Alcohol Activates the Hedgehog Pathway and Induces Related Procarcinogenic Processes in the Alcohol-Preferring Rat Model of Hepatocarcinogenesis

Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients

(2013) Li Che et al.   Chinese Journal of Cancer Research

Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice

(2013) Guanhua Xie et al.   HEPATOLOGY

The Hedgehog System Machinery Controls Transforming Growth Factor-β–Dependent Myofibroblastic Differentiation in Humans

(2012) Natacha Cigna et al.   AMERICAN JOURNAL OF PATHOLOGY

Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis

(2012) Angelika Horn et al.   ARTHRITIS AND RHEUMATISM

Paracrine Hedgehog Signaling Drives Metabolic Changes in Hepatocellular Carcinoma

(2012) I. S. Chan et al.   CANCER RESEARCH

Regulation of EMT by TGFβ in cancer

(2012) Carl-Henrik Heldin et al.   FEBS LETTERS

Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism

(2012) Yuping Chen et al.   GASTROENTEROLOGY

Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation

(2012) Guanhua Xie et al.   GUT

Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development

(2012) Kun Wu et al.   HEPATOLOGY

Sonic Hedgehog Signaling Mediates Epithelial-Mesenchymal Communication and Promotes Renal Fibrosis

(2012) H. Ding et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hepatocellular carcinoma

(2012) Alejandro Forner et al.   LANCET

Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links

(2012) Christina Scheel et al.   SEMINARS IN CANCER BIOLOGY

RNA-Sequencing Analysis of 5' Capped RNAs Identifies Many New Differentially Expressed Genes in Acute Hepatitis C Virus Infection

(2012) Neven Papic et al.   Viruses-Basel

Alcohol Induces Liver Neoplasia in a Novel Alcohol-Preferring Rat Model

(2011) Michele T. Yip-Schneider et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Hedgehog Overexpression Is Associated with Stromal Interactions and Predicts for Poor Outcome in Breast Cancer

(2011) S. A. O'Toole et al.   CANCER RESEARCH

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

ASH and NASH

(2011) F. Scaglioni et al.   DIGESTIVE DISEASES

Up-regulation of Hedgehog pathway is associated with cellular permissiveness for hepatitis C virus replication

(2011) Steve S. Choi et al.   HEPATOLOGY

Myofibroblast-derived PDGF-BB promotes hedgehog survival signaling in cholangiocarcinoma cells

(2011) Christian D. Fingas et al.   HEPATOLOGY

Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease

(2011) Cynthia D. Guy et al.   HEPATOLOGY

Hedgehog Signaling Antagonist Promotes Regression of Both Liver Fibrosis and Hepatocellular Carcinoma in a Murine Model of Primary Liver Cancer

(2011) George M. Philips et al.   PLoS One

Alcohol and Hepatitis C Virus-Interactions in Immune Dysfunctions and Liver Damage

(2010) Gyongyi Szabo et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Signals from dying hepatocytes trigger growth of liver progenitors

(2010) Y. Jung et al.   GUT

Osteopontin: A missing link between hedgehog signaling and fibrosis in nonalcoholic steatohepatitis

(2010) Mariana Verdelho Machado et al.   HEPATOLOGY

Hedgehog signaling in the liver

(2010) Alessia Omenetti et al.   JOURNAL OF HEPATOLOGY

Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis and hepatocellular carcinoma

(2010) Thiago de Almeida Pereira et al.   LABORATORY INVESTIGATION

Nuclear β-Catenin Induces an Early Liver Progenitor Phenotype in Hepatocellular Carcinoma and Promotes Tumor Recurrence

(2009) Gudrun Zulehner et al.   AMERICAN JOURNAL OF PATHOLOGY

Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis

(2009) Steve S. Choi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hedgehog-Mediated Epithelial-to-Mesenchymal Transition and Fibrogenic Repair in Nonalcoholic Fatty Liver Disease

(2009) Wing–Kin Syn et al.   GASTROENTEROLOGY

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hepatic tumor–stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge

(2009) F van Zijl et al.   ONCOGENE

Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog

(2009) K. Machida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secular Trends in Alcohol Consumption over 50 Years: The Framingham Study

(2008) Yuqing Zhang et al.   AMERICAN JOURNAL OF MEDICINE

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Accumulation of Hedgehog-Responsive Progenitors Parallels Alcoholic Liver Disease Severity in Mice and Humans

(2008) Youngmi Jung et al.   GASTROENTEROLOGY

Liver cirrhosis

(2008) Detlef Schuppan et al.   LANCET

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE