Review
Biochemistry & Molecular Biology
Arslan Iftikhar, Rimsha Nausheen, Humaira Muzaffar, Muhammad Ahsan Naeem, Muhammad Farooq, Mohsin Khurshid, Ahmad Almatroudi, Faris Alrumaihi, Khaled S. Allemailem, Haseeb Anwar
Summary: Honey, rich in antioxidants, is considered a potent pharmaceutical candidate for multiple neurological disorders, with various constituent polyphenols exhibiting multiple antioxidant effects.
Review
Biochemistry & Molecular Biology
Rami S. Najjar, Arielle M. Schwartz, Brett J. Wong, Puja K. Mehta, Rafaela G. Feresin
Summary: Ischemia with no obstructive coronary artery disease (INOCA) is a common diagnosis with a higher prevalence in women, associated with major adverse cardiovascular outcomes and angina. Coronary microvascular dysfunction (CMD) is a major feature, driven by inflammatory and oxidative stress signaling, and treatment focuses on addressing cardiovascular risk factors. Potential treatment options include berry-derived polyphenols to modulate these pathways, with future clinical trials needed to investigate their effectiveness in INOCA patients with CMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Mohammad Adi Mohammad Fadzil, Suraiami Mustar, Aswir Abd Rashed
Summary: As the global population ages, there is increasing interest in the neuroprotective properties of honey in managing neurodegenerative diseases that primarily affect the elderly. This review explores the effectiveness of honey as a neuroprotective agent through in vitro, in vivo, and clinical research. The study identified the Tualang and Thyme honey as the most promising in terms of antioxidant, anti-inflammatory, and anticholinesterase activity, suggesting their potential use in the prevention and management of neurodegenerative diseases such as Alzheimer's disease. While considerable evidence from in vitro and in vivo studies supports the anti-neurodegenerative properties of honey, further clinical intervention studies are needed for stronger validation.
Review
Agriculture, Multidisciplinary
Hui Xu, Qian Zhou, Bin Liu, Ka-Wing Cheng, Feng Chen, Mingfu Wang
Summary: Mung beans are rich in neuroprotective polyphenols that may be beneficial for preventing Alzheimer's disease. These polyphenols, including vitexin, isovitexin, sinapic acid, and ferulic acid, show potential in neuroprotection. Studies have also shown changes in the phenolic profile of mung beans after germination, indicating the importance of further research on the neuroprotective activities and mechanisms of different phenolic compounds.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Amanda Shen-Yee Kong, Kok-Song Lai, Swee-Hua Erin Lim, Sivakumar Sivalingam, Jiun-Yan Loh, Sathiya Maran
Summary: Ischemic heart disease is the leading cause of mortality and morbidity globally, and microRNAs play a crucial role in the diagnosis and treatment of this disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Pooja Mittal, Sanchit Dhankhar, Samrat Chauhan, Nitika Garg, Tanima Bhattacharya, Maksood Ali, Anis Ahmad Chaudhary, Hassan Ahmad Rudayni, Mohammed Al-Zharani, Wasim Ahmad, Salah Ud-Din Khan, Thakur Gurjeet Singh, Somdutt Mujwar
Summary: Parkinson's disease is caused by the depletion of dopamine neurons in the basal ganglia, and oxidative stress is one of the factors contributing to its development. Antioxidants can reduce oxidative stress and lower the risk of neurodegenerative disorders. While there is no cure for neurodegenerative illnesses, treatment can help control the disease and improve the patient's quality of life. Natural antioxidants, such as polyphenols, have emerged as a promising alternative management strategy.
Review
Food Science & Technology
Xiaowen Pi, Yuxue Sun, Jianjun Cheng, Guiming Fu, Mingruo Guo
Summary: This review summarizes recent studies on the effects of polyphenols on the allergenicity of allergenic proteins. It discusses the mechanisms by which polyphenols reduce allergenicity and concludes that polyphenols can react with allergens to induce structural changes, resulting in the masking or destruction of epitopes and the reduction of allergenicity. Oral administration in murine models shows that polyphenols can suppress allergic reactions by regulating immune cell function, changing cytokine levels, suppressing certain pathways, and improving intestinal function. The outcome is influenced by factors such as polyphenol types, concentration, allergen types, pH, oral timing, and dosage. Furthermore, treatment with polyphenols improves the physicochemical and functional properties of allergenic proteins. Thus, polyphenols have the potential to produce hypoallergenic food.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Jose Joao Caires Serina, Paula Cristina Machado Ferreira Castilho
Summary: Diabetes is a global health concern with major risk factors including hyperglycemia, hypertension, obesity, and oxidative stress leading to complications. Polyphenols and other compounds have been shown to manage and improve these complications, playing a relevant role in reducing risk factors and enhancing associated complications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Nutrition & Dietetics
Anna Debinska, Barbara Sozanska
Summary: This review discusses the potential anti-allergic actions of dietary polyphenols, including their ability to reduce protein allergenicity, regulate immune response, and modify gut microbiome. It reviews current evidence that various polyphenols can attenuate allergic inflammation and alleviate symptoms of allergic diseases. It suggests that dietary polyphenols have great anti-allergic potential and could be used for preventive or therapeutic interventions.
Review
Biochemistry & Molecular Biology
Wei An, Shaoqing Li, Lizheng Qin
Summary: The study suggests that honey has a certain effect in preventing and treating radiotherapy-induced mucositis, especially in higher grades of mucositis. Additionally, honey also provides some relief from severe pain.
Review
Dentistry, Oral Surgery & Medicine
Jonathan Deng, Vaidehi Misra, Neehal Vilash, Wendi Wu, Cindy Hua, Kate Son, Federica Canfora, Fabian Y. S. Kong, Rita Paolini, Michael Mccullough, Antonio Celentano
Summary: This article reviews the evidence on the anticancer effects of coffee constituents and discusses their potential therapeutic use for oral squamous cell carcinoma (OSCC). The results indicate that coffee constituents have positive effects on inhibiting cancer cell proliferation and influencing apoptotic mechanisms. However, there is currently a lack of literature on the specific utilization of coffee constituents for the treatment of oral cancers.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Review
Nutrition & Dietetics
Oliver Chen, Eunice Mah, ElHadji Dioum, Ankita Marwaha, Shobana Shanmugam, Nagappa Malleshi, Vasudevan Sudha, Rajagopal Gayathri, Ranjit Unnikrishnan, Ranjit Mohan Anjana, Kamala Krishnaswamy, Viswanathan Mohan, YiFang Chu
Summary: Optimal nutrition is crucial for the development and maintenance of a healthy immune system, reducing the risk of infectious diseases. Oats, a nutritious whole grain, contain a variety of immune-supporting nutrients that play a key role in optimizing the immune system.
Review
Chemistry, Applied
Hui Yang, Yezhi Qu, Yaran Gao, Shuyuan Sun, Ruixue Ding, Weihe Cang, Rina Wu, Junrui Wu
Summary: It is concerning that food allergies are becoming more common due to factors such as hygiene, microbiota, inappropriate complementary foods, and processed food consumption. Understanding the role of dietary components can improve the diagnosis, treatment, and prevention of food allergies.
Review
Nutrition & Dietetics
Azizah Ugusman, Syarifah Amirah Syed Shahrin, Nurul Hana Azizan, Siva Balan Pillai, Khamini Krishnan, Norizam Salamt, Amilia Aminuddin, Adila A. Hamid, Jaya Kumar, Mohd Helmy Mokhtar
Summary: The study systematically reviewed the effects of honey on obesity, finding that honey showed anti-obesity effects in animal studies but had conflicting results in clinical trials. While honey supplementation did not show significant weight reduction in some trials, there was also no evidence that it increased body weight.
FRONTIERS IN NUTRITION
(2022)
Review
Geriatrics & Gerontology
Nasim Rezaee, W. M. A. D. Binosha Fernando, Eugene Hone, Hamid R. R. Sohrabi, Stuart K. K. Johnson, Stuart Gunzburg, Ralph N. N. Martins
Summary: Alzheimer's disease is characterized by neuronal damage, cell death, and memory impairments, with no effective therapeutic approach currently available. Natural polyphenols can potentially affect the development of Alzheimer's disease through various pathways, and sorghum, with its high polyphenol content, may offer health benefits through the reduction of oxidative stress.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
