Article
Biology
Sang-Gyun Kang, Zhuang Zhuang Han, Nathalie Daude, Emily McNamara, Serene Wohlgemuth, Laura Molina-Porcel, Jiri G. Safar, Sue-Ann Mok, David Westaway
Summary: The microtubule-associated protein tau forms aggregates in different neurodegenerative diseases, with different mutations leading to divergent clinical diagnoses. Research shows that tau proteins can exist in different conformers with diverse folding pathways. Moreover, abnormal tau may be associated with liquid-liquid phase separation in cells.
Article
Neurosciences
Joshua T. Emmerson, Janice C. Malcolm, Sonia Do Carmo, Phuoc Nguyen, Lionel Breuillaud, Julio C. Martinez-Trujillo, A. Claudio Cuello
Summary: In this study, a transgenic rat model of tauopathy was used to investigate the early pathological processes of tauopathy. The results showed that rats with lifelong accumulation of mutated human tau exhibited deficits in learning and memory tasks after 24 months of age. Furthermore, these rats presented evidence of neuroinflammation, detriments to myelin morphology, and detectable neuronal loss, despite the absence of overt neurofibrillary lesions and brain atrophy.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Sophie A. I. Sanford, Lauren V. C. Miller, Marina Vaysburd, Sophie Keeling, Benjamin J. Tuck, Jessica Clark, Michal Neumann, Victoria Syanda, Leo C. James, William A. Mcewan
Summary: This study demonstrates the critical role of IFN-I in promoting tau aggregation, suggesting IFN-I as a potential therapeutic target in Alzheimer's disease and other tauopathies.
ALZHEIMERS & DEMENTIA
(2023)
Article
Agriculture, Multidisciplinary
Decheng Bi, Shifeng Xiao, Zhijian Lin, Lijun Yao, Weishan Fang, Yan Wu, Hong Xu, Jun Lu, Xu Xu
Summary: Research found that MOS extracted from edible brown seaweeds can attenuate Tau protein-related diseases by inhibiting Tau aggregation and decreasing GSK-3β activity, enhancing autophagy to achieve this effect.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Geriatrics & Gerontology
Henika Patel, Pablo Martinez, Abigail Perkins, Xavier Taylor, Nur Jury, David McKinzie, Cristian A. Lasagna-Reeves
Summary: Pathological aggregation of tau and neuroinflammatory changes are crucial in the clinical course of Alzheimer's disease and related tauopathies. The PS19 mouse model study suggests that different pathological tau species may be associated with different functional deficits, and neuroinflammation may contribute to functional deficits independently of tau pathology.
NEUROBIOLOGY OF AGING
(2022)
Article
Neurosciences
Nina Rostgaard, Pia Holm Jul, Mats Garmer, Christiane Volbracht
Summary: The study demonstrates that the OGA inhibitor Thiamet G can increase brain O-GlcNAc levels, reduce hyperphosphorylation of tau protein and its pathological progression, and alleviate symptoms of AD and other tauopathies.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2023)
Article
Clinical Neurology
Shuai Zhao, Ziqi Fan, Xinyi Zhang, Zheyu Li, Ting Shen, Kaicheng Li, Yaping Yan, Yunfeng Yuan, Jiali Pu, Jun Tian, Zhirong Liu, Yanxing Chen, Baorong Zhang
Summary: This study found that metformin can inhibit the propagation of tau protein in Alzheimer's disease and reduce its hyperphosphorylation. It also improves learning and memory deficits, suggesting that metformin could be a promising drug for the prevention and early treatment of AD.
Article
Neurosciences
Kayo Yukawa, Satomi Yamamoto-Mcguire, Louis Cafaro, Christine Hong, Fredrik Kamme, Tsuneya Ikezu, Seiko Ikezu
Summary: TTBK1 is an attractive therapeutic target in the early stages of AD, as it can delay the progression of tau pathology by suppressing the expression of phosphorylated tau.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Marie Tautou, Sabiha Eddarkaoui, Florian Descamps, Paul-Emmanuel Larchanche, Jamal El Bakali, Liesel Mary Goveas, Melanie Dumoulin, Chloe Lamarre, David Blum, Luc Buee, Patricia Melnyk, Nicolas Sergeant
Summary: The study identified two molecules, MAGS02-14 and PEL24-199, with ss-secretase modulatory effects in cellulo. PEL24-199 was shown to restore short-term memory and reduce neurofibrillary degeneration, suggesting that lysosomotropic activity may not be essential for the effect on tau pathology.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Guilian Xu, Susan Fromholt, David R. Borchelt
Summary: The amyloid pathology features of Alzheimer's disease can be classified into fibrillary and diffuse. Studies suggest that different populations of misfolded A beta conformers compete to populate the brain.
Article
Multidisciplinary Sciences
James M. McCarthy, Jasmeet Virdee, Jessica Brown, Daniel Ursu, Zeshan Ahmed, Annalisa Cavallini, Hugh N. Nuthall
Summary: Intracellular tau inclusions are a hallmark of several neurodegenerative diseases, and recent studies have shown that tau aggregates can propagate to neighboring cells, leading to further tau aggregation. The ex vivo system using organotypic hippocampal slice cultures (OHCs) provides a model for studying this phenomenon and assessing potential therapeutic approaches.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Allal Boutajangout, Wei Zhang, Justin Kim, Wed Ali Abdali, Frances Prelli, Thomas Wisniewski
Summary: Passive immunization with the TW1 antibody can significantly decrease tau pathology, leading to improved cognitive function in a tau transgenic mouse model of AD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Yanxing Chen, Shuai Zhao, Ziqi Fan, Zheyu Li, Yueli Zhu, Ting Shen, Kaicheng Li, Yaping Yan, Jun Tian, Zhirong Liu, Baorong Zhang
Summary: The study uncovered a crosstalk between amyloid and NP tau pathology, where Aβ plaques promoted the aggregation of NP tau, and metformin enhanced microglial autophagy capability to promote the phagocytosis of pathological Aβ and tau proteins, reducing Aβ deposits and limiting the spreading of NP tau pathology.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Neurosciences
Joshua T. Emmerson, Sonia Do Carmo, Yingying Liu, Ali Shalhoub, Ai Liu, Quentin Bonomo, Janice C. Malcolm, Lionel Breuillaud, A. Claudio Cuello
Summary: Tauopathies, such as FTD and AD, lead to cognitive decline and neurofibrillary tangle deposition. The relationship between tau and the neurovascular unit is less understood. An existing transgenic rat model, McGill-R955-hTau, successfully recapitulates the characteristics of brain tauopathy with hyperphosphorylation, neurofibrillary lesions, and cognitive deficits. The model also demonstrates compromised neurovascular integrity in aged rats.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Lea Langer Horvat, Ena Spanic Popovacki, Mirjana Babic Leko, Klara Zubcic, Luka Horvat, Maja Mustapic, Patrick R. Hof, Goran Simic
Summary: The study found that both human tau oligomers and tau fibrils can rapidly propagate and induce tau-related changes, but with some differences in the spreading pattern and regions. Rats injected with human tau fibrils showed more severe tau protein changes after 4 months, which correlated well with cognitive impairment.