Article
Allergy
Marc E. Rothenberg
Summary: The health consequences of climate change, particularly its impact on global allergy epidemic, require further research and action.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Helen C. S. Meier, Dale P. Sandler, Jesse Wilkerson, Frederick W. Miller, Gregg E. Dinse, Christine G. Parks
Summary: The prevalence of autoimmunity, measured by antinuclear antibodies (ANA), is increasing in U.S. adolescents. Improved hygiene and cleaner environments in childhood may result in improper immune responses in later life. This study explores the associations between indicators of hygiene hypothesis (such as asthma, allergies, and antibodies to infectious agents) and ANA prevalence in adolescents. The findings suggest that ANA may be a useful indicator of inadequate immune education in adolescence.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Isabella Annesi-Maesano, Manja Fleddermann, Mathias Hornef, Erika von Mutius, Oliver Pabst, Monika Schaubeck, Alessandro Fiocchi
Summary: Allergic diseases have significantly increased in prevalence in the new millennium, with factors such as cesarean section and early childhood exposure to farm environments influencing the risk. The components in human milk, including immunoglobulins and cytokines, play important roles in allergy prevention. Understanding the complexities of how these factors interact is crucial for developing new protective interventions.
WORLD ALLERGY ORGANIZATION JOURNAL
(2021)
Review
Immunology
Petra I. Pfefferle, Corinna U. Keber, Robert M. Cohen, Holger Garn
Summary: The Hygiene Hypothesis, proposed over 30 years ago, has evolved into a comprehensive concept that explains the impact of post-modern lifestyle on human health by focusing on the relationship between the immune system and the microbiome. This model explores the consequences of this impact and suggests potential solutions to restore immunological homeostasis in developed societies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Holger Garn, Daniel Piotr Potaczek, Petra Ina Pfefferle
Summary: The Hygiene Hypothesis has proven to be adaptive and continuously evolving over its 30-year history, adjusting to new scientific developments. This review discusses the impact of recent discoveries on the hypothesis, including new classes of immune cells, allergy/asthma phenotypes with diverse underlying mechanisms, and insights from epigenetic studies. Additionally, it explores potential expansion of the Hygiene Hypothesis to other disease areas like psychiatric disorders and cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Jibeom Choi
Summary: Immunity is essential for survival, but can sometimes cause allergic responses to benign stimuli. This study used Bayes' theorem to explain the hygiene hypothesis of allergies and found that infrequent exposure to virulent pathogens in childhood may increase allergic responses.
MEDICAL HYPOTHESES
(2023)
Article
Microbiology
Carlos Gomez-Gallego, Mira Forsgren, Marta Selma-Royo, Merja Nermes, Maria Carmen Collado, Seppo Salminen, Shea Beasley, Erika Isolauri
Summary: The study found significant differences in gut microbiota composition between children with and without pet dogs, with probiotic intervention in dogs impacting the gut microbiota in both dogs and children. The presence of household pets, such as dogs, was shown to directly affect children's microbiota.
Article
Microbiology
Nan Xu, Chong Qiu, Qiyuan Yang, Yunzeng Zhang, Mingqi Wang, Chao Ye, Minliang Guo
Summary: The study identified Acinetobacter lwoffii NL1 as a potential microorganism for efficient phenol degradation in heavy metal wastewater treatment, showing resistance to heavy metals and antibiotics.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Fisheries
Mengjie Zhang, Yaqi Dou, Zidong Xiao, Mingyang Xue, Nan Jiang, Wei Liu, Chen Xu, Yuding Fan, Qinghua Zhang, Yong Zhou
Summary: In this study, a dominant bacterial strain named I-702 was isolated from diseased hybrid sturgeons in China. The strain was identified as Acinetobacter lwoffii. Infection experiments showed that strain I-702 caused similar symptoms in the fish as those in natural diseased sturgeons. The study also revealed the pathogenicity and effects of A. lwoffii infection on fish.
Article
Microbiology
Jialei Liang, Kexin Zhou, Qiaoling Li, Xu Dong, Peiyao Zhang, Hongmao Liu, Hailong Lin, Xueya Zhang, Junwan Lu, Xi Lin, Kewei Li, Teng Xu, Hailin Zhang, Qiyu Bao, Mei Zhu, Yunliang Hu, Ping Ren
Summary: The study identified a novel plasmid-encoded aminoglycoside 3-nucleotidyltransferase ANT(3)-IId in Acinetobacter lwoffi strain H7, conferring resistance to spectinomycin and streptomycin with a narrow substrate profile. ANT(3)-IId was associated with insertion sequences (IS) element and found in various Acinetobacter species.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Allergy
Hanbit Kang, Ji-Young Bang, Yosep Mo, Jae Woo Shin, Boram Bae, Sang-Heon Cho, Hye Young Kim, Hye-Ryun Kang
Summary: The study showed that intranasal exposure to A. Iwoffii can suppress asthma development by modulating lung macrophage activation, shifting M2a and M2c macrophages to M2b macrophages.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Multidisciplinary Sciences
B. Brett Finlay, Katherine R. Amato, Meghan Azad, Martin J. Blaser, Thomas C. G. Bosch, Hiutung Chu, Maria Gloria Dominguez-Bello, Stanislav Dusko Ehrlich, Eran Elinav, Naama Geva-Zatorsky, Philippe Gros, Karen Guillemin, Frederic Keck, Tal Korem, Margaret J. McFall-Ngai, Melissa K. Melby, Mark Nichter, Sven Pettersson, Hendrik Poinar, Tobias Rees, Carolina Tropini, Liping Zhao, Tamara Giles-Vernick
Summary: The COVID-19 pandemic has the potential to impact the human microbiome in infected and uninfected individuals, especially high-risk groups. Current pandemic control measures may have opaque and long-term effects on the global microbiome.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Agricultural Engineering
Siyue Han, Yue Tao, Yunhe Cui, Jiaming Xu, Hanxun Ju, Linlin Fan, Lin Zhang, Ying Zhang
Summary: A novel biobased composite consisting of La3+ and poly-dopamine (PDA) was developed and immobilized onto an atrazine-degrading bacterium to remove phosphate (P) and atrazine from agricultural wastewater. The composite showed high affinity for P and enhanced adsorption energy for atrazine, resulting in efficient removal rates. The nanoparticles surrounding the bacterium provided stability and resistance under contamination stress. This study highlights the potential of this composite in reducing P and atrazine pollution in agriculture.
BIORESOURCE TECHNOLOGY
(2023)
Review
Immunology
Sean Jeffreys, James P. Chambers, Jieh-Juen Yu, Chiung-Yu Hung, Thomas Forsthuber, Bernard P. Arulanandam
Summary: Acinetobacter baumannii is a drug-resistant bacteria that causes hospital-acquired infections, which have contributed to increased costs and mortality during the COVID-19 pandemic. Immune-based therapy, including vaccines and monoclonal antibodies, is a promising strategy to combat this pathogen.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Andrea L. Graham, Edward C. Schrom, C. Jessica E. Metcalf
Summary: This article discusses how the immune system balances the benefits and costs in fighting infection and explains the timing and reasons for maladaptive immunopathological responses. The study found that the evolutionary genetic characteristics, coevolution with symbionts, and human demographic history collectively affect human susceptibility to overzealous, pathology-inducing cytokine responses.
TRENDS IN IMMUNOLOGY
(2022)
Editorial Material
Medicine, General & Internal
J. Debarry, D. Heinz, M. P. Manns
Article
Allergy
Karina Stein, Stephanie Brand, Andre Jenckel, Anna Sigmund, Zhijian James Chen, Carsten J. Kirschning, Marion Kauth, Holger Heine
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2017)
Article
Toxicology
Karina Lindner, Michael Stroebele, Sandra Schlick, Sina Webering, Andre Jenckel, Johannes Kopf, Olga Danov, Katherina Sewald, Christian Buj, Otto Creutzenberg, Thomas Tillmann, Gerhard Pohlmann, Heinrich Ernst, Christina Ziemann, Gereon Huettmann, Holger Heine, Henning Bockhorn, Tanja Hansen, Peter Koenig, Heinz Fehrenbach
PARTICLE AND FIBRE TOXICOLOGY
(2017)
Article
Multidisciplinary Sciences
Corinna Bang, Tim Vierbuchen, Thomas Gutsmann, Holger Heine, Ruth A. Schmitz
Article
Biochemistry & Molecular Biology
Ofentse Jacob Pooe, Gabriele Koellisch, Holger Heine, Addmore Shonhai
PROTEIN AND PEPTIDE LETTERS
(2017)
Article
Immunology
Tim Vierbuchen, Corinna Bang, Hanna Rosigkeit, Ruth A. Schmitz, Holger Heine
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Chemistry, Multidisciplinary
Florian Adanitsch, Jianjin Shi, Feng Shao, Rudi Beyaert, Holger Heine, Alla Zamyatina
Review
Allergy
Tim Vierbuchen, Karina Stein, Holger Heine
Article
Chemistry, Medicinal
Alessio Borio, Aurora Holgado, Jose Antonio Garate, Rudi Beyaert, Holger Heine, Alla Zamyatina
Article
Biochemistry & Molecular Biology
Isabel Freund, Daniel K. Buhl, Sebastien Boutin, Annika Kotter, Florian Pichot, Virginie Marchand, Tim Vierbuchen, Holger Heine, Yuri Motorin, Mark Helm, Alexander H. Dalpke, Tatjana Eigenbrod
Article
Oncology
Judith Bossen, Karin Uliczka, Line Steen, Roxana Pfefferkorn, Mandy Mong-Quyen Mai, Lia Burkhardt, Michael Spohn, Iris Bruchhaus, Christine Fink, Holger Heine, Thomas Roeder
MOLECULAR CANCER THERAPEUTICS
(2019)
Article
Gastroenterology & Hepatology
Carlos Oltmanns, Zhaoli Liu, Jasmin Mischke, Jan Tauwaldt, Yonatan Ayalew Mekonnen, Melanie Urbanek-Quaing, Jennifer Debarry, Benjamin Maasoumy, Heiner Wedemeyer, Anke R. M. Kraft, Cheng-Jian Xu, Markus Comberg
Summary: This study investigates the association between chronic hepatitis C virus (HCV) infection and epigenetic changes and biological age acceleration, as well as the reversibility of these changes after sustained virologic response (SVR). The results show that patients with chronic HCV infection have significant epigenetic age acceleration, which partially reverses after SVR. However, some patients still show incomplete reversal of biological age after treatment.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Maximilian Wubbolding, Juan Carlos Lopez Alfonso, Chun-Yen Lin, Sebastian Binder, Christine Falk, Jennifer Debarry, Paul Gineste, Anke R. M. Kraft, Rong-Nan Chien, Benjamin Maasoumy, Heiner Wedemeyer, Wen-Juei Jeng, Michael Meyer Hermann, Markus Cornberg, Christoph Honer zu Siederdissen
Summary: The study utilized machine learning to identify SIM combinations as predictors for early virological relapse after stopping NA treatment in HBeAg-negative patients. The combination of SIMs IL-2, MIG/CCL9, RANTES/CCL5, SCF, and TRAIL showed a high predictive value for VR, indicating the potential of SIM patterns in guiding treatment cessation in this patient population.
HEPATOLOGY COMMUNICATIONS
(2021)
Review
Immunology
Uta Jappe, Christian Schwager, Andra B. Schromm, Nestor Gonzalez Roldan, Karina Stein, Holger Heine, Katarzyna A. Duda
FRONTIERS IN IMMUNOLOGY
(2019)
Review
Allergy
G. Jatzlauk, S. Bartel, H. Heine, M. Schloter, S. Krauss-Etschmann