Article
Chemistry, Inorganic & Nuclear
Payal Srivastava, Madhu Verma, Anmol Kumar, Priyanka Srivastava, Ramranjan Mishra, Sri Sivakumar, Ashis K. Patra
Summary: Two water-soluble piano-stool shaped ruthenium(ii)-arene complexes were designed as emissive photocytotoxic agents tagged with morpholine as the lysosome targeting moiety. They showed enhanced photo-cytotoxicity under low-power blue LED light irradiation, preferentially localized in lysosomes and nuclei, effectively targeting and damaging nuclear DNA for photodynamic therapy. Due to enhanced lipophilicity of one complex, it showed higher internalization into cancer cells, with possible binding through histidine residues and internalization via endocytosis. Luminescence properties were utilized to study cellular uptake mechanisms via endocytosis.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, Tyson Brown, Jonathan J. Mills, Christopher G. Hamaker, Gregory M. Ferrence, Michael I. Webb
Summary: The evolution of high virulence bacterial strains has led to the development of novel therapeutic agents. Metal-based therapeutics, with their structural variability and unique modes of action, show great promise. This study focused on the preparation and evaluation of ruthenium(ii)-arene complexes containing Schiff base ligands with an attached ferrocene, and identified a complex with prominent activity against clinically relevant bacterial strains.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Sankar Monika, Rengan Ramesh
Summary: This study reports the synthesis of a new series of organometallic dinuclear ruthenium(ii) arene complexes and investigates their in vitro antiproliferative activity and cancer cell death mechanism. The formation of complexes was confirmed by various spectroscopic techniques. The synthesized complexes showed higher inhibition of cancer cells compared to the standard cisplatin drug, and apoptosis was confirmed through morphological changes and phosphatidylserine externalization.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Franco Bisceglie, Giorgio Pelosi, Nicolo Orsoni, Marianna Pioli, Mauro Carcelli, Paolo Pelagatti, Silvana Pinelli, Peter J. Sadler
Summary: We synthesized and characterized three half-sandwich Ru(II) arene complexes with different ligands, where one of the complexes exhibited good phototoxicity towards lung cancer cells upon blue light irradiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Christoph A. Riedl, Alexander Rosner, Sophia Harringer, Philipp Salomon, Michaela Hejl, Michael A. Jakupec, Wolfgang Kandioller, Bernhard K. Keppler
Summary: The use of bisphosphonate-functionalized ligands in the synthesis of trithiolato-bridged dinuclear ruthenium(II) and osmium(II) arene complexes improved aqueous solubility but decreased antiproliferative activity in vitro.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Dmitry I. Pavlov, Denis G. Samsonenko, Laura Bonfili, Massimiliano Cuccioloni, Enrico Benassi, Riccardo Pettinari, Andrei S. Potapov, Vladislava V. Matveevskaya
Summary: Six new arene-ruthenium(II) complexes with different arene and oxime ligands were synthesized and characterized. The complexes exhibited a half-sandwich piano-stool geometry and showed promising anti-proliferative activity.
INORGANICA CHIMICA ACTA
(2022)
Review
Chemistry, Inorganic & Nuclear
Magdalena Malecka, Anna Skoczynska, David M. Goodman, Christian G. Hartinger, Elzbieta Budzisz
Summary: This review highlights the progress in the development of ruthenium(II)/(III) complexes with flavone derivatives as potential therapeutic agents, focusing on their antimicrobial, antitumor activity, and enzyme inhibition. The design concept for the Ru complexes as multitargeted compounds consisting of a bioactive ligand and a ruthenium center is also emphasized.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Inorganic & Nuclear
Sonia Infante-Tadeo, Vanessa Rodriguez-Fanjul, Cintia C. Vequi-Suplicy, Ana M. Pizarro
Summary: The passage describes the rapid hydrolysis and high basicity of complexes [Os(eta 6-arene)(C,N-phenylpyridine)Z] with chlorido or tethered oxygen as the ligand. It also reveals the structure-activity relationship between Os-CN and Os-NN complexes.
INORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Emanuele Zanda, Natalia Busto, Lorenzo Biancalana, Stefano Zacchini, Tarita Biver, Begona Garcia, Fabio Marchetti
Summary: The study found that certain ruthenium complexes exhibited remarkable stability in water and cell culture medium, showing strong cytotoxicity against cancer cell lines, with RUCYN being the most promising one with significant selectivity compared to non-cancerous cells. The variability of affinity of the complexes for BSA and DNA binding was determined, with certain complexes showing enhanced cell internalization and cytotoxicity at the expense of selectivity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Abirami Arunachalam, Ramesh Rengan, Devan Umapathy, Antony Joseph Velanganni Arockiam
Summary: This study describes the synthesis and characterization of six new arene ruthenium(II) complexes containing biphenyl benzhydrazone ligands and evaluates their antiproliferative properties. The complexes demonstrated significant cytotoxicity against cancer cells and have the potential to be used as alternate anticancer drugs to platinum drugs.
Article
Chemistry, Multidisciplinary
Denise Lovison, Dario Alessi, Lorenzo Allegri, Federica Baldan, Maurizio Ballico, Giuseppe Damante, Marilisa Galasso, Daniele Guardavaccaro, Silvia Ruggieri, Andrea Melchior, Daniele Veclani, Chiara Nardon, Walter Baratta
Summary: The paper describes a chiral ruthenium complex with high cytotoxic activity against various cell lines, particularly showing strong inhibition against the anaplastic thyroid cancer cell line 8505 C.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Marianna Pioli, Cecilia Loffi, Paolo Pio Mazzeo, Alessia Bacchi, Paolo Pelagatti
Summary: Two different N-substituted naphthalimide ligands have been synthesized and reacted with a cationic organometallic fragment, showing different coordination behaviors. One ligand forms a sandwich complex with six coordination sites, while the other forms two isomeric complexes with different stabilities.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
Stefan Nikolic, Jemma Arakelyan, Vladimir Kushnarev, Samah Mutasim Alfadul, Dalibor Stankovic, Yaroslav I. Kraynik, Sanja Grguric-Sipka, Maria V. Babak
Summary: The astable half-sandwich Ru-dipyridophenazine complex can significantly decrease tumor burden in mouse xenografts without causing kidney and liver toxicity, and its mechanism of action is linked to DNA degradation and ROS induction.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Mark D. Straub, Erik T. Ouellette, Michael A. Boreen, R. David Britt, Khetpakorn Chakarawet, Iskander Douair, Colin A. Gould, Laurent Maron, Iker Del Rosal, David Villarreal, Stefan G. Minasian, John Arnold
Summary: The paragraph translated above discusses the reduction reactions of U(III) and Th(IV) metal complexes with KC8, analyzing the structures and reactivity of the resulting products.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Neurosciences
Khalid A. Alahmari, Harini Prabhakaran, Krishnan Prabhakaran, Harish C. Chandramoorthy, Ramakrishnan Ramugounder
Meeting Abstract
Oncology
Monet Stevenson, Jameel Joyner, Khadija Dildar, Oladipo Adedeji, Krishnan Prabhakaran, Hirendra N. Banerjee, Santosh Mandal, Fazlul Sarkar
Meeting Abstract
Oncology
Hirendra N. Banerjee, Jameel Joyner, Alexis Barfield, B. Morris, D. Bell, William Kahan, Monet Stevenson, D. Crummity, K. Prabhakaran, Santosh Mandal, Fazlul Sarkar
Article
Neurosciences
K. Prabhakaran, D. Ghosh, G. D. Chapman, P. G. Gunasekar
BRAIN RESEARCH BULLETIN
(2008)
Article
Neurosciences
L. Li, K. Prabhakaran, X. Zhang, L. Zhang, H. Liu, J. L. Borowitz, G. E. Isom
JOURNAL OF NEUROSCIENCE RESEARCH
(2008)
Article
Neurosciences
Krishnan Prabhakaran, Gail D. Chapman, Palur G. Gunasekar
Article
Pharmacology & Pharmacy
George Murnyak, John Vandenberg, Paul J. Yaroschak, Larry Williams, Krishnan Prabhakaran, John Hinz
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2011)
Article
Toxicology
Krishnan Prabhakaran, Gail D. Chapman, Palur G. Gunasekar
TOXICOLOGY MECHANISMS AND METHODS
(2011)
Editorial Material
Neurosciences
Sandeep Kumar Barodia, Krishnan Prabhakaran, Smitha Karunakaran, Vikas Mishra, Victor Tapias
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Neurosciences
K. Prabhakaran, L. Li, L. Zhang, J. L. Borowitz, G. E. Isom
Article
Pharmacology & Pharmacy
X. Zhang, L. Li, K. Prabhakaran, L. Zhang, H. B. Leavesley, J. L. Borowitz, G. E. Isom
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2007)
Article
Biochemistry & Molecular Biology
L. Zhang, L. Li, H. Liu, K. Prabhakaran, X. Zhang, J. L. Borowitz, G. E. Isom
FREE RADICAL BIOLOGY AND MEDICINE
(2007)
Article
Pharmacology & Pharmacy
L. Zhang, L. Li, K. Prabhakaran, J. L. Borowitz, G. E. Isom
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2006)
Article
Toxicology
Heather B. Leavesley, Li Li, Krishnan Prabhakaran, Joseph L. Borowitz, Gary E. Isom
TOXICOLOGICAL SCIENCES
(2008)
Article
Chemistry, Inorganic & Nuclear
Angela Lis, Viorica Gladchi, Gheorghe Duca, Sergey Travin
Summary: This work presents studies on the photochemical transformations of TU and Cys with the addition of Cu(II) or Fe(III) ions. The results show that the oxidation rate of the thiols increases significantly when Cu(II) or Fe(III) ions are added to the system. It has also been found that TU and Cys can form stable complex compounds with the studied metal ions. The oxidation rates of the thiols are found to depend on the radiation intensity and emission spectrum of the irradiation sources.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Cristiane F. A. Teixeira, Estefane I. Teixeira, J. P. C. Nascimento, M. Amilcar Junior, L. M. C. Pinto, Anderson R. L. Caires, G. B. Alcantara, Ana C. Micheletti, Victor M. Deflon, Davi F. Back, Heveline Silva, Lucas Pizzuti, Gleison Antonio Casagrande
Summary: Novel binuclear heteroleptic copper(I) complexes based on mixed DPPE/thiocarbamoyl-pyrazoline ligands were synthesized and structurally characterized. These complexes exhibited similar structural behavior around the Copper(I) atoms and showed promising antimicrobial and anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Chen Chen, Li Liu, Xin-Xin Zhong, Fa-Bao Li, Hai-Mei Qin
Summary: Thermally activated delayed fluorescent (TADF) Cu(I) halide complexes with short lifetimes and intense emissions were synthesized and characterized. These complexes exhibit intense green to yellow-green delayed fluorescence and are suitable for OLED devices.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Tian-Yu Zhang, Xue-Qian Wu, Heng-Yu Ruan, Yi Yuan, Le Wang, Ya-Pan Wu, Qing-Wen Han, Ruan Chi, Dong-Sheng Li
Summary: In this study, a novel Ni(II)-based metal-organic framework with good electrocatalytic oxidation performance was successfully synthesized, showing potential for direct alcohol fuel cells.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Susanta Das Baishnab, R. N. Dutta Purkayastha, Waldemar Maniukiewicz, Rosa M. Gomila, Antonio Frontera
Summary: The synthesis, structure, and DNA binding ability of three decavanadate complexes containing cationic organic moieties were reported. The complexes were characterized by various techniques and their solid-state structures were analyzed. The complexes showed interesting assembly patterns and exhibited moderately strong intercalative binding with CTDNA. Additionally, their micellization behavior in the presence of the surfactant CTAB was studied.
INORGANICA CHIMICA ACTA
(2024)
Review
Chemistry, Inorganic & Nuclear
Jubaraj B. Baruah
Summary: Isomorphous series are generated by replacing atoms or molecules to form materials with similar compositions. They allow modulation of structure and properties, and generate equivalent compositions with novel material properties. The study of stereo-electronic aspects of different equivalent compositions can improve the utility of the original composition.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Kamelah S. Al-Rashdi, Bandar A. Babgi, Ehab M. M. Ali, Bambar Davaasuren, Abdul-Hamid M. Emwas, Mariusz Jaremko, Mark G. Humphrey, Mostafa A. Hussien
Summary: Tridentate ligands were used to synthesize a set of palladium complexes, which were characterized and found to have DNA and BSA binding abilities. The complexes also showed differences in anticancer activities.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Diane Isaacs, Chandler Cox, Mark A. Bezpalko, W. Scott Kassel, William G. Dougherty
Summary: The structure and electrochemical properties of zinc(II) complexes with a face-capping ligand have been investigated, revealing the effect of the ligand on bound semiquinonate (SQ) radicals. The substitution pattern of the SQ ring plays a crucial role in determining the fate of the bound SQ radicals. Additionally, the protective pocket formed by the ligand's phenyl substituents is unable to prevent decomposition of SQ radicals with minimal steric bulk, suggesting that substitution of the SQ ring is the main contributor to their stabilization.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Xingliang Chen, Zhiqiang Jiang
Summary: Here, a series of zinc tetrahedral tetrazolate frameworks (Zn-TTFs) are presented, and it is demonstrated that rotation of carboxyl group can generate structural diversity. Compound 3 exhibits a unique zeolite-like structure, while compound 4 shows both super acid and alkali resistance.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Ankita Puri, Allison Mcaninch, Sheng Shu, Khashayar Rajabimoghadam, Maxime A. Siegler, Marcel Swart, Isaac Garcia-Bosch
Summary: In this article, the synthesis and characterization of copper, nickel, and palladium complexes bound by bidentate ligands derived from ortho-phenylenediamine are described. The complexes contain tunable H-bond donors and their crystal structures reveal intramolecular H-bonding interactions between the ligand scaffolds. Variations in the coordination sphere led to the isolation of the complexes in square-planar or twisted pseudo-tetrahedral geometries. Structural analysis showed that intramolecular H-bonding interactions can be altered by disrupting the bonds between countercations, solvent of crystallization, and ligand scaffold, resulting in changes in the geometry of the complexes. DFT calculations confirmed that Cu complexes prefer twisted geometries while Ni and Pd complexes favor square-planar geometries.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Laiane dos Santos Oliveira, Pedro Henrique de Souza Guarda, Leticia Bazilio Rosa, Gustavo Clauss Rodrigues, Daniele Daiane Affonso, Joao Ernesto de Carvalho, Igor Andrade Santos, Mark Harris, Douglas Hideki Nakahata, Jose Ricardo Sabino, Danilo Ciccone Miguel, Ana Lucia Tasca Gois Ruiz, Ana Carolina Gomes Jardim, Camilla Abbehausen
Summary: Chalcones are chemical precursors of flavonoids that have various biological properties. In this study, novel copper(II)-2'-hydroxy-4-benzyloxychalcone complexes were synthesized and evaluated for their antileishmanial, antiproliferative, and antiviral activities. The results demonstrated that these complexes showed potential effects against tumor cells, leishmania parasites, and SARS-CoV-2 virus. The study also highlighted the influence of ligand structure on biological activity.
INORGANICA CHIMICA ACTA
(2024)
Review
Chemistry, Inorganic & Nuclear
Archana Thakur, Harpreet Kaur, Vishal Tyagi
Summary: This review article discusses the findings of research on the 13C NMR spectra of di- and tri-butyltin carboxylates, highlighting the importance of 13C NMR chemical shifts in determining the chemical surroundings of carbon nuclei and their role in structure elucidation.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Qiang Zhao, Qi-Yang Li, Zhi Shen, Guo Zang, Wen-Jun Lv
Summary: In this study, five metal complexes were synthesized using a solvothermal reaction and their structures were analyzed by single crystal X-ray diffraction. Fluorescence and magnetic properties of some complexes were also investigated.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Jeremy Erb, Darcy Setter, Jake Swavey, Frederick Willits, Shawn Swavey
Summary: Three BODIPY-Ru(II) complexes were synthesized by coordinating [Ru(bpy)2Cl]+ complexes to BODIPY ligands. The spectroscopic and electrochemical properties of the complexes were characterized. The complexes exhibited intense absorption peaks due to the pi pi* transitions localized on the BODIPY core, and additional charge transfer transitions associated with the metal center. The complexes showed significant singlet oxygen generation and were able to induce photo-nicking of DNA.
INORGANICA CHIMICA ACTA
(2024)
Article
Chemistry, Inorganic & Nuclear
Sahin Reja, Dilip Sarkar, Kaushik Sarkar, Deboshmita Mukherjee, T. K. S. Fayaz, Palash Sanphui, Rajesh Kumar Das
Summary: A promising bioinspired metallocatalyst has been produced and characterized, showing high catalytic activity in oxygen dependant enzymatic radical pathway. The catalyst also exhibits inter and intra molecular H-bonding and C-H-pi interactions.
INORGANICA CHIMICA ACTA
(2024)