Review
Biochemistry & Molecular Biology
Qingluo Wang, Guoyu Xia, Jianmin Li, Longlong Yuan, Shujie Yu, Dingyang Li, Nan Yang, Zhongxiong Fan, Jinyao Li
Summary: Tumors are a major public health issue, and the application of near-infrared second region (NIR-II) optical imaging and nanomaterials in tumor diagnosis and treatment has garnered significant attention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Yuyue Zhao, Yuanwei Pan, Kelong Zou, Zhou Lan, Guowang Cheng, Qiuying Mai, Hao Cui, Qianfang Meng, Tongkai Chen, Lang Rao, Limin Ma, Guangtao Yu
Summary: We have developed a nanoplatform capable of improving the immunosuppressive tumor microenvironment (TME) by actively targeting it. By camouflaging the surface of gold nanorods (GNRs) with myeloid-derived suppressor cells (MDSCs) membrane, we have achieved targeted adjustment of the TME. This nanoplatform also enables multimodal cancer imaging and dual immunotherapy.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Physical
Yifei Zhou, Biao Huang, Shi-Hui Chen, Shu-Lin Liu, Mingxi Zhang, Ran Cui
Summary: In this research, zinc-doped silver telluride quantum dots with excellent fluorescence performance and stability were synthesized for near-infrared-IIb fluorescence imaging. Zinc doping improved the fluorescence properties and lifetime of the quantum dots, and enhanced their colloidal stability. PEGylated zinc-doped silver telluride quantum dots achieved high-resolution imaging of cerebral blood vessels and could be used to monitor brain condition after traumatic brain injury.
Article
Chemistry, Physical
Yifei Zhou, Biao Huang, Shi-Hui Chen, Shu-Lin Liu, Mingxi Zhang, Ran Cui
Summary: In this study, zinc-doped silver telluride quantum dots (Zn:Ag2Te QDs) with bright fluorescence in the near-infrared-IIb (NIR-IIb) window were synthesized. The introduction of Zn dopants improved the quantum yield and fluorescence lifetime by inhibiting crystal defects and reducing non-radiative transitions. Additionally, Zn-doping enhanced the colloidal stability of Zn:Ag2Te QDs by increasing the number of ligands on their surface. The PEGylated Zn:Ag2Te QDs with high absolute quantum yield enabled noninvasive imaging of the cerebral vasculature in mice, allowing for the monitoring of brain conditions after traumatic brain injury.
Article
Multidisciplinary Sciences
Yuqi Sun, Lishuang Ge, Linjie Dai, Changsoon Cho, Jordi Ferrer Orri, Kangyu Ji, Szymon J. Zelewski, Yun Liu, Alessandro J. Mirabelli, Youcheng Zhang, Jun-Yu Huang, Yusong Wang, Ke Gong, May Ching Lai, Lu Zhang, Dan Yang, Jiudong Lin, Elizabeth M. Tennyson, Caterina Ducati, Samuel D. Stranks, Lin-Song Cui, Neil C. Greenham
Summary: Perovskite LEDs with exceptional performance at high brightness have been achieved by introducing a multifunctional molecule that removes non-radiative regions and suppresses luminescence quenching at the interface. These LEDs show a peak EQE of 23.8% at 33 mA cm(-2) and retain EQEs more than 10% at high current densities of up to 1,000 mA cm(-2). An operational half-lifetime of 32 h at high brightness has been achieved, representing the best stability for perovskite LEDs.
Article
Chemistry, Multidisciplinary
Shaochen Zhou, Lotta Gustavsson, Gregory Beaune, Sourov Chandra, Jukka Niskanen, Janne Ruokolainen, Jaakko V. I. Timonen, Olli Ikkala, Bo Peng, Robin H. A. Ras
Summary: This work presents a general and efficient method to synthesize pH-responsive near-infrared (NIR) emitting gold nanoclusters by introducing aliphatic tertiary amine (TA) groups as ligands. The pH-responsive NIR emission is achieved through the protonation and deprotonation of TA groups, which induce electronic structure changes. The pH-responsive gold nanoclusters can serve as specific and sensitive probes for lysosomes in cells, offering non-invasive emissions without interference from intracellular autofluorescence.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Materials Science, Multidisciplinary
R. Yang, G. Bao, H. Li, H. Liu, J. Chen, J. Li, D. Ma
Summary: This study presents the rational design and engineering of a multifunctional nanoplatform that combines magnetic resonance and near-infrared photoluminescence capabilities for tumor imaging. The nanoplatform shows great potential in in vitro tissue imaging and pH-responsive drug release, and exhibits reduced cytotoxicity compared to other nanoparticles containing toxic heavy metals.
MATERIALS TODAY ADVANCES
(2022)
Article
Nanoscience & Nanotechnology
Dongyang Shen, Zhenwei Ren, Qinyi Li, Chengzhao Luo, Wenlin Xia, Zhishuai Zheng, Wenchen Ma, Jie Li, Yu Chen
Summary: In this study, a multifunctional molecule, tetrabutylammonium dihydrogen phosphate (TDP), was introduced to enhance the emission efficiency of quasi-2D perovskite. TDP effectively suppressed low-order phases, passivated defects, and increased the exciton binding energy of the perovskite, resulting in improved radiative recombination and high emission efficiency. The TDP-incorporated perovskite films exhibited significantly higher photoluminescence quantum yield, external quantum efficiency, and brightness.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Erving Ximendes, Riccardo Marin, Yingli Shen, Diego Ruiz, Diego Gomez-Cerezo, Paloma Rodriguez-Sevilla, Jose Lifante, Perla X. Viveros-Mendez, Francisco Gamez, David Garcia-Soriano, Gorka Salas, Carmen Zalbidea, Ana Espinosa, Antonio Benayas, Nuria Garcia-Carrillo, Lorena Cusso, Manuel Desco, Francisco J. Teran, Beatriz H. Juarez, Daniel Jaque
Summary: Magnetic hyperthermia therapy involves increasing the temperature within solid tumors by using magnetic nanoparticles, but these nanoparticles lack real-time thermal feedback and accurate localization. This study combines magnetic nanoparticles with infrared luminescent nanothermometers in nanocapsules to provide accurate thermal feedback and multimodal imaging capabilities, representing a milestone towards controlled magnetothermal therapy with minimal side effects.
ADVANCED MATERIALS
(2021)
Editorial Material
Optics
Joo Sung Kim, Tae-Woo Lee
Summary: Perovskite light emitters can achieve bright, stable, and efficient light-emitting diodes through a molecular design strategy, with strong endurance on high-current operation.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Mingzhou Wu, Shuqing He, Xin Hu, Jingqin Chen, Enna Ha, Fujin Ai, Tao Ji, Junqing Hu, Shuangchen Ruan
Summary: The study synthesized Cu7.2S4/5MoS(2) composite nanoflowers, optimized the synthesis strategy to obtain excellent photothermal therapy agents, exhibited high photothermal conversion efficiency, and demonstrated effective synergistic therapeutic effects in vivo.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Xin Wei, Jingsheng Huang, Chi Zhang, Cheng Xu, Kanyi Pu, Yan Zhang
Summary: Researchers have synthesized a highly bright near-infrared chemiluminophore through molecular engineering of the electron-withdrawing group. This chemiluminophore shows a 3 to 5-fold higher quantum yield compared to existing ones. By combining it with a cathepsin B-responsive moiety, an activatable chemiluminescence probe has been developed for real-time detection of deeply buried tumor tissues and accurate chemiluminescence-guided laparotomy in living mice.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Chen Cheng, Weixi Jiang, Yuanli Luo, Li Wan, Xun Guo, Zhuoyan Xie, Rui Tang, Tong Huang, Jingxue Wang, Chier Du, Zhigang Wang, Haitao Ran, Pan Li, Zhiyi Zhou, Jianli Ren
Summary: Metal-phenolic network-functionalized nanoparticles (t-P@TFP NPs) are designed to combat multidrug resistance (MDR) and metastasis in cancer by reshaping the tumor microenvironment from insensitive to sensitive. These NPs trigger a near-infrared laser-activated multistage reaction, releasing perfluoropentane (PFP) and hyperthermia to efficiently kill cancer cells. Furthermore, they inhibit ATP-dependent drug efflux and induce immunogenic cell death (ICD) to improve sensitivity to chemotherapeutic agents and evoke antitumor immunogenicity.
Article
Chemistry, Multidisciplinary
Lauren E. McNamara, Jan-Niklas Boyn, Christopher Melnychuk, Sophie W. Anferov, David A. Mazziotti, Richard D. Schaller, John S. Anderson
Summary: This study reports a new class of compact and tunable near-infrared fluorescent compounds that exhibit air, water, light, and temperature stability. These compounds have brighter emission and better electrochemical sensitivity compared to commercially available near-infrared dyes. The brightness, stability, and modularity of this system make it a promising candidate for the development of new technologies based on near-infrared emission.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Hwan-Hee Cho, Sebastian Gorgon, Hsiao-Chun Hung, Jun-Yu Huang, Yuh-Renn Wu, Feng Li, Neil C. Greenham, Emrys W. Evans, Richard H. Friend
Summary: This research reports highly efficient and bright doublet electroluminescence devices by combining a thermally activated delayed fluorescence (TADF) host and a tris(2,4,6-trichlorophenyl)methyl-based radical emitter. The study shows improved efficiency roll-off at high current densities, making this technology more promising for practical applications.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xingfei Wei, Chi Chen, Yinong Zhao, Ewa Harazinska, Mark Bathe, Rigoberto Hernandez
Summary: This study investigates the wrapping mechanism of chimeric single-stranded DNA (ssDNA) on CdSe-ZnS quantum dots (QDs) with different ratios of phosphorothioate (PS) modification. Results show that 3-mercaptopropionic acid (MPA) and O-(2-mercaptoethyl)-O-methyl-hexa (ethylene glycol) (mPEG) reduce the binding affinity of ssDNA through electrostatic repulsion and steric exclusion. Both simulation and experiment demonstrate that larger QD size brings ssDNA closer to the QD surface. The effect of the PS base ratio on ssDNA conformation is also revealed.
Correction
Nanoscience & Nanotechnology
Chuangjun Liu, Lihua Zhou, Fangfang Wei, Ling Li, Shunan Zhao, Ping Gong, Lintao Cai, Keith Man-Chung Wong
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Xing Yang, Ting Yang, Qiqi Liu, Xiuwen Zhang, Xinghua Yu, Ryan T. K. Kwok, Luo Hai, Pengfei Zhang, Ben Zhong Tang, Lintao Cai, Ping Gong
Summary: In this study, biomimetic aggregation-induced emission (AIE) photothermal agents with hitchhiking ability (DC@BPBBT dots) were developed by coating the nanoaggregates of the NIR AIE polymeric photothermal agents with dendritic cell (DC) membranes. The DC@BPBBT dots can be hitchhiked on endogenous T cells, leading to enhanced tumor delivery efficiency. Additionally, these dots were found to activate T cells to secrete TNF-alpha, effectively reducing the expression of HSP70 and rendering tumor cells more sensitive to heat.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Gongcheng Ma, Zhongke Liu, Chunguang Zhu, Huajie Chen, Ryan T. K. Kwok, Pengfei Zhang, Ben Zhong Tang, Lintao Cai, Ping Gong
Summary: Low-temperature photothermal therapy (PTT) is a promising therapeutic strategy, but the expression of heat shock proteins (HSPs) can hinder its efficacy. Researchers have developed a smart nanobomb that can explode in the tumor microenvironment and release carbon monoxide (CO) to inhibit the expression of HSPs, thereby improving the effectiveness of low-temperature PTT.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Analytical
Jingjing Xiang, Chunbai Xiang, Lihua Zhou, Mengsi Sun, Lixiong Feng, Chuangjun Liu, Lintao Cai, Ping Gong
Summary: In this study, a rational design strategy for A beta 42 fluorescence probes based on rhodamine-copper complexes was reported. The results showed that the Rho4-Cu probe exhibited high sensitivity, high affinity, and high selectivity, and was able to effectively differentiate normal mice and AD mice.
ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Chi Chen, Xingfei Wei, Molly F. Parsons, Jiajia Guo, James L. Banal, Yinong Zhao, Madelyn N. Scott, Gabriela S. Schlau-Cohen, Rigoberto Hernandez, Mark Bathe
Summary: This study presents a general synthetic approach to control the 3D spatial relationships between quantum dots and other non-nucleic-acid molecules using highly programmable wireframe DNA origami structures. By understanding the relationship between chimeric single-stranded DNA length and quantum dot size, single quantum dots were integrated into DNA origami structures and arbitrary 3D spatial relationships between quantum dots and dyes were programmed. This approach enables the fabrication of hybrid materials for functional nanoscale photonic devices.
NATURE COMMUNICATIONS
(2022)
Review
Nanoscience & Nanotechnology
Yuhan Wang, Guojun Huang, Qi Hou, Hong Pan, Lintao Cai
Summary: Cell nanomodification is a reliable and efficient strategy that combines cell activity with nanomaterials to achieve remarkable treatment results.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Review
Chemistry, Physical
Guojun Huang, Lanlan Liu, Hong Pan, Lintao Cai
Summary: This review summarizes the recent advances in using biomimetic active materials to guide immunogenic cell death (ICD) for cancer immunotherapy. It introduces two main strategies, including naive organism-derived nanoagents and engineered bioactive platforms. The challenges and future developments of using biomimetic active materials guided ICD in cancer immunotherapy applications are also discussed.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Baozhen Zhang, Ruijing Liang, Hui Ran, Denghui Zhu, Jian Ren, Lanlan Liu, Aiqing Ma, Lintao Cai
Summary: A self-driving yeast micro/nanorobot (Cur@ CaY-robot) is designed via dual biomineralization and acid catalysis, which demonstrates efficient motion in gastric acid and can penetrate the thick gastric mucus for improved drug accumulation in the stomach wall tissue. Additionally, the released Ca2+ cations from the robot synergistically repair the gastric motility of gastritis mice. The biocompatible and biodegradable nature of these yeast micro/nanorobots, along with their good drug loading capacity, make them promising for active drug delivery and precise therapy.
Article
Multidisciplinary Sciences
Baozhen Zhang, Hong Pan, Ze Chen, Ting Yin, Mingbin Zheng, Lintao Cai
Summary: A twin-bioengine yeast micro/nanorobot (TBY-robot) with self-propelling and self-adaptive capabilities has been developed for targeted gastrointestinal inflammation therapy. The TBY-robot uses an enzyme-macrophage switching mechanism to autonomously navigate to inflamed sites. It successfully overcomes barriers in the gastrointestinal tract and enhances drug accumulation at the diseased site, demonstrating its potential for precision treatment of inflammatory diseases.
Article
Multidisciplinary Sciences
Chi Chen, Xin Luo, Alexander E. K. Kaplan, Moungi G. Bawendi, Robert J. Macfarlane, Mark Bathe
Summary: A new method for fabricating 2D arrays of quantum dots and quantum rods with high density DNA conjugation is proposed in this study. The fabrication time is significantly reduced from days to minutes by using a dehydration and rehydration process. The surface-assisted large-scale assembly method is used to construct 2D DNA templates on solid substrates, enabling the orientational control and high loading yield of 2D quantum dot and quantum rod arrays.
Article
Chemistry, Multidisciplinary
Zhiwei Zhang, Jingjing Xiang, Lijiao Guan, Pu Chen, Changzhong Li, Chunlei Guo, Yan Hu, Saipeng Huang, Lintao Cai, Ping Gong
Summary: By designing and synthesizing a pH-activated photothermal sensitizer IR-PE, it is possible to trigger the lysosomal dysfunction-mediated Fenton pathway under near-infrared light irradiation, thereby inducing ferroptosis and improving antitumor efficacy while mitigating systemic side effects.
Article
Chemistry, Multidisciplinary
Zhihong Sun, Zhuokai Sun, Jie Liu, Xiaohan Gao, Liping Jiao, Qi Zhao, Yongli Chu, Xiaozhong Wang, Guanjun Deng, Lintao Cai
Summary: This study presents a strategy that combines photodynamic therapy (PDT), immune checkpoints, and EV antigens to greatly improve the efficiency of tumor immunotherapy and overcome immune escape by improving the tumor immunosuppressive microenvironment.
Article
Chemistry, Multidisciplinary
Daoyong Jiang, Xiuwen Zhang, Yizhao Chen, Pengfei Zhang, Ping Gong, Lintao Cai, Yong Wang
Summary: A novel fluorescent probe, PM, was successfully synthesized and designed for the colorimetric fluorescent detection of Hg2+ in aqueous THF solution. The sensing mechanism of PM involves the metal ion-induced hydrolysis of the Schiff-base skeleton, which was confirmed by various experiments and calculations. A portable smartphone-assisted platform was established for the convenient and reliable Hg2+ detection. PM was also applied to monitor intracellular Hg2+ ions and has the potential for developing specific chemoprobes for Hg2+ detection in sulfur-rich living organisms.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Chunbai Xiang, Musa Dirak, Yuan Luo, Yonglin Peng, Lintao Cai, Ping Gong, Pengfei Zhang, Safacan Kolemen
Summary: Acetylcholinesterase (AChE) is an important enzyme involved in various physiological and pathological processes. This study introduces a novel fluorescent probe with aggregation-induced emission (AIE) characteristics for selective and sensitive real-time imaging of AChE activity in vivo. The probe showed a selective turn-on fluorescence response to AChE with low detection limit and was successfully used to visualize AChE activity in glioblastoma cells, Alzheimer's disease mouse brain tissue, and living mouse brains.
MATERIALS CHEMISTRY FRONTIERS
(2022)
