Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice

Phosphorylated tau sites that are elevated in Alzheimer's disease fluid biomarkers are visualized in early neurofibrillary tangle maturity levels in the post mortem brain

(2022) Christina M. Moloney et al.   Alzheimers & Dementia

Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation

(2021) Luis Aragão Gomes et al.   ACTA NEUROPATHOLOGICA

Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo

(2021) Tamara Halkina et al.   JOURNAL OF MEDICINAL CHEMISTRY

TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons

(2020) Emily Bowie et al.   eLife

The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small-molecule inhibitor

(2020) Douglas J. Marcotte et al.   Acta Crystallographica Section F-Structural Biology Communications

Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms

(2020) Channa Bao et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Acute inhibition of the CNS-specific kinase TTBK1 significantly lowers tau phosphorylation at several disease relevant sites

(2020) Gregory M. Dillon et al.   PLoS One

Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons

(2020) Zhi Ruan et al.   BRAIN

Identification of human tau-tubulin kinase 1inhibitors: an integrated e-pharmacophore based virtual screening and molecular dynamics simulation

(2019) Srabanti Jana et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Genetic Variation in the Tau Kinases Pathway May Modify the Risk and Age at Onset of Alzheimer's Disease

(2018) José Luis Vázquez-Higuera et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Tubulin Kinase 1 (TTBK1), a new player in the fight against neurodegenerative diseases

(2018) Vanesa Nozal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock

(2017) Yuta Shinohara et al.   MOLECULAR CELL

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Evaluation of Antisense Oligonucleotides Targeting ATXN3 in SCA3 Mouse Models

(2017) Lauren R. Moore et al.   Molecular Therapy-Nucleic Acids

Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport

(2016) Chelsea T. Tiernan et al.   EXPERIMENTAL NEUROLOGY

The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor

(2014) Susan E. Kiefer et al.   Acta Crystallographica Section F-Structural Biology Communications

X-ray Structural Analysis of Tau-Tubulin Kinase 1 and Its Interactions with Small Molecular Inhibitors

(2013) Yafeng Xue et al.   ChemMedChem

An Unbiased Approach to Identifying Tau Kinases That Phosphorylate Tau at Sites Associated with Alzheimer Disease

(2013) Annalisa Cavallini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau-Tubulin Kinase 1 Expression, Phosphorylation and Co-Localization with Phospho-Ser422 Tau in the Alzheimer's Disease Brain

(2012) Harald Lund et al.   BRAIN PATHOLOGY

Targeting Phospho-Ser422 by Active Tau Immunotherapy in the THYTau22 Mouse Model: A Suitable Therapeutic Approach

(2012) Nadege Zommer et al.   Current Alzheimer Research

Progression of Tau Pathology in Cholinergic Basal Forebrain Neurons in Mild Cognitive Impairment and Alzheimer's Disease

(2011) Laurel Vana et al.   AMERICAN JOURNAL OF PATHOLOGY

Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han Chinese

(2011) Nan-Nan Yu et al.   NEUROSCIENCE LETTERS

Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice

(2010) Jiqing Xu et al.   FASEB JOURNAL

Kinase Inhibitors as Potential Therapeutics for Acute and Chronic Neurodegenerative Conditions

(2009) G. Cuny   CURRENT PHARMACEUTICAL DESIGN

Spatial Learning Impairment, Enhanced CDK5/p35 Activity, and Downregulation of NMDA Receptor Expression in Transgenic Mice Expressing Tau-Tubulin Kinase 1

(2009) S. Sato et al.   JOURNAL OF NEUROSCIENCE