Review
Pediatrics
George Daskalakis, Alexandros Psarris, Antonios Koutras, Zacharias Fasoulakis, Ioannis Prokopakis, Antonia Varthaliti, Christina Karasmani, Thomas Ntounis, Ekaterini Domali, Marianna Theodora, Panos Antsaklis, Kalliopi I. Pappa, Angeliki Papapanagiotou
Summary: Preterm birth, a major public health concern worldwide, is the leading cause of neonatal morbidity and mortality. This review analyzes the association between infections and premature birth. Intrauterine infection/inflammation is commonly associated with spontaneous preterm birth. Inflammation-induced overproduction of prostaglandins can lead to uterine contractions and contribute to preterm delivery. Various pathogens, including Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Gardnerella vaginalis, Ureaplasma urealyticum, Mycoplasma hominis, Actinomyces, Candida spp., and Streptococcus spp., have been implicated in premature delivery, chorioamnionitis, and neonatal sepsis. Further research is needed to develop effective preventive methods and reduce neonatal morbidity.
Article
Nutrition & Dietetics
Valerie Steckle, Oksana Shynlova, Stephen Lye, Alan Bocking
Summary: The innate immune system plays an important role in the onset of labor, and maternal antenatal physical activity can influence immune function and timing of labor. There were no significant differences in exercise patterns between women who later had spontaneous preterm labor and those who delivered at term. Plasma concentration of IL-10 was significantly higher in women with spontaneous preterm labor, while TNF-alpha, IL-8, and MCP-1 concentrations were increased at 27 weeks gestational age.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Medicine, General & Internal
Marcelo Farias-Jofre, Roberto Romero, Jose Galaz, Yi Xu, Derek Miller, Valeria Garcia-Flores, Marcia Arenas-Hernandez, Andrew D. Winters, Bruce A. Berkowitz, Robert H. Podolsky, Yimin Shen, Tomi Kanninen, Bogdan Panaitescu, Catherine R. Glazier, Roger Pique-Regi, Kevin R. Theis, Nardhy Gomez-Lopez
Summary: This study investigates the role of IL-6 and IL-1 alpha in sterile intra-amniotic inflammation (SIAI) and their impact on preterm birth and neonatal outcomes. The researchers found that IL-6 plays a critical role in the inflammatory response and that IL-1 alpha injection leads to preterm birth and neonatal mortality. Prenatal treatment with an IL-6R blockade shows promising results in preventing preterm birth and improving neonatal outcomes.
Review
Nutrition & Dietetics
Kathryn Burge, Frederico Vieira, Jeffrey Eckert, Hala Chaaban
Summary: NEC is a significant cause of morbidity and mortality in neonates, with formula feeding being one of the risk factors. The differences in structure and nutritional components between breast milk and formula may affect the digestion and absorption of lipids, which could impact premature infants at risk for NEC.
Article
Microbiology
Fardou H. Heida, Elisabeth M. W. Kooi, Josef Wagner, Thi-Yen Nguyen, Jan B. F. Hulscher, Anne G. J. F. van Zoonen, Arend F. Bos, Hermie J. M. Harmsen, Marcus C. de Goffau
Summary: The intestinal microbiome of preterm infants is affected by the mode of delivery and infant weight. As infants gradually increase in weight, a transition in microbiome composition is observed.
Review
Biochemistry & Molecular Biology
Silke Haeusler, Nicola J. Robertson, Klervi Golhen, John van den Anker, Katie Tucker, Thomas K. Felder
Summary: Despite improvements in survival after preterm birth, the long-term cognitive and behavioral consequences remain a significant challenge. Neuroprotective treatment options, such as melatonin, are urgently needed to improve neurodevelopmental outcomes in preterm infants. Melatonin can alleviate inflammatory and oxidative stress and may have a direct neurotrophic impact, making it a promising therapeutic option.
Article
Medicine, General & Internal
Erez Tsumi, Itai Hazan, Tamir Regev, Samuel Leeman, Chiya Barrett, Noa Fried Regev, Eyal Sheiner
Summary: Objective of this study was to investigate the association between the degree of prematurity and long-term ophthalmic morbidity among preterm infants. A retrospective cohort study was conducted using data from 243,363 deliveries. The results showed that the risk of ophthalmic-related hospitalization gradually decreased as gestational age increased.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Critical Care Medicine
Viraraghavan Vadakkencherry Ramaswamy, Thangaraj Abiramalatha, Tapas Bandyopadhyay, Nasreen Banu Shaik, Abdul Kareem S. Pullattayil, Francesco Cavallin, Charles Christoph Roehr, Daniele Trevisanuto
Summary: This study aimed to investigate the impact of delivery room continuous positive airway pressure (DRCPAP) on the outcomes of preterm neonates in low- and middle-income countries (LMICs) compared to other interventions. The results suggested that the current evidence is not sufficient to support the use of DRCPAP, but there was also no evidence of harm. Future research should focus on identifying barriers to improving the effectiveness of DRCPAP in LMICs.
Article
Obstetrics & Gynecology
Gary M. Shaw, Jonathan A. Mayo, Michael L. Eisenberg, Ralph Catalano, David K. Stevenson
Summary: An analysis of over 10 million California births from 1991 to 2012 revealed that disparities in spontaneous preterm birth risk among women of different race/ethnic groups were influenced by the sex of the infants. Male-to-female ratios in preterm births were generally higher for all groups except non-Hispanic blacks, where the ratios remained similar to term births. Possible explanations for these differences include factors such as inflammation, stress, and other environmental influences.
AMERICAN JOURNAL OF PERINATOLOGY
(2021)
Article
Immunology
Sara De Biasi, Anita Neroni, Milena Nasi, Domenico Lo Tartaro, Rebecca Borella, Lara Gibellini, Laura Lucaccioni, Emma Bertucci, Licia Lugli, Francesca Miselli, Luca Bedetti, Isabella Neri, Fabrizio Ferrari, Fabio Facchinetti, Alberto Berardi, Andrea Cossarizza
Summary: Preterm newborns have altered innate immunity and impaired monocyte function, as well as a pro-inflammatory plasma profile. Our research found higher proportions of immature monocytes and CD56(+/-)CD16(+)NK cells, and lower proportions of classical monocytes in preterm infants compared to full-term infants. Gene expression analysis revealed lower inflammasome activation and higher concentrations of alarmin S100A8 in preterm infants' monocytes and plasma. These findings may explain the increased susceptibility of preterm infants to infections and have implications for developing new therapeutic strategies.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Pediatrics
Tiina Teivaanmaki, Lotta Hallamaa, Krista Rantakari, Sture Andersson, Markus Leskinen
Summary: The study found that deliveries of premature infants peaked on Fridays. Premature infants born on Fridays had lower mortality rates compared to other weekdays. Infants born during nighttime had a higher risk of intraventricular hemorrhage and necrotizing enterocolitis.
Article
Infectious Diseases
Kanwal Raghav, Seerat Anand, Anirudh Gothwal, Pooja Singh, Arvind Dasari, Michael J. Overman, Jonathan M. Loree
Summary: Although racial/ethnic disparities in healthcare have long been recognized, recent discourse around structural racism will hopefully lead to improved transparency surrounding these issues. Despite the disproportionate impact of COVID-19 on racial/ethnic minorities, the extent and reliability of race reporting in COVID research is unclear. Research during the first wave of the pandemic lacked appropriate racial/ethnicity reporting, but mirrored COVID-19 incidence in the USA, highlighting the increased burden of infection among Black individuals.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Physiology
Daniele De Luca, Raquel Arroyo, Silvia Foligno, Chiara Autilio, Lhousseine Touqui, Paul S. Kingma
Summary: This study aimed to investigate the association between surfactant protein-D (SP-D) expression and clinical outcomes in extremely preterm neonates. The results showed that SP-D levels increased with gestational age and were inversely associated with the development of bronchopulmonary dysplasia (BPD). SP-D was also correlated with the duration of hospital stay, invasive ventilation, and total sPLA2 activity.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Medical Laboratory Technology
Jose Galaz, Kenichiro Motomura, Roberto Romero, Zhenjie Liu, Valeria Garcia-Flores, Li Tao, Yi Xu, Bogdan Done, Marcia Arenas-Hernandez, Tomi Kanninen, Marcelo Farias-Jofre, Derek Miller, Adi L. Tarca, Nardhy Gomez-Lopez
Summary: Preterm birth is a major cause of neonatal morbidity and mortality worldwide. Sterile intra-amniotic inflammation, triggered by alarmins, is a common condition associated with preterm labor. The NLRP3 inflammasome has been implicated in this process, but its mechanisms are not fully understood. By studying Nlrp3-/- mice, researchers found that NLRP3 deficiency prevents preterm birth and neonatal mortality by inhibiting premature labor activation and reducing inflammation. Furthermore, both maternal and fetal Nlrp3 signaling contribute to alarmin-induced preterm birth. These findings highlight the importance of targeting NLRP3 signaling to prevent adverse perinatal outcomes.
TRANSLATIONAL RESEARCH
(2023)
Article
Microbiology
Zhenjie Zhang, Jingjing Jiang, Zhenghong Li, Weilin Wan
Summary: Bronchopulmonary dysplasia (BPD) is a devastating form of chronic lung disease that develops in preterm infants, speculated to arise from abnormal inflammatory responses related to commensal microbiota, leading to the hypothesis that BPD susceptibility could be influenced by gut microbiota through inflammatory responses. The study found differences in cytokines and fecal gut microbial composition between the BPD group and controls, with higher levels of certain cytokines and alterations in microbiota composition in the BPD group. Further research is needed to explore the imbalance of cytokines and microbiome in BPD infants and potential reversibility through probiotics.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sabrina H. Tsang, M. Larissa Aviles-Santa, Christian C. Abnet, Maximo O. Brito, Martha L. Daviglus, Sylvia Wassertheil-Smoller, Sheila F. Castaneda, Sharon Minnerath, Gregory A. Talavera, Barry Graubard, Bharat Thyagarajan, M. Constanza Camargo
Summary: The prevalence of Helicobacter pylori infection remains high among Hispanics/Latinos in the US, with significant variations based on background. Poor socioeconomic conditions are strongly associated with H. pylori seropositivity.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Bashir Dabo, Claudio Pelucchi, Matteo Rota, Harshonnati Jain, Paola Bertuccio, Rossella Bonzi, Domenico Palli, Monica Ferraroni, Zuo-Feng Zhang, Aurora Sanchez-Anguiano, Yen Thi-Hai Pham, Chi Thi-Du Tran, Anh Gia Pham, Guo-Pei Yu, Tin C. Nguyen, Joshua Muscat, Shoichiro Tsugane, Akihisa Hidaka, Gerson S. Hamada, David Zaridze, Dmitry Maximovitch, Manolis Kogevinas, Nerea Fernandez de Larrea, Stefania Boccia, Roberta Pastorino, Robert C. Kurtz, Areti Lagiou, Pagona Lagiou, Jesus Vioque, M. Constanza Camargo, Maria Paula Curado, Nuno Lunet, Paolo Boffetta, Eva Negri, Carlo La Vecchia, Hung N. Luu
Summary: This study investigated the association between type 2 diabetes and gastric cancer using data from an international consortium. The results showed that there was no overall association between diabetes and gastric cancer, but there was a significant association between diabetes and cardia gastric cancer risk.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2022)
Article
Oncology
Minkyo Song, Charles S. Rabkin, Hidemi Ito, Isao Oze, Yuriko N. Koyanagi, Ruth M. Pfeiffer, Yumiko Kasugai, Keitaro Matsuo, M. Constanza Camargo
Summary: The study did not identify any inflammation-related biomarkers that may be useful for early disease detection. Further investigation of other biomarkers is warranted.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2022)
Article
Oncology
Georgia Martimianaki, Paola Bertuccio, Gianfranco Alicandro, Claudio Pelucchi, Francesca Bravi, Greta Carioli, Rossella Bonzi, Charles S. Rabkin, Linda M. Liao, Rashmi Sinha, Ken Johnson, Jinfu Hu, Domenico Palli, Monica Ferraroni, Nuno Lunet, Samantha Morais, Shoichiro Tsugane, Akihisa Hidaka, Gerson Shigueaki Hamada, Lizbeth Lopez-Carrillo, Raul Ulises Hernandez-Ramirez, David Zaridze, Dmitry Maximovitch, Nuria Aragones, Vicente Martin, Mary H. Ward, Jesus Vioque, Manoli Garcia de la Hera, Zuo-Feng Zhang, Robert C. Kurtz, Pagona Lagiou, Areti Lagiou, Antonia Trichopoulou, Anna Karakatsani, Reza Malekzadeh, M. Constanza Camargo, Maria Paula Curado, Stefania Boccia, Paolo Boffetta, Eva Negri, Carlo La Vecchia
Summary: This study aims to evaluate the relationship between coffee consumption and gastric cancer and finds no significant association between coffee consumption and gastric cancer. A positive association is observed between high coffee consumption (five or more cups per day) and gastric cardia cancer.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2022)
Article
Gastroenterology & Hepatology
Minkyo Song, M. Constanza Camargo, Andriy Derkach, Charles S. Rabkin, Eric A. Engels
Summary: Pernicious anemia is a risk factor for gastric cancer, and it is also associated with other autoimmune conditions.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Enbo Ma, Taichi Shimazu, Minkyo Song, Hadrien Charvat, Norie Sawada, Taiki Yamaji, Manami Inoue, M. Constanza Camargo, Troy J. Kemp, Ruth M. Pfeiffer, Ligia A. Pinto, Charles S. Rabkin, Shoichiro Tsugane
Summary: This study found no significant associations between 62 inflammatory markers and pancreatic cancer risk, but further investigation is warranted for the suggestive association with circulating levels of leukocyte recruiting cytokine CCL8/MCP2.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Minkyo Song, M. Constanza Camargo, Hormuzd A. Katki, Stephanie J. Weinstein, Satu Mannisto, Demetrius Albanes, Helja-Marja Surcel, Charles S. Rabkin
Summary: The cohort study showed that autoantibody positivity may indicate subclinical autoimmune gastritis in younger women, particularly in H pylori-seronegative individuals. The findings among young females and corpus subsite align with increasing cancer incidence trends for these groups, suggesting autoimmune gastritis may be replacing H pylori as the driving factor.
Article
Oncology
Gianfranco Alicandro, Paola Bertuccio, Giulia Collatuzzo, Claudio Pelucchi, Rossella Bonzi, Linda M. Liao, Charles S. Rabkin, Rashmi Sinha, Eva Negri, Michela Dalmartello, David Zaridze, Dmitry Maximovich, Jesus Vioque, Manoli Garcia de la Hera, Shoichiro Tsugane, Akihisa Hidaka, Gerson Shigueaki Hamada, Lizbeth Lopez-Carrillo, Raul Ulises Hernandez-Ramirez, Reza Malekzadeh, Farhad Pourfarzi, Zuo-Feng Zhang, Robert C. Kurtz, M. Constanza Camargo, Maria Paula Curado, Nuno Lunet, Paolo Boffetta, Carlo La Vecchia
Summary: This study evaluated the mediating role of lifestyle factors in the relationship between education and gastric cancer. The results showed that the relationship between education and gastric cancer is mediated by lifestyle factors, and this mediation effect is limited to men.
BRITISH JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Lusheng Song, Minkyo Song, Charles S. Rabkin, Yunro Chung, Stacy Williams, Javier Torres, Alejandro H. Corvalan, Robinson Gonzalez, Enrique Bellolio, Mahasish Shome, Joshua LaBaer, Ji Qiu, M. Constanza Camargo
Summary: Our study provides a comprehensive assessment of anti-H. pylori antibody profiles in gastric intestinal metaplasia (IM). The identified novel antibodies against target antigens, in addition to CagA, may play a role in the progression of IM. Specific H. pylori antibodies, along with other biomarkers, can help identify IM patients for surveillance.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Petra Krike, Zakera Shums, Inese Polaka, Ilze Kikuste, Aigars Vanags, Ivars Tolmanis, Sergejs Isajevs, Inta Liepniece-Karele, Daiga Santare, Lilian Tzivian, Dace Rudzite, Minkyo Song, M. Constanza Camargo, Gary L. Norman, Marcis Leja
Summary: This study aimed to determine the diagnostic value of anti-parietal cell antibodies (anti-PCA), anti-intrinsic factor antibodies (anti-IFA), pepsinogen ratio (PGI/II), and gastrin-17 (G-17) in corpus-restricted atrophic gastritis (CRAG) detected by ELISA. The study found that the combination of PGI/II and anti-PCA was the best non-invasive biomarker combination for detecting CRAG.
Letter
Gastroenterology & Hepatology
M. Blanca Piazuelo, Fatima Carneiro, M. Constanza Camargo
Article
Nutrition & Dietetics
Giulia Collatuzzo, Eva Negri, Claudio Pelucchi, Rossella Bonzi, Federica Turati, Charles S. Rabkin, Linda M. Liao, Rashmi Sinha, Domenico Palli, Monica Ferraroni, Lizbeth Lopez-Carrillo, Nuno Lunet, Samantha Morais, Demetrius Albanes, Stephanie J. Weinstein, Dominick Parisi, David Zaridze, Dmitry Maximovitch, Trinidad Dierssen-Sotos, Jose Juan Jimenez-Moleon, Jesus Vioque, Manoli Garcia de la Hera, Maria Paula Curado, Emmanuel Dias-Neto, Raul Ulises Hernandez-Ramirez, Malaquias Lopez-Cervantes, Mary H. Ward, Shoichiro Tsugane, Akihisa Hidaka, Areti Lagiou, Pagona Lagiou, Zuo-Feng Zhang, Antonia Trichopoulou, Anna Karakatsani, Maria Constanza Camargo, Carlo La Vecchia, Paolo Boffetta
Summary: A meta-analysis of 16 studies found no significant association between yoghurt consumption and gastric cancer risk.
Editorial Material
Health Care Sciences & Services
Arnoldo Riquelme, Christian C. Abnet, Karen J. Goodman, M. Blanca Piazuelo, Erika Ruiz-Garcia, Paulo Pimentel de Assumpcao, M. Constanza Camargo
LANCET REGIONAL HEALTH-AMERICAS
(2023)
Article
Oncology
Minkyo Song, Harindra Jayasekara, Claudio Pelucchi, Charles S. Rabkin, Kenneth C. Johnson, Jinfu Hu, Domenico Palli, Monica Ferraroni, Linda M. Liao, Rossella Bonzi, David Zaridze, Dmitry Maximovitch, Nuria Aragones, Vicente Martin, Gemma Castano-Vinyals, Marcela Guevara, Shoichiro Tsugane, Gerson Shigueaki Hamada, Akihisa Hidaka, Eva Negri, Mary H. Ward, Rashmi Sinha, Areti Lagiou, Pagona Lagiou, Paolo Boffetta, Maria Paula Curado, Nuno Lunet, Jesus Vioque, Zuo-Feng Zhang, Carlo La Vecchia, M. Constanza Camargo
Summary: This study aims to investigate and quantify the relationship between reproductive factors, menopausal hormone therapy (MHT), and gastric cancer risk in women. The results suggest a lower risk of gastric cancer in women with a longer duration of fertility and those who have used MHT after menopause.
CANCER CAUSES & CONTROL
(2023)
Article
Oncology
M. Constanza Camargo, Minkyo Song, Xia Xu, Isaac Zhao, Joshua N. Sampson, Arash Etemadi, Hermann Brenner, Hwi-Won Lee, Britton Trabert, Bernd Holleczek, Ben Schoettker, Kathleen Spaid, Sanford M. Dawsey, Sangjun Lee, Takaya Shimura, Sue K. Park, Reza Malekzadeh, Daehee Kang, Charles S. Rabkin
Summary: The study evaluated the associations of gastric cancer with estrogen metabolites in postmenopausal women, finding that urinary levels of estrogen-related molecules were not associated with gastric cancer.