Article
Chemistry, Multidisciplinary
Yuanyu Gu, Rafael Pinol, Raquel Moreno-Loshuertos, Carlos D. S. Brites, Justyna Zeler, Abelardo Martinez, Guillaume Maurin-Pasturel, Patricio Fernandez-Silva, Joaquin Marco-Brualla, Pedro Tellez, Rafael Cases, Rafael Navarro Belsue, Debora Bonvin, Luis D. Carlos, Angel Millan
Summary: The generation of temperature gradients on nanoparticles heated externally by a magnetic field is crucial in magnetic hyperthermia therapy. However, the low heating power of magnetic nanoparticles limits the technique's implementation. This paper reports the real-time measurement of local temperature on gamma-Fe2O3 magnetic nanoheaters, showing that even within health safety limits, local temperature increments are sufficient to cause cell death, demonstrating the feasibility of local hyperthermia.
Article
Chemistry, Multidisciplinary
Yuanyu Gu, Rafael Pinol, Raquel Moreno-Loshuertos, Carlos D. S. Brites, Justyna Zeler, Abelardo Martinez, Guillaume Maurin-Pasturel, Patricio Fernandez-Silva, Joaquin Marco-Brualla, Pedro Tellez, Rafael Cases, Rafael Navarro Belsue, Debora Bonvin, Luis D. Carlos, Angel Millan
Summary: The generation of temperature gradients on nanoparticles by an external magnetic field is crucial in magnetic hyperthermia therapy. However, the low heating power of magnetic nanoparticles at human-allowed conditions limits the technique's implementation. Local intracellular hyperthermia holds promise as an alternative, as it achieves cell death with small amounts of heat at thermosensitive intracellular sites. Reliable intracellular temperature measurements are needed to resolve the discrepancy between experimental and theoretical predictions.
Article
Chemistry, Physical
Fengkai Shang, Chunhai Hu, Wei Xu, Xin Zhu, Di Zhao, Wenbin Zhang, Zhiguo Zhang, Wenwu Cao
Summary: Rare earth ions activated nanomaterials show promise for optical thermometry due to their unique photoluminescence characteristics. By utilizing phonon-assisted energy transfer, sensitive temperature measurement has been achieved with maximum relative sensitivities of approximately 2.3% K-1 in specific temperature ranges. Laser-induced heating effect significantly influences measurement sensitivity, but can be enhanced by utilizing square wave laser excitation in physiological temperature region.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Biochemistry & Molecular Biology
Luyan Wu, Yili Liu, Junya Zhang, Yinxing Miao, Ruibing An
Summary: Accurate detection of H2S is crucial to understanding H2S-related diseases. A H2S-activatable ratiometric NIR fluorescence liposome nanoprobe HS-CG was developed for sensitive visualization of tumor H2S levels in vivo. The probe showed enhanced fluorescence upon reaction with H2S, enabling improved sensitivity of imaging.
Article
Nanoscience & Nanotechnology
Daihua Fu, Fan Yang, Jiayi Zhang, Zhen Xiang, Yunbing Wang
Summary: This study reports a background interference-free persistent luminescent implant (PLI) with excellent luminescent performance, which can be detected by an optical imaging system for a long time after implantation. The implant has good biocompatibility and is not affected by tissue autofluorescence interference. This research provides new insights for designing biomedical imaging systems.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Tahani A. Alrebdi, Abdullah N. Alodhayb, Zoran Ristic, Miroslav D. Dramicanin
Summary: In this study, the performance of single- and multiparametric luminescence thermometry based on the temperature-dependent spectral features of Ca6BaP4O17:Mn5+ near-infrared emission was investigated. Experimental results showed that as the temperature increased, the intensities of the T-3(2) and Stokes bands increased, while the peak of the E-1 emission band redshifted. The multiparametric luminescence thermometry showed comparable performance to the best single-parameter thermometry.
Article
Chemistry, Multidisciplinary
Jose Lifante, Yingli Shen, Irene Zabala Gutierrez, Irene Rubia-Rodriguez, Daniel Ortega, Nuria Fernandez, Sonia Melle, Miriam Granado, Jorge Rubio-Retama, Daniel Jaque, Erving Ximendes
Summary: Luminescent nano-thermometry has great potential for in vivo sensing, diagnosis, and therapy, but faces limitations due to tissue attenuation and accuracy issues. This study demonstrates the use of high-brightness Ag2S nanothermometers for reliable and absolute internal organ thermal sensing, through a combination of in vivo and in silico measurements to assess hyperthermia processes and nanoparticle contribution to heating.
Article
Materials Science, Multidisciplinary
Meimei Xu, Wanyin Ge, Ye Tian, Yuanting Wu, Yongxiang Li
Summary: The morphology of the sensing material plays a crucial role in achieving better sensitivity. In this study, Bi2Ti2O7:Yb3+/Er3+ nanofibers and nanoparticles were synthesized and their temperature sensing properties were compared. The nanofibers showed enhanced temperature sensitivity and could potentially be used as outstanding candidates for temperature sensors with high resolution.
JOURNAL OF MATERIALS SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Ljubica Dacanin Far, Miroslav D. Dramicanin
Summary: Luminescence thermometry is a versatile optical technique for remote temperature measurements, with a wide range of applicability. Recent developments in the field have focused on the use of luminescent nanoparticles, and this review article provides a comprehensive survey of the literature in this area. The benefits and limitations of nanoparticles compared to conventional probes for luminescent thermometry are also discussed.
Article
Optics
Alisson Torquato, Rafael A. de Oliveira, Tasso O. Sales, Carlos Jacinto, M. Reza Dousti
Summary: The study investigated the effect of silver nanoparticles on the luminescence thermometry parameters of Er3+ ions doped zinc tellurite glasses, showing potential in enhancing thermal sensitivity.
Review
Chemistry, Multidisciplinary
Jia Yu, Guoyu Jiang, Jianguo Wang
Summary: In vivo fluorescence imaging has gained attention for its excellent biosafety, high sensitivity, real-time monitoring ability, and non-invasiveness. Aggregation-induced emission luminogens (AIEgens) with near-infrared (NIR) absorption and emission wavelengths are ideal for this imaging due to their large Stokes shift, high brightness, and photostability. This review summarizes the strategies for constructing high-performance NIR AIEgens and highlights the encapsulation strategies to increase their water solubility and biocompatibility. The challenges and prospects of fabricating NIR AIEgens for in vivo fluorescence imaging are also discussed.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Chemistry, Physical
Lipeng Jiang, Liangliang Zhang, Xue Jiang, Guocai Lv, Yanjing Su
Summary: This paper reports a new multifunctional near infrared phosphor AlTaO4:Cr3+, which exhibits both narrow-band and broadband emissions, high relative sensitivity, and efficient broadband NIR luminescence. The NIR LED prepared with this phosphor has practical application value in NIR light sources.
JOURNAL OF ALLOYS AND COMPOUNDS
(2024)
Article
Chemistry, Analytical
Junling Yin, Xiuqi Kong, Weiying Lin
Summary: This study introduces a biomarker based on tumor microenvironment viscosity, TBM-V, which can achieve cancer diagnosis, therapeutic effect tracking, and anticancer drug screening.
ANALYTICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Sylwia Ryszczynska, Inocencio R. Martin, Tomasz Grzyb
Summary: Recently, the upconversion phenomenon has attracted attention in luminescence thermometry due to its potential for precise and remote optical thermal sensing. In this study, unique nanoparticles were synthesized and showed significant changes in emission intensity with temperature. By comparing the luminescence intensity ratios of the near-infrared bands, we demonstrate that they possess unique and excellent optical temperature sensing properties.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Shen-Jie Li, Fang Li, Na Kong, Jian-Ren Liu, Xingjun Zhu
Summary: This study introduces a temperature-responsive, near infrared (NIR) emissive lanthanide-doped nanoparticle for early diagnosis of ischemic stroke. The nanoparticles can not only judge the location and severity of cerebral ischemic injury, but also report the brain temperature variation in the ischemic area through a visualized way.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Physical
Bruno Martinez-Haya, Juan Ramon Aviles-Moreno, Francisco Gamez, Jonathan Martens, Jos Oomens, Giel Berden
Summary: The interaction between organic molecules and oxonium cations in their solvation shell can lead to the formation of dynamic supramolecular structures that undergo recurrent changes in their host-guest chemical identity. This phenomenon is illustrated in proton-bonded complexes of water with polyether macrocycles. Despite water's lower proton affinity compared to the ether group, water actually retains the proton as H3O+ with increased stability as the coordination number increases. Hindrance in many-fold coordination induces dynamic reversible interconversion between (ether)·H3O+ (etherH+)·H2O. Infrared action ion spectroscopy reveals the vibrational signatures of loose proton bonding in these systems, which cannot be described by static equilibrium structures but can be accurately modeled using ab initio molecular dynamics.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Nanoscience & Nanotechnology
Esther Benayas, Ana Espinosa, M. Teresa Portoles, Virginia Vila-del Sol, M. Puerto Morales, Maria C. Serrano
Summary: In this study, two different superparamagnetic iron oxide multicore nanoparticles (SPIONs) with slightly different physicochemical properties were used to investigate their interaction with primary neural cells. The results showed that the minor differences in surface charge, magnetic properties, and structure of the SPIONs had a significant impact on cell uptake, viability, lipid composition, and membrane fluidity. These findings highlight the importance of considering even minor physicochemical differences in nanomaterials for specific cellular and molecular targeting.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
R. Flores-Sanchez, M. Bigorra-Mir, F. Gamez, T. Lopes-Costa, P. G. Argudo, M. T. Martin-Romero, L. Camacho, J. M. Pedrosa
Summary: The mechanical and morphological effects of octadecylamine monolayers on aspirin adsorption were investigated using Langmuir isotherms measurements and Brewster angle microscopy. Aspirin caused a significant expansion of the corresponding isotherms, and the mechanical stability of the films showed a concentration-dependent behavior due to the delicate balance between the solubility of the amine and the monolayer stabilization induced by ion-pairs. The incorporation of aspirin into the interface was confirmed by UV-vis reflection spectroscopy. The feasibility of using aliphatic amines for drug delivery of anionic species was also discussed.
CHEMICAL PHYSICS LETTERS
(2023)
Article
Chemistry, Physical
F. Gamez, L. F. Sedano, S. Blazquez, J. Troncoso, C. Vega
Summary: The temperature of the maximum in density (TMD) of aqueous solutions of halides with various ions was experimentally evaluated. Adding salts diminished the TMD of the solutions compared to pure water, and the magnitude of the change depended on the nature of the electrolyte. The experimental values of the shift in the TMD can be split into individual ion contributions, allowing for the establishment of an ion ranking based on their efficiency in shifting down the TMD.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Miguel Angel Fernandez-Rodriguez, Sergio Orozco-Barrera, Wei Sun, Francisco Gamez, Carlos Caro, Maria L. Garcia-Martin, Raul Alberto Rica
Summary: Microgels are soft microparticles that undergo a volume phase transition at a critical temperature. A study using optical tweezers showed that individual microgels undergo a discontinuous volume phase transition while the average behavior is continuous. The self-heating microgels exhibit bistability behavior above the critical temperature and can be used as potential micro-thermometers and micro-heaters.
Article
Chemistry, Multidisciplinary
Liyan Ming, Irene Zabala-Gutierrez, Paloma Rodriguez-Sevilla, Jorge Rubio Retama, Daniel Jaque, Riccardo Marin, Erving Ximendes
Summary: This article introduces a luminescence lifetime estimation method based on U-NET to improve the estimation accuracy under extremely low signal-to-noise ratio conditions. The effectiveness of U-NET is demonstrated in luminescence lifetime thermometry and its sensing performance improvement is verified through two experiments under extreme measurement conditions.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Carlos D. S. Brites, Riccardo Marin, Markus Suta, Albano N. Carneiro Neto, Erving Ximendes, Daniel Jaque, Luis D. Carlos
Summary: Luminescence (nano)thermometry is a remote sensing technique that utilizes the temperature dependency of luminescence features to measure temperature. It has potential applications in various fields and requires the establishment of a theoretical background, standardized practices, and improved readouts through multiparametric analysis and artificial intelligence algorithms. Challenges in luminescence thermometry and the need for continuous innovation are also discussed.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Amalia Coro, Ada Herrero Ruiz, Mateo Pazo-Gonzalez, Alonso Sanchez-Cruz, Tobias Busch, Alejandro Hernandez Medel, Erving C. Ximendes, Dirk H. Ortgies, Rosalia Lopez-Mendez, Ana Espinosa, Dorleta Jimenez de Aberasturi, Daniel Jaque, Nuria Fernandez Monsalve, Enrique J. de la Rosa, Catalina Hernandez-Sanchez, Emma Martin Rodriguez, Beatriz H. Juarez
Summary: In this study, the application of Ag2S nanoparticles in ocular imaging was extended by preparing them with a biocompatible amphiphilic block copolymer. This method protects the photoluminescence properties of the nanoparticles and allows for the controlled preparation of submicrometric scattering centers, enhancing colloidal stability and biocompatibility. The resulting nanoparticles exhibit improved contrast for optical coherence tomography and near-infrared imaging.
Article
Chemistry, Multidisciplinary
Ana C. C. Soares, Tasso O. Sales, Erving C. Ximendes, Daniel Jaque, Carlos Jacinto
Summary: In recent years, there has been significant interest in infrared emitting luminescent nanothermometers due to their potential for new diagnosis and therapy procedures. However, concerns have been raised regarding their reliability, as tissues can induce spectral distortions even in the commonly used second biological window. In this study, the effectiveness of shifting the operation range of these nanothermometers to the third biological window is demonstrated, showing minimal distortion by tissue and opening the path to reliable luminescence thermometry. Advanced analysis of emission spectra allows for sub-degree thermal uncertainties.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Physical
Bruno Martinez-Haya, Juan Ramon Aviles-Moreno, Francisco Gamez, Jonathan Martens, Jos Oomens, Giel Berden
Summary: Proton and hydrogen-bonded networks are crucial for understanding structural and charge transfer processes in supramolecular materials. The study of proton dynamics in 3-hydroxyglutaric acid provides insights into correlated proton dynamics and vibrational signatures.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Materials Science, Multidisciplinary
Wojciech M. Piotrowski, Maja Szymczak, Emma Martin Rodriguez, Riccardo Marin, Marta Henklewska, Blazej Pozniak, Miroslav Dramicanin, Lukasz Marciniak
Summary: The increasing popularity of luminescent nanothermometry in recent years is due to its potential application in biomedicine. This study introduces a biocompatible bimodal luminescent thermometer that operates in ratiometric and luminescence lifetime modes, offering high sensitivity and low cytotoxicity, making it suitable for bioapplications.
MATERIALS CHEMISTRY AND PHYSICS
(2024)
Review
Chemistry, Multidisciplinary
Aurore Van de Walle, Albert Figuerola, Ana Espinosa, Ali Abou-Hassan, Marta Estrader, Claire Wilhelm
Summary: Due to their unique physicochemical features, nanoparticles, especially magnetic nanoparticles with iron-based composition, have become effective multifunctional tools for biomedical applications. In oncology, these nanoparticles have been widely used in magnetic resonance imaging, magnetic hyperthermia, photothermal therapy, and ferroptosis induction.
MATERIALS HORIZONS
(2023)
Article
Materials Science, Multidisciplinary
Walaa Mohammad, K. David Wegner, Clothilde Comby-Zerbino, Vanessa Trouillet, Marina Paris Ogayar, Jean-luc Coll, Riccardo Marin, Daniel Jaque Garcia, Ute Resch-Genger, Rodolphe Antoine, Xavier Le Guevel
Summary: In this study, ultra-small gold nanoparticles stabilized by co-ligands were synthesized, and their physicochemical properties were controlled by the amount of reducing agent used. The absorption cross-section was significantly increased by precisely controlling the reducing agent, which in turn influenced the photoluminescence quantum yield. The results suggest that the physicochemical properties of the ligand shell can be tuned to control the near-infrared absorption and photoluminescence of the gold nanoparticles.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Materials Science, Biomaterials
Jose Maria Paez-Munoz, Francisco Gamez, Yilian Fernandez-Afonso, Roberto Gallardo, Manuel Pernia Leal, Lucia Gutierrez, Jesus M. de la Fuente, Carlos Caro, Maria Luisa Garcia-Martin
Summary: The effects of nanoparticle size and shape on the magnetic hyperthermia performance have not been fully understood. Spherical nanoparticles showed higher magnetic relaxivity than cubic nanoparticles, but no significant differences were observed in specific absorption rate (SAR). Additionally, spherical nanoparticles exhibited low cytotoxicity and were tested in tumor-bearing mice.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Chemistry, Multidisciplinary
Aurore Van de Walle, Albert Figuerola, Ana Espinosa, Ali Abou-Hassan, Marta Estrader, Claire Wilhelm
Summary: With their unique physicochemical features, nanoparticles, especially magnetic nanoparticles with iron-based composition, have been recognized as effective multifunctional tools for biomedical applications. This review focuses on the recent applications of iron-based nanomaterials in oncology, specifically photothermal therapy (PTT) and ferroptosis. These emerging physical and chemical methods for cancer therapy, facilitated by magnetic nanoparticles, offer versatile opportunities, combining multiple functionalities.
MATERIALS HORIZONS
(2023)