ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity

Regulation of Protein Tyrosine Phosphatase Oxidation in Cell Adhesion and Migration

(2013) Jeroen Frijhoff et al.   ANTIOXIDANTS & REDOX SIGNALING

Novel in vitro cardiovascular constructs composed of vascular-like networks and cardiomyocytes

(2013) Hanna Vuorenpää et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to Cardiomyopathy

(2013) Filipa S. Carvalho et al.   MEDICINAL RESEARCH REVIEWS

Abl kinases are required for vascular function, Tie2 expression, and angiopoietin-1-mediated survival

(2013) E. M. Chislock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rac1 signalling mediates doxorubicin-induced cardiotoxicity through both reactive oxygen species-dependent and -independent pathways

(2012) Jian Ma et al.   CARDIOVASCULAR RESEARCH

Glutathione/thioredoxin systems modulate mitochondrial H2O2emission: An experimental-computational study

(2012) Miguel Antonio Aon et al.   JOURNAL OF GENERAL PHYSIOLOGY

Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies

(2012) Yanti Octavia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac-Specific Over-Expression of Epidermal Growth Factor Receptor 2 (ErbB2) Induces Pro-Survival Pathways and Hypertrophic Cardiomyopathy in Mice

(2012) Polina Sysa-Shah et al.   PLoS One

Mechanistic Investigation of Imatinib-Induced Cardiac Toxicity and the Involvement of c-Abl Kinase

(2012) Wenyue Hu et al.   TOXICOLOGICAL SCIENCES

Strong EGFR signaling in cell line models of ERBB2-amplified breast cancer attenuates response towards ERBB2-targeting drugs

(2012) F Henjes et al.   Oncogenesis

Herceptin, a recombinant humanized anti-ERBB2 monoclonal antibody, induces cardiomyocyte death

(2011) Krishna K. Singh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thioredoxin Reductase-2 Is Essential for Keeping Low Levels of H2O2Emission from Isolated Heart Mitochondria

(2011) Brian A. Stanley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox-optimized ROS balance: A unifying hypothesis

(2010) M.A. Aon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines

(2010) Sergey I. Dikalov et al.   FREE RADICAL RESEARCH

The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro

(2010) Sarah J. Watkins et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitro

(2010) Brian B. Hasinoff et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Reciprocal regulation of Abl and receptor tyrosine kinases

(2009) Divyamani Srinivasan et al.   CELLULAR SIGNALLING

Mitochondria and reactive oxygen species

(2009) Alicia J. Kowaltowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tissue-, substrate-, and site-specific characteristics of mitochondrial reactive oxygen species generation

(2009) Erich B. Tahara et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of Cu,Zn-Superoxide Dismutase in the Absence of Oxygen and the Copper Chaperone CCS

(2009) Jeffry M. Leitch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison of two methods for assaying complex I activity in mitochondria isolated from rat liver, brain and heart

(2009) Jiangang Long et al.   LIFE SCIENCES

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

c-Abl tyrosine kinase regulates cardiac growth and development

(2009) Z. Qiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Morphological alterations induced by doxorubicin on H9c2 myoblasts: nuclear, mitochondrial, and cytoskeletal targets

(2008) Vilma A. Sardão et al.   CELL BIOLOGY AND TOXICOLOGY

Glycogen Synthase Kinase 3 Inhibition Slows Mitochondrial Adenine Nucleotide Transport and Regulates Voltage-Dependent Anion Channel Phosphorylation

(2008) Samarjit Das et al.   CIRCULATION RESEARCH

Blockade of the erbB2 Receptor Induces Cardiomyocyte Death through Mitochondrial and Reactive Oxygen Species-dependent Pathways

(2008) Leo I. Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY