Article
Plant Sciences
Li Xiang, Yue Gao, Shiyu Chen, Jiayi Sun, Jiasi Wu, Xianli Meng
Summary: This review summarizes the pharmacological effects and molecular mechanisms of Scutellaria baicalensis in lung cancer therapy. Scutellaria baicalensis and its constituents exhibit multiple anti-cancer mechanisms against lung cancer and show high antitumor efficacy and safety in animal models.
Article
Integrative & Complementary Medicine
Peng Yu, Jingyang Li, Yanqing Luo, Jiayi Sun, Yingfan Hu, Bo Lin, Xianli Meng, Li Xiang
Summary: Breast cancer is a common and deadly malignancy in women. Traditional Chinese medicine, especially Scutellaria baicalensis, has shown promising activity against breast cancer through multiple mechanisms, including proliferation inhibition, apoptosis induction, and modulation of signaling pathways.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Wentao Wang, Suying Hu, Caijuan Zhang, Jing Yang, Tong Zhang, Donghao Wang, Xiaoyan Cao, Zhezhi Wang
Summary: R2R3-MYB transcription factors play important roles in various biological processes, particularly in the regulation of secondary metabolites. This study focused on the R2R3-MYB gene family in Scutellaria baicalensis and identified 95 genes. These genes were categorized into 34 subgroups based on their exon-intron structures and conserved motifs. The study also revealed that segmental duplications drove the evolution and expansion of the R2R3-MYB gene family. Additionally, the expression patterns of these genes varied in different tissues and under different conditions. Some genes exhibited specific expression profiles in response to hormone stimuli and abiotic stresses. Furthermore, certain genes were found to be localized in the nucleus and possessed transcriptional activation activity. This study provides a comprehensive understanding of the R2R3-MYB gene family in S. baicalensis and serves as a foundation for further investigation of their biological function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Heping Hui, Weijun Gao
Summary: In this study, an arabinogalactoglucan SBP-1 was purified from Scutellaria baicalensis and its structure was characterized. SBP-1 showed antioxidant and hypoglycemic activities, indicating its potential therapeutic value.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Pharmacology & Pharmacy
Jun Wang, Shanshan Chen, Jizhou Zhang, Jiasi Wu
Summary: Autoimmune diseases are caused by lymphocytes self-tolerance failure. Scutellaria baicalensis Georgi and its bioactive contents have the potential to be used in the treatment of these diseases, but further research is needed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Xiaoqiang Chen, Yu Han, Tiefeng Zhou, Yang Liu, Ni Zhang, Jing Wang, Chunpeng Wang, Yayuan Luo, Zhengqi Wu, Yong Cheng, Yundong Shao
Summary: The O/W emulsions prepared using SBPC as an emulsifier showed smaller particle size and increased stability compared to emulsions with other emulsifiers. The emulsions exhibited tolerance to metal ions and thermal treatment, and also demonstrated antioxidant properties by inhibiting the polymerization of EGC, with an average retention rate of 88.28% on the 10th day. This research provides insights into the potential use of SBPC as an emulsifier in various applications.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wentao Wang, Suying Hu, Jing Yang, Caijuan Zhang, Tong Zhang, Donghao Wang, Xiaoyan Cao, Zhezhi Wang
Summary: This study identified a novel S20 R2R3-MYB regulator, SbMYB12, which positively regulates the biosynthesis of baicalin and wogonoside in Scutellaria baicalensis. These findings enhance our understanding of the transcriptional and regulatory mechanisms of baicalin biosynthesis and provide new insights for metabolic engineering in S. baicalensis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Meng-Ying Cui, An-Rui Lu, Jian-Xu Li, Jie Liu, Yu-Min Fang, Tian-Lin Pei, Xin Zhong, Yu-Kun Wei, Yu Kong, Wen-Qing Qiu, Yong-Hong Hu, Jun Yang, Xiao-Ya Chen, Cathie Martin, Qing Zhao
Summary: The study found that methoxylated flavones have strong ability to induce apoptosis and enhance bioactivity, with methoxylation not causing side effects on healthy cells. Both type I and type II OMT enzymes are involved in the biosynthesis of methoxylated flavones in S. baicalensis.
PLANT BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Jian-Bo Yang, Cheng-Shuo Yang, Jiang Li, Guo-Zhu Su, Jin-Ying Tian, Ying Wang, Yue Liu, Feng Wei, Yong Li, Fei Ye, Shuang-Cheng Ma
Summary: This study explores the important role of PTP1B as a key negative regulator of tyrosine phosphorylation associated with insulin receptor signaling in the therapy for diabetes and obesity. It also investigates the anti-diabetic activity of dianthrone derivatives from Polygonum multiflorum Thunb., their structure-activity relationships, mechanism, and molecular docking. Among these derivatives, trans-emodin dianthrone (compound 1) enhances insulin sensitivity and displays considerable anti-diabetic activity. It was found that compound 1 may bind to PTP1B allosteric pocket, providing new insights into the identification of novel anti-diabetic agents.
BIOORGANIC CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Guanghui Sun, Yongkang Dang, Yanke Lin, Wanying Zeng, Zongjian Wu, Xingwang Zhang, Dong Dong, Baojian Wu
Summary: The study reveals that Scutellaria baicalensis Georgi (SBG) can counteract skin aging by antagonizing REV-ERB alpha and increasing BMAL1 expression. This leads to reduced skin wrinkles, increased levels of antioxidant enzymes and collagen, and improved skin structure and function.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Yaqian Zhou, Qianqian Xue, Miaomiao Wang, Liyan Mu, Danni Chen, Qiao Liu, Xun Liu, Wu Yin, Fangzhou Yin
Summary: This study established an integrated strategy of biosynthetic pathway - plant metabolomics - bioactivity evaluation to evaluate the quality differences between Scutellaria baicalensis (SG) and Scutellaria rehderiana (SD). The study found differences in chemical components between SG and SD, and identified chemical markers for quality analysis. Moreover, both SG and SD exhibited prominent anti-inflammatory activity, but SD was less effective.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Plant Sciences
Kajetan Grzelka, Adam Matkowski, Sylwester Slusarczyk
Summary: Scutellaria baicalensis Georgi is a valuable medicinal plant with high levels of flavones in its roots, which are responsible for its anti-inflammatory, antiviral, and antitumor activities. The variability in flavonoid content and composition can be influenced by factors such as electroporation, which can significantly impact plant growth and the content of flavonoids.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Donglin Gu, Ying Wang, Hongyu Jin, Shuai Kang, Yue Liu, Ke Zan, Jing Fan, Feng Wei, Shuangcheng Ma
Summary: There are differences in physicochemical properties and activities between raw and processed Polygonum multiflorum Thunb (PM) roots. The polysaccharide composition can be used to distinguish between raw and processed PM, and processed PM exhibits better immunomodulatory activity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Defu Wang, Jiangran Wang, Yufen Wang, Dongzuo Yao, Yanbing Niu
Summary: This study investigated the metabolic and transcriptional profiles of Scutellaria baicalensis in response to flower coloration, providing insights into the anthocyanin synthesis pathway and differentially expressed candidate genes involved in flower color formation. The results suggested that anthocyanin accumulation in S. baicalensis flowers is closely related to the expression of key genes such as SbDFR and Sb3GT, as well as transcription factors WRKY, bHLH, and NAC.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Medicine, Research & Experimental
Hengfeng Liao, Jun Ye, Lili Gao, Yuling Liu
Summary: Scutellaria baicalensis, a traditional Chinese medicinal plant, has diverse biological activities and can directly modulate immune cells and inhibit inflammatory mediators. Its active compounds may be promising candidates for preventing infection-related cytokine storms.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Agronomy
Liang Zhang, Zhiyu Zhu, Fangfang Chen, Yueqing Zhu, Xiaocan Guo, Minjie Fu, Jiahong Chen, Jianguo Wu, Zhujun Zhu
Summary: In this study, distant hybridization between radish and kohlrabi was successfully achieved using tissue culture and chromosome doubling technology, resulting in the production of xBrassicoraphanus allotetraploids. The allotetraploid hybrids exhibited normal morphology and fertility, providing a basis for the production of new radish germplasm and serving as a bridge for gene transfer between Brassica and Raphanus vegetable species.
NEW ZEALAND JOURNAL OF CROP AND HORTICULTURAL SCIENCE
(2023)
Article
Engineering, Electrical & Electronic
Guolin Yang, Xingliang Jiang, Jianlin Hu, Xiaodong Ren, Tao Li, Jianguo Wu, Zhijin Zhang, Qin Hu, Hualong Zheng
Summary: This study investigates the effects of particle concentration, particle size, and particle dielectric constant on the DC breakdown characteristics of unclean air gap. It is found that the presence of solid particles increases the breakdown voltage of the gap, with the increase being related to the particle concentration, size, and dielectric constant. Additionally, the presence of particles enhances both the ionization process and particle adsorption, leading to an increase in the gap breakdown voltage.
Article
Computer Science, Artificial Intelligence
Chi Zhang, Jian Cui, Jianguo Wu, Xi Zhang
Summary: A steel plate surface defect detection method is proposed in this study, utilizing contextual information and attention mechanism, as well as a multi-layer feature extraction method and fusion framework based on low-level statistical textures. Through pixel-level spatial and correlation relationship identification, characteristics of low-level defects are extracted. A novel quantization technique is developed to effectively incorporate statistical texture in Convolutional Neural Networks (CNN). The empirical results demonstrate the feasibility of the proposed approach in practical steel plate testing and ablation experiments show that it enhances surface defect detection for steel plates.
JOURNAL OF INTELLIGENT MANUFACTURING
(2023)
Article
Polymer Science
Alejandro Gallegos, Jianzhong Wu
Summary: In this work, a hierarchical method that incorporates liquid-state theories with the site-binding model is proposed to quantify the charging behavior of weak polyelectrolytes over a broad range of solution conditions.
Article
Thermodynamics
Alejandro Gallegos, Jianzhong Wu
Summary: The study aims to develop a predictive model for describing the electrostatic behavior of amino acids in aqueous solutions. A three-bead coarse-grained model is proposed, and a thermodynamic model accounting for nonideality effects is developed to capture how the interaction varies with solution conditions.
JOURNAL OF CHEMICAL AND ENGINEERING DATA
(2023)
Article
Engineering, Civil
Guanghui Zhao, Dongqi Wang, Taihu Sun, Yan Ding, Shu Chen, Yizhe Li, Hechen Sun, Chenyang Wu, Zhongjie Yu, Zhenlou Chen
Summary: Urban rivers are significant hotspots for greenhouse gas (GHG) emissions. This study investigated the impact of different rainfall events on GHG emissions from Suzhou Creek in Shanghai. It was found that typhoon events significantly increased GHG emissions, with factors such as rainfall dilution, pump station drainage, sediment disturbance, and high gas transfer coefficient playing important roles. The study highlights the importance of understanding the dynamic response of urban river GHG emissions to rainfall and typhoons.
JOURNAL OF HYDROLOGY
(2023)
Article
Chemistry, Physical
Debadutta Prusty, Alejandro Gallegos, Jianzhong Wu
Summary: The interfacial behavior of associating species is crucial for both fundamental physics and industrial applications. This study investigates the adsorption behavior of a mixture of nanoparticles and polymer chains, representing asphaltene and resin molecules, onto an attractive surface. The results provide insights into the effects of various characteristics of these molecules on the adsorption amount and reveal the interplay between different driving forces.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Analytical
Yijing Wu, Wenjun Zheng, Canrong Chen, Linyan Yang, Ping Tong, Yanhui Zhong, Zian Lin, Zongwei Cai
Summary: In this study, a spherical covalent organic framework (COf) based on imine linkages was prepared and utilized as an adsorbent in dispersive solid-phase extraction. The dSPE-HPLC-MS/MS method based on the spherical COF demonstrated high efficiency and accuracy in the determination of aryl organophosphate esters in biological samples.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Materials Science, Coatings & Films
Yinchun Fang, Jianguo Wu, Shuo Chang, Lingshuang Wu
Summary: This study used bio-based phytic acid (PA) and gelatine (G) to improve the flame retardancy and anti-dripping properties of polyethylene terephthalate (PET) fabric. The coated PET fabric showed a limiting oxygen index (LOI) value greater than 29.5% and no dripping phenomenon, indicating significant improvement in flame retardancy and anti-dripping properties. The PA/G coating altered the decomposition stability and degradation process of PET fabric, promoting the formation of a stable char. The coating formed an intumescent flame retardant (IFR) system on PET fabric, functioning through the IFR mechanism.
SURFACE ENGINEERING
(2023)
Article
Virology
Weijie Chen, Yukun Li, Xiuling Yu, Zhenwei Wang, Wenbiao Wang, Menglan Rao, Yongkui Li, Zhen Luo, Qiwei Zhang, Jinbiao Liu, Jianguo Wu
Summary: In this study, it was found that Zika virus infection upregulated 7-dehydrocholesterol reductase (DHCR7) expression, which in turn facilitated viral infection. The nonstructural protein NS4B of Zika virus interacted with DHCR7 to induce its expression, thereby inhibiting the immune response and facilitating viral evasion. This study expands our understanding of the mechanisms by which viral nonstructural proteins antagonize innate immunity during viral infection via cholesterol metabolic enzymes and intermediates.
Article
Automation & Control Systems
Zhiyong Hu, Chao Wang, Jianguo Wu, Dongping Du
Summary: The development of sensor technologies has allowed the acquisition of high dimensional sensing data, which has led to the development of multi-output modeling techniques for decision making. However, missing values in the data often result in information loss and affect the modeling performance. This study proposes a new multi-output modeling method based on GPLVM to exploit useful information in the data and improve modeling accuracy. The method demonstrates superior performance in both simulation and case studies, making it a powerful tool for process automation.
IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
Hui Chen, Cheng Jin, Li Xie, Jian Wu
Summary: Succinate, an intermediate of the TCA cycle, is crucial in mitochondrial metabolism, energy production, and is also considered a signaling molecule in metabolism and hepatic diseases. Its downstream signaling pathway through GPR91 leads to various intracellular responses, including succinylation, ROS production, HIF-1 alpha stabilization, and significant impact in cellular metabolism due to its role in the TCA cycle. Understanding the signaling mechanisms of succinate in hepatic fibrosis, metabolic reprogramming, inflammatory or immune responses, and carcinogenesis is of great interest. This review aims to provide the current understanding of succinate in mediating metabolism, inflammatory and immune responses in liver diseases, with the aim of establishing a molecular basis for therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Medicine, Research & Experimental
Yuan Zhou, Li Zhang, Yue Ma, Li Xie, Yong-Yu Yang, Cheng Jin, Hui Chen, Ying Zhou, Guang-Qi Song, Jia Ding, Jian Wu
Summary: This study found that senescent hepatic stellate cells (HSCs) play a crucial role in the development of nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Senescent HSCs secrete proteins that activate morphogenic hedgehog or oncogenic Wnt signaling pathways, promoting the malignant transformation of steatotic or dysplastic hepatocytes.
Article
Mathematics, Applied
Marco Tosato, Xue Zhang, Jianhong Wu
Summary: We investigate the behavior of solutions to a scalar Delay Differential Equation (DDE) with periodic switching between two constant values. This equation naturally arises in structured vector populations involved in the spread of various vector-borne diseases in a periodically changing environment. We examine the influence of two different time lags and the switching time on the existence and patterns of periodic solutions, with a specific focus on multi-cycles within the prime period.
DIFFERENTIAL EQUATIONS AND DYNAMICAL SYSTEMS
(2023)