Regio- and Stereoselective Hydroxylation of Optically Active α-Ionone Enantiomers by Engineered Cytochrome P450 BM3 Mutants

CYP264B1 from Sorangium cellulosum So ce56: a fascinating norisoprenoid and sesquiterpene hydroxylase

(2012) Thuy T. B. Ly et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A Single Active Site Mutation Inverts Stereoselectivity of 16-Hydroxylation of Testosterone Catalyzed by Engineered Cytochrome P450 BM3

(2012) Harini Venkataraman et al.   CHEMBIOCHEM

Expanding the organic toolbox: a guide to integrating biocatalysis in synthesis

(2012) Christopher M. Clouthier et al.   CHEMICAL SOCIETY REVIEWS

Malleability and Versatility of Cytochrome P450 Active Sites Studied by Molecular Simulations

(2012) Chris Oostenbrink et al.   CURRENT DRUG METABOLISM

The Role of Protein Plasticity in Computational Rationalization Studies on Regioselectivity in Testosterone Hydroxylation by Cytochrome P450 BM3 Mutants

(2012) Stephanie B.A. de Beer et al.   CURRENT DRUG METABOLISM

Tuning P450 Enzymes as Oxidation Catalysts

(2012) Rudi Fasan   ACS Catalysis

Active Site Substitution A82W Improves the Regioselectivity of Steroid Hydroxylation by Cytochrome P450 BM3 Mutants As Rationalized by Spin Relaxation Nuclear Magnetic Resonance Studies

(2011) V. Rea et al.   BIOCHEMISTRY

An Efficient Route to Selective Bio-oxidation Catalysts: an Iterative Approach Comprising Modeling, Diversification, and Screening, Based on CYP102A1

(2011) Alexander Seifert et al.   CHEMBIOCHEM

Cytochromes P450 as useful biocatalysts: addressing the limitations

(2011) Elaine O'Reilly et al.   CHEMICAL COMMUNICATIONS

P450BM3(CYP102A1): connecting the dots

(2011) Christopher J. C. Whitehouse et al.   CHEMICAL SOCIETY REVIEWS

Cytochrome P450: taming a wild type enzyme

(2011) Sang Taek Jung et al.   CURRENT OPINION IN BIOTECHNOLOGY

Efficient Screening of Cytochrome P450 BM3 Mutants for Their Metabolic Activity and Diversity toward a Wide Set of Drug-Like Molecules in Chemical Space

(2011) J. Reinen et al.   DRUG METABOLISM AND DISPOSITION

Role of Residue 87 in the Activity and Regioselectivity of Clozapine Metabolism by Drug-Metabolizing CYP102A1 M11H: Application for Structural Characterization of Clozapine GSH Conjugates

(2011) V. Rea et al.   DRUG METABOLISM AND DISPOSITION

Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11

(2011) Eduardo Vottero et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

P450 Fingerprinting Method for Rapid Discovery of Terpene Hydroxylating P450 Catalysts with Diversified Regioselectivity

(2011) Kaidong Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Predictable Stereoselective and Chemoselective Hydroxylations and Epoxidations with P450 3A4

(2011) Aaron T. Larsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cytochrome P450 monooxygenases: an update on perspectives for synthetic application

(2011) Vlada B. Urlacher et al.   TRENDS IN BIOTECHNOLOGY

Regioselective hydroxylation of norisoprenoids by CYP109D1 from Sorangium cellulosum So ce56

(2010) Yogan Khatri et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Characterization of the versatile monooxygenase CYP109B1 from Bacillus subtilis

(2010) Marco Girhard et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Structural Analysis of CYP101C1 from Novosphingobium aromaticivorans DSM12444

(2010) Ming Ma  et al.   CHEMBIOCHEM

Cytochromes P450: exploiting diversity and enabling application as biocatalysts

(2010) Gideon Grogan   CURRENT OPINION IN CHEMICAL BIOLOGY

Protein engineering of microbial enzymes

(2010) Dominique Böttcher et al.   CURRENT OPINION IN MICROBIOLOGY

The Role of Water Molecules in Computational Drug Design

(2010) Stephanie de Beer et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Enzyme-mediated oxidations for the chemist

(2010) Frank Hollmann et al.   GREEN CHEMISTRY

Monooxygenases as biocatalysts: Classification, mechanistic aspects and biotechnological applications

(2010) D.E. Torres Pazmiño et al.   JOURNAL OF BIOTECHNOLOGY

Rational Design of a Minimal and Highly Enriched CYP102A1 Mutant Library with Improved Regio-, Stereo- and Chemoselectivity

(2009) Alexander Seifert et al.   CHEMBIOCHEM

Sequestration of 3-oxygenated α-ionone derivatives in the male rectal gland of the solanaceous fruit fly,Bactrocera latifrons

(2009) Ritsuo Nishida et al.   ENTOMOLOGIA EXPERIMENTALIS ET APPLICATA

Total Synthesis of (3R,3′R,6′R)-Lutein and Its Stereoisomers

(2009) Frederick Khachik et al.   JOURNAL OF ORGANIC CHEMISTRY

Directed evolution drives the next generation of biocatalysts

(2009) Nicholas J Turner   Nature Chemical Biology

New Attractants for Males of the Solanaceous Fruit Fly Bactrocera latifrons

(2008) Tatsuaki Ishida et al.   JOURNAL OF CHEMICAL ECOLOGY

Impact of Plasticity and Flexibility on Docking Results for Cytochrome P450 2D6: A Combined Approach of Molecular Dynamics and Ligand Docking

(2008) Jozef Hritz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites

(2007) Micaela C. Damsten et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Structural rationalization of novel drug metabolizing mutants of cytochrome P450 BM3

(2007) Eva Stjernschantz et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS