Review
Pharmacology & Pharmacy
Darija Cor Andrejc, Zeljko Knez, Masa Knez Marevci
Summary: Ganoderma lucidum is a medicinal mushroom with various biologically active compounds that have antioxidant, antitumor, anti-inflammatory properties.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Applied
Lingrong Wen, Zhili Sheng, Jinping Wang, Yueming Jiang, Bao Yang
Summary: This study obtained water-soluble polysaccharides (GLSP) from Ganoderma lucidum spore through hot water extraction, revealing that GLSP is mainly composed of β-glucan and arabinogalactan. GLSP has the potential to induce cell proliferation and possess strong anti-inflammatory activity by inhibiting the overproduction of NO and pro-inflammatory cytokines induced by LPS.
Article
Chemistry, Applied
Man Hyung Koo, Hae-Jung Chae, Jun Hyuck Lee, Sung-Suk Suh, Ui Joung Youn
Summary: Phytochemical and biological studies of methanolic extracts from Ganoderma lucidum led to the discovery of a new lanostane triterpenoid, ganosidone A, and eight known derivatives. The compounds showed potential for cancer chemoprevention by inhibiting nitric oxide production in vitro, with compounds 4 and 7 exhibiting significant inhibition rates at a concentration of 50 μM.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Shaodan Chen, Xiaoying Guan, Tianqiao Yong, Xiong Gao, Chun Xiao, Yizhen Xie, Diling Chen, Huiping Hu, Qingping Wu
Summary: In this study, Ganoderma lucidum crude polysaccharide (GLP) was found to have a protective effect on liver damage caused by restraint stress in mice by improving oxidative status. Two polysaccharides, including a neutral beta-glucan (GLPB2) and an acidic beta-glucan (GLPC2), were purified from GLP. GLPC2 exhibited a stronger hepatoprotective effect compared to GLPB2. The findings provide a theoretical basis for the potential application of G. lucidum polysaccharides as hepatoprotective agents in the food and pharmaceutical industry.
Article
Biochemistry & Molecular Biology
Zhen-Zhu Zhao, Bao-Yu Ji, Zhen-Zhen Wang, Ying-Ying Si, Yan-Jun Sun, Hui Chen, Wei-Sheng Feng, Xiao-Ke Zheng, Ji-Kai Liu
Summary: Eight new lanostane triterpenoids and nine known ones were discovered in the fruiting bodies of Ganoderma lingzhi S.H. Wu, Y. Cao & Y.C. Dai. Their structures were determined using spectroscopic data and quantum chemical calculations. Among them, ganoderane GL-1, containing a hydrogenated tetramethylsphenanthraquinone, is the first example in the lanostane nor-triterpenoid group. In terms of biological activity, ganoderanes GL-2 and GL-3, which have a rare 1,11-epoxy moiety, showed significant inhibition against nitric oxide production induced by lipopolysaccharide in RAW264.7 macrophage cells, while ganoderanes GL-4 and GL-8 exhibited bifunctional activities of anti-proliferation and anti-inflammation.
Review
Biochemistry & Molecular Biology
Emin Cadar, Ticuta Negreanu-Pirjol, Carolina Pascale, Rodica Sirbu, Irina Prasacu, Bogdan-Stefan Negreanu-Pirjol, Cezar Laurentiu Tomescu, Ana-Maria Ionescu
Summary: This review examines the scientific research on the natural bioactive compounds found in extracts of Ganoderma lucidum (G. lucidum) and their potential in cancer treatment. The study reveals that G. lucidum contains important bioactive compounds such as polysaccharides, triterpenoids, and sterols, which have demonstrated multiple anticancer effects including immunomodulatory, anti-proliferative, cytotoxic, and antioxidant actions. However, there is still uncertainty about the effects of G. lucidum bioactive compounds in treating different types of cancer, and further clinical trials are needed to clarify their potential benefits in cancer prevention and treatment.
Article
Biochemistry & Molecular Biology
Xueqing Zhang, Xiaoxu Gao, Guoqing Long, Yongcheng Yang, Gang Chen, Guoli Hou, Xuting Huo, Jingming Jia, Anhua Wang, Gaosheng Hu
Summary: This study isolated and identified 10 undescribed lanostane triterpenoids and 21 known compounds from statically cultured mycelial mat of G. lucidum. The hepatoprotective activities of these compounds in H2O2-induced HepG2 cells were evaluated, and the structure-activity relationship was discussed.
Review
Biochemistry & Molecular Biology
Fang Kou, Yunfei Ge, Weihao Wang, Yuxia Mei, Longkui Cao, Xuetuan Wei, Hang Xiao, Xian Wu
Summary: Ganoderma lucidum polysaccharides have unique functional properties and various processing technologies have been used to improve their yield and utilization. This review summarizes the structure and health benefits of G. lucidum polysaccharides, and discusses factors that may affect their quality, including chemical modifications. These modifications improve the physicochemical characteristics and utilization of G. lucidum polysaccharides, making them more stable and suitable for encapsulating active substances. Ultimately, G. lucidum polysaccharide-based nanoparticles are designed to deliver functional ingredients for better health-promoting effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Qi-Zhang Li, Xin Chen, Pei-Wen Mao, Meng-Yuan Jin, Qin Wu, Xuan-Wei Zhou
Summary: This study revealed that N-glycosylation can enhance the anti-inflammatory activity of FIP-glu by regulating the expression of inflammatory cytokines and inhibiting p38 MAPK phosphorylation. N-glycosylation significantly improved the functional properties of FIP-glu, providing theoretical and technical support for expanding the application of FIPs in the food and pharmaceutical industries.
Article
Chemistry, Applied
Ming Cai, Haoyong Xing, Baoming Tian, Jing Xu, Zhenhao Li, Hua Zhu, Kai Yang, Peilong Sun
Summary: The study revealed that Ganoderma lucidum polysaccharides can extend swimming time, enhance endurance, and promote fatigue recovery, especially polysaccharides with molecular weights above 10 kDa. These GLPs may reduce the activities of SUN and CK, decrease the levels of MDA and BLA, increase the level of Gly, accelerate fat transformation, and improve the activities of GPx, SOD, and LDH in all treated mice. Therefore, GLPs above 10 kDa could be potential agents with antifatigue activity.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Loreto Robles-Hernandez, Nora A. Salas-Salazar, Ana C. Gonzalez-Franco
Summary: This study aimed to purify and characterize the antibacterial activity against plant pathogenic bacteria from culture fluids of Ganoderma lucidum, revealing that the bioactive compounds are small polysaccharides. This is the first report of such polysaccharides produced by G. lucidum with activity against bacterial plant pathogens.
Article
Chemistry, Medicinal
G. A. Khalilova, A. S. Turaev, B. I. Mulkhitdinov, S. B. Khaitmetova, N. S. Normakhamatov
Summary: The study focused on the isolation and study of polysaccharides from Ganoderma lucidum basidiomycete raw material. It was found that the isolated polysaccharides showed potential in inhibiting tumor growth in vivo.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2022)
Article
Chemistry, Applied
Shayane da Silva Milhorini, Daniel de Lima Bellan, Matheus Zavadinack, Fernanda Fogagnoli Simas, Fhernanda Ribeiro Smiderle, Arquimedes Paixa de Santana-Filho, Guilherme Lanzi Sassaki, Marcello Iacomini
Summary: In this study, a fucoxylomannan (FXM) was isolated from Ganoderma lucidum mushroom, which exhibited anti-proliferative effects on melanoma cells, including reduction in cell viability, cell density, and anchorage-independent clonogenic capacity. However, no impact on non-tumoral cells was observed.
CARBOHYDRATE POLYMERS
(2022)
Article
Plant Sciences
Wenshuai Wang, Yaohan Zhang, Zhiying Wang, Jianjun Zhang, Le Jia
Summary: This study investigated the protective effects of Ganoderma lucidum polysaccharides (GLP) on high-fat diet-induced hyperlipidemia and explored the underlying mechanism. The results showed that GLP decreased body weight gain, reduced lipid levels, alleviated tissue injury, and improved oxidative stress and inflammation response. GLP also modulated bile acids synthesis, lipid regulatory factors, and promoted reverse cholesterol transport.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Guo Liu, Jun Zhang, Qixin Kan, Mingyue Song, Tao Hou, Siyu An, Hongyu Lin, Hongzhang Chen, Liuyun Hu, Jie Xiao, Yunjiao Chen, Yong Cao
Summary: Ganoderma lucidum polysaccharides (GLP) have excellent immunomodulatory activity. Among them, the high molecular weight Restriction Fragment Length Polymorphism (RGLP) exhibits stronger immunomodulatory activity than the low molecular weight EGLP. Structural analysis reveals that RGLP-1 is a β-pyran polysaccharide with specific glycosyl bonds, showing potential immunomodulatory properties.
FRONTIERS IN NUTRITION
(2022)
