p62/SQSTM1 at the interface of aging, autophagy, and disease

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

(2014) Márton L. Tóth et al.   Autophagy

Lysine 63-linked polyubiquitin potentially partners with p62 to promote the clearance of protein inclusions by autophagy

(2014) Jeanne M.M Tan et al.   Autophagy

Autophagy is required for extension of yeast chronological life span by rapamycin

(2014) Ashley L. Alvers et al.   Autophagy

Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts

(2013) Chad Lerner et al.   AGING CELL

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The aging respiratory system—Pulmonary structure, function and neural control

(2013) Peter M. Lalley   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Fibroblasts from long-lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress

(2012) Min Wang et al.   AGING CELL

Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan

(2012) Michael J. Steinbaugh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

IGF-I enhances cellular senescence via the reactive oxygen species–p53 pathway

(2012) Anastasia-Evi Handayaningsih et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Assurance of mitochondrial integrity and mammalian longevity by the p62–Keap1–Nrf2–Nqo1 cascade

(2012) Jeongho Kwon et al.   EMBO REPORTS

An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

(2012) Adam L. Hughes et al.   NATURE

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

Analysis of neural subtypes reveals selective mitochondrial dysfunction in dopaminergic neurons from parkin mutants

(2012) J. L. Burman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p62 at the Interface of Autophagy, Oxidative Stress Signaling, and Cancer

(2011) Ioannis P. Nezis et al.   ANTIOXIDANTS & REDOX SIGNALING

Selective autophagy mediated by autophagic adapter proteins

(2011) Terje Johansen et al.   Autophagy

Rapamycin decelerates cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease

(2011) M. C. Barone et al.   Disease Models & Mechanisms

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype

(2011) Antero Salminen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis

(2011) Tomasz M. Stępkowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition

(2011) Robert W. Gilkerson et al.   HUMAN MOLECULAR GENETICS

Autophagy Suppresses Interleukin-1β (IL-1β) Signaling by Activation of p62 Degradation via Lysosomal and Proteasomal Pathways

(2011) Jongdae Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

(2011) Eisuke Itakura et al.   JOURNAL OF CELL BIOLOGY

p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate

(2011) Y. Watanabe et al.   JOURNAL OF CELL SCIENCE

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Novel demonstration of conformationally modified tau in sporadic inclusion-body myositis muscle fibers

(2011) Anna Nogalska et al.   NEUROSCIENCE LETTERS

Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts

(2011) Hyun Tae Kang et al.   PLoS One

Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells

(2011) K. Cao et al.   Science Translational Medicine

Novel demonstration of amyloid-β oligomers in sporadic inclusion-body myositis muscle fibers

(2010) Anna Nogalska et al.   ACTA NEUROPATHOLOGICA

Protein homeostasis and aging: The importance of exquisite quality control

(2010) Hiroshi Koga et al.   AGEING RESEARCH REVIEWS

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

(2010) Sven Geisler et al.   Autophagy

AMPK activation represses the human gene promoter of the cardiac isoform of acetyl-CoA carboxylase: Role of nuclear respiratory factor-1

(2010) Tasneem Adam et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease

(2010) Malin von Otter et al.   BMC Medical Genetics

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

PKCζ-Regulated Inflammation in the Nonhematopoietic Compartment Is Critical for Obesity-Induced Glucose Intolerance

(2010) Sang Jun Lee et al.   Cell Metabolism

Brown adipose tissue and aging

(2010) Virgile Lecoultre et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Stress-induced senescence in human and rodent astrocytes

(2010) Alessandro Bitto et al.   EXPERIMENTAL CELL RESEARCH

Age-associated alterations of the neuromuscular junction

(2010) Youngmok C. Jang et al.   EXPERIMENTAL GERONTOLOGY

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

(2010) Ian M. Copple et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New insights into the role of mitochondria in aging: mitochondrial dynamics and more

(2010) A. Y. Seo et al.   JOURNAL OF CELL SCIENCE

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Long-Term IGF-I Exposure Decreases Autophagy and Cell Viability

(2010) Alessandro Bitto et al.   PLoS One

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

p62/SQSTM1 is overexpressed and prominently accumulated in inclusions of sporadic inclusion-body myositis muscle fibers, and can help differentiating it from polymyositis and dermatomyositis

(2009) Anna Nogalska et al.   ACTA NEUROPATHOLOGICA

Perspective: Does brown fat protect against diseases of aging?

(2009) Mark P. Mattson   AGEING RESEARCH REVIEWS

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling

(2009) Zhaoyu Jin et al.   CELL

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

Nucleocytoplasmic Shuttling of p62/SQSTM1 and Its Role in Recruitment of Nuclear Polyubiquitinated Proteins to Promyelocytic Leukemia Bodies

(2009) Serhiy Pankiv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent advances in understanding the molecular basis of Paget disease of bone

(2009) A Goode et al.   JOURNAL OF CLINICAL PATHOLOGY

The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway

(2009) Y. T. Zheng et al.   JOURNAL OF IMMUNOLOGY

Nrf2 Signaling, a Mechanism for Cellular Stress Resistance in Long-Lived Mice

(2009) S. F. Leiser et al.   MOLECULAR AND CELLULAR BIOLOGY

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Oxidative damage to the promoter region of SQSTM1/p62 is common to neurodegenerative disease

(2009) Yifeng Du et al.   NEUROBIOLOGY OF DISEASE

Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis

(2009) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p62 serves as a shuttling factor for TrkA interaction with the proteasome

(2008) Thangiah Geetha et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

(2008) Pazit Polak et al.   Cell Metabolism

Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

(2008) Claude A. Piantadosi et al.   CIRCULATION RESEARCH

The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Jiefei Geng et al.   EMBO REPORTS

Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease

(2008) Yifeng Du et al.   FREE RADICAL BIOLOGY AND MEDICINE

Functional Mitochondria Are Required for α-Synuclein Toxicity in Aging Yeast

(2008) Sabrina Büttner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ref(2)P, theDrosophila melanogasterhomologue of mammalian p62, is required for the formation of protein aggregates in adult brain

(2008) Ioannis P. Nezis et al.   JOURNAL OF CELL BIOLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration

(2008) J. Ramesh Babu et al.   JOURNAL OF NEUROCHEMISTRY

Atg8 Controls Phagophore Expansion during Autophagosome Formation

(2008) Zhiping Xie et al.   MOLECULAR BIOLOGY OF THE CELL

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9

(2008) Min Wei et al.   PLoS Genetics

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

Autophagy and aging: keeping that old broom working

(2008) Ana Maria Cuervo   TRENDS IN GENETICS

The Atg1 Kinase Complex Is Involved in the Regulation of Protein Recruitment to Initiate Sequestering Vesicle Formation for Nonspecific Autophagy in Saccharomyces cerevisiae

(2007) Heesun Cheong et al.   MOLECULAR BIOLOGY OF THE CELL