Article
Biochemistry & Molecular Biology
Khalid Saad Alharbi, Obaid Afzal, Waleed Hassan Almalki, Imran Kazmi, Mohammad Arshad Javed Shaikh, Lakshmi Thangavelu, Monica Gulati, Sachin Kumar Singh, Niraj Kumar Jha, Piyush Kumar Gupta, Dinesh Kumar Chellappan, Brian George Oliver, Kamal Dua, Gaurav Gupta
Summary: Nutraceuticals, as dietary supplements, have the potential to improve health, prevent diseases, and maintain normal body function. This review discusses the medical value of nutraceuticals in targeting the NF-kappa B pathway to mitigate inflammatory lung diseases.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Food Science & Technology
Abeer A. Al-Masri, Fuad Ameen
Summary: Banana is an important fruit crop worldwide. In this study, an anthocyanin-rich extract from banana bract (BBA) was prepared and characterized. BBA showed antioxidant and anti-inflammatory activity in LPS-stimulated macrophage-like cells. The presence of phenolic compounds, flavonoids, and anthocyanin in BBA was identified. BBA increased endogenous antioxidants and inhibited the nuclear translocation of NF-kappaB under LPS-stimulated conditions, indicating its potential as an anti-inflammatory agent.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Environmental Sciences
Dan Wang, Zhenzhen Tan, Jing Yang, Longfei Li, Haoran Li, Huaxing Zhang, Heqiong Liu, Yi Liu, Lei Wang, Qian Li, Huicai Guo
Summary: This study aimed to investigate the effects of PFOS exposure on atherosclerosis progression and the underlying mechanisms. The results showed that PFOS increased pulse wave velocity, intima-media thickness, aortic plaque burden, and levels of serum lipids and inflammatory cytokines. PFOS promoted M1 macrophage polarization and suppressed M2 macrophage polarization, leading to inflammation. NF-κB activation in macrophages was associated with this process. These findings highlight the role of PFOS in accelerating atherosclerosis progression through NF-κB-mediated inflammation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Immunology
Marion Mussbacher, Martina Derler, Jose Basilio, Johannes A. Schmid
Summary: Nuclear factor kappa B (NF-kappa B) is a dimeric transcription factor that regulates the expression of chemokines, cytokines, transcription factors, and regulatory proteins, playing a crucial role in inflammation and immunity. Understanding its specific roles in different cell types, tissues, and under different stimuli is important. This review focuses on the role of NF-kappa B in monocytes and macrophages, innate immune cells that exhibit high plasticity and adjust their functions against pathogens and cues from the environment. NF-kappa B activation in macrophages has significant implications in inflammatory diseases and its temporal dynamics are complex.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Kehinde S. Olaniyi, Stephanie E. Areloegbe
Summary: This study investigated the effects of acetate on cardiometabolic abnormalities associated with polycystic ovarian syndrome (PCOS) in a rat model. The results suggest that acetate protects against cardiac inflammation by suppressing PCSK9 and NF-kB-dependent mechanisms.
Article
Dentistry, Oral Surgery & Medicine
Shaohua Cong, Qian Peng, Liou Cao, Qingqing Yi, Yi Liu, Linhui Li, Qingchun Tong, Dongyu Liang
Summary: This study investigated the effects of diosgenin on periodontitis and found that it inhibited inflammatory responses and the activation of NF-kappa B pathway while promoting osteogenesis. Administering diosgenin to periodontitis rats also reduced the levels of inflammatory factors and NF-kappa B in gingival tissue, and promoted the expression of osteoblast-related genes. These findings suggest that diosgenin may be a potential therapeutic strategy for treating periodontitis in the future.
Article
Urology & Nephrology
Guibao Ke, Xueqin Chen, Ruyi Liao, Lixia Xu, Li Zhang, Hong Zhang, Sujuan Kuang, Yue Du, Juan Hu, Zhiwen Lian, Caoshuai Dou, Qianmei Zhang, Xingchen Zhao, Fengxia Zhang, Shuangshuang Zhu, Jianchao Ma, Zhuo Li, Sijia Li, Chaosheng He, Xia Chen, Yingzhen Wen, Zhonglin Feng, Minghao Zheng, Ting Lin, Ruizhao Li, Bohou Li, Wei Dong, Yuanhan Chen, Wenjian Wang, Zhiming Ye, Chunyu Deng, Houqin Xiao, Jie Xiao, Xinling Liang, Wei Shi, Shuangxin Liu
Summary: The expression of Receptor activator of NF-kappa B (RANK) is increased in podocytes of patients with diabetic nephropathy. Mouse models of podocyte-specific RANK depletion and overexpression showed that RANK depletion alleviated the development of kidney diseases, while RANK overexpression aggravated the condition. The findings suggest that RANK mediates the development of diabetic nephropathy by promoting glomerular oxidative stress and proinflammatory cytokine production.
KIDNEY INTERNATIONAL
(2021)
Review
Chemistry, Medicinal
Saeed Mohammadian Haftcheshmeh, Maliheh Abedi, Kazem Mashayekhi, Mohammad Javad Mousavi, Jamshid Gholizadeh Navashenaq, Asadollah Mohammadi, Amir Abbas Momtazi-Borojeni
Summary: This review discusses the modulatory effects of berberine (BBR) on various inflammatory signaling pathways in the immune system and explores its therapeutic efficacy and anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2022)
Article
Plant Sciences
Yating Wang, Xiurong Bao, Hao Xian, Fang Wei, Yining Song, Siyu Zhao, Yujie Zhang, Yumeng Wang, Ying Wang
Summary: This study investigates the role and potential mechanisms of ginsenoside metabolite compound K (CK) in the treatment of rheumatoid arthritis (RA). The results demonstrate that CK can reduce arthritis symptoms and inhibit inflammation-related genes and pathways. These findings contribute to the understanding of the molecular mechanism of CK in treating RA.
PHARMACEUTICAL BIOLOGY
(2023)
Review
Immunology
Yan Liu, Kai Xu, Yin Yao, Zheng Liu
Summary: This article reviews the role of A20 in allergic airway diseases, finding that A20 can regulate the inflammatory response in these diseases by inhibiting the NF-κB signaling pathway, thus exerting anti-inflammatory effects. The gene polymorphisms of A20 are also associated with allergic airway diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Mingkwan Na Takuathung, Saranyapin Potikanond, Siriwoot Sookkhee, Pitchaya Mungkornasawakul, Thanathorn Jearanaikulvanich, Kittinan Chinda, Nitwara Wikan, Wutigri Nimlamool
Summary: The study demonstrated that Kaempferia parviflora extract has significant anti-inflammatory and anti-psoriatic effects by suppressing key inflammatory markers and inhibiting NF-kappa B pathway activation and protein phosphorylation. The results suggest that KP extract has potential as a promising agent for treating inflammation and psoriasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Ying-Ya Cao, Zhen Wang, Zhong-Han Wang, Xiao-Gan Jiang, Wei-Hua Lu
Summary: The study found that the miR-155 inhibitor alleviates sepsis-induced inflammation and intestinal barrier dysfunction by inactivating NF-kappa B signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Na Yang, Minxiu Wang, Ke Lin, Mengyang Wang, Diyun Xu, Xue Han, Xia Zhao, Yi Wang, Gaojun Wu, Wu Luo, Guang Liang, Peiren Shan
Summary: The study demonstrates that Dectin-1 plays a critical role in the pathogenesis of diabetic cardiomyopathy by regulating inflammation. Dectin-1 deficient mice are protected against diabetes-induced cardiac dysfunction, cardiomyocyte hypertrophy, tissue fibrosis, and inflammation. Dectin-1 may be a potential target for the treatment of diabetic cardiomyopathy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Pharmacology & Pharmacy
Xuye Jiang, Yingying Gu, Yuanling Huang, Yujia Zhou, Nengzhi Pang, Jing Luo, Zhaoyang Tang, Zhenfeng Zhang, Lili Yang
Summary: The study found that CBD can prevent liver steatosis and oxidative stress induced by high-fat high-cholesterol diet, and alleviate inflammation by inhibiting activation of the hepatic NF kappa B-NLRP3 inflammasome-pyroptosis pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Khalid Saad Alharbi, Neeraj Kumar Fuloria, Shivkanya Fuloria, Sk Batin Rahman, Waleed Hassan Al-Malki, Mohammad Arshad Javed Shaikh, Lakshmi Thangavelu, Sachin K. Singh, Venkata Sita Rama Raju Allam, Niraj Kumar Jha, Dinesh Kumar Chellappan, Kamal Dua, Gaurav Gupta
Summary: NF-xB is a crucial transcription factor involved in inflammation, immune response, and various physiological processes, playing a key role in many respiratory disorders.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Review
Nutrition & Dietetics
Bocheng Xu, Jinping Cao, Jie Fu, Zhi Li, Mingliang Jin, Xinxia Wang, Yizhen Wang
Summary: This meta-analysis examined the effects of nondigestible fermentable carbohydrates (NDFCs) on adiposity and cardiovascular risk factors in adults with overweight or obesity. The findings suggest that increased intake of NDFCs is significantly effective in reducing body weight, waist and hip circumference, blood pressure, cholesterol levels, and low-density lipoprotein in individuals with overweight and obesity.
Article
Biochemistry & Molecular Biology
Jinping Cao, Xin Liu, Yuanzhi Cheng, Yizhen Wang, Fengqin Wang
Summary: The study found that supplementation of SeEPS significantly improved the average daily weight gain and reduced the feed-to-gain ratio of mice, without causing liver damage. SeEPS supplementation also enhanced antioxidant capacity in the liver and serum, as well as regulated selenium deposition in mice.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Biology
Wei Chen, Yushi Chen, Ruifan Wu, Guanqun Guo, Youhua Liu, Botao Zeng, Xing Liao, Yizhen Wang, Xinxia Wang
Summary: This study found that DHA can promote mitochondrial biogenesis and skeletal muscle fiber remodeling through the FTO/m(6)A/DDIT4/PGC1 alpha signaling pathway, protecting against obesity-induced decline in skeletal muscle function.
Article
Biochemistry & Molecular Biology
Lixia Kai, Xin Zong, Qin Jiang, Zeqing Lu, Fengqin Wang, Yizhen Wang, Tenghao Wang, Mingliang Jin
Summary: The water-soluble polysaccharides AMP from Atractylodes macrocephalae Koidz. have protective effects on intestinal mucosal barrier injury induced by DSS in mice. AMP alleviates body weight decreases, shortens colon length, ameliorates colonic damage, decreases proinflammatory cytokines, and modulates intestinal microbiota to increase beneficial bacteria ratio.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Food Science & Technology
Weifa Su, Zipeng Jiang, Cheng Wang, Bocheng Xu, Zeqing Lu, Fengqin Wang, Xin Zong, Mingliang Jin, Yizhen Wang
Summary: In this study, co-fermentation of defatted rice bran (DFRB) using Bacillus subtilis, Saccharomyces cerevisiae, and Lactiplantibacillus plantarum was investigated. The co-fermentation effectively improved the nutritional value of DFRB by degrading antinutritional factors and fiber, and increasing protein content. It also prevented lipid oxidation and optimized the microbial community. High-throughput sequencing and metabolic analysis provided insights into the metabolic pathways during the co-fermentation of DFRB.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Immunology
Luoyi Zhu, Xin Zong, Xiao Xiao, Yuanzhi Cheng, Jie Fu, Zeqing Lu, Mingliang Jin, Fengqin Wang, Yizhen Wang
Summary: Liver injury in colitis mice may be related to intestinal dysbiosis and host-microbiota interactions, as revealed by an integrated analysis of host transcriptome and colonic microbiome. The liver and colon transcriptome showed significant changes, and genes associated with liver injury were correlated with the abundance of liver and gut health-related bacteria. These findings provide new insights for potential targets in the treatment of IBD and its induced liver injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Luoyi Zhu, Jie Fu, Xiao Xiao, Fengqin Wang, Mingliang Jin, Weihuan Fang, Yizhen Wang, Xin Zong
Summary: The study found that Faecal Microbiota Transplantation (FMT) can prevent high-fat diet-induced obesity and lipid metabolism disorders by altering the jejunal microbiota composition and increasing the abundance of Lactobacillus and Romboutsia, which are negatively correlated with obesity-related indicators. The anti-obesity effect of wild boar faecal suspension is associated with jejunal N6-methyladenosine (m(6)A) levels. Overall, these results suggest that FMT has a mitigating effect on HFD-induced obesity by altering microbial composition and structure of the jejunum.
MICROBIAL BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xing Liao, Jiaqi Liu, Yushi Chen, Youhua Liu, Wei Chen, Botao Zeng, Yuxi Liu, Yaojun Luo, Chaoqun Huang, Guanqun Guo, Yizhen Wang, Xinxia Wang
Summary: This study found that metformin can combat obesity by inhibiting adipogenesis and regulating the cell cycle, leading to significant weight loss and decreased adipose tissue weight.
JOURNAL OF DRUG TARGETING
(2022)
Review
Immunology
Weifa Su, Tao Gong, Zipeng Jiang, Zeqing Lu, Yizhen Wang
Summary: Early weaning is important for improving sow production efficiency, but often leads to postweaning diarrhea (PWD) in piglets. Traditional antibiotic supplementation has drawbacks, while probiotics have shown potential for preventing and treating PWD by regulating intestinal barriers.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Cheng Wang, Siyu Wei, Bojing Liu, Fengqin Wang, Zeqing Lu, Mingliang Jin, Yizhen Wang
Summary: Research has found that a maternal fermented diet can improve the performance of sows and piglets, accelerate the maturation of neonatal gut microbiota, and reduce susceptibility to colonic inflammation in offspring. Milk L-glutamine and gut Lactobacillus were identified as important factors in the fermented diet, which can modulate the gut microbiota and alleviate inflammation.
Article
Nutrition & Dietetics
Cheng Wang, Siyu Wei, Mingliang Jin, Bojing Liu, Min Yue, Yizhen Wang
Summary: The present study investigated the dynamics of microbiota and metabolites during solid-state fermentation of plant-based food using two-stage fermentation. It revealed the changes in predominant bacteria and metabolic pathways at different fermentation stages, with phenylalanine metabolism identified as the most important pathway. The correlations between microbiota and metabolites were also analyzed, showing significant associations between specific bacteria and amino acid metabolism.
FRONTIERS IN NUTRITION
(2022)
Article
Agriculture, Dairy & Animal Science
Qingqing Xiong, Jing Zhao, Chenying Tian, Wan Ma, Linfeng Miao, Li Liang, Kang Zhang, Huahua Du
Summary: A high-iron diet reduces lipid accumulation in mice but causes intestinal inflammation and changes in gut microbiota.
Article
Veterinary Sciences
Zipeng Jiang, Weifa Su, Chaoyue Wen, Wentao Li, Yu Zhang, Tao Gong, Shuai Du, Xinxia Wang, Zeqing Lu, Mingliang Jin, Yizhen Wang
Summary: Clostridium perfringens is a main pathogen that can cause various diseases in humans and animals. This study aimed to build a mouse model infected with porcine C. perfringens and investigated its effects on growth performance, immune status, and intestinal integrity in mice. The results showed that high dose of C. perfringens caused a decline in growth performance, severe damage to intestinal structure, and increased inflammation in mice.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jiahui Li, Li Jia, Wan Ma, Yunfei Feng, Hong Yu, Huahua Du
Summary: High dietary iron intake can increase hepatic glycogen deposition and suppress hepatic gluconeogenesis, potentially through enhanced glucose uptake and regulation of AMPK and PGC-1 alpha.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Chenying Tian, Jing Zhao, Qingqing Xiong, Hong Yu, Huahua Du
Summary: Secondary iron overload can lead to chronic pancreatitis, causing abnormal pancreatic function. Iron deposition, inflammatory cell infiltration, pancreatic fibrosis, oxidative stress, and ferroptosis were observed in iron-overloaded mice. These findings highlight the importance of maintaining normal iron balance in the pancreas.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)