Article
Biochemistry & Molecular Biology
Zeyu Qin, Yucheng Zou, Yipeng Zhang, Peng Wang, Hui Zhang
Summary: In this study, zanthoxylum bungeanum essential oil/beta-cyclodextrin inclusion complexes (ZBEO/beta-CD-ICs) were prepared by precipitation method and then incorporated into nanofiber films by electrospinning. The inclusion complexes changed the crystalline structure, enhanced molecular interaction, and improved thermal stability. The properties of the nanofiber films were influenced by the content of ZBEO/beta-CD-ICs, and the release behavior of ZBEO was affected by temperature and humidity. The increase in ZBEO content enhanced antibacterial and antioxidant activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biotechnology & Applied Microbiology
Lisong Hu, Zhongping Xu, Rui Fan, Guanying Wang, Fuqiu Wang, Xiaowei Qin, Lin Yan, Xunzhi Ji, Minghui Meng, Soonliang Sim, Wei Chen, Chaoyun Hao, Qinghuang Wang, Huaguo Zhu, Shu Zhu, Pan Xu, Hui Zhao, Keith Lindsey, Henry Daniell, Jonathan F. Wendel, Shuangxia Jin
Summary: This study reports the reference-grade genomes of Chinese pepper species Zanthoxylum armatum and Zanthoxylum bungeanum. The analysis of these genomes reveals the relationship between genomic evolution, environmental factors, and phenotypic innovation. The genomic resources provided in this study will be valuable for investigating diversification and phenotypic innovation in Chinese pepper.
PLANT BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Mingjing Zheng, Menghan Ma, Yuanfan Yang, Zhiyu Liu, Shuji Liu, Tao Hong, Hui Ni, Zedong Jiang
Summary: This study investigated the structure and antioxidant activity of Porphyra haitanensis polysaccharides (PHPs) extracted using different methods. Ultra-high pressure, ultrasonic, and microwave assisted treatments enhanced the total sugar, sulfate, and uronic acid contents of PHPs, particularly with ultra-high pressure treatment. These treatments also affected the monosaccharide ratio and physical characteristics of PHPs, resulting in a loose microstructure with increased porosity. All PHPs exhibited in vitro antioxidant capacity, with ultra-high pressure treated PHPs showing the strongest activity. Moreover, these PHPs effectively improved cell viability and reduced ROS levels in H2O2 induced cells, indicating their potential as natural antioxidants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Aiguo Luo, Jing Chen, Bianfang Hu
Summary: This study aimed to prepare a composite film with antioxidant activity for fruit and vegetable preservation. Polyphenols were extracted from Zanthoxylum bungeanum leaves (ZMP), and their composition was studied. The ZMP-chitosan film (ZMP/C-film) was prepared and evaluated. The results showed that ZMP was mainly composed of seven components, and the ZMP/C-film had improved properties and exhibited antioxidant activity. The ZMP/C-film was also effective in prolonging the shelf life of strawberries.
Article
Agricultural Engineering
Nana Jing, Minyan Wang, Menglu Gao, Zixuan Zhong, Yanping Ma, Anzhi Wei
Summary: Among four different drying techniques, freeze drying showed the best maintenance of nutrients and antioxidant activity of Zanthoxylum bungeanum Maxim. (Z. bungeanum).
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Chemistry, Applied
Bin Wang, Jie Sui, Bin Yu, Chao Yuan, Li Guo, A. M. Abd El-Aty, Bo Cui
Summary: The study showed that corn starch-based films incorporated with Zanthoxylum bungeanum essential oil (ZYO) had higher elongation at break and lower tensile strength, moisture content, solubility in water, and water vapor permeability rate compared to oil-free films. Additionally, the films with ZYO had increased opacity and antibacterial activity.
CARBOHYDRATE POLYMERS
(2021)
Article
Food Science & Technology
Anna Wang, Yun Wang, Huan Kan, Jiabo Hao, Qing Hu, Bin Lu, Yun Liu
Summary: This study investigated the effects of different drying methods on the qualities of Zanthoxylum bungeanum leaves. Vacuum drying treatment retained the original color of leaves to a greater extent. Heat air drying showed the highest antioxidant capacities. Different drying methods had variations in the number and contents of volatile organic compounds.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Agricultural Engineering
Jie Zhang, Li Yu, Nuan Han, Dongmei Wang
Summary: This study analyzed the characteristics, accumulation kinetics, and tissue localization of phenolic compounds in Zanthoxylum bungeanum leaves. Four chemotypes were identified and the main components accumulated mainly in the epidermis, palisade tissue, and parenchyma cells.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Acoustics
Qiang Wei, Yi-han Zhang
Summary: The purpose of this study was to improve the extraction of polysaccharide from Cercis chinensis Bunge leaves using ultrasound, and compare it with boiling extraction in terms of polysaccharide content, monosaccharide compounds, and bioactivity. The optimal conditions were determined to be ultrasound intensity of 180 W, extraction duration of 40 min, water to material ratio of 15:1 (g/g), resulting in a higher polysaccharide yield of 20.02 +/- 0.55 (mg/g) compared to boiling extraction (16.09 +/- 0.82 mg/g). The ultrasound-extracted polysaccharides exhibited higher antioxidant activity and contained more total sugars and uronic acids compared to the boiling method.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Hailong Zhang, Xia Lang, Xiao Li, Guoshun Chen, Cailian Wang
Summary: This study investigated the effect of essential oil of Zanthoxylum bungeanum (EOZB) on rumen enzyme activity, rumen microbiology, and metabolites in Small Tail Han Sheep hybrid male lambs (STH lambs) by adding different doses of EOZB to their diets. The results showed that EOZB increased rumen pectinase and lipase activities, altered the abundance of rumen microbiota, and produced various differential metabolites. These findings contribute to our understanding of the impact of plant essential oils as feed additives on animal health and performance.
Article
Food Science & Technology
Mingming Wang, Chuangchuang Zhang, Yuting Xu, Mengting Ma, Tianming Yao, Zhongquan Sui
Summary: This study compares six different fiber extraction techniques and analyzes the composition, structure, antioxidant activities, and rheological properties of the extracted fibers. The results show that the combined enzymatic extraction method had the highest extraction yield, while the alkaline extraction method had the highest antioxidant activity. There were differences in the monosaccharide composition among the different extraction methods, and the crude polysaccharides had relatively low molecular weights.
Article
Chemistry, Applied
Ruijie Ni, Haiyan Yan, Honglei Tian, Ping Zhan, Yuyu Zhang
Summary: The different aroma profiles of red and green Fried huajiao oil (FHO) samples were investigated using quantitative descriptive sensory analysis (QDA) and gas chromatography-olfactometry/aroma intensity (GC-O/AI). The results showed distinct differences among FHOs in terms of sensory attributes. A total of 30 odorants with high OAVs and AIs were identified as the major characteristic compounds of FHOs. Linalool, linalyl acetate, and 1,8-cineole were considered as volatile markers for classifying FHOs with red and green huajiao.
Article
Biochemistry & Molecular Biology
Jing Zhou, Jiaxin Meng, Shuangyu Zhang, Rufei Chi, Cheng Wang, Dongmei Wang, Houhua Li
Summary: In this study, the researchers identified the HY5 gene, which is highly correlated to changes in anthocyanin content, through the combined analysis of metabolome and transcriptome in Zanthoxylum bungeanum. They found that under natural ripening conditions, the fruit gradually changed in color from green to red, and that bagging inhibited this color change. The expression of ZbHY5 and anthocyanin content increased after unbagging. The researchers also observed that exposure to UV-B radiation led to color change in the leaves, increased ZbHY5 expression, and anthocyanin accumulation. Overexpression of ZbHY5 deepened the redness of the leaves and promoted the expression of ZbHY5 and ZbMYB113, as well as anthocyanin accumulation. The study concludes that ZbHY5 may regulate anthocyanin biosynthesis through interaction with ZbMYB113, providing insights into UV-B-induced anthocyanin accumulation in Z. bungeanum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Asmaa Abbas, Colin W. Wright, Nagwa El-Sawi, Tapani Yli-Mattila, Anssi M. Malinen
Summary: It was discovered that a methanolic extract of the food additive Zanthoxylum bungeanum can suppress the production of Aflatoxin B1 (AFB1) in Aspergillus flavus. The M20 sub-fraction showed high antioxidant activity and potent anti-aflatoxigenic potency. This extract triggers significant changes in secondary metabolite pathways and global regulators, leading to the repression of the AFB1 biosynthesis pathway.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Shijing Feng, Zhenshan Liu, Jian Cheng, Zihe Li, Lu Tian, Min Liu, Tuxi Yang, Yulin Liu, Yonghong Liu, He Dai, Zujun Yang, Qing Zhang, Gang Wang, Jisen Zhang, Huifeng Jiang, Anzhi Wei
Summary: Zanthoxylum bungeanum, an important spice and medicinal plant, has a genome size tenfold larger than its close relative Citrus sinensis, due to lineage-specific whole-genome duplication event and a recent transposable element burst. The genome underwent numerous fusion/fission events and massive species-specific gene family expansions and changes in gene expression, shaping the biosynthesis of important compounds that contribute to the unique flavor and appearance of Z. bungeanum. This reference genome provides valuable insights for studying the impact of WGDs and TE activity on gene gain and loss, genome reconstruction, and accelerating Zanthoxylum improvement.
HORTICULTURE RESEARCH
(2021)
Article
Chemistry, Applied
Ali Wang, Peng Li, Peipei Han, Gan Gu, Tijiang Shan, Daowan Lai, Ligang Zhou
Summary: New nitrogen-containing metabolites and natural products were isolated from the rice false smut pathogen, Villosiclava virens UV-8b, and evaluated for antibacterial and phytotoxic activities. Some compounds showed weak inhibition against bacteria, while others displayed inhibitory activity against the radicle elongation of rice seeds.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Jiajia Meng, Siji Zhao, Pengqin Dang, Zhiyao Zhou, Daowan Lai, Ligang Zhou
Summary: Ustilaginoidin M-1, a novel bis-naphtho-gamma-pyrone isolated from the pathogenic fungus Villosiclava virens, was tested for cytotoxicity against five human cancer cell lines after its structure was elucidated through spectroscopic analysis and comparison with literature data.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Daowan Lai, Jing Li, Siji Zhao, Gan Gu, Xiao Gong, Peter Proksch, Ligang Zhou
Summary: Several compounds isolated from the endophytic fungus Xylomelasma sp. Samif07 showed significant antibacterial, antitubercular, and antioxidant activities, indicating their potential as natural products for drug development.
NATURAL PRODUCT RESEARCH
(2021)
Review
Food Science & Technology
Dan Xu, Mengyao Xue, Zhen Shen, Xiaowei Jia, Xuwen Hou, Daowan Lai, Ligang Zhou
Summary: Fungal phytotoxic secondary metabolites are toxic substances produced by fungi through biochemical reactions, with a high level of diversity in their properties. These metabolites are mainly isolated from phytopathogenic fungal species, with aromatic polyketides and sesquiterpenoids being the main phytotoxic compounds.
Article
Microbiology
Xuwen Hou, Xuping Zhang, Mengyao Xue, Zhitong Zhao, Huizhen Zhang, Dan Xu, Daowan Lai, Ligang Zhou
Summary: This review summarizes the structures and bioactivities of 69 sorbicillinoids newly identified from 2016 to 2021. These compounds are classified into different categories and exhibit various biological activities, including cytotoxic, antimicrobial, anti-inflammatory, and phytotoxic effects.
Article
Biochemistry & Molecular Biology
Xuping Zhang, Dan Xu, Xuwen Hou, Penglin Wei, Jiajin Fu, Zhitong Zhao, Mingpeng Jing, Daowan Lai, Wenbing Yin, Ligang Zhou
Summary: This study identified a sorbicillinoid biosynthetic gene cluster in U. virens and demonstrated that UvSorA and UvSorB are responsible for sorbicillinoid biosynthesis and play important roles in the fungal response to external stresses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Weixuan Wang, Gan Gu, Ruya Yin, Jiajin Fu, Mingpeng Jing, Zhen Shen, Daowan Lai, Baomin Wang, Ligang Zhou
Summary: In this study, a nanobody phage display library was established and two nanobodies were selected for the development of an indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) to detect ustilaginoidins in rice. Nb-B15 showed superior characteristics compared to Nb-C21 and was chosen for the detection of actual contaminated rice samples. The developed ic-ELISA based on Nb-B15 showed consistent results with HPLC-DAD analysis, suggesting it can be a rapid and effective method for detecting total ustilaginoidins in contaminated rice samples.
Review
Microbiology
Mengyao Xue, Xuwen Hou, Jiajin Fu, Jiayin Zhang, Jiacheng Wang, Zhitong Zhao, Dan Xu, Daowan Lai, Ligang Zhou
Summary: Genomic analysis has identified cryptic biosynthetic gene clusters in fungi that are normally silenced but can be induced using chemical-epigenetic modifiers. These modifiers, such as 5-azacytidine and suberoylanilide hydroxamic acid, alter the structure of DNA and histones to activate the production of bioactive secondary metabolites. This review summarizes the research progress from 2007 to 2022 on using chemical epigenetic modifiers to trigger silent or low-expressed biosynthetic pathways in fungi, resulting in the production of over 540 fungal secondary metabolites with significant biological activities.
Article
Microbiology
Xuping Zhang, Xuwen Hou, Dan Xu, Mengyao Xue, Jiayin Zhang, Jiacheng Wang, Yonglin Yang, Daowan Lai, Ligang Zhou
Summary: In this study, the effects of environmental factors on U. virens were investigated. It was found that fructose, glucose, complex nitrogen sources, acidic conditions, and light exposure favored the production of sorbicillinoids. The relative transcript levels of sorbicillinoid biosynthesis genes were up-regulated when U. virens was exposed to these favorable environmental factors, indicating that sorbicillinoid biosynthesis is mainly regulated at the transcriptional level. Two pathway-specific transcription factor genes, UvSorR1 and UvSorR2, were identified to be involved in the regulation of sorbicillinoid biosynthesis. These findings provide valuable insights into the regulation mechanisms of sorbicillinoid biosynthesis and can contribute to the development of effective means for controlling sorbicillinoid production in U. virens.
Article
Biochemistry & Molecular Biology
Mengyao Xue, Siji Zhao, Gan Gu, Dan Xu, Xuping Zhang, Xuwen Hou, Jiankun Miao, Hai Dong, Dongwei Hu, Daowan Lai, Ligang Zhou
Summary: Rice false smut caused by Villosiclava virens is a highly destructive fungal disease that reduces the yield and quality of rice grains. This study isolated an albino strain LN02 from white false smut balls collected in China. The genome analysis revealed the deficiency of ustilaginoidin biosynthesis in strain LN02, which led to albinism. This finding highlights the potential of strain LN02 in the development and application of secondary metabolites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Gan Gu, Xiao Gong, Dan Xu, Yonglin Yang, Ruya Yin, Jungui Dai, Kui Zhu, Daowan Lai, Ligang Zhou
Summary: Ten new diphenyl ether polyketides, rhexocerins A-D(1-4)and rhexocercosporins A-F(5-10), as well as three known congeners (11-13), were isolated from the endophytic fungus Rhexocercosporidium sp.Dzf14 from Dioscorea zingiberensis. Their structures were determined by NMR, HRESIMS, quantum chemical ECD calculations, and X-ray crystallography. Compounds 1 and 5-9 exhibited antibacterial activities against methicillin-resistant S. aureus T144 and vancomycin-resistant E. faecalis.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Microbiology
Gan Gu, Xiaowei Jia, Weixuan Wang, Peng Li, Siji Zhao, Zhiyao Zhou, Ruya Yin, Daowan Lai, Suqin Song, Ligang Zhou
Summary: A total of 99 endophytic fungal isolates were obtained from the roots of Glycyrrhiza inflata, with 11 different genera identified, dominated by Aspergillus, Alternaria, and Fusarium. Among 22 fungi extracts, Alternaria angustiovoidea Glinf007 showed significant mycelial growth inhibitory activity against three rice fungal pathogens. The study suggests that G. inflata harbors a diverse community of endophytic fungi with potential natural antimicrobial properties beneficial for agriculture and pharmaceutical industries.
MICROBIOLOGY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Dan Xu, Ruya Yin, Zhiyao Zhou, Gan Gu, Siji Zhao, Jin-Rong Xu, Junfeng Liu, You-Liang Peng, Daowan Lai, Ligang Zhou
Summary: Ustilaginoidins are a type of mycotoxin produced by Ustilaginoidea virens, featuring a dimeric naphtho-gamma-pyrone skeleton. The biosynthesis process involves multiple steps, including the discovery of dimeric compounds and double bond reduction. Different enzymes play roles at different stages, leading to the formation of diverse ustilaginoidins.
Article
Chemistry, Multidisciplinary
Ali Wang, Siji Zhao, Gan Gu, Dan Xu, Xuping Zhang, Daowan Lai, Ligang Zhou
Article
Chemistry, Multidisciplinary
Ziling Mao, Mengyao Xue, Gan Gu, Weixuan Wang, Dianpeng Li, Daowan Lai, Ligang Zhou
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)