Article
Agriculture, Multidisciplinary
Xiao-Yu Cui, Shan Jiang, Cheng-Cheng Wang, Jin-Yue Yang, Ying-Cai Zhao, Chang-Hu Xue, Yu-Ming Wang, Tian-Tian Zhang
Summary: The study demonstrated that EPA-PC, EPA-LPC, and DHA-LPC have different effects on DHA or EPA recovery and supplementation efficiency in different tissues, providing important references for understanding the time course of DHA or EPA recovery in phospholipid molecular species in different tissues.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Ulrika Sjoebom, Mats X. Andersson, Aldina Pivodic, Anna -My Lund, Mireille Vanpee, Ingrid Hansen-Pupp, David Ley, Dirk Wackernagel, Karin Savman, Lois E. H. Smith, Chatarina Lofqvist, Ann Hellstrom, Anders K. Nilsson
Summary: This study focused on the risk of deficits in long-chain polyunsaturated fatty acids (LCPUFAs) in preterm infants, which may lead to morbidities and hinder neurodevelopment. By analyzing the serum fatty acid profiles of preterm infants and the impact of enteral and parenteral lipid sources, the study found that enteral supplementation of fatty acids can increase the target fatty acids without significant impact on other fatty acids, while parenteral lipid administration can result in decreased levels of AA and DHA relative to other fatty acids. The study also observed differences in fatty acid patterns when expressed in relative or absolute units.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Sakurako Niwa, Terue Kawabata, Kumiko Shoji, Hiromitsu Ogata, Yasuo Kagawa, Kazuhiro Nakayama, Yoshiko Yanagisawa, Sadahiko Iwamoto, Nozomi Tatsuta, Kaname Asato, Takahiro Arima, Nobuo Yaegashi, Kunihiko Nakai
Summary: Increasing the amount of long-chain polyunsaturated fatty acids (LCPUFA) in human milk is important for infant growth and development. This study found that maternal diet, specifically fish and shellfish intake, and gene-diet interactions influenced the composition of LCPUFA in human milk.
Article
Biochemistry & Molecular Biology
Shuai-Shuai Fu, Min Wen, Ying-Cai Zhao, Hao-Hao Shi, Yu-Ming Wang, Chang-Hu Xue, Zi-Hao Wei, Tian-Tian Zhang
Summary: A study found that dietary supplementation with EPA-pPE can significantly change the fatty acid composition in the brain and liver, especially in increasing the content of DHA. EPA-pPE has a more significant effect on increasing DHA compared to EPA-PC, making it a good nutritional supplement to increase DHA levels in n-3 PUFA-deficient offspring's brains.
Article
Nutrition & Dietetics
Silvia Savastio, Erica Pozzi, Valentina Mancioppi, Valentina Boggio Sola, Deborah Carrera, Valentina Antoniotti, Paola Antonia Corsetto, Gigliola Montorfano, Angela Maria Rizzo, Marco Bagnati, Ivana Rabbone, Flavia Prodam
Summary: This study aimed to explore the relationship between metabolic control, vitamin D status, and the AA/EPA ratio in children with type 1 diabetes (T1D). The study found that the AA/EPA ratio has an impact on insulin demand and vitamin D levels in T1D children. Additionally, the composition of the diet may affect the severity of T1D onset.
Article
Agriculture, Multidisciplinary
Xina Yu, Qingcheng Wang, Weibo Lu, Min Zhang, Kang Chen, Jing Xue, Qiaoling Zhao, Pingya Wang, Pei Luo, Qing Shen
Summary: An PreIS-HILIC-MS method was established to specifically and selectively screen PLEPA/DHA in different fish oil samples, including saury, grass carp, hairtail, and yellow croaker. The method demonstrated high sensitivity, good linearity, and suitability for quantitative analysis of PLEPA/DHA in fish oil samples, with the ability to identify and quantify 24 different compounds. The performance of this method was compared with traditional full-scan mode and showed unique superiority in targeted screening of PLEPA/DHA in fish oils.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agriculture, Multidisciplinary
Jing Xue, Lijun Ge, Honghai Wang, Jingjing Liang, Qingcheng Wang, Weibo Lu, Yiwei Cui, Hujun Xie, Shikai Jian, Danping Jin, Qizhi Jin, Ting Li, Qing Shen
Summary: A newly developed PreIS-HILIC/MS method was used to screen PLEPA/DHA in 16 aquatic products. Antarctic krill was found to have the highest level of PLEPA/DHA (2574.69μg/g), while sea bass and sea cucumber had the highest contents of EPA-structured and DHA-structured ether phospholipids, respectively. Multivariate statistical analysis revealed multiple discrepancies between the 16 aquatic products.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Editorial Material
Nutrition & Dietetics
Birgitta Strandvik
Summary: Nutrition plays a crucial role in cystic fibrosis (CF) due to its association with increased energy consumption, specific nutritional deficiencies, and malabsorption related to pancreatic insufficiency. The deterioration of lung function in CF patients has been linked to nutrition. However, despite the general recommendation of high energy intake, clinical deterioration remains difficult to control, suggesting the need for identifying and specifying special nutritional needs. Lipid abnormalities, particularly in essential or conditionally essential fatty acids, are commonly observed in CF patients. This article focuses on the qualitative aspects of fat metabolism, which has been neglected in dietary fat recommendations that only emphasize fat quantity. The deficiency of linoleic acid, an essential fatty acid important for membrane structure and function, has been recognized for over 60 years in CF patients. The ratio between arachidonic acid and docosahexaenoic acid, conditionally essential fatty acids in the n-6 and n-3 series respectively, is often increased. Recent discoveries regarding the connection between CFTR modulators and lipid metabolism have generated new interest in this field, and advancements in technology provide opportunities for more personalized therapy.
Article
Immunology
Zhubiao Ye, Jianru Chen, Pengran Du, Qingrong Ni, Baizhang Li, Zhe Zhang, Qi Wang, Tingting Cui, Xiuli Yi, Chunying Li, Shuli Li
Summary: This study aimed to determine the differences in specific fatty acids between vitiligo patients and healthy individuals and to investigate their association with clinical features. The results showed that the serological level of alpha-linolenic acid (ALA) was increased in vitiligo patients, while the levels of arachidonic acid (ARA), arachidic acid (AA), and behenic acid were decreased. ALA levels were positively associated with the vitiligo area scoring index (VASI). Supplementation with ARA or nordihydroguaiaretic acid (NDGA) could suppress the function of CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Keri Lanier, Breanna Wisseman, Cody Strom, Carol A. Johnston, Christy Isler, James DeVente, Edward Newton, Roman Pawlak, Brittany R. Allman-Tucker, Samantha McDonald, Linda E. May
Summary: In the United States, pregnant women have low concentrations of DHA and EPA, which are essential for fetal development. The consumption of PUFA-containing foods can reflect the status of DHA and EPA in maternal blood. This study aimed to determine the association between maternal self-reported dietary intake of foods high in DHA and EPA and maternal blood concentrations of DHA and EPA.
Article
Nutrition & Dietetics
Yu Wang, Byron J. Gajewski, Christina J. Valentine, Sarah A. Crawford, Alexandra R. Brown, Dinesh Pal Mudaranthakam, Juliana Teruel Camargo, Susan E. Carlson
Summary: The purpose of this study was to investigate the relationships among DHA intake, nutrient intake, and maternal characteristics on pregnancy outcomes. The results showed that DHA supplementation reduced the risk of preterm birth and NICU admission and increased gestation and birth weight. Maternal red blood cell DHA concentration at delivery was associated with DHA supplementation and higher education level. DHA supplementation and maternal age were associated with a higher risk of gestational diabetes. Fructose, vitamin A, and arachidonic acid intake were associated with gestation duration.
CLINICAL NUTRITION
(2023)
Article
Food Science & Technology
Fang Wu, Dan-Dan Wang, Hao-Hao Shi, Cheng-Cheng Wang, Chang-Hu Xue, Yu-Ming Wang, Tian-Tian Zhang
Summary: Early dietary n-3 PUFA deficiency exacerbates the development of Parkinson's disease in old age, while supplementation with DHA/EPA-PLs can restore brain DHA levels and exert neuroprotective effects in long-term n-3 PUFA-deficient mice.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Neurosciences
Sarah B. Scheinman, Dhavamani Sugasini, Monay Zayed, Poorna C. R. Yalagala, Felecia M. Marottoli, Papasani V. Subbaiah, Leon M. Tai
Summary: Research suggests that LPC-DHA/EPA-enriched krill oil can increase brain DHA and improve memory-related behavior in mice with the APOE4 gene. Therefore, long-term use of LT-krill oil supplements may provide some level of protection against age-related neurodegeneration.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Cell Biology
Mario Diaz, Daniel Pereda de Pablo, Catalina Valdes-Baizabal, Guido Santos, Raquel Marin
Summary: Lipid raft aging in nerve cells is an early event in aging-related neurodegenerative diseases and affects synaptic plasticity. Dietary supplementation of n-3 LCPUFA has been found to reverse fatty acid alterations, decrease microviscosity, and modulate the distribution of glutamate receptors and ion channels in hippocampal lipid rafts. These changes ultimately impact synaptic plasticity and memory formation. The study also uncovers unexpected modifications in the lipidome and size of lipid rafts, suggesting a potential role in age-associated cognitive decline.
Article
Food Science & Technology
Alejandra Valencia-Naranjo, Luz M. Manjarres-Correa, Juliana Bermudez-Cardona
Summary: This study aimed to evaluate the changes in the concentrations of EPA and DHA in the erythrocytes and breast milk of lactating women after three months of supplementation. The study found low consumption of omega-3 food sources and low EPA and DHA content initially. After supplementation, there was a significant increase in DHA levels in both erythrocytes and breast milk, while EPA levels did not change significantly.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Nutrition & Dietetics
Dominique Turck, Christian P. Braegger, Carla Colombo, Dimitri Declercq, Alison Morton, Ruzha Pancheva, Eddy Robberecht, Martin Stern, Birgitta Strandvik, Sue Wolfe, Stephane M. Schneider, Michael Wilschanski
CLINICAL NUTRITION
(2016)
Article
Endocrinology & Metabolism
Frida Dalin, Gabriel Nordling Eriksson, Per Dahlqvist, Asa Hallgren, Jeanette Wahlberg, Olov Ekwall, Stefan Soderberg, Johan Ronnelid, Per Olcen, Ola Winqvist, Sergiu-Bogdan Catrina, Berit Kristrom, Maria Laudius, Magnus Isaksson, Maria Halldin Stenlid, Jan Gustafsson, Gennet Gebre-Medhin, Sigridur Bjornsdottir, Annika Janson, Anna-Karin Akerman, Jan Aman, Karel Duchen, Ragnhildur Bergthorsdottir, Gudmundur Johannsson, Emma Lindskog, Mona Landin-Olsson, Maria Elfving, Erik Waldenstrom, Anna-Lena Hulting, Olle Kampe, Sophie Bensing
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2017)
Article
Medicine, Research & Experimental
Birgitta Strandvik, Wanda K. O'Neal, Mohamed A. Ali, Ulf Hammar
EXPERIMENTAL BIOLOGY AND MEDICINE
(2018)
Article
Gastroenterology & Hepatology
Emma Kjellberg, Josefine Roswall, Stefan Bergman, Birgitta Strandvik, Jovanna Dahlgren
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2018)
Article
Gastroenterology & Hepatology
Salvatore Auricchio, Samy Cadranel, Stefano Guandalini, Deirdre Kelly, Berthold Koletzko, Michael J. Lentze, Alexander S. McNeish, Peter J. Milla, Jean Rey, Jacques Schmitz, Raanan Shamir, Birgitta Strandvik, Riccardo Troncone, Jarmo Visakorpi
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2018)
Article
Gastroenterology & Hepatology
Michael J. Lentze, Salvatore Auricchio, Samy Cadranel, Peter J. Milla, Deirdre Kelly, Alexander S. McNeish, Jean Rey, Jacques Schmitz, Birgitta Strandvik, Jan Taminiau, Jarmo Visakorpi
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2018)
Article
Pediatrics
Peter Wide, Karel Duchen, Sven Mattsson, Gunilla Glad Mattsson
JOURNAL OF PEDIATRIC UROLOGY
(2020)
Article
Nursing
Gunilla Flankegard, Evalotte Morelius, Karel Duchen, Patrik Rytterstrom
JOURNAL OF ADVANCED NURSING
(2020)
Editorial Material
Nutrition & Dietetics
Birgitta Strandvik
Summary: Nutrition plays a crucial role in cystic fibrosis (CF) due to its association with increased energy consumption, specific nutritional deficiencies, and malabsorption related to pancreatic insufficiency. The deterioration of lung function in CF patients has been linked to nutrition. However, despite the general recommendation of high energy intake, clinical deterioration remains difficult to control, suggesting the need for identifying and specifying special nutritional needs. Lipid abnormalities, particularly in essential or conditionally essential fatty acids, are commonly observed in CF patients. This article focuses on the qualitative aspects of fat metabolism, which has been neglected in dietary fat recommendations that only emphasize fat quantity. The deficiency of linoleic acid, an essential fatty acid important for membrane structure and function, has been recognized for over 60 years in CF patients. The ratio between arachidonic acid and docosahexaenoic acid, conditionally essential fatty acids in the n-6 and n-3 series respectively, is often increased. Recent discoveries regarding the connection between CFTR modulators and lipid metabolism have generated new interest in this field, and advancements in technology provide opportunities for more personalized therapy.
Article
Infectious Diseases
Chiara Gabbi, Alessandra Renieri, Birgitta Strandvik
Summary: COVID-19 exhibits significant heterogeneity in its spread and fatality among countries, indicating a potential influence of host genetic factors. This study suggests a correlation between the prevalence of carriers of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene and the spread and fatality of COVID-19. Population genetics of CFTR may contribute to understanding the spatial distribution of COVID-19.
JOURNAL OF INFECTION
(2022)
Article
Allergy
Emelie Ahlberg, Magali Marti, Dhanapal Govindaraj, Elisabet Severin, Karel Duchen, Maria C. Jenmalm, Lina Tingo
Summary: This study evaluated the expression of immune-related miRNAs in breast milk and their association with maternal supplementation with L. reuteri and omega-3 PUFAs, as well as infant Treg frequencies. The results showed that supplementation did not significantly affect miRNA expression in breast milk, but some miRNAs correlated with Treg subpopulations in breastfed infants, supporting the importance of breast milk miRNAs in infant immune regulation.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Birgitta Strandvik, Abdul Rashid Qureshi, Johanna Painer, Carolina Backman-Johansson, Martin Engvall, Ole Froebert, Jonas Kindberg, Peter Stenvinkel, Sylvain Giroud
Summary: Factors for initiating hibernation are still unknown but it is related to consciousness/sleep and n-3 fatty acids in humans. This study examined the fatty acid profiles in the plasma of brown bears and garden dormice during hibernation and summer. The results showed consistent differences in fatty acid composition between hibernation and summer in both species, suggesting a potential link between hibernation phenotype and metabolism.
Article
Endocrinology & Metabolism
Karel Duchen, Mike Jones, Ashild Olsen Faresjo, Tomas Faresjo, Johnny Ludvigsson
OBESITY SCIENCE & PRACTICE
(2020)
Article
Endocrinology & Metabolism
Karel Duchen, Ashild Olsen Faresjo, Sofia Klingberg, Tomas Faresjo, Johnny Ludvigsson
OBESITY SCIENCE & PRACTICE
(2020)
Article
Pediatrics
Karel Duchen, Anders Lindberg, Kaire Kiplok, Berit Kristrom
