and lipid metabolism in both mother and offspring. This systematic review and meta-analysis found that probiotics/synbiotics could improve fasting plasma glucose, fasting serum insulin, insulin resistance, and total cholesterol levels in women with GDM. The use of specific probiotic supplementation may be a promising strategy for the prevention and treatment of GDM.
Article
Endocrinology & Metabolism
Gergely A. Visolyi, Attila Kun, Orsolya Szalai, Mark M. Svebis, Beatrix A. Domjan, Laszlo Zsirai, Adam G. Tabak
Summary: Untreated 'mild' gestational diabetes mellitus (GDM) in pregnant women had worse pregnancy outcomes compared to normal glucose tolerant women, but these differences were explained by pre-pregnancy BMI after adjustment.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Medicine, General & Internal
Grammata Kotzaeridi, Julia Blaetter, Daniel Eppel, Ingo Rosicky, Veronica Falcone, Gabriela Adamczyk, Tina Linder, Guelen Yerlikaya-Schatten, Karen Weisshaupt, Wolfgang Henrich, Andrea Tura, Christian S. Goebl
Summary: Women with a history of gestational diabetes mellitus show alterations in glucose metabolism at the beginning of a subsequent pregnancy, increasing the risk of gestational diabetes recurrence.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Caro Minschart, Astrid Lammertyn, Paul Van Crombrugge, Carolien Moyson, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Toon Maes, Els Dufraimont, Nele Roggen, Christophe De Block, Yves Jacquemyn, Farah Mekahli, Katrien De Clippel, Annick Van Den Bruel, Anne Loccufier, Annouschka Laenen, Roland Devlieger, Chantal Mathieu, Katrien Benhalima
Summary: The level of gestational weight gain (GWG) during pregnancy is associated with adverse pregnancy outcomes in women with gestational diabetes (GDM) compared to women with normal glucose tolerance (NGT). Low GWG below recommended levels frequently occurs in GDM women without increased risk for adverse outcomes. Excessive GWG is associated with increased risk for neonatal hypoglycemia and worse metabolic profile postpartum in GDM women, and with higher rates of instrumental delivery and larger infants in NGT women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Ethan K. Gough, Thaddeus J. Edens, Hyun Min Geum, Iman Baharmand, Sandeep K. Gill, Ruairi C. Robertson, Kuda Mutasa, Robert Ntozini, Laura E. Smith, Bernard Chasekwa, Florence D. Majo, Naume Tavengwa, Batsirai Mutasa, Freddy Francis, Lynnea Carr, Joice Tome, Rebecca J. Stoltzfus, Lawrence H. Moulton, Andrew J. Prendergast, Jean H. Humphrey, Amee R. Manges
Summary: The study in rural Zimbabwe found that the maternal intestinal microbiome composition and functions during pregnancy are closely related to infant birth weight and growth outcomes, with resistant starch-degrading bacteria playing a key role in predicting birth outcomes.