Review
Pharmacology & Pharmacy
Baoqi Yu, Xia Wang, Yanting Song, Guomin Xie, Shiyu Jiao, Li Shi, Xuejie Cao, Xinyao Han, Aijuan Qu
Summary: Cardiovascular diseases are the leading cause of death worldwide, and hypoxia-inducible factors (HIFs) play an important role in their pathogenesis. Recent studies have revealed the role of cell-specific HIFs in various cardiovascular diseases, but the potential clinical application of HIF inhibitors in the treatment of cardiovascular diseases is not well understood.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biology
Corine M. van der Weele, William R. Jeffery
Summary: Dark caves lacking primary productivity expose subterranean animals to hypoxia. Cavefish cope with hypoxia by increasing erythrocyte development and constitutive hif1 gene overexpression.
Review
Cell Biology
Ana R. Neves, Tania Albuquerque, Telma Quintela, Diana Costa
Summary: There is clear evidence of the correlation between circadian rhythm dysregulation and disease origin/development, and clock-related therapies have emerged as significant progress in the clinical field.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Environmental Sciences
Hagit Kvitt, Assaf Malik, Smadar Ben-Tabou de-Leon, Eli Shemesh, Maya Lalzar, David F. Gruber, Hanna Rosenfeld, Tuo Shi, Tali Mass, Dan Tchernov
Summary: Deoxygenation had minimal physiological effects on corals but triggered significant changes in gene expression. Corals adapted to deoxygenation by increasing mitochondrial DNA copy numbers and reducing nematocyst formation. Gene expression patterns in corals showed similarity to other coral species and other metazoans in response to hypoxia.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Urology & Nephrology
Lina K. Sciesielski, Matthias Felten, Laura Michalick, Karin M. Kirschner, Georgia Lattanzi, Charlotte L. J. Jacobi, Thomas Wallach, Veronika Lang, Dominic Landgraf, Achim Kramer, Christof Dame
Summary: The generation of circadian rhythms is cell-autonomous and relies on a transcription/translation feedback loop controlled by a family of circadian clock transcription factors. The study found that circadian erythropoietin regulation in the normoxic adult murine kidney is transcriptionally controlled by master circadian activators CLOCK/BMAL1, and repressors CRY1/CRY2, which may have implications for kidney physiology and disease, laboratory diagnostics, and anemia therapy.
KIDNEY INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Yiwei Liu, Qipeng Luo, Zhanhao Su, Junyue Xing, Jinlin Wu, Li Xiang, Yuan Huang, Haizhou Pan, Xie Wu, Xiaoling Zhang, Jun Li, Fuxia Yan, Hao Zhang
Summary: Cyanotic congenital heart disease (CCHD) leads to maladaptation of cardiac metabolism during puberty, accompanied by impaired cardiac function. The study identified HIF-1 alpha as the key regulator of cardiac metabolic adaptation in CH animal models, with pubertal insulin resistance potentially suppressing its expression.
Review
Biochemistry & Molecular Biology
Jiayang Zhang, Ruoyu Sun, Tingting Jiang, Guangrui Yang, Lihong Chen
Summary: Blood pressure follows a circadian rhythm, with disruptions potentially leading to worsened cardiovascular and renal outcomes. This review summarizes current understanding of the circadian blood pressure regulation and provides a therapeutic overview of its relationship to cardiovascular and renal health and disease.
Review
Biochemistry & Molecular Biology
Benoit Pourcet, Helene Duez
Summary: Cardiovascular diseases remain the leading cause of death worldwide, largely due to the development of atherosclerotic plaque. In addition to traditional risk factors, alterations in circadian rhythms have been identified as an additional risk factor for CVD. Targeting core clock components may present a therapeutic approach to dampen atherosclerosis progression and treat CVD effectively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Min Chen, Yanke Lin, Yongkang Dang, Yifei Xiao, Fugui Zhang, Guanghui Sun, Xuejun Jiang, Li Zhang, Jianhao Du, Shuyi Duan, Xiaojian Zhang, Zifei Qin, Jing Yang, Kaisheng Liu, Baojian Wu
Summary: This study reveals that the intestinal clock plays a crucial role in regulating liver rhythmicity and metabolism. The loss of the intestinal clock leads to a large-scale reprogramming of the liver transcriptome and alters hepatic metabolism. The intestinal clock controls the rhythmicity of the hepatic transcription factor SREBP-1c, which further affects hepatic lipogenesis and gluconeogenesis. These findings suggest that targeting intestinal rhythms may be a new approach for improving metabolic health.
JOURNAL OF HEPATOLOGY
(2023)
Review
Medicine, General & Internal
Yu-Lu Liu, Si-Yi Gong, Shu-Ting Xia, Ya-Li Wang, Hao Peng, Yun Shen, Chun-Feng Liu
Summary: Light therapy (LT) has shown potential as a safe and convenient physical treatment method for patients with neurodegenerative disease. While some studies have reported limited or no effects, LT remains an attractive therapeutic approach for further investigation in ND. Further research through animal experiments and large clinical trials is needed to fully understand its mechanisms of action and true efficacy.
CHINESE MEDICAL JOURNAL
(2021)
Article
Environmental Sciences
Jiong Wu, Weiwei Zhang, Chenghua Li
Summary: As global warming progresses, heat and hypoxia have become important factors threatening marine organisms. Research on Apostichopus japonicus shows that the species can respond to heat, hypoxia, and heat-hypoxia stress by modulating the DNA methylation levels of circadian rhythm-related genes, ultimately increasing the activity of energy-related enzymes.
FRONTIERS IN MARINE SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Inna Rabinovich-Nikitin, Matthew Love, Lorrie A. Kirshenbaum
Summary: Autophagy is an important cellular mechanism for removing damaged or dysfunctional cellular components. It plays a crucial role in the cardiovascular system and contributes to normal cardiac function. The activation of autophagy during cardiac stress can be adaptive or maladaptive. This review highlights the molecular mechanisms and signaling pathways underlying autophagy in response to cardiac stress, as well as therapeutic approaches to modulate autophagy. The intersection between autophagy and circadian regulation in the heart is also discussed.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Endocrinology & Metabolism
Eder Zavala
Summary: Rhythmic hormonal secretion is crucial for maintaining health. Mathematical modelling can help understand the stability and clinical significance of hormonal rhythm misalignment. Examples of coupled endocrine axes can provide insights into the contributions of each endocrine system to a dynamic environment.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Pilar Codoner-Franch, Marie Gombert, Jose Martinez-Raga, Maria Carmen Cenit
Summary: Mental illness is increasing alarmingly, and the disruptions in circadian rhythms caused by modern lifestyle may be the main explanation for this trend. Impaired circadian rhythms are associated with mental disorders, and evening chronotype is a risk factor for severe psychiatric symptoms and metabolic comorbidities. Resynchronization of circadian rhythms improves psychiatric symptoms, and preventing circadian misalignment may reduce the risk and impact of psychiatric disorders. The gut microbiota, regulated by meal timing, exhibits diurnal rhythmicity and can aid in preventing circadian misalignment and resynchronizing circadian rhythms, making it a potential therapeutic strategy for mental illnesses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Beatrice Foglia, Erica Novo, Francesca Protopapa, Marina Maggiora, Claudia Bocca, Stefania Cannito, Maurizio Parola
Summary: Liver fibrosis is a potentially reversible pathophysiological event characterized by excess deposition of extracellular matrix components, which is primarily driven by activated myofibroblasts and other hepatic cell populations involved in chronic liver disease progression. The emerging pathogenic role of hypoxia, hypoxia-inducible factors, and related mediators in the fibrogenic progression of chronic liver diseases is a key focus of research.
Article
Biology
Michael G. Jonz, Leslie T. Buck, Steve F. Perry, Thorsten Schwerte, Giacomo Zaccone
SPECIAL ISSUE: RESPIRATORY SCIENCE
(2016)
Article
Medicine, Research & Experimental
Roland F. R. Schindler, Chiara Scotton, Jianguo Zhang, Chiara Passarelli, Beatriz Ortiz-Bonnin, Subreena Simrick, Thorsten Schwerte, Kar-Lai Poon, Mingyan Fang, Susanne Rinne, Alexander Froese, Viacheslav O. Nikolaev, Christiane Grunert, Thomas Mueller, Giorgio Tasca, Padmini Sarathchandra, Fabrizio Drago, Bruno Dallapiccola, Claudio Rapezzi, Eloise Arbustini, Francesca Romana Di Raimo, Marcella Neri, Rita Selvatici, Francesca Gualandi, Fabiana Fattori, Antonello Pietrangelo, Wenyan Li, Hui Jiang, Xun Xu, Enrico Bertini, Niels Becher, Jun Wang, Thomas Brand, Alessandra Ferlini
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Cell Biology
Adolf M. Sandbichler, Bianca Jansen, Bettina A. Peer, Monika Paulitsch, Bernd Pelster, Margit Egg
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Renate Kopp, Ines Bauer, Anil Ramalingam, Margit Egg, Thorsten Schwerte
Article
Biochemistry & Molecular Biology
Valentina Dikova, Julia Vorhauser, Anne Geng, Bernd Pelster, Adolf Michael Sandbichler
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Biochemical Research Methods
Richard Haindl, Abigail J. Deloria, Caterina Sturtzel, Harald Sattmann, Wolfgang Rohringer, Balthasar Fischer, Marco Andreana, Angelika Unterhuber, Thorsten Schwerte, Martin Distel, Wolfgang Drexler, Rainer Leitgeb, Mengyang Liu
BIOMEDICAL OPTICS EXPRESS
(2020)
Article
Ecology
Bettina Thalinger, Andreas Rieder, Anna Teuffenbach, Yannick Puetz, Thorsten Schwerte, Josef Wanzenboeck, Michael Traugott
Summary: The study reveals the importance of fish physiology and behavior in the interpretation of eDNA quantities, with differences found between species. Through experiments, it was demonstrated that fish activity levels and energy use are positively correlated with target eDNA quantities, highlighting the need to incorporate species-specific traits into eDNA monitoring and conservation efforts.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2021)
Article
Environmental Sciences
Christine Binder-mendl, Cem Ekmekcioglu, Wolfgang Marktl, Thorsten Schwerte
Summary: This study aims to investigate the possibility of improving the health status of shift workers and found that dietary counseling and lifestyle modification have positive effects, reducing inflammation, body weight, and waist circumference.
Article
Entomology
Karin Bakran-Lebl, Stefanie Pree, Thomas Brenner, Eleni Daroglou, Barbara Eigner, Antonia Griesbacher, Johanna Gunczy, Peter Hufnagl, Stefanie Jaeger, Hans Jerrentrup, Lisa Klocker, Wolfgang Paill, Jana S. Petermann, Bita Shahi Barogh, Thorsten Schwerte, Carina Suchentrunk, Christian Wieser, Licha N. Wortha, Thomas Zechmeister, David Zezula, Klaus Zimmermann, Carina Zittra, Franz Allerberger, Hans-Peter Fuehrer
Summary: In recent years, several alien mosquito species have been introduced into Austria, posing a threat to public health. This study provides a nationwide overview of the situation of these alien mosquitoes in Austria. The results show the presence and distribution patterns of the Asian tiger mosquito and Asian bush mosquito, as well as the factors influencing their abundance. The findings contribute to a better understanding of the risk of mosquito-borne diseases and provide a useful baseline for monitoring future changes.
Article
Engineering, Multidisciplinary
Sigrid Zobl, Bodo D. Wilts, Willi Salvenmoser, Peter Poelt, Ille C. Gebeshuber, Thorsten Schwerte
Correction
Engineering, Multidisciplinary
Sigrid Zobl, Willi Salvenmoser, Thorsten Schwerte, Ille C. Gebeshuber, Manfred Schreiner
BIOINSPIRATION & BIOMIMETICS
(2016)
Article
Engineering, Multidisciplinary
Sigrid Zobl, Willi Salvenmoser, Thorsten Schwerte, Ille C. Gebeshuber, Manfred Schreiner
BIOINSPIRATION & BIOMIMETICS
(2016)
Review
Biochemistry & Molecular Biology
Adolf Michael Sandbichler, Martina Hoeckner
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)