Article
Multidisciplinary Sciences
Sheng Xing, Jin-Ze Tian, Shu-Hua Yang, Xue-Ting Huang, Yan-Fu Ding, Qian-Yun Lu, Jin-Shu Yang, Wei-Jun Yang
Summary: Blood vessels in adult mammals are highly organized and stable, but in cases of ischemic heart, c-Kit(+) cells play a crucial role in the development and homeostasis of cardiac endothelial cells. Setd4-expressing quiescent c-Kit(+) cells can regulate vascular endothelial cells and improve cardiac function in myocardial infarction injured mice. This suggests the potential for targeted treatments for cardiac ischemic injury by controlling the quiescence of c-Kit(+) cells through epigenetic mechanisms.
SCIENTIFIC REPORTS
(2021)
Article
Biochemical Research Methods
Marine H. Laporte, Nikolai Klena, Virginie Hamel, Paul Guichard
Summary: Cryo-ExM is a method that combines cryofixation with expansion microscopy to preserve native cellular organization. This approach bypasses artifacts associated with chemical fixation and its simplicity will contribute to its widespread use in super-resolution microscopy.
Article
Biochemistry & Molecular Biology
Avnish Verma, Ayse Orme Merve, Vytautas Remeskevicius, Pola Sobiecka, Luke Taylor, Scott Lawton, Ben P. Jones, Elena Polycarpou, Jason Bennett, Brian Rooney
Summary: Cocaine has been shown to enhance migration and adhesion of cardiac cells while having little effect on cell proliferation, with higher doses leading to increased cell death. Additionally, cocaine affects cellular morphology and intercellular contacts, influencing cardiomyocyte function and cytotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ayse Orme Merve, Pola Sobiecka, Vytautas Remeskevicius, Luke Taylor, Lili Saskoy, Scott Lawton, Ben P. Jones, Ahmed Elwakeel, Francesca E. Mackenzie, Elena Polycarpou, Jason Bennett, Brian Rooney
Summary: This study investigates the effects of cannabis metabolites on the heart, finding that they can increase the migration and proliferation of cardiac myocytes, with no effect on cell adhesion. Higher doses of these metabolites result in cell death and deterioration of cell structure. The metabolites also modulate the expression of key extracellular matrix proteins. Animal model research demonstrates that these metabolites can cause increased protein deposition and, at higher doses, lead to lethality and reduced regeneration. These findings highlight the importance of cannabis metabolites in cardiotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Sean P. Reuter, Mark H. Soonpaa, Dorothy Field, Ed Simpson, Michael Rubart-von der Lohe, Han Kyu Lee, Arthi Sridhar, Stephanie M. Ware, Nick Green, Xiaochun Li, Susan Ofner, Douglas A. Marchuk, Kai C. Wollert, Loren J. Field
Summary: Genetic analysis found that Tnni3k expression increases cardiomyocyte S-phase activity after injury. This study may help guide the development of therapeutic interventions for cardiac regeneration.
Article
Cardiac & Cardiovascular Systems
Hidenori Tani, Taketaro Sadahiro, Yu Yamada, Mari Isomi, Hiroyuki Yamakawa, Ryo Fujita, Yuto Abe, Tatsuya Akiyama, Koji Nakano, Yuta Kuze, Masahide Seki, Yutaka Suzuki, Manabu Fujisawa, Mamiko Sakata-Yanagimoto, Shigeru Chiba, Keiichi Fukuda, Masaki Ieda
Summary: By conducting experiments on mice, this study found that cardiac reprogramming can repair chronic myocardial infarction, promote myocardial regeneration, and reduce fibrosis. The results of this study provide new insights for the treatment of chronic myocardial infarction and heart failure.
Article
Multidisciplinary Sciences
Xiaolei Sun, Hang Chen, Rifeng Gao, Ya Huang, Yanan Qu, Heng Yang, Xiang Wei, Shiyu Hu, Jian Zhang, Peng Wang, Yunzeng Zou, Kai Hu, Junbo Ge, Aijun Sun
Summary: Mitochondrial transplantation can inhibit doxorubicin-induced cardiotoxicity by directly supplying functional mitochondria, improving cardiomyocyte function, and reducing apoptosis and oxidative stress. Mitochondria from various sources all exert similar cardioprotective effects.
Article
Cardiac & Cardiovascular Systems
Hidenori Tani, Taketaro Sadahiro, Yu Yamada, Mari Isomi, Hiroyuki Yamakawa, Ryo Fujita, Yuto Abe, Tatsuya Akiyama, Koji Nakano, Yuta Kuze, Masahide Seki, Yutaka Suzuki, Manabu Fujisawa, Mamiko Sakata-Yanagimoto, Shigeru Chiba, Keiichi Fukuda, Masaki Ieda
Summary: Adult cardiomyocytes have limited regenerative ability, and the synthesis of extracellular matrix by cardiac fibroblasts (CFs) results in fibrosis and heart dysfunction after myocardial infarction (MI). The overexpression of cardiac transcription factors, MGTH, can directly reprogram CFs into induced cardiomyocytes (iCMs) and improve cardiac function in acute MI. However, it is unclear whether in vivo cardiac reprogramming can repair chronic MI with established scars.
Article
Cardiac & Cardiovascular Systems
Marisa J. Stachowski-Doll, Maria Papadaki, Thomas G. Martin, Weikang Ma, Henry M. Gong, Stephanie Shao, Shi Shen, Nitha Aima Muntu, Mohit Kumar, Edith Perez, Jody L. Martin, Christine S. Moravec, Sakthivel Sadayappan, Stuart G. Campbell, Thomas Irving, Jonathan A. Kirk
Summary: The study reveals that GSK-3 beta plays a regulatory role in myofilament function by localizing to the sarcomere, specifically the Z-disc, to modulate length-dependent activation. Furthermore, reduced localization of GSK-3 beta in the Z-disc is observed in patients with heart failure, indicating it may be a potential therapeutic target for restoring the Frank-Starling mechanism in these patients.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Vinayak Kumar, Alexander J. Ryu, Armando Manduca, Chaitanya Rao, Raymond J. Gibbons, Bernard J. Gersh, Krishnaswamy Chandrasekaran, Samuel J. Asirvatham, Philip A. Araoz, Jae K. Oh, Alexander C. Egbe, Atta Behfar, Barry A. Borlaug, Nandan S. Anavekar
Summary: This study found that healthy myocardium is compressible, while myocardium in patients with heart failure with reduced ejection fraction is incompressible. The ratio MVs/MVd may need further investigation in different populations to understand its variations.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Carmela Nappi, Mariarosaria Panico, Maria Falzarano, Carlo Vallone, Andrea Ponsiglione, Paolo Cutillo, Emilia Zampella, Mario Petretta, Alberto Cuocolo
Summary: Ischemic heart disease is the leading cause of mortality worldwide. Myocardial viability refers to the myocardium that maintains metabolic and electrical function despite contractile dysfunction, and has the potential for functional enhancement upon revascularization. Recent advances in the development of new radiotracers for cardiac imaging have improved methods to detect myocardial viability.
Article
Cardiac & Cardiovascular Systems
Christian U. Oeing, Seungho Jun, Sumita Mishra, Brittany L. Dunkerly-Eyring, Anna Chen, Maria Grajeda, Usman A. Tahir, Robert E. Gerszten, Nazareno Paolocci, Mark J. Ranek, David A. Kass
Summary: The phosphorylation status of TSC2-S1365 plays a crucial role in regulating myocardial substrate utilization, activating mTORC1 to shift metabolism away from fatty acid oxidation towards glycolysis for protection against ischemia-reperfusion injury. Reduced phosphorylation of TSC2-S1365 is also required for effective ischemic preconditioning (IPC) process.
CIRCULATION RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Natalie N. N. Khalil, Megan L. L. McCain
Summary: Myocardial infarctions are a common form of cardiac injury and death globally, with the reparative process ultimately leading to scar tissue formation and heart failure. Traditional approaches to studying post-infarct cellular microenvironments have limited control over relevant features, while Organ on a Chip models have emerged as new paradigms for dissecting this complex environment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Bhairab N. Singh, Dogacan Yucel, Bayardo I. Garay, Elena G. Tolkacheva, Michael Kyba, Rita C. R. Perlingeiro, Jop H. Berlo, Brenda M. Ogle
Summary: During cardiac development and morphogenesis, the differentiation of cardiac progenitor cells into mature cardiomyocytes is regulated by factors that also influence proliferation. Understanding the interaction between proliferation and maturation could enhance the use of human induced pluripotent stem cell-derived cardiomyocytes for modeling adult-level cardiac function in engineered cardiac tissues.
CIRCULATION RESEARCH
(2023)
Article
Computer Science, Information Systems
Rohit Gavirni, Divij Gupta, Deepak Mishra, Arbind Gupta, Sanjaya Viswamitra
Summary: This paper proposes a refinement model to improve the accuracy of deep learning-based myocardium segmentation by addressing irregularities and satisfying clinical constraints. The proposed model achieves consistent improvements in segmentation outputs across different datasets, indicating its effectiveness.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)