Review
Biochemistry & Molecular Biology
Moong Yan Leong, Yeo Lee Kong, Kevin Burgess, Won Fen Wong, Gautam Sethi, Chung Yeng Looi
Summary: Nano-engineered medical products have emerged in the past decade. Current research focuses on developing safe drugs with minimal adverse effects. Transdermal drug delivery offers convenience, local targeting, and reduced toxicity. Nanomaterials provide alternatives to conventional methods and this article reviews the recent research and emphasizes the mechanisms and nano-formulations in use.
Article
Pharmacology & Pharmacy
Putri Wulandari Resky Ananda, Diany Elim, Hilman Syamami Zaman, Wahdaniyah Muslimin, Muhamad Gilang Ramadhan Tunggeng, Andi Dian Permana
Summary: Malaria caused by various Plasmodium strains is a global health issue, and developing effective treatment methods is crucial. This study formulated primaquine into a transdermal patch for the first time, demonstrating good bioadhesive and permeation properties through various evaluations. Additionally, the transdermal patch showed promising drug release and permeation profiles in ex vivo studies.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Mengjia Zheng, Yuyue Zhang, Tianli Hu, Chenjie Xu
Summary: Microneedle-based diagnostic devices can detect health-related biomarkers accurately and minimally invasively by extracting interstitial fluid through the skin and analyzing it using electrochemical test strips. The experiment shows that this device can accurately detect glucose and alcohol concentrations, and successfully determine the glycemic status of mice in in vivo experiments.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Instruments & Instrumentation
Fang-Ying Wang, Yunching Chen, Yi-You Huang, Chao-Min Cheng
Summary: Transdermal drug delivery systems (TDDS), especially those that employ microneedles, offer a convenient and less invasive alternative for disease and viral infection treatment, prevention, detection, and surveillance. Microneedle TDDS patches enable improved skin barrier penetration for the delivery of macromolecules or hydrophilic drugs, potentially providing a viable alternative vaccine modality with numerous advantages.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Jushan Gao, Shanbo Ma, Xinxin Zhao, Jinpeng Wen, Datao Hu, Xiaoye Zhao, Xiaopeng Shi, Ke Wang
Summary: The study explored the potential mechanisms of a dual-labeled nano drug delivery system for transdermal absorption, revealing that the nanoparticles can impact cell functions through various pathways to promote transdermal absorption. Visual demonstrations confirmed the penetration of the nanoparticle delivery system into the dermis, suggesting a new method for future investigations into transdermal drug delivery mechanisms.
CHINESE CHEMICAL LETTERS
(2021)
Review
Pharmacology & Pharmacy
Rabin Neupane, Sai H. S. Boddu, Mariam Sami Abou-Dahech, Rinda Devi Bachu, David Terrero, R. Jayachandra Babu, Amit K. Tiwari
Summary: Transdermal drug delivery is a promising alternative for cancer treatment, reducing dose frequency and severity of adverse effects. It can be used for localized tumor treatment and sustained delivery of low-dose chemotherapeutics or vaccines. However, challenges remain in designing effective transdermal formulations.
Article
Psychology, Experimental
Genyue Fu, Xinyue Zhou, Si Jia Wu, Hassan Nikoo, Darshan Panesar, Paul Pu Zheng, Keith Oatley, Kang Lee
Summary: Measuring the physiological aspects of emotions has been a challenge, but this study developed a contactless method using a Transdermal Optical Imaging system. By analyzing facial blood flow patterns, the study found distinct physiological signatures for different emotions.
COGNITION & EMOTION
(2022)
Article
Medicine, General & Internal
Tory R. Spindle, Dennis J. Sholler, Edward J. Cone, Timothy P. Murphy, Mahmoud ElSohly, Ruth E. Winecker, Ronald R. Flegel, Marcel O. Bonn-Miller, Ryan Vandrey
Summary: This study evaluated the accuracy of CBD and THC labeling in topical cannabinoid products and found that they are often inaccurately labeled and many contain THC. These findings suggest the need for clinical studies to determine whether topical cannabinoid products with THC can produce psychoactive effects or positive drug tests for cannabis.
Review
Chemistry, Analytical
Muhammet Avcil, Ayhan Celik
Summary: The innovative transdermal delivery technology of microneedle patch has great potential for various applications, but also faces limitations that need to be addressed for further improvements. Scientists and technologists should be aware of these concerns and allocate resources wisely.
Article
Environmental Sciences
Karina Sommerfeld-Klatta, Wiktoria Jiers, Magdalena Lukasik-Glebocka, Artur Tezyk, Klaudia Dolinska-Kaczmarek, Kamil Walter, Pawel Swiderski, Szymon Rzepczyk, Barbara Zielinska-Psuja, Czeslaw Zaba
Summary: In recent years, the administration of fentanyl in transdermal drug delivery systems for chronic pain treatment has increased significantly. This study presents three cases of fentanyl poisonings, including two deaths, due to abuse of transdermal fentanyl delivery systems. The various routes of administration and toxic effects highlight the potential dangers of fentanyl in transdermal drug delivery systems.
Article
Pharmacology & Pharmacy
Linh Dinh, Soohun Lee, Sharif Md Abuzar, Heejun Park, Sung-Joo Hwang
Summary: A new method for transdermal delivery of donepezil was developed using a drug-in-adhesive patch. The synthesized ionic liquid (IL) showed inhibition of crystallization and excellent skin permeability.
Article
Multidisciplinary Sciences
Michael D. Kleinhenz, Mikaela Weeder, Shawnee Montgomery, Miriam Martin, Andrew Curtis, Geraldine Magnin, Zhoumeng Lin, Jason Griffin, Johann F. Coetzee
Summary: This study found that feeding industrial hemp with a high CBDA content can increase lying behavior and decrease stress and inflammation biomarkers in cattle.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Lina Shen, Xiaolin Hou, Zhi Wang, Teng Guo, Zehui He, Shuyao Ruan, Zhenda Liu, Hang Ruan, Yongtai Zhang, Nianping Feng
Summary: Microemulsions can be used as a carrier to enhance the solubility and skin permeability of total flavones of Arisaematis rhizoma for transdermal delivery. By adding 1% sodium hyaluronate, transparent microemulsion-based hydrogels with pseudoplastic-fluid and shear-thinning characteristics were obtained. Nanoscale droplets of microemulsions migrate in the gel network, with their migration capacity and transdermal permeation flux negatively correlated with sodium hyaluronate concentration.
Review
Biotechnology & Applied Microbiology
Yi-Qun Yu, Xue Yang, Xiao-Fang Wu, Yi-Bin Fan
Summary: The transdermal route of administration offers benefits such as reduced toxicity and sustained drug delivery, but is limited by the stratum corneum barrier. Nanocarriers provide a promising solution to enhance drug penetration, while physical methods like iontophoresis and microneedles can further improve transdermal drug delivery efficacy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Gopika Gopan, Jobin Jose, Kartik Bhairu Khot, Akshay Bandiwadekar
Summary: Obesity is a clinical condition with detrimental impacts on human health, and traditional treatment methods have severe side effects and recurrence. Recent studies have shown that utilizing cellulose, chitosan, and hyaluronic acid can enhance the release and efficacy of obesity medications, and transdermal drug delivery through microneedles offers a promising solution to overcome therapy limitations in managing obesity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Psychology, Biological
Andrew T. Voss, Margaret K. Jorgensen, James G. Murphy
Summary: The current study supports the feasibility and acceptability of an academic goal-relevant episodic future thinking intervention, indicating potential for further research to establish treatment efficacy.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Melissa A. Little, Robert C. Klesges, Indika Mallawaarachchi, Timothy McMurry, Kinsey Pebley, Meghan McDevitt-Murphy, James Murphy, G. Wayne Talcott
Summary: This study aimed to investigate whether a booster BAI administered at the end of Airmen's training could reduce alcohol-related incidents (ARIs) up to a 1-year follow-up. The results showed no significant difference in ARIs at the 1-year follow-up between the condition that received the booster session and the condition that received bystander intervention. Future research should consider alternative outcome measures or more intensive interventions.
Article
Substance Abuse
Kathryn S. Gex, Eun-Young Mun, Nancy P. Barnett, Meghan E. McDevitt-Murphy, Kenneth J. Ruggiero, Idia B. Thurston, Cecilia C. Olin, Andrew T. Voss, Alton J. Withers, James G. Murphy
Summary: This study explored the feasibility, acceptability, and preliminary efficacy of a live text-message delivered alcohol brief motivational intervention (BMI). The results showed that participants found the interventions useful and interesting, with a high retention rate at the 3-month follow-up. Although there were no significant group differences in drinks per week or alcohol-related problems, participants who received alcohol BMI plus behavioral economic substance-free activity session (SFAS) reported fewer heavy drinking episodes (HDEs) in the past month.
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2023)
Article
Substance Abuse
Samuel F. Acuff, Cassandra L. Boness, Yoanna McDowell, James G. Murphy, Kenneth J. Sher
Summary: The study found a positive correlation between delayed reward discounting and giving up AUD criteria, and probability discounting was associated with social/interpersonal problems. These results suggest that AUD symptoms are etiologically distinct and are associated with behavioral economic discounting.
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2023)
Article
Substance Abuse
Jalie A. Tucker, Joanna Buscemi, James G. Murphy, Derek D. Reed, Rudy E. Vuchinich
Summary: This research emphasizes the importance of understanding addictive behaviors as dynamic patterns influenced by environmental contexts. Current research tends to focus on identifying the causes of addictive behavior, but lacks investigation into how addictive behavior patterns emerge, are maintained, and remit over time. Broadening the scope of research to include individual and contextual factors holds promise for advancing our understanding of addictive behaviors.
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2023)
Article
Substance Abuse
Amber Copeland, Tom Stafford, Samuel F. Acuff, James G. Murphy, Matt Field
Summary: This study examines the mechanisms of alcohol moderation among heavy drinkers without treatment. The results show that moderated drinkers have lower alcohol demand and more allocation towards alcohol-free reinforcement. However, the findings on value-based decision-making are inconclusive.
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2023)
Review
Substance Abuse
Alba Gonzalez-Roz, Victor Martinez-Loredo, Elizabeth R. Aston, Jane Metrik, James Murphy, Iris Balodis, Roberto Secades-Villa, Kyla Belisario, James MacKillop
Summary: This meta-analysis evaluated the concurrent validity of the Marijuana Purchase Task (MPT) in relation to cannabis involvement. The results showed that the MPT has adequate concurrent validity in measuring cannabis demand, particularly in intensity, O-max, and elasticity. There may be meaningful sex differences in the reinforcing value of cannabis.
Article
Psychology, Biological
Brandon P. Miller, James G. Murphy, James MacKillop, Michael Amlung
Summary: This study examines the impact of different next-day responsibilities on alcohol demand among community adults, finding that individuals report they would drink less alcohol on nights before important next-day responsibilities such as taking care of children or going to work. By using behavioral economics to investigate community adults, the results suggest that planning personally relevant next-day activities may help reduce alcohol consumption and potential adverse consequences.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Biological
Rudy E. Vuchinich, Jalie A. Tucker, Samuel F. Acuff, Derek D. Reed, Joanna Buscemi, James G. Murphy
Summary: Howard Rachlin and his contemporaries pioneered basic behavioral science innovations that have been effectively applied in understanding human substance use disorder and related health behaviors. The innovations of molar behaviorism, behavioral economics, and teleological behaviorism are summarized. The focus on final causes in behavioral economics and teleological behaviorism is particularly beneficial for applied fields. The translational and applied research in laboratory studies, cohort studies, and experimental behavioral economic modeling have successfully translated basic science into practical applications, and have the potential for further advancements.
JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR
(2023)
Article
Substance Abuse
Nioud Mulugeta Gebru, Danielle N. Jones, James G. Murphy, Keanan J. Joyner
Summary: This study examined the predictive ability of relative resource allocation on substance use outcomes using a hypothetical lottery task. Results showed that relative allocation of funds towards alcohol and cannabis was positively associated with the use and problems of each substance. This research provides initial support for relative resource allocation as a unique predictor of clinically relevant outcomes.
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2023)
Article
Substance Abuse
Samuel F. Acuff, Justin C. Strickland, Elizabeth R. Aston, Kathryn S. Gex, James G. Murphy
Summary: The study found that social context and level of responsibility have an impact on cannabis demand. The presence of peers increases demand intensity and maximum expenditure, while higher responsibilities decrease demand intensity, breakpoint, and maximum expenditure and increase price sensitivity. Demand is least elastic in social context compared to other conditions. The severity of cannabis use is associated with differences in demand intensity and maximum expenditure between solitary and social conditions, and in demand elasticity between typical and substantial responsibility conditions.
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2023)
Article
Substance Abuse
Samuel F. Acuff, Kyla Belisario, Ashley Dennhardt, Michael Amlung, Jalie A. Tucker, James MacKillop, James G. Murphy
Summary: This study explores the relationship between drinking behaviors and various behavioral economic indicators among emerging adults. The results suggest that proportionate alcohol-related reinforcement and demand play significant roles in predicting reductions in drinking, although the effects may vary across different demographic groups.
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2023)
Review
Psychology, Multidisciplinary
Samuel F. Acuff, James Mackillop, James G. Murphy
Summary: Behavioural economic accounts explain the psychological mechanisms underlying harmful drug use, emphasizing the overvaluation of immediate rewards and the reinforcing effects of drugs. The influence of environmental factors on drug use is also discussed in the article.
NATURE REVIEWS PSYCHOLOGY
(2023)
Article
Psychology, Clinical
Matthew T. Luciano, Samuel F. Acuff, Cecilia C. Olin, Rivian K. Lewin, Justin C. Strickland, Meghan E. McDevitt-Murphy, James G. Murphy
Summary: The association between posttraumatic stress disorder (PTSD) and harmful alcohol use is often explained through the self-medication hypothesis via coping-related drinking motives. This study conducted a meta-analytic structural equation modeling approach to aggregate the indirect effect of PTSD on harmful alcohol use and explored moderators that influenced the indirect effect.
JOURNAL OF PSYCHOPATHOLOGY AND CLINICAL SCIENCE
(2022)
Article
Psychology, Clinical
Matthew T. Luciano, Meghan E. McDevitt-Murphy, James G. Murphy, Rebecca J. Zakarian, Cecilia Olin
Summary: This study conducted an open trial of a two-session intervention for veterans with symptoms of PTSD and hazardous drinking. The results showed that the intervention was well-received and may have resulted in improvements in intervention targets. Veterans showed improvement in alcohol consumption and PTSD severity.
JOURNAL OF BEHAVIORAL AND COGNITIVE THERAPY
(2022)
