Direct Reprogramming Improves Cardiac Function and Reverses Fibrosis in Chronic Myocardial Infarction

Cross-tissue organization of the fibroblast lineage

(2021) Matthew B. Buechler et al.   NATURE

Direct reprogramming with Sendai virus vectors repaired infarct hearts at the chronic stage

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Overexpression of Gata4, Mef2c, and Tbx5 Generates Induced Cardiomyocytes Via Direct Reprogramming and Rare Fusion in the Heart

(2021) Mari Isomi et al.   CIRCULATION

Cardiac Cell Therapy Fails to Rejuvenate the Chronically Scarred Rodent Heart

(2021) Ronald J. Vagnozzi et al.   CIRCULATION

A transcriptional switch governs fibroblast activation in heart disease

(2021) Michael Alexanian et al.   NATURE

In vivo reprogramming as a new approach to cardiac regenerative therapy

(2021) Taketaro Sadahiro et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice

(2020) Elvira Forte et al.   Cell Reports

High-Resolution Transcriptomic Profiling of the Heart During Chronic Stress Reveals Cellular Drivers of Cardiac Fibrosis and Hypertrophy

(2020) Micheal A. McLellan et al.   CIRCULATION

Intracoronary ALLogeneic heart STem cells to Achieve myocardial Regeneration (ALLSTAR): a randomized, placebo-controlled, double-blinded trial

(2020) Raj R Makkar et al.   EUROPEAN HEART JOURNAL

Generalizing RNA velocity to transient cell states through dynamical modeling

(2020) Volker Bergen et al.   NATURE BIOTECHNOLOGY

Fibrosis: from mechanisms to medicines

(2020) Neil C. Henderson et al.   NATURE

Controlling cardiac fibrosis through fibroblast state space modulation

(2020) Isabella M. Reichardt et al.   CELLULAR SIGNALLING

Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming

(2019) Naoto Muraoka et al.   Nature Communications

PU.1 controls fibroblast polarization and tissue fibrosis

(2019) Thomas Wohlfahrt et al.   NATURE

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

(2019) Nona Farbehi et al.   eLife

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Targeting cardiac fibrosis with engineered T cells

(2019) Haig Aghajanian et al.   NATURE

Direct In Vivo Reprogramming with Sendai Virus Vectors Improves Cardiac Function after Myocardial Infarction

(2018) Kazutaka Miyamoto et al.   Cell Stem Cell

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

(2018) Xing Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart

(2018) Daniel A. Skelly et al.   Cell Reports

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

The Biological Basis for Cardiac Repair After Myocardial Infarction

(2016) Sumanth D. Prabhu et al.   CIRCULATION RESEARCH

Chronic Heart Failure and Inflammation

(2016) Sarah A. Dick et al.   CIRCULATION RESEARCH

Genetic lineage tracing defines myofibroblast origin and function in the injured heart

(2016) Onur Kanisicak et al.   Nature Communications

Revisiting Cardiac Cellular CompositionNovelty and Significance

(2015) Alexander R. Pinto et al.   CIRCULATION RESEARCH

c-kit+ cells minimally contribute cardiomyocytes to the heart

(2014) Jop H. van Berlo et al.   NATURE

Remodeling of the Mononuclear Phagocyte Network Underlies Chronic Inflammation and Disease Progression in Heart Failure

(2013) Mohamed Ameen Ismahil et al.   CIRCULATION RESEARCH

Reprogramming of mouse fibroblasts into cardiomyocyte-like cells in vitro

(2013) Li Qian et al.   Nature Protocols

Induction of Cardiomyocyte-Like Cells in Infarct Hearts by Gene Transfer of Gata4, Mef2c, and Tbx5

(2012) Kohei Inagawa et al.   CIRCULATION RESEARCH

Effect of Transendocardial Delivery of Autologous Bone Marrow Mononuclear Cells on Functional Capacity, Left Ventricular Function, and Perfusion in Chronic Heart Failure

(2012) Emerson C. Perin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Heart repair by reprogramming non-myocytes with cardiac transcription factors

(2012) Kunhua Song et al.   NATURE

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

(2012) Li Qian et al.   NATURE

Efficient inducible Cre-mediated recombination in Tcf21cell lineages in the heart and kidney

(2011) Asha Acharya et al.   GENESIS

Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors

(2010) Masaki Ieda et al.   CELL

Cre-loxP system as a versatile tool for conferring increased levels of tissue-specific gene expression from a weak promoter

(2007) Shingo Nakamura et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT