Review
Biochemistry & Molecular Biology
Anna Ashton, Russell G. Foster, Aarti Jagannath
Summary: Circadian rhythms are essential for survival, allowing organisms to predict environmental changes and time behavior. The circadian clock is a self-sustaining molecular oscillator that needs to be continually adjusted to stay in alignment with the external world. Light is the primary time cue in mammals and plays a complex role in entraining the circadian clock in the SCN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Geraldine Maier, Julien Delezie, Pal O. Westermark, Gesa Santos, Danilo Ritz, Christoph Handschin
Summary: The study found that exercising in the early daytime can trigger energy provisioning and tissue regeneration, while early nighttime exercise activates stress-related and catabolic pathways. Scheduled training has limited effects on the muscle and liver circadian clocks, but exercising at different times of day results in vastly different activation of signaling pathways.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Review
Pharmacology & Pharmacy
Bingyi Shen, Changxiao Ma, Guanlin Wu, Haibin Liu, Lihong Chen, Guangrui Yang
Summary: The biological clock system is an essential timekeeping device that integrates internal physiology and external cues. Disruptions to the body's internal clock can lead to the development of various diseases. Light and exercise have significant impacts on the biological clock system.
FRONTIERS IN PHARMACOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Christine Merlin
Summary: The molecular mechanism behind organisms' ability to anticipate variations in environmental conditions caused by tides in the intertidal zone has been unknown. A recent study shows that the circadian clock gene bmal1 is necessary for circatidal rhythms.
Article
Plant Sciences
Liangyu Guo, Zhiming Xu, Shuo Wang, Yuqi Nie, Xiaoxue Ye, Xuejiao Jin, Jianhua Zhu, Wenwu Wu
Summary: This study investigates the regulatory networks involved in cold responses in three different species of rosids. It demonstrates that some transcription factors and RNA-binding proteins are conserved in the cold response across rosids, and it reveals a hierarchical regulation of differentially expressed genes and alternative splicing genes. The study also identifies a common enrichment related to circadian rhythm in the cold response pathways in all three studied species.
PHYSIOLOGIA PLANTARUM
(2023)
Review
Medicine, Research & Experimental
Yi Qin, Zhong-hua Chen, Jun-Jie Wu, Zhen-Yu Zhang, Zheng-Dong Yuan, Dan-Yang Guo, Meng-Nan Chen, Xia Li, Feng-Lai Yuan
Summary: The circadian clock plays a crucial role in regulating bone metabolism, including bone loss. Clock-related genes control signaling pathways and transcription factors in osteoblasts and osteoclasts, while also regulating osteocytes and endothelial cells. Furthermore, the regulation of circadian clock genes by novel modulators presents a potential strategy for preventing and treating bone diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Plant Sciences
Carolin Delker, Marcel Quint, Philip A. Wigge
Summary: Plants have the ability to adjust their morphology and development in response to environmental stimuli, a phenomenon known as phenotypic plasticity. In Arabidopsis thaliana, the morphological response to elevated temperatures, termed thermomorphogenesis, is largely regulated by the transcription factor PIF4, which is in turn influenced by various thermosensing mechanisms and modulators. Recent advances have identified factors that affect PIF4 expression and activity, and have shed light on organ- and tissue-specific regulation of thermomorphogenesis.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Weiyun Zhang, Chi-Tang Ho, Muwen Lu
Summary: This study found that piperine improves lipid metabolism disorders in HepG2 cells by regulating the Bmal1 and Clock genes, reducing circadian desynchrony, ROS overproduction, and mitochondrial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Si-Ke He, Jia-Hao Wang, Tao Li, Shan Yin, Jian-Wei Cui, Yun-Fei Xiao, Yin Tang, Jia Wang, Yun-Jin Bai
Summary: This article reviews the relationship between circadian rhythm disturbance and kidney stone disease (KSD), summarizing the risk factors and treatment methods. The results indicate that KSD is associated with systemic disorders such as metabolic syndrome, inflammatory bowel disease, and microbiome dysbiosis, and some chronotherapies have been proven effective.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Louise N. Lindback, Yuzhao Hu, Amanda Ackermann, Oliver Artz, Ullas Pedmale
Summary: Light is a crucial signal sensed by CRY receptors to regulate growth and circadian clock. This study uncovers the role of UBP12/13 deubiquitinases in negatively regulating CRY2 and modulating hypocotyl growth. UBP12/13 interacts with COP1 to stabilize it, leading to degradation of CRY2 under blue light. The findings provide insight into the regulation of deubiquitinase activity and its role in controlling plant growth.
Article
Multidisciplinary Sciences
Jia Hwei Cheong, Xiao Qiu, Yang Liu, Ahmad Al-Omari, James Griffith, Heinz-Bernd Schuttler, Leidong Mao, Jonathan Arnold
Summary: We investigated the phase synchronization of cellular clocks and found that the macroscopic limit is 150,000 cells or less. The maximum radius of a hypothesized quorum sensing signal molecule was estimated to be 13.05 nm using a diffusion approximation for signal travel. By using a second microwell device, we refined the macroscopic limit to a cell density of 2166 cells per fixed area for phase synchronization.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Erica R. Kwiatkowski, Yisrael Schnytzer, Joshua J. C. Rosenthal, Patrick Emery
Summary: Organisms in the intertidal zone face a challenging environment with daily and seasonal changes in light intensity, weather patterns, and tides. To adapt to these conditions, intertidal animals have developed circatidal clocks, but the molecular components have been difficult to identify. This study introduces the crustacean Parhyale hawaiensis as a genetic model to study circatidal rhythms and shows that the core circadian clock gene Bmal1 is required for these rhythms. This research establishes the connection between circatidal and circadian clocks and provides a powerful system to study the molecular mechanisms of circatidal rhythms.
Article
Multidisciplinary Sciences
Nisha Misra, Manohar Damara, Pierre Chambon
Summary: This article investigates the role of transcriptional regulators RevErbα, E4BP4, and CRY1/PER1 in generating circadian rhythms. Molecular and genetic analyses reveal that the chromatin protein HP1α plays a crucial role in transcriptional repressions of circadian clock genes and their output genes. The presence of HP1α is critical for chromatin compaction, formation of repressed biomolecular hydrophobic condensates, and recruitment and methylation of DNA methylating enzymes on the intronic deoxyCpG islands within the circadian output genes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Physiology
Satoshi Homma, Akihisa Murata, Masato Ikegami, Masakazu Kobayashi, Maki Yamazaki, Kento Ikeda, Takaaki Daimon, Hideharu Numata, Akira Mizoguchi, Kunihiro Shiomi
Summary: This study investigates the roles of circadian clock genes in temperature-dependent diapause induction in the domestic silkworm. The results show that these genes regulate temperature-induced diapause by acting upstream of cerebral GABAergic and diapause hormone signaling pathways. Furthermore, the temporal expression of clock genes differs significantly between wild-type silkworms and TRPA1 knockout mutants during embryonic development. These findings provide target genes for regulating temperature-dependent diapause induction in silkworms.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shir Confino, Talya Dor, Adi Tovin, Yair Wexler, Zohar Ben-Moshe Livne, Michaela Kolker, Odelia Pisanty, Sohyun Kathy Park, Nathalie Geyer, Joel Reiter, Shimon Edvardson, Hagar Mor-Shaked, Orly Elpeleg, Daniela Vallone, Lior Appelbaum, Nicholas S. Foulkes, Yoav Gothilf
Summary: The circadian clock is a mechanism that regulates various physiological rhythms with a period of approximately 24 hours. A mutation in FBXL3 has been found in patients with syndromic developmental delay, morphological abnormalities, and intellectual disability. Using zebrafish as a model, it was discovered that loss of fbxl3a function disrupts the circadian rhythms, locomotor activity, and sleep-wake cycles, but does not cause morphological effects. These findings suggest a conserved role for FBXL3 in the circadian clock system across vertebrates and its acquisition of developmental roles in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Michael G. Jonz, Leslie T. Buck, Steve F. Perry, Thorsten Schwerte, Giacomo Zaccone
SPECIAL ISSUE: RESPIRATORY SCIENCE
(2016)
Article
Medicine, Research & Experimental
Roland F. R. Schindler, Chiara Scotton, Jianguo Zhang, Chiara Passarelli, Beatriz Ortiz-Bonnin, Subreena Simrick, Thorsten Schwerte, Kar-Lai Poon, Mingyan Fang, Susanne Rinne, Alexander Froese, Viacheslav O. Nikolaev, Christiane Grunert, Thomas Mueller, Giorgio Tasca, Padmini Sarathchandra, Fabrizio Drago, Bruno Dallapiccola, Claudio Rapezzi, Eloise Arbustini, Francesca Romana Di Raimo, Marcella Neri, Rita Selvatici, Francesca Gualandi, Fabiana Fattori, Antonello Pietrangelo, Wenyan Li, Hui Jiang, Xun Xu, Enrico Bertini, Niels Becher, Jun Wang, Thomas Brand, Alessandra Ferlini
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Biology
Margit Egg, Louise Koeblitz, Jun Hirayama, Thorsten Schwerte, Clemens Folterbauer, Antje Kurz, Birgit Fiechtner, Markus Moest, Willi Salvenmoser, Paolo Sassone-Corsi, Bernd Pelster
CHRONOBIOLOGY INTERNATIONAL
(2013)
Article
Biology
Margit Egg, Monika Paulitsch, Yvonne Ennemoser, Andrea Wuestenhagen, Thorsten Schwerte, Adolf Michael Sandbichler, Birgit Fiechtner, Louise Koeblitz, Caroline Prem, Bernd Pelster
CHRONOBIOLOGY INTERNATIONAL
(2014)
Article
Multidisciplinary Sciences
Renate Kopp, Ines Bauer, Anil Ramalingam, Margit Egg, Thorsten Schwerte
Review
Physiology
Bernd Pelster, Thorsten Schwerte
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2012)
Article
Biochemical Research Methods
Richard Haindl, Abigail J. Deloria, Caterina Sturtzel, Harald Sattmann, Wolfgang Rohringer, Balthasar Fischer, Marco Andreana, Angelika Unterhuber, Thorsten Schwerte, Martin Distel, Wolfgang Drexler, Rainer Leitgeb, Mengyang Liu
BIOMEDICAL OPTICS EXPRESS
(2020)
Article
Ecology
Bettina Thalinger, Andreas Rieder, Anna Teuffenbach, Yannick Puetz, Thorsten Schwerte, Josef Wanzenboeck, Michael Traugott
Summary: The study reveals the importance of fish physiology and behavior in the interpretation of eDNA quantities, with differences found between species. Through experiments, it was demonstrated that fish activity levels and energy use are positively correlated with target eDNA quantities, highlighting the need to incorporate species-specific traits into eDNA monitoring and conservation efforts.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2021)
Article
Environmental Sciences
Christine Binder-mendl, Cem Ekmekcioglu, Wolfgang Marktl, Thorsten Schwerte
Summary: This study aims to investigate the possibility of improving the health status of shift workers and found that dietary counseling and lifestyle modification have positive effects, reducing inflammation, body weight, and waist circumference.
Article
Entomology
Karin Bakran-Lebl, Stefanie Pree, Thomas Brenner, Eleni Daroglou, Barbara Eigner, Antonia Griesbacher, Johanna Gunczy, Peter Hufnagl, Stefanie Jaeger, Hans Jerrentrup, Lisa Klocker, Wolfgang Paill, Jana S. Petermann, Bita Shahi Barogh, Thorsten Schwerte, Carina Suchentrunk, Christian Wieser, Licha N. Wortha, Thomas Zechmeister, David Zezula, Klaus Zimmermann, Carina Zittra, Franz Allerberger, Hans-Peter Fuehrer
Summary: In recent years, several alien mosquito species have been introduced into Austria, posing a threat to public health. This study provides a nationwide overview of the situation of these alien mosquitoes in Austria. The results show the presence and distribution patterns of the Asian tiger mosquito and Asian bush mosquito, as well as the factors influencing their abundance. The findings contribute to a better understanding of the risk of mosquito-borne diseases and provide a useful baseline for monitoring future changes.
Article
Engineering, Multidisciplinary
Sigrid Zobl, Bodo D. Wilts, Willi Salvenmoser, Peter Poelt, Ille C. Gebeshuber, Thorsten Schwerte
Correction
Engineering, Multidisciplinary
Sigrid Zobl, Willi Salvenmoser, Thorsten Schwerte, Ille C. Gebeshuber, Manfred Schreiner
BIOINSPIRATION & BIOMIMETICS
(2016)
Article
Engineering, Multidisciplinary
Sigrid Zobl, Willi Salvenmoser, Thorsten Schwerte, Ille C. Gebeshuber, Manfred Schreiner
BIOINSPIRATION & BIOMIMETICS
(2016)
Meeting Abstract
Cardiac & Cardiovascular Systems
K. L. Poon, B. C. Kirchmaier, T. Schwerte, J. Huisken, C. Winkler, B. C. Jungblut, D. Y. Stainier, T. Brand
CARDIOVASCULAR RESEARCH
(2012)
Review
Physiology
Minyu Zhang, Biyang Xiao, Xiaoqi Chen, Bingming Ou, Songtao Wang
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely related to bile acid and gut microbiota disorders. Exercise plays an important role in maintaining the homeostasis of the enterohepatic circulation and the health of the host gut microbiota by regulating the composition and function of the bile acid pool in the enterohepatic axis. Exercise has been recommended as a first-line intervention for NAFLD, and regulating bile acids through exercise may be a promising treatment strategy.