Review
Medicine, Research & Experimental
Hui Jia, Zuojun Wang, Jingyi Zhang, Fan Feng
Summary: The gamma-secretase complex plays a crucial role in the activation and regulation of the Notch pathway, which is closely associated with the occurrence and development of various types of tumors. This review provides a detailed description of the basic situation and biological functions of the gamma-secretase complex, as well as its applications in the treatment of breast cancer and liver cancer.
Article
Oncology
Inge M. Krul, Naomi B. Boekel, Iris Kramer, Cecile P. M. Janus, Augustinus D. G. Krol, Marten R. Nijziel, Josee M. Zijlstra, Richard W. M. van der Maazen, Judith M. Roesink, Judy N. Jacobse, Michael Schaapveld, Marjanka K. Schmidt, Annemieke W. J. Opstal-van Winden, Gabe S. Sonke, Nicola S. Russell, Berthe M. P. Aleman, Flora E. van Leeuwen
Summary: Breast cancer patients after Hodgkin lymphoma (BC-HL) have limited treatment options due to prior HL treatment and increased risk of cardiovascular disease (CVD). BC-HL patients have worse BC outcomes and higher burden of CVD compared to BC-1 patients. Clinicians need to consider the increased CVD risk when selecting BC treatment for HL survivors.
Article
Oncology
Angeleke Saridakis, Elizabeth R. Berger, Malini Harigopal, Tristen Park, Nina Horowitz, Justin Le Blanc, Gregory Zanieski, Anees Chagpar, Rachel Greenup, Mehra Golshan, Donald R. Lannin
Summary: Invasive apocrine carcinomas have more aggressive features than non-apocrine carcinomas but the breast cancer-specific survival is the same. Half of these apocrine tumors are triple negative but these have more favorable features and much better survival than non-apocrine triple-negative cancers. The characteristics of apocrine carcinomas vary dramatically by molecular type, with triple-negative apocrine patients having better survival outcomes compared to non-apocrine triple-negative patients, while luminal apocrine patients have worse survival outcomes compared to non-apocrine luminal patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Dermatology
Pushkar Aggarwal, Peter Knabel, Alan B. Fleischer
Summary: This study evaluated the burden of skin cancer in the US from 1990 to 2019, finding that incidence and prevalence rates of melanoma and non-melanoma skin cancer have increased, while mortality rates have remained stable. Males have had higher incidence and mortality rates since 1990, and melanoma incidence was relatively higher in the northern half of the US.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Amrita Goyal, Daniel O'Leary, Kavita Goyal, Krishnan Patel, David Pearson, Murali Janakiram
Summary: Patients with cutaneous T-cell lymphoma (CTCL) have an increased risk of developing second malignancies, especially Hodgkin and non-Hodgkin lymphoma, lung cancer, bladder cancer, and melanoma. These findings provide evidence of a population at increased risk of malignancy, emphasizing the importance of early detection for decreasing the morbidity burden of second malignancies.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Hematology
Simone de Vries, Inge M. Krul, Michael Schaapveld, Cecile P. M. Janus, Saskia E. Rademakers, Judith M. Roesink, Marten R. Nijziel, Berthe M. P. Aleman, Flora E. van Leeuwen
Summary: Male survivors of Hodgkin lymphoma who received chest radiotherapy have a significantly increased risk of breast cancer. The risk is higher for those who received chest radiotherapy and alkylating chemotherapy compared to those who only received chest radiotherapy.
Article
Gastroenterology & Hepatology
Moiz Ahmed, Ahmed Al-Khazraji, Umer Syed, Tasur Seen, Aaron Walfish
Summary: A middle-aged male with decompensated alcoholic cirrhosis presented with metastatic primary gastric lymphoma, pathologically characterized as high-grade B-cell lymphoma, necessitating targeted liver biopsy for differentiation from hepatocellular carcinoma.
BMC GASTROENTEROLOGY
(2021)
Article
Dermatology
A. Goyal, D. O'Leary, K. Goyal, N. Rubin, M. Janakiram
Summary: Patients with mycosis fungoides (MF) have an increased risk of developing various types of cancers, with those developing non-Hodgkin lymphoma (NHL), lung cancer, and bladder cancer tending to be diagnosed at earlier stages and showing better 5-year overall survival. Regular pigmented-lesion-focused skin examinations are recommended for MF patients, along with smoking cessation counseling and ensuring up-to-date cancer screenings. Regular imaging and lab testing for second malignancy screening require further study and expert consensus.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Gastroenterology & Hepatology
Romain Donne, Amaia Lujambio
Summary: The liver is a common site for primary cancer and a major cause of cancer death. Hepatocellular carcinoma (HCC) accounts for the majority of liver cancers. Immune-checkpoint inhibitors have shown promise in the treatment of HCC, but further understanding of the tumor microenvironment and the development of additional biomarkers are needed. Other immune-targeting strategies are also being developed. This review provides an overview of the HCC immune microenvironment and current immunotherapies.
Letter
Medicine, General & Internal
Connor J. Kinslow, David M. DeStephano, Christine H. Rohde, Lisa A. Kachnic, Simon K. Cheng, Alfred I. Neugut, David P. Horowitz
Summary: This study investigates the risk of ALCL after postmastectomy implant reconstruction among US women with breast cancer and DCIS.
Review
Medicine, Research & Experimental
Xiaomeng Dai, Yixuan Guo, Yan Hu, Xuanwen Bao, Xudong Zhu, Qihan Fu, Hangyu Zhang, Zhou Tong, Lulu Liu, Yi Zheng, Peng Zhao, Weijia Fang
Summary: The rapid development and remarkable success of checkpoint inhibitors in cancer treatment, including hepatocellular carcinoma, has provided significant breakthroughs. However, only a small percentage of patients benefit from these inhibitors, as cancer stem cells play a crucial role in recurrence, metastasis, and resistance to therapy. Understanding the mechanisms of immune evasion by CSCs in HCC is essential for developing effective therapies.
Article
Multidisciplinary Sciences
Paulino Tallon de Lara, Hector Castanon, Marijne Vermeer, Nicolas Nunez, Karina Silina, Bettina Sobottka, Joaquin Urdinez, Virginia Cecconi, Hideo Yagita, Farkhondeh Movahedian Attar, Stefanie Hiltbrunner, Isabelle Glarner, Holger Moch, Sonia Tugues, Burkhard Becher, Maries van den Broek
Summary: The study reveals that CD39(+)PD-1(+)CD8(+) T cells play a critical role in dormant metastasis of breast tumors and are associated with dormancy in the lungs.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Philip Surmanowicz, Arunima Sivanand, Amy X. Du, Muhammad N. Mahmood, Robert Gniadecki
Summary: The muffin technique micrographic surgery (MTMS) is a superior alternative to Mohs micrographic surgery (MMS) in providing full margin control and residual tumor mapping for high-risk facial non-melanoma skin cancer. Preliminary results from its implementation in an academic dermatology center show a high success rate, no observed tumor recurrence or major adverse events in 69 patients.
FRONTIERS IN MEDICINE
(2021)
Review
Oncology
Gabor Cserni, Cecily M. Quinn, Maria Pia Foschini, Simonetta Bianchi, Grace Callagy, Ewa Chmielik, Thomas Decker, Falko Fend, Aniko Kovacs, Paul J. van Diest, Ian O. Ellis, Emad Rakha, Tibor Tot
Summary: Triple-negative breast cancers (TNBC) are known for their poor prognosis and lack of effective targeted treatments, often requiring aggressive chemotherapy. However, recent studies have shown that TNBC is not a homogenous group, with some special histological subtypes having a favourable prognosis and not requiring aggressive treatment.
Article
Gastroenterology & Hepatology
Hashem B. El-Serag, John W. Ward, Sumeet K. Asrani, Amit G. Singal, Nicole Rich, Aaron P. Thrift, Salil Deshpande, Barbara J. Turner, Ahmed O. Kaseb, Ariel C. Harrison, Brett E. Fortune, Fasiha Kanwal
Summary: Texas has the highest incidence rate of hepatocellular carcinoma (HCC) in the United States. The Texas Collaborative Center for Hepatocellular Cancer (TeCH) co-sponsored a conference on HCC to discuss strategies for prevention and evaluate their implementation readiness.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Genetics & Heredity
Zhihong Yang, James Lin, John Zhang, Wai Ieng Fong, Pei Li, Rong Zhao, Xiaohong Liu, William Podevin, Yanping Kuang, Jiaen Liu
BMC MEDICAL GENOMICS
(2015)
Article
Genetics & Heredity
Jessica A. Valadez, Math P. Cuajungco
Article
Microbiology
Kristina V. Stott, Shannon M. Wood, Jimmy A. Blair, Bao T. Nguyen, Anabel Herrera, Yannet G. Perez Mora, Math P. Cuajungco, Sean R. Murray
Review
Physiology
Math P. Cuajungco, Joshua Silva, Ania Habibi, Jessica A. Valadez
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Math P. Cuajungco, Kirill Kiselyov
FRONTIERS IN BIOSCIENCE-LANDMARK
(2017)
Article
Cell Biology
Math P. Cuajungco, Luigi C. Basilio, Joshua Silva, Thomas Hart, Jonathan Tringali, Cheng-Chang Chen, Martin Biel, Christian Grimm
Article
Multidisciplinary Sciences
Ian Parker, Katrina T. Evans, Kyle Ellefsen, Devon A. Lawson, Ian F. Smith
SCIENTIFIC REPORTS
(2017)
Article
Neurosciences
Jonathan Chacon, Lauren Rosas, Math P. Cuajungco
Article
Biochemistry & Molecular Biology
Vanessa B. Sanchez, Saima Ali, Adrian Escobar, Math P. Cuajungco
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2019)
Article
Immunology
Hamad Alshetaiwi, Nicholas Pervolarakis, Laura Lynn McIntyre, Dennis Ma, Quy Nguyen, Jan Akara Rath, Kevin Nee, Grace Hernandez, Katrina Evans, Leona Torosian, Anushka Silva, Craig Walsh, Kai Kessenbrock
SCIENCE IMMUNOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Daniel J. Styrpejko, Math P. Cuajungco
Summary: The review highlights the role of TMEM163 as a zinc binding protein and transporter, potentially belonging to the CDF superfamily. It discusses its implications in human health and various diseases, suggesting a significant impact on zinc metabolism.
Review
Biochemistry & Molecular Biology
Math P. Cuajungco, Maria Soledad Ramirez, Marcelo E. Tolmasky
Summary: This article discusses the influence of zinc on various mechanisms of bacterial proliferation and its synergistic action as an antimicrobial element. It also touches upon the importance of zinc among eukaryotic cells and how it modulates their survival and death.
Article
Cell Biology
Chifei Kang, Ran Rostoker, Sarit Ben-Shumel, Rola Rashed, James Andrew Duty, Deniz Demircioglu, Irini M. Antoniou, Lika Isakov, Zila Shen-Orr, Jose Javier Bravo-Cordero, Nathan Kase, Math P. Cuajungco, Thomas M. Moran, Derek LeRoith, Emily Jane Gallagher
Summary: TMEM176B plays a crucial role in regulating key signaling pathways and genes in breast cancer cells, affecting cancer cell growth and progression. It is a potential target for therapeutic antibodies to inhibit tumor growth.
Article
Biochemistry & Molecular Biology
Adrian Escobar, Daniel J. Styrpejko, Saima Ali, Math P. Cuajungco
Summary: In this study, the researchers investigated the interaction between TMEM163 and distinct ZNT proteins and found that they can form heterodimers. They also observed partial co-localization of TMEM163 and ZNT proteins in cells. Functional zinc flux assays showed that TMEM163/ZNT heterodimers exhibit similar efflux function as TMEM163 homodimers. The findings suggest that the interaction between TMEM163 and ZNT proteins plays a physiologically relevant role in cells.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Article
Biochemical Research Methods
Saima Ali, Math P. Cuajungco
Article
Cell Biology
Abril Alondra Barrientos-Bonilla, Paola Belem Pensado-Guevara, Abraham Puga-Olguin, Rasajna Nadella, Aurora del Carmen Sanchez-Garcia, Laura Mireya Zavala-Flores, Arnulfo Villanueva-Olivo, Iliana Tamara Cibrian-Llanderal, Maria de Jesus Rovirosa-Hernandez, Daniel Hernandez-Baltazar
Summary: This study evaluated the impact of BrdU on liver function and found that multiple injections of BrdU did not induce hepatocellular damage.
Article
Cell Biology
Pan Zhang, Qun Feng, Wenxiao Chen, Xizhuang Bai
Summary: It was found that catalpol antagonizes LPS-mediated inflammation and suppressive osteoblast differentiation by inhibiting inflammation and promoting osteoblast differentiation. This finding contributes to a better understanding of the pathogenesis of osteoporosis.