期刊
COORDINATION CHEMISTRY REVIEWS
卷 436, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2021.213849
关键词
Flavonoids; Ruthenium(II)/(III) complexes; Antitumor activity
资金
- Medical University of Lodz [503/3-066-02/503-31-001]
- University of Lodz [B1811100000050.01]
- University of Auckland
This review highlights the progress in the development of ruthenium(II)/(III) complexes with flavone derivatives as potential therapeutic agents, focusing on their antimicrobial, antitumor activity, and enzyme inhibition. The design concept for the Ru complexes as multitargeted compounds consisting of a bioactive ligand and a ruthenium center is also emphasized.
This review highlights the progress in the development of ruthenium(II)/(III) complexes with flavone derivatives as potential therapeutic agents. We focused on natural hydroxyflavone derivatives and their synthetic amino analogues as ligands in ruthenium(II)/(III) complexes which demonstrate antimicrobial, antitumor activity and/or enzyme inhibition. Some enzymes targeted by flavone derivatives are important for the development and progression of cancer cells which underpins the design concept for the Ru complexes as multitargeted compounds consisting of a bioactive ligand and a ruthenium center. (C) 2021 The Authors. Published by Elsevier B.V.
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