Article
Biochemistry & Molecular Biology
Jesus Fernandez-Felipe, Adrian Plaza, Gema Dominguez, Javier Perez-Castells, Victoria Cano, Francesco Cioni, Nuria Del Olmo, Mariano Ruiz-Gayo, Beatriz Merino
Summary: High-fat diets enriched with lauric acid do not increase leptin production and reduce the effect of leptin on kinase phosphorylation. Both high-fat diets affect adipocyte-size distribution and gene expression related to adipogenesis and inflammation. The composition of white adipose tissue is different between the two diets, which may impact the biophysical properties and signaling of leptin receptor.
Article
Marine & Freshwater Biology
Gilles Tinant, Melusine Van Larebekea, Benjamin Lemaire, Marine Courteille, Cecile Gardin, Ineke Neefs, Krishna Das, Melissa M. Page, Jean-Francois Rees, Yvan Larondelle, Cathy Debier
Summary: This study investigated the impacts of dietary MeHg and fatty acids on lipid metabolism in rainbow trout. The results showed that a diet enriched in linoleic acid (LA) increased the overall lipid content, while the addition of MeHg significantly reduced the lipid content. The size of adipocytes was influenced by both LA and MeHg. The fatty acid composition of adipose tissue and liver was significantly altered by the dietary fatty acids. Exposure to MeHg led to a release of n-6 PUFA from the hepatic membranes. This study highlights the important impact of MeHg exposure and dietary fatty acids on lipid metabolism in fish.
AQUATIC TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Petra Roskaric, Marcela Speranda, Tomislav Masek, Donatella Verbanac, Kristina Starcevic
Summary: The study shows that fructose intake leads to increased blood lipids, insulin resistance, and oxidative stress, as well as elevated monounsaturated fatty acid levels in adipose tissue. However, supplementation with DHA can reduce oxidative stress and improve adiponectin levels.
Article
Nutrition & Dietetics
K. A. Boeckman, A. von Stumpff, W. Bernhard, A. Shunova, M. Minarski, B. Frisch, S. Warmann, E. Schleicher, C. F. Poets, A. R. Franz
Summary: This study found that in preterm infants, the levels of ARA and DHA in adipose tissue and blood were lower, while linoleic acid (LA) levels were higher. This may be due to nutritional issues in preterm infants.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Cell Biology
Nicholas Borcherding, Wentong Jia, Rocky Giwa, Rachael L. Field, John R. Moley, Benjamin J. Kopecky, Mandy M. Chan, Bin Q. Yang, Jessica M. Sabio, Emma C. Walker, Omar Osorio, Andrea L. Bredemeyer, Terri Pietka, Jennifer Alexander-Brett, Sharon Celeste Morley, Maxim N. Artyomov, Nada A. Abumrad, Joel Schilling, Kory Lavine, Clair Crewe, Jonathan R. Brestoff
Summary: Adipocytes transfer mitochondria to macrophages to maintain metabolic homeostasis, but this transfer is inhibited in obesity. Lard-rich diet diverts mitochondria into the blood for delivery to other organs, such as the heart.
Article
Endocrinology & Metabolism
Chao Cao, Han-Chow E. Koh, Stephan Van Vliet, Bruce W. Patterson, Dominic N. Reeds, Richard Laforest, Robert J. Gropler, Bettina Mittendorfer
Summary: This study found that enhanced FFA clearance in people with obesity is negatively correlated with muscle insulin sensitivity, and the stimulatory effect of insulin on FFA clearance is more significant in obese individuals.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Chemistry, Medicinal
Long Cheng, Lu Shi, Changhao He, Chen Wang, Yinglan Lv, Huimin Li, Yongcheng An, Hongyu Dai, Yuhui Duan, Huilin Zhang, Yan Huang, Wanxin Fu, Yanyan Meng, Baosheng Zhao
Summary: The study found that rutin can activate thermogenesis in brown and white adipose tissue by increasing the concentration of short-chain fatty acids, thereby improving obesity and diabetes.
PHYTOTHERAPY RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Debora Maria Soares de Souza, Maria Claudia Silva, Silvia Elvira Barros Farias, Ana Paula de J. Menezes, Cristiane Maria Milanezi, Karine de P. Lucio, Nivia Carolina N. Paiva, Paula Melo de Abreu, Daniela Caldeira Costa, Kelerson Mauro de Castro Pinto, Guilherme de Paula Costa, Joao Santana Silva, Andre Talvani
Summary: The study showed that tissue from mice subjected to a lard diet was more favorable for the growth of T. cruzi parasites, supporting the hypothesis of a relationship between the source of dietary lipids and parasite-induced immunopathology.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Zhuang Li, Enchen Zhou, Cong Liu, Hope Wicks, Sena Yildiz, Farhana Razack, Zhixiong Ying, Sander Kooijman, Debby P. Y. Koonen, Marieke Heijink, Sarantos Kostidis, Martin Giera, Ingrid M. J. G. Sanders, Ed J. Kuijper, Wiep Klaas Smits, Ko Willems van Dijk, Patrick C. N. Rensen, Yanan Wang
Summary: This study found that short-chain fatty acids, including butyrate, do not have multiple metabolic benefits in individuals with metabolic syndrome. However, the underlying mechanisms are still unclear. The researchers used antibiotic-induced microbiota depletion and fecal microbiota transplantation (FMT) to investigate the role of gut microbiota in the metabolic benefits of dietary butyrate. They found that dietary butyrate reduced appetite and ameliorated high-fat diet-induced weight gain, and these effects were dependent on the presence of gut microbiota.
Review
Nutrition & Dietetics
Laurent Turner, Sylvia Santosa
Summary: In obesity, increased adiposity leads to dysfunction of adipose tissue macrophages and elevated proinflammatory cytokines, resulting in chronic inflammation and metainflammation which raises the risk of metabolic diseases. Lifestyle and surgical interventions have been somewhat effective in reversing the negative consequences of obesity, with evidence showing that exercise, dietary changes, and bariatric surgery can modulate the immune response and reduce chronic inflammation by affecting macrophage presence and phenotypes.
ADVANCES IN NUTRITION
(2021)
Review
Cell Biology
Manuela Del Corno, Rosaria Vari, Beatrice Scazzocchio, Barbara Varano, Roberta Masella, Lucia Conti
Summary: Colorectal cancer (CRC) is a major threatening disease with a global incidence expected to increase, where enhanced adiposity, particularly visceral fat, is a major risk factor. Obesity-associated low-grade chronic inflammation is considered a key determinant in CRC development, with fatty acids playing a significant role in regulating adipose tissue homeostasis and immune cell function.
Article
Food Science & Technology
Stefanie F. Maurer, Sebastian Dieckmann, Jens Lund, Tobias Fromme, Anne Lundby Hess, Cecilia Colson, Louise Kjolbaek, Arne Astrup, Matthew Paul Gillum, Lesli Hingstrup Larsen, Gerhard Liebisch, Ez-Zoubir Amri, Martin Klingenspor
Summary: The study suggests that dietary fish oil supplementation may enhance the recruitment of thermogenic capacity in adipocytes, but does not significantly affect body weight or adiposity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Piotr Domaradzki, Bozena Nowakowicz-Debek, Lukasz Wlazlo, Mateusz Ossowski, Malgorzata Dmoch, Mariusz Florek
Summary: This study investigated the effect of adding natural sorbents to pig feed on the fatty acid content of pig meat and fat. The results showed that the sorbents had limited effects on muscle tissue but had significant effects on kidney fat. The impact of different sorbents varied, but overall, they did not have a negative effect on the nutritional and pro-health quality of pig adipose tissue during fattening.
Article
Medicine, General & Internal
Oscar Osorio-Conles, Ainitze Ibarzabal, Jose Maria Balibrea, Josep Vidal, Emilio Ortega, Ana de Hollanda
Summary: Hypertriglyceridemia is associated with increased risk of pancreatitis and cardiovascular disease. Fibrosis of subcutaneous adipose tissue is related to changes in triglyceride levels. FABP4 gene may be a potential drug target for the treatment of hypertriglyceridemia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Agriculture, Multidisciplinary
Yu Wang, Aiqing Zhao, Haiping Du, Yueyue Liu, Bangran Qi, Xingbin Yang
Summary: The study indicates that theabrownin can enhance BAT activity and promote WAT browning by activating the AMPK-PGC la pathway and modulating SCFAs, thereby improving inflammatory disorder in HFD-fed mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Cell Biology
Kimberly A. Cox-York, Christopher B. Erickson, Rocio I. Pereira, Daniel H. Bessesen, Rachael E. Van Pelt
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2017)
Article
Obstetrics & Gynecology
Young-Min Park, Rocio I. Pereira, Christopher B. Erickson, Tracy A. Swibas, Chounghun Kang, Rachael E. Van Pelt
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2017)
Article
Multidisciplinary Sciences
Young-Min Park, Rocio I. Pereira, Christopher B. Erickson, Tracy A. Swibas, Kimberly A. Cox-York, Rachael E. Van Pelt
Review
Cell & Tissue Engineering
Nichole Shaw, Christopher Erickson, Stephanie J. Bryant, Virginia L. Ferguson, Melissa D. Krebs, Nancy Hadley-Miller, Karin A. Payne
TISSUE ENGINEERING PART B-REVIEWS
(2018)
Article
Cell & Tissue Engineering
Yangyi Yu, Francisco Rodriguez-Fontan, Kevin Eckstein, Archish Muralidharan, Asais Camila Uzcategui, Joseph R. Fuchs, Shane Weatherford, Christopher B. Erickson, Stephanie J. Bryant, Virginia L. Ferguson, Nancy Hadley Miller, Guangheng Li, Karin A. Payne
TISSUE ENGINEERING PART C-METHODS
(2019)
Article
Engineering, Biomedical
Christopher B. Erickson, Jake P. Newsom, Nathan A. Fletcher, Zachary M. Feuer, Yangyi Yu, Francisco Rodriguez-Fontan, Nancy Hadley Miller, Melissa D. Krebs, Karin A. Payne
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2020)
Article
Orthopedics
Christopher B. Erickson, Jake P. Newsom, Nathan A. Fletcher, Yangyi Yu, Francisco Rodriguez-Fontan, Shane A. Weatherford, Nancy Hadley-Miller, Melissa D. Krebs, Karin A. Payne
Summary: The study shows that quick release of alpha-VEGF in rats can reduce bony bar and vessel formation, while increasing cartilage repair tissue. This treatment does not affect limb lengthening and does not lead to detrimental side effects in the adjacent, uninjured area. This approach could have positive implications for children with physeal injuries.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Engineering, Biomedical
Christopher Erickson, Michael Stager, Michael Riederer, Karin A. Payne, Melissa Krebs
Summary: This study presents a method to fabricate chitosan-genipin microgels without solvent rinses, using a non-cytotoxic, non-emulsion based approach. The microgels can be loaded with chemokines and growth factors, and were tested for their potential in treating growth plate injuries. The results show increased cartilage repair tissue and full degradation of the microgels within 28 days in vivo, indicating their potential for growth plate injury treatment.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Critical Care Medicine
Terry R. Schaid, Kirk C. Hansen, Angela Sauaia, Ernest E. Moore, Margot DeBot, Alexis L. Cralley, Christopher Erickson, Christopher C. Silliman, Anirban Banerjee, Arsen Ghasabyan, Kenneth Jones, Ian Lacroix, Sanchayita Mitra, Angelo D'Alessandro, Mitchell J. Cohen
Summary: The study found that trauma induces C4 activation, which is associated with worse outcomes, and FFP resuscitation may enhance this complement activation. The use of FFP within the first 6 hours is associated with increased C4 activation.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Multidisciplinary Sciences
Michael A. Stager, Christopher B. Erickson, Karin A. Payne, Melissa D. Krebs
Summary: Chitosan microgels have significant applications in tissue engineering. This protocol presents a non-emulsion-based method for fabricating chitosan-genipin microgels without the need for toxic organic solvent rinses. These microgels show precise size control, sustained release of biomolecules, and potential for tissue repair in vivo.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Surgery
Alexis L. Cralley, Ernest E. Moore, Charles J. Fox, Daniel Kissau, Margot DeBot, Terry R. Schaid, Sanchayita Mitra, Patrick Hom, Miguel Fragoso, Arsen Ghasabyan, Christopher Erickson, Angelo D'Alessandro, Kirk C. Hansen, Mitchell J. Cohen, Christopher C. Silliman, Angela Sauaia
Summary: This study evaluated the effects of resuscitative endovascular balloon occlusion of the aorta zone I on intracranial pressure and cerebral edema in a combat casualty relevant swine model. The results showed that zone 1 aortic occlusion did not significantly increase intracranial pressure and did not lead to increased brain water content. Additionally, troponin levels did not increase in the zone 1 aortic occlusion group. These findings suggest that zone 1 aortic occlusion may provide neuro- and cardioprotection in the setting of blast traumatic brain injury.
Article
Pediatrics
Joseph R. Fuchs, Romie F. Gibly, Christopher B. Erickson, Stacey M. Thomas, Nancy Hadley Miller, Karin A. Payne
Summary: This study aimed to characterize physeal fractures in pediatric long-bone fractures based on sex, age, anatomic location, and Salter-Harris classification. The findings showed a lower incidence of physeal fractures compared to previous studies, with distal tibia fractures being the most common. The results provide valuable insights for further investigation into physeal fractures.
Article
Critical Care Medicine
Margot DeBot, Christopher Erickson, Marguerite Kelher, Terry R. Schaid, Ernest E. Moore, Angela Sauaia, Alexis Cralley, Ian LaCroix, Angelo D'Alessandro, Kirk Hansen, Mitchell J. Cohen, Christopher C. Silliman, Julia Coleman
Summary: By studying the sex differences in platelets and cryoprecipitate coagulation factors, it was found that blood products from female donors are more effective in improving coagulation dysfunction compared to male blood products. Additionally, female-donor cryoprecipitate contains more factor V and factor XIII, and several proteins with potential immunological significance. These sex differences may influence how transfusions modulate thromboinflammation caused by trauma, suggesting the potential role of sex-specific transfusion guidelines in hemostatic resuscitation.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2023)
Article
Critical Care Medicine
Terry R. Schaid Jr, Mitchell J. Cohen, Angelo D'Alessandro, Christopher C. Silliman, Ernest E. Moore, Angela Sauaia, Monika Dzieciatkowska, William Hallas, Otto Thielen, Margot DeBot, Alexis Cralley, Ian LaCroix, Christopher Erickson, Sanchayita Mitra, Anirban Banerjee, Kenneth Jones, Kirk C. Hansen
Summary: Severe injury can lead to organ dysfunction, and hemolysis of red blood cells may contribute to this process. Hemolysis can release erythrocyte proteins, disrupting arginine metabolism and reducing NO production. This study aimed to quantify hemolysis and arginine metabolism in trauma patients and measure their association with injury severity, transfusions, and outcomes.
Article
Engineering, Biomedical
Ming Pei, Yixuan Amy Pei, Sheng Zhou, Elmira Mikaeiliagah, Christopher Erickson, Benjamin Giertych, Halima Akhter, Lei Wang, Amanda Stewart, Joshua Parenti, Bin Wang, Sijin Wen, Sotcheadt Sim, Eric Quenneville, Kirk C. Hansen, Steven Frisch, Gangqing Hu
Summary: Articular cartilage has limited self-healing capacity. Tissue-specific stem cells can be used for cartilage regeneration, but ex vivo expansion leading to cell senescence is a challenge. Cell-derived extracellular matrix (C-dECM) has been shown to rejuvenate stem cells and promote cartilage regeneration. In this study, the authors evaluated the rejuvenation of rabbit stem cells by C-dECM in both ex vivo and in vivo models, and identified potential cellular and molecular mechanisms involved.
BIOACTIVE MATERIALS
(2023)