Article
Endocrinology & Metabolism
Britta Kunkemoeller, Kuangyang Chen, Sam M. Lockhart, Xuanchun Wang, Christian Rask-Madsen
Summary: Endothelial cell insulin resistance is a major contributor to diabetic complications. The study shows that CITED2 inhibits endothelial insulin signaling through the PI3K/Akt pathway by repressing HIF-dependent IRS-2 expression, and deletion of CITED2 enhances insulin signaling. Therefore, CITED2 is a novel and promising target to improve insulin sensitivity in endothelial cells and prevent vascular complications in diabetes.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Hana Sutovska, Katarina Babarikova, Michal Zeman, Lubos Molcan
Summary: Prenatal hypoxia can lead to hypertension in adulthood by affecting cardiovascular regulatory mechanisms, which may vary depending on circadian variability and phase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Thiago Borges Madureira Sabino, Denise Maria Martins Vancea, Manoel da Cunha Costa, Raphael Jose Perrier de Melo, Iago Vilela Dantas, Jonathan Nicolas dos Santos Ribeiro
Summary: This systematic review aimed to analyze the effects of different resistance training intensities on endothelial function in people with T2DM. A total of 29 eligible articles were included, and the results showed that a single session of high-intensity resistance training improved endothelial function. However, this improvement was not consistently observed in long-term studies. More research is needed to determine the ideal intensity and effectiveness of resistance training in improving endothelial function in T2DM.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Suiane Cavalcante, Sofia Viamonte, Rui S. Cadilha, Ilda P. Ribeiro, Ana Cristina Goncalves, Joao Sousa-Venancio, Marisol Gouveia, Manuel Teixeira, Mario Santos, Jose Oliveira, Fernando Ribeiro
Summary: This study aims to evaluate the effects of a single exercise bout on the circulating levels of EPCs and CECs in heart failure patients. The results showed that a single exercise bout increased the levels of EPCs but didn't change the levels of CECs. Heart failure patients had lower levels of EPCs compared to the age-matched group, but the exercise bout restored their EPCs levels to a level similar to the age-matched group.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Maria D. A. Nogueira, Ribanna A. M. Braga, Yannis Manios, Odysseas Androutsos, Denes Molnar, Angela Polito, Sonia Gomez-Martinez, Laurent Beghin, Kurt Widhalm, Gloria Bueno, Manuel J. Castillo, Stefaan De Henauw, Luis A. Moreno, Carla S. C. Maia
Summary: This study aimed to evaluate the predictive power of TyG, TG/HDL-c, HLAP, and VAI indices in identifying cardiometabolic risk factors and their relationship with endothelial dysfunction biomarkers in European adolescents. The results showed that TG/HDL-c and HLAP indices performed well in predicting cardiometabolic risk in male adolescents, but their association with endothelial dysfunction caused by insulin resistance was not clear.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Review
Nutrition & Dietetics
Juanita J. Fewkes, Nicole J. Kellow, Stephanie F. Cowan, Gary Williamson, Aimee L. Dordevic
Summary: A single high-fat meal adversely affects endothelial function, with younger, healthy-weight individuals experiencing a greater reduction. The percentage of fat in the meal is inversely associated with the magnitude of endothelial function changes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Biology
Julie Favre, Emilie Vessieres, Anne-Laure Guihot, Coralyne Proux, Linda Grimaud, Jordan Rivron, Manuela Cl Garcia, Lea Rethore, Rana Zahreddine, Morgane Davezac, Chanaelle Febrissy, Marine Adlanmerini, Laurent Loufrani, Vincent Procaccio, Jean-Michel Foidart, Gilles Flouriot, Francoise Lenfant, Coralie Fontaine, Jean-Francois Arnal, Daniel Henrion
Summary: The study found that endothelial membrane ER alpha promotes NO bioavailability through inhibition of oxidative stress, and thereby participates in the regulation of flow-mediated dilation (FMD).
Review
Pharmacology & Pharmacy
Baoqi Yu, Xia Wang, Yanting Song, Guomin Xie, Shiyu Jiao, Li Shi, Xuejie Cao, Xinyao Han, Aijuan Qu
Summary: Cardiovascular diseases are the leading cause of death worldwide, and hypoxia-inducible factors (HIFs) play an important role in their pathogenesis. Recent studies have revealed the role of cell-specific HIFs in various cardiovascular diseases, but the potential clinical application of HIF inhibitors in the treatment of cardiovascular diseases is not well understood.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Albino Carrizzo, Rosario Lizio, Paola Di Pietro, Michele Ciccarelli, Antonio Damato, Eleonora Venturini, Patrizia Iannece, Eduardo Sommella, Pietro Campiglia, Philipp Ockermann, Carmine Vecchione
Summary: The research demonstrated that Healthberry 865(R) has a significant vasodilatory effect on resistance artery function in mice, mediated by nitric oxide release through the PI3K/Akt signaling pathway. It also exerts an antioxidant effect by modulating NADPH oxidase. The selective action of different anthocyanins mediates the cardiovascular properties of Healthberry 865(R), reducing oxidative stress and improving nitric oxide bioavailability.
Article
Cell Biology
Moritz Reiterer, Amanda Eakin, Randall S. Johnson, Cristina M. Branco
Summary: Organ function depends on microvascular networks to maintain homeostasis, and the response of microvascular endothelial cells from brain and lung tissue to different oxygen levels varies. Supra-physiological oxygen tensions can compromise the viability of microvascular endothelial cells, and their metabolism and function can be reprogramed by external oxygen. The culture conditions significantly affect ex vivo modeling of endothelial function.
Article
Biochemistry & Molecular Biology
Dan Yi, Bin Liu, Ting Wang, Qi Liao, Maggie M. Zhu, You-Yang Zhao, Zhiyu Dai
Summary: This study identified a novel mechanism of endothelial autocrine signaling in regulating PVEC proliferation and pulmonary vascular remodeling in PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Alexey Sokolov, Nadezhda M. Dubrovskaya, Valeria A. Kostevich, Dmitrii S. Vasilev, Irina V. Voynova, Elena T. Zakharova, Olga L. Runova, Igor Semak, Alexander Budevich, Natalia N. Nalivaeva, Vadim B. Vasilyev
Summary: The protective effects of apo-rhLF on the cognitive functions of rat offspring subjected to prenatal hypoxia have been analyzed. The results showed that apo-rhLF can rescue cognitive deficits caused by prenatal hypoxia and improve memory.
Article
Biochemistry & Molecular Biology
Julie Favre, Emilie Vessieres, Anne-Laure Guihot, Linda Grimaud, Coralyne Proux, Laurent Loufrani, Francoise Lenfant, Coralie Fontaine, Jean-Francois Arnal, Daniel Henrion
Summary: Flow-mediated dilation (FMD) of resistance arteries is essential for tissue perfusion but decreases with ageing. Membrane ER alpha plays an important role in FMD and its early defect recapitulates phenotypically and functionally ageing in these resistance arteries. Oxidative stress is a key event in the decline of FMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Fosca Quarti-Trevano, Gino Seravalle, Guido Grassi
Summary: The sympathetic nervous system plays a crucial role in regulating cardiovascular functions, influencing both small and large arteries. Evidence suggests a close relationship between sympathetic activity, vascular function, and factors such as nitric oxide, reactive oxygen species, and endothelin. Understanding these relationships can provide insight into cardiovascular diseases like essential hypertension and congestive heart failure.
Review
Biochemistry & Molecular Biology
Mohammad Shohel Akhter, Julie Elizabeth Goodwin
Summary: The endothelium plays a crucial role in controlling vascular inflammation and function. The glucocorticoid receptor (GR) in endothelial cells negatively regulates vascular inflammation through the suppression of Wnt signaling. GR also affects fibrosis in various organs by modulating the fatty acid oxidation pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Zoology
Vinicius A. Armelin, Victor H. da Silva Braga, Mariana T. Teixeira, Igor N. Guagnoni, Tobias Wang, Luiz H. Florindo
Summary: The study compared the sequence method with the Oxford technique in two teleost species and found that calculating baroreflex gain through the sequence method is adequate and reliable with a specific software configuration. When properly configured, the sequence and Oxford methods yielded similar determinations of the baroreflex gain in fish.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY
(2021)
Article
Biology
Naim M. Bautista, Christian Damsgaard, Angela Fago, Tobias Wang
Summary: This study demonstrates that during diving, crocodilians primarily accumulate CO2 within erythrocytes, where most of it binds to hemoglobin. The binding of HCO3- is tightly associated with the progressive blood deoxygenation during diving, showing a difference from the classic vertebrate pattern.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Editorial Material
Clinical Neurology
Halvor Osterby Guldbrandsen, Christian Staehr, Nina Kerting Iversen, Dmitry D. Postnov, Vladimir V. Matchkov
Summary: Despite successful recanalization in ischemic stroke patients, impaired local brain tissue reperfusion still occurs in a significant number of patients, leading to adverse clinical outcomes. Current attention is focused on dysfunction in the blood-brain barrier and capillary blood flow, but the contribution of exaggerated constriction of cerebral arterioles has also been suggested. The activation of Na,K-ATPase-dependent Src kinase is proposed as a key mechanism responsible for the elevation of cerebrovascular tone after reperfusion, potentially contributing to impaired reperfusion after stroke.
Article
Biology
Denis Abramochkin, Vladislav S. Kuzmin, Vladimir Matchkov, Andrey A. Kamensky, Tobias Wang
Summary: The study identified the primary pacemaker site in squamate heart at the base of the right leaflet of the sinoatrial valve, with latent pacemakers found in a circular region around it. Introduction of acetylcholine or noradrenaline near the SAV induced shifts in the pacemaker site. Additionally, cardiomyocytes in the SAV region exhibited similar properties to working myocytes from the sinus venosus, but some cells lacked the background inward rectifier current (I-K1) and had a pacemaker current identified as 'funny' (I-f).
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Biology
Tobias Wang, Augusto S. Abe, Ariovaldo P. Cruz-Neto, Denis Andrade, Edwin W. Taylor
Summary: The study found that digesting snakes exhibit a strong tachycardia response to hypotension, while showing a decrease in heart rate in response to hypertension. Despite having higher resting heart rates, digesting snakes can still maintain compensatory heart rate responses to hypotension.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Biology
Naim M. Bautista, Hans Malte, Chandrasekhar Natarajan, Tobias Wang, Jay F. Storz, Angela Fago
Summary: The study provides evidence that both bicarbonate and CO2 bind to crocodilian Hb with high affinity, leading to a decrease in O2 saturation. This direct binding of bicarbonate to Hb independently of CO2 promotes O2 delivery. These results suggest that the unique mode of allosteric regulation by CO2 and bicarbonate evolved over 80-100 million years ago in the common ancestor of crocodilians.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Review
Physiology
William Joyce, Tobias Wang
Summary: Acute exposure to low oxygen leads to conflicting demands on the heart, resulting in tachycardia or bradycardia. While mammals and fishes show different mechanisms in heart rate regulation during hypoxia, there are similarities in the underlying mechanisms. Bradycardia may primarily serve to protect the heart.
Editorial Material
Physiology
Steve F. Perry, Tobias Wang
Article
Biochemistry & Molecular Biology
Vibeke Bay, Nina K. Iversen, Seyedeh Marziyeh Jabbari Shiadeh, R. Andrew Tasker, Gregers Wegener, Maryam Ardalan
Summary: Transient cerebral ischemia followed by reperfusion in an infarcted brain results in predictable morphological changes in neuronal and non-neuronal cells. Accurately delineating the cerebral infarct is challenging, but using a macroscopic histological approach can lead to faster and more reliable preclinical research results. The study found that the MAP2 staining method can reliably identify the ischemic area macroscopically in cryo-preserved and paraffin-embedded brain sections, regardless of immersion-fixed or perfusion-fixed brains.
JOURNAL OF CHEMICAL NEUROANATOMY
(2021)
Article
Biology
Magnus L. Aaskov, Rasmus J. Jensen, Peter Vilhelm Skov, Chris M. Wood, Tobias Wang, Hans Malte, Mark Bayley
Summary: The South American Arapaima gigas, a highly air-reliant fish, utilizes distinct transfer pathways for oxygen and carbon dioxide. In severely hypoxic water, the fish shifts the partitioning of carbon dioxide to the air phase, eliminating the risk of oxygen loss in the gills. Furthermore, the fish's metabolic fuel utilization remains unchanged under different water oxygenation levels.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tingting Gu, Jesper Just, Katrine Tang Stenz, Yan Yan, Peter Sieljacks, Jakob Wang, Thomas Skjaerlund Groennebaek, Jesper Emil Jakobsgaard, Emil Rindom, Jon Herskind, Anders Gravholt, Thomas Ravn Lassen, Mathias Jorgensen, Rikke Baek, Eugenio Gutierrez-Jimenez, Nina Kerting Iversen, Peter Mondrup Rasmussen, Jens Randel Nyengaard, Malene Moller Jorgensen, Frank de Paoli, Hans Erik Botker, Jorgen Kjems, Kristian Vissing, Kim Ryun Drasbek
Summary: Ischemic conditioning and exercise can protect against brain ischemia-reperfusion injury by inducing the release of circulating EVs. However, further experimental verification is needed for the in vivo and translational effects of conditioned EVs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Benjamin J. van Soldt, Tobias Wang, Renato Filogonio, Carl Christian Danielsen
Summary: This study compared the morphological and mechanical characteristics of aortas and pulmonary arteries in different snake species to investigate the relationship between intraventricular pressure separation and vessel properties. The findings suggest that genetic factors may play a stronger role in protecting fragile pulmonary vasculature than physiological parameters.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Physiology
Vibeke S. S. Elbrond, Morten B. B. Thomsen, Jonas L. L. Isaksen, Ester D. D. Lunde, Stefano Vincenti, Tobias Wang, Jorgen Tranum-Jensen, Kirstine Calloe
Summary: The purpose of this study was to investigate and evaluate the relationship between the unique electrical axis pattern in the horse heart and the distribution and histology of the conduction system. The results showed that the direction of the electrical axis in the equine heart is determined by the structure of the intramural Purkinje fiber network, rather than being related to ventricular mass.
Editorial Material
Multidisciplinary Sciences
Bjarke Jensen, Antoon Fransiscus Maria Moorman, Tobias Wang, Peter Rask Moller, Jose Manuel Icardo, Henrik Lauridsen
Article
Multidisciplinary Sciences
Simone K. A. Videsen, Malene Simon, Fredrik Christiansen, Ari Friedlaender, Jeremy Goldbogen, Hans Malte, Paolo Segre, Tobias Wang, Mark Johnson, Peter T. Madsen
Summary: Giant rorqual whales have a massive food turnover driven by a high-intake lunge feeding style, which is considered the largest biomechanical action. This feeding behavior, although high-drag, is energetically cheap, allowing rorquals to be flexible in exploiting different prey patches and resilient to environmental fluctuations and disturbance. As a result, the ecological role and food turnover of these marine giants are likely overestimated.
Review
Physiology
Minyu Zhang, Biyang Xiao, Xiaoqi Chen, Bingming Ou, Songtao Wang
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely related to bile acid and gut microbiota disorders. Exercise plays an important role in maintaining the homeostasis of the enterohepatic circulation and the health of the host gut microbiota by regulating the composition and function of the bile acid pool in the enterohepatic axis. Exercise has been recommended as a first-line intervention for NAFLD, and regulating bile acids through exercise may be a promising treatment strategy.