A GCH1 haplotype confers sex-specific susceptibility to pain crises and altered endothelial function in adults with sickle cell anemia

Daily Assessment of Pain in Adults with Sickle Cell Disease

(2013) Wally R. Smith et al.   ANNALS OF INTERNAL MEDICINE

Severe Painful Vaso-Occlusive Crises and Mortality in a Contemporary Adult Sickle Cell Anemia Cohort Study

(2013) Deepika S. Darbari et al.   PLoS One

The Search for Genetic Modifiers of Disease Severity in the  -Hemoglobinopathies

(2013) G. Lettre   Cold Spring Harbor Perspectives in Medicine

Extensive admixture in Brazilian sickle cell patients: implications for the mapping of genetic modifiers

(2011) M. C. F. da Silva et al.   BLOOD

Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity

(2011) R. F. Machado et al.   BLOOD

Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: a phase III randomized, placebo-controlled, double-blind study of the gardos channel blocker senicapo

(2011) Kenneth I. Ataga et al.   BRITISH JOURNAL OF HAEMATOLOGY

GCH1, BH4 and Pain

(2011) Alban Latremoliere et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis

(2011) Mark T. Gladwin   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Temporal dynamics and genetic control of transcription in the human prefrontal cortex

(2011) Carlo Colantuoni et al.   NATURE

Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction

(2011) Jeffrey S Mogil et al.   NATURE NEUROSCIENCE

A Genome-wide Drosophila Screen for Heat Nociception Identifies α2δ3 as an Evolutionarily Conserved Pain Gene

(2010) G. Gregory Neely et al.   CELL

Acute Care Utilization and Rehospitalizations for Sickle Cell Disease

(2010) David C. Brousseau   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Different SNP Combinations in the GCH1 Gene and Use of Labor Analgesia

(2010) Fatimah Dabo et al.   Molecular Pain

Nitric oxide and pain: ‘Something old, something new’

(2009) A. MICLESCU et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster

(2009) N. Solovieff et al.   BLOOD

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Do Genetic Predictors of Pain Sensitivity Associate with Persistent Widespread Pain?

(2009) Kate L Holliday et al.   Molecular Pain

A GTP cyclohydrolase 1 genetic variant delays cancer pain

(2009) Jörn Lötsch et al.   PAIN

Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress

(2008) Dhananjay K. Kaul et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype

(2008) Irmgard Tegeder et al.   EUROPEAN JOURNAL OF PAIN

GCH1 Haplotype Determines Vascular and Plasma Biopterin Availability in Coronary Artery Disease

(2008) Charalambos Antoniades et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Does the Pain-Protective GTP Cyclohydrolase Haplotype Significantly Alter the Pattern or Severity of Pain in Humans with Chronic Pancreatitis?

(2008) Mark Lazarev et al.   Molecular Pain

Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain

(2008) Claudia M. Campbell et al.   PAIN

DNA polymorphisms at the BCL11A, HBS1L-MYB, and  -globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease

(2008) G. Lettre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease

(2007) James G. Taylor et al.   AMERICAN JOURNAL OF HEMATOLOGY