Article
Nutrition & Dietetics
Yu Li, Cheng Chi, Cheng Li, Junyan Song, Zanmin Song, Wenjun Wang, Jing Sun
Summary: Donated breast milk can significantly reduce the incidence of NEC, the duration of parenteral nutrition, and the time of full enteral feeding compared with formula. Adding fortifiers in donated milk could make it as effective as formula in promoting the physical growth of premature infants.
Article
Cardiac & Cardiovascular Systems
Siddhartha S. Ghosh, Jing Wang, Paul J. Yannie, Remy C. Cooper, Yashnoor K. Sandhu, Genta Kakiyama, William J. Korzun, Shobha Ghosh
Summary: The study aimed to evaluate the effects of intestine-specific IAP overexpression on Western-type diet-induced atherosclerosis in Ldlr(-/-) mice. The results showed that overexpression of IAP improved intestinal barrier function and reduced intestinal lipid absorption, leading to attenuation of atherosclerosis development.
CIRCULATION RESEARCH
(2021)
Article
Nutrition & Dietetics
Reka A. Vass, Gabriella Kiss, Edward F. Bell, Robert D. Roghair, Attila Miseta, Jozsef Bodis, Simone Funke, Tibor Ertl
Summary: Pituitary hormones like prolactin and luteinizing hormone were found to be higher in breast milk from mothers of preterm infants compared to term infants. Infant formulas have higher total protein content but do not contain detectable levels of pituitary hormones.
Article
Nutrition & Dietetics
Marta Rivera-Pasquel, Mario Flores-Aldana, Maria-Socorro Parra-Cabrera, Amado David Quezada-Sanchez, Armando Garcia-Guerra, Jorge Maldonado-Hernandez
Summary: The study showed significant improvement in lipid profile among children who consumed PUFAs-fortified milk formula, with no significant differences in growth and micronutrient status between the two groups. Consumption of both supplements was adequate and stable throughout the intervention.
Article
Food Science & Technology
Jie Zhang, John A. Duley, David M. Cowley, Paul N. Shaw, Nidhi Bansal
Summary: This study presents a highly sensitive fluorometric method for measuring lipase activities in milk. The linear range for human milk lipoprotein lipase (LPL) was found to be 65-347 U/L, while for bile salt-stimulated lipase (BSSL), it was 10-267 U/L. Heating the milk to 55 degrees Celsius dramatically reduced the residual activities of LPL and BSSL, whereas heating to 50 degrees Celsius caused only nominal reductions. No BSSL activity was detected in cow, camel, goat milk or in infant formula.
Review
Nutrition & Dietetics
Moganatharsa Ganeshalingam, Samantha Enstad, Sarbattama Sen, Sukhinder Cheema, Flavia Esposito, Raymond Thomas
Summary: Breast milk is the best source of nutrition for infants, with functional lipids playing a crucial role. Lipidomics, an emerging field, helps to determine the physiological mechanisms of lipids and discover biomarkers for early disease diagnosis.
FRONTIERS IN NUTRITION
(2022)
Article
Pediatrics
Karishma Rao, Alain Cuna, Susana Chavez-Bueno, Heather Menden, Wei Yu, Ishfaq Ahmed, Pugazhendhi Srinivasan, Shahid Umar, Venkatesh Sampath
Summary: The study demonstrates that different preterm formulas have varying effects on intestinal inflammation, apoptosis, and microbiome composition in developing infants. Formula feeding with EleCare and Similac Special Care resulted in greater intestinal injury compared to NeoSure, but pre-treatment with Lactobacillus rhamnosus GG alleviated the severity of the damage.
FRONTIERS IN PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Fangmin Wang, Jiahui Yu, Li Wang, Shuai Wang, Qingzhe Jin, Qingyun Wang, Wei Wei, Xingguo Wang
Summary: This study analyzed the fatty acid composition in breast milk from different regions of China and found that the type of edible oil consumed by lactating mothers significantly influenced the fatty acid profile in breast milk. Mothers consuming rapeseed oil had lower levels of linoleic acid and higher levels of alpha-linolenic acid in their breast milk, while mothers consuming high oleic acid oils had higher levels of monounsaturated fatty acids, particularly oleic acid.
Article
Food Science & Technology
Danjie Wu, Le Zhang, Yan Zhang, Jiachen Shi, Chin Ping Tan, Zhaojun Zheng, Yuanfa Liu
Summary: Using lipidomics, the researchers analyzed and compared the lipid patterns of human milk (HM) and infant formulas (IFs) and found significant differences in the lipid compositions. HM was rich in unsaturated and long-chain fatty acids, while IFs mainly consisted of saturated and medium-chain fatty acids. The glycerophospholipid metabolism pathway was found to be the most significant. These findings provide valuable insights for the development of Chinese infant formulas.
Article
Medicine, Research & Experimental
Parul Singh, Noora Al Mohannadi, Selvasankar Murugesan, Fajr Almarzooqi, Basirudeen Syed Ahamed Kabeer, Alexandra Katharina Marr, Tomoshige Kino, Tobias Brummaier, Annalisa Terranegra, Rose McGready, Francois Nosten, Damien Chaussabel, Souhaila Al Khodor
Summary: This study investigated the microbial communities in breast milk of mothers with preterm deliveries and found that the microbial communities became increasingly diverse and distinct as the breast milk matured. There were significant differences in the community structures between preterm and term breast milk samples. This study highlights the significant influence of pregnancy-related complications on the composition and diversity of breast milk microbiota, paving the way for improving maternal and infant health outcomes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jonathan P. Jacobs, Martin L. Lee, David J. Rechtman, Adam K. Sun, Chloe Autran, Victoria Niklas
Summary: Human milk oligosaccharides (HMOs) play a critical role in shaping the gut microbiome of neonates, but their effects on the adult gut microbiome are not well understood. This study found that oral administration of a HMO-Concentrate derived from pooled donor breast milk to healthy adults resulted in the expansion of Bifidobacterium, reduced microbial diversity, and altered microbial gene content. After discontinuation of HMO intake, a microbial succession occurred, including the expansion of Bacteroides. These findings suggest that HMOs in donor milk can have direct effects on the adult gut microbiota, and complex mixtures of low abundance HMOs may be required for maximum effect.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Xuan Jiang, Xiaoqiang Zou, Zhonghao Chao, Xiuli Xu
Summary: Human milk is considered the best choice for infant feeding, and human milk fat plays a crucial role in infant growth and development. When breastfeeding is not possible, infant formula should have a composition similar to human milk fat in order to meet the nutritional needs of infants. Currently, the preparation of human milk fat substitutes focuses on simulating fatty acid composition, using structured lipids, and adding milk fat globule membrane supplements. Evaluation and regulation of these substitutes in infant formula are also important.
Review
Pediatrics
Valeria Calcaterra, Hellas Cena, Francesca Sottotetti, Virginia Rossi, Federica Loperfido, Gianvincenzo Zuccotti
Summary: This narrative review explores the connection between feeding methods and the timing of puberty. It suggests that breast milk plays a pivotal role in puberty onset, while the potential harmful effects of soy-based formulas require further research.
Article
Biochemistry & Molecular Biology
Helene Fougere, Karine Greffard, Mireille Guillot, Iwona Rudkowska, Etienne Pronovost, David Simonyan, Isabelle Marc, Jean-Francois Bilodeau
Summary: This study investigated the oxylipin profile in breast milk after DHA supplementation in mothers of preterm infants. The results showed that DHA supplementation increased anti-inflammatory oxylipins and reduced pro-inflammatory prostaglandins in breast milk.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Food Science & Technology
Shuangshuang Wang, Yuxuan Song, Rui He, Guanli Du, Lei Zhang, Bangjun Zhang, Jiaying Zhang, Lili Zhao, Jing Zhang, Wupeng Ge
Summary: In this study, a comprehensive lipidomic analysis was conducted to characterize polar lipids in mature breast milk and ewe milk. A total of 362 polar lipid species were identified, and 139 significantly differentially expressed lipids were screened between the two milk types. PE (16:1_18:0) was found to be significantly higher in ewe milk compared to breast milk. Sphingolipid metabolism and glycerophospholipid metabolism were determined as vital metabolic pathways.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Kathryn Burge, Jeffrey Eckert, Adam Wilson, MaJoi Trammell, Shiloh R. Lueschow, Steven J. McElroy, David Dyer, Hala Chaaban
Summary: This study found that hyaluronic acid 35 kDa (HA35) can reduce the pathological damage and mortality of necrotizing enterocolitis, potentially providing new translational targets for preventing premature infant diseases by activating protective and reparative mechanisms in the small intestine.
Article
Microbiology
Hala Chaaban, Maulin M. Patel, Kathryn Burge, Jeffrey Eckert, Cristina Lupu, Ravi S. Keshari, Robert Silasi, Girija Regmi, MaJoi Trammell, David Dyer, Steven J. McElroy, Florea Lupu
Summary: Increasing evidence suggests a correlation between prolonged antibiotic therapy in preterm infants and increased mortality and morbidities such as NEC. This study used neonatal mice to test the effects of systemic antibiotic treatment on intestinal development and found that it impaired intestinal development and increased the risk of intestinal injury.
Article
Pediatrics
David M. Box, Abhishek Makkar, Zhongxin Yu, Hala Chaaban, Henry H. Tran, Kathryn Y. Burge, Jeffrey Eckert
Summary: Maternal tobacco exposure during pregnancy is associated with increased placental neutrophil infiltration and upregulated inflammatory gene expression, but is not associated with bronchopulmonary dysplasia in preterm infants.
Review
Medicine, General & Internal
Kathryn Y. Burge, Aarthi Gunasekaran, Marjorie M. Makoni, Arshid M. Mir, Harold M. Burkhart, Hala Chaaban
Summary: This review discusses the risk factors, pathogenesis, and treatment strategies of necrotizing enterocolitis in neonates with congenital heart disease. Understanding the mechanisms underlying cardiac NEC may aid in future diagnosis and treatment of this condition.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Microbiology
Kathryn Y. Burge, Troy A. Markel
Review
Microbiology
Adam Wilson, Brett Bogie, Hala Chaaban, Kathryn Burge
Summary: The intestinal microbiome is implicated in NEC pathogenesis, but research has mainly focused on bacteria and ignored other microorganisms such as fungi and viruses. The role of fungi and viruses in preterm intestinal development and NEC pathogenesis is not well understood. Host and environmental factors, interkingdom interactions, and human milk also influence the abundance, diversity, and function of fungal and viral microbes in the preterm intestinal ecosystem.
Letter
Infectious Diseases
Rebecca A. Mayes, Peter N. Johnson, Bryan P. White, Stephen B. Neely, Hala Chaaban, Jamie L. Miller
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Meeting Abstract
Medicine, General & Internal
A. Wilson, K. Y. Burge, J. Eckert, H. Chaaban
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)
Meeting Abstract
Medicine, General & Internal
K. Y. Burge, M. A. Trammell, J. Eckert, A. Wilson, S. R. Lueschow, S. J. McElroy, D. W. Dyer, H. Chaaban
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)
Meeting Abstract
Medicine, General & Internal
C. DeVette, K. Y. Burge, A. Wilson, H. Chaaban
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)