☆ 4.5 Article

Comparison of Predicted and Experimentally Measured Aerosol Deposition Efficiency in BALB/C Mice in a New Nose-Only Exposure System

AEROSOL SCIENCE AND TECHNOLOGY (2009)

期刊

AEROSOL SCIENCE AND TECHNOLOGY

卷 43, 期 10, 页码 970-977

出版社

TAYLOR & FRANCIS INC

DOI: 10.1080/02786820903082029

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Engineering, Chemical Engineering, Mechanical Environmental Sciences Meteorology & Atmospheric Sciences

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TSE Systems, Inc., Chesterfield, MO 63005, USA

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Reagent

摘要

The use of respiratory tract dosimetry predictions to estimate the desired aerosol exposure concentration required for a specific target deposited dose in animal inhalation studies has been hindered by: (1) a lack of species/strain specific quantitative respiratory tract anatomy; and (2) verification by comparison of calculated and experimentally measured deposited doses. Using recent literature on tracheobronchial and pulmonary respiratory tract anatomy, dosimetry predictions for the Balb/c mouse were compared with deposited doses for 0.5, 1.0, and 2.0 micrometer diameter aerosols in a newly available nose-only exposure system. Spatial and temporal aerosol port to port uniformity of this nose-only exposure system was within +/- 10% of the mean. Dosimetry predictions were in agreement with the measured mean deposited doses for the aerosols tested.

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