Article
Food Science & Technology
Jing Dong, Tianhui Yan, Qiuhong Yang, Yi Song, Bo Cheng, Shun Zhou, Yongtao Liu, Xiaohui Ai
Summary: Aeromonas hydrophila is a common pathogen in freshwater aquaculture that can also cause health problems in humans. Antibiotic-resistant strains of A. hydrophila are a concern as they limit antibiotic usage and can lead to treatment failure. Additionally, antibiotic residues in aquatic products pose a risk to quality and safety. This study explores alternative strategies to combat infections caused by antibiotic-resistant bacteria, focusing on palmatine, a compound that inhibits the expression of a key virulence factor in A. hydrophila. The findings suggest that palmatine could be a promising treatment for A. hydrophila-associated infections in aquaculture.
Article
Veterinary Sciences
Jing Dong, Tianhui Yan, Qiuhong Yang, Shun Zhou, Yi Song, Yongtao Liu, Liang Ma, Ning Xu, Yibin Yang, Xiaohui Ai
Summary: The fast-growing demand for aquatic products has led to the rapid development of aquaculture. However, antibiotic resistance caused treatment failure in the control of diseases caused by bacterial pathogens. In this study, researchers identified aerolysin as a target for developing drugs and found that polydatin could decrease the pathogenesis of antibiotic-resistant A. hydrophila infections.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Kyoo-Tae Kim, Seung-Hun Lee, Kyoung-Ki Lee, Jee Eun Han, Dongmi Kwak
Summary: The research suggests that stress can increase the virulence of Aeromonas hydrophila and lead to animal mortality, while serial passaging in mice can dramatically enhance the virulence of A. hydrophila.
Article
Immunology
Jing Dong, Lushan Zhang, Yongtao Liu, Ning Xu, Shun Zhou, Yibin Yang, Qiuhong Yang, Xiaohui Ai
Summary: The study found that luteolin can reduce aerolysin-induced hemolysis by inhibiting aerolysin activity, and hinder the formation of functional heptamer. In addition, luteolin can protect cells from aerolysin-induced cell death and increase the survival rate in A. hydrophila-infected channel catfish.
Article
Microbiology
Antonio Camilo da Silva Filho, Jeroniza Nunes Marchaukoski, Roberto Tadeu Raittz, Camilla Reginatto De Pierri, Diogo de Jesus Soares Machado, Cyntia Maria Telles Fadel-Picheth, Geraldo Picheth
Summary: This study analyzed 17 complete genomes of A. hydrophila isolates to determine the contribution of genomic islands to this species. Variations in the number and characteristics of predicted genomic islands were found between phylogenetic groups, with some containing virulence, metabolism, and resistance genes. Strains from different phylogenetic groups showed distinctive genomic island features, with potential contributions to host colonization and environmental competitiveness.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Junwei Wang, Ting Qin, Kai Chen, Liangkun Pan, Jun Xie, Bingwen Xi
Summary: The study found that carvacrol has significant antibacterial and antivirulence effects on A. hydrophila, and it does not have an antagonistic effect when used in combination with commonly used antibiotics in aquaculture.
Article
Microbiology
Lushan Zhang, Liang Ma, Qiuhong Yang, Yongtao Liu, Xiaohui Ai, Jing Dong
Summary: The study aimed to find alternative treatments to antibiotics. Through disrupting quorum sensing, sanguinarine was found to inhibit the growth and biofilm formation of A. hydrophila. The results showed that sanguinarine protected A549 cells and reduced mortality in infected channel catfish.
Article
Food Science & Technology
Jing Dong, Lushan Zhang, Yongtao Liu, Shun Zhou, Yibin Yang, Ning Xu, Qiuhong Yang, Xiaohui Ai
Summary: Aeromonas hydrophila is a widely distributed pathogen that has developed antibiotic resistance, necessitating the exploration of novel treatment strategies. The bacterium's pathogenicity is primarily attributed to virulence factors such as aerolysin and biofilm.
Article
Fisheries
Aldo Aparecido Proietti-Junior, Luciana Sampaio Lima, Emily Moraes Roges, Yan Correa Rodrigues, Karla Valeria Batista Lima, Dalia Prazeres Rodrigues, Marcos Tavares-Dias
Summary: This study reported an outbreak of disease in pirarucu caused by Aeromonas, conducted experimental co-infection research, and characterized resistance profile, virulence factors, and phenotypic and molecular differentiation. The findings support the existence of synergism between A. hydrophila and A. jandaei in pirarucu, with implications for occurrences of this co-infection and determinants of virulence.
AQUACULTURE RESEARCH
(2021)
Article
Immunology
Hongmei Yin, Qiaohua Yan, Guoqiang Cheng, Li Zhang, Meiqing Li, Tingting Hu, Sihui Gao, Yuanhang Chen, Huaqiao Tang, Jie Luo
Summary: This study investigated the effects of EGCG on A. hydrophila and its virulence factors, and its impact on adhesion, invasion, and cytotoxicity in Caco-2 cells. Transcriptomic analysis revealed the potential antibacterial mechanism of EGCG. Results showed that EGCG inhibited the production of biofilm and virulence factors, as well as weakened the chemotaxis and stress response of the bacteria. In addition, animal studies demonstrated the effectiveness of EGCG in improving survival rate and reducing organ damage.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Fisheries
Ping Ouyang, Jiehao Chen, Lizi Yin, Yi Geng, Defang Chen, Kaiyu Wang, Weiming Lai, Hongrui Guo, Jing Fang, Zhengli Chen, Li Tang, Chao Huang, Xiaoli Huang
Summary: Aeromonas hydrophila is a significant pathogen with increasing drug resistance, requiring novel agents and strategies for treatment. Cinnamaldehyde inhibits the production of W-pili through downregulating gene expression, reducing the adhesion ability of A. hydrophila.
AQUACULTURE INTERNATIONAL
(2021)
Article
Microbiology
Gang Xiao, Xiaofeng Zheng, Jiyun Li, Yang Yang, Jie Yang, Ning Xiao, Junqi Liu, Zhiliang Sun
Summary: This study revealed the significant role of the EnvZ/OmpR TCS in the growth, motility, virulence, and stress response of A. hydrophila, providing important insights for the development of novel antibacterial and vaccine therapies targeting EnvZ/OmpR against A. hydrophila.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jing Dong, Defu Zhang, Jianrong Li, Yongtao Liu, Shun Zhou, Yibin Yang, Ning Xu, Qiuhong Yang, Xiaohui Ai
Summary: Genistein can reduce the virulence of A. hydrophila by decreasing the production of aerolysin and biofilm formation, significantly improving aerolysin-mediated cell injury and providing remarkable protection to channel catfish infected with A. hydrophila. Targeting quorum sensing and virulence can be a useful approach developing drugs against A. hydrophila infections in aquaculture, with genistein as a promising candidate.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Ting Qin, Kai Chen, Bingwen Xi, Liangkun Pan, Jun Xie
Summary: The study demonstrates that NE stimulates the growth, biofilm formation, and hemolytic activity of A. hydrophila and enhances the virulence of the pathogen in fish via the QseBC system. Deletion of qseB and qseC inhibits NE-promoted growth, biofilm formation, and hemolytic activity of A. hydrophila. QseBC does not affect the swimming and swarming motility of A. hydrophila.
MICROBIAL PATHOGENESIS
(2023)
Article
Veterinary Sciences
Jihong Li, Zhihao Wu, Changsong Wu, Dan-Dan Chen, Yang Zhou, Yong-An Zhang
Summary: The study identified a virulent strain of Aeromonas hydrophila, GD18, which possesses a functional Type VI secretion system (T6SS) and highlighted the essential role of VasH in T6SS functionality, bacterial cytotoxicity, and resistance. This contributes to the understanding of the regulatory mechanism of VasH and the virulence and bactericidal effects of A. hydrophila mediated by T6SS.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Multidisciplinary Sciences
Simone M. Haag, Muhammet F. Gulen, Luc Reymond, Antoine Gibelin, Laurence Abrami, Alexiane Decout, Michael Heymann, F. Gisou van der Goot, Gerardo Turcatti, Rayk Behrendt, Andrea Ablasser
Article
Multidisciplinary Sciences
Oksana A. Sergeeva, F. Gisou van der Goot
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Biochemistry & Molecular Biology
Mohamed Rasheed Gadalla, Laurence Abrami, F. Gisou van der Goot, Michael Veit
BIOCHEMICAL JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Patrick A. Sandoz, Christopher Tremblay, F. Gisou van der Goot, Mathieu Frechin
Review
Cell Biology
Francisco Sarmento Mesquita, F. Gisou van der Goot, Oksana A. Sergeeva
CELLULAR MICROBIOLOGY
(2020)
Article
Cell Biology
Jerome Buergi, Laurence Abrami, Irinka Castanon, Luciano Andres Abriata, Beatrice Kunz, Shixu Emili Yan, Manuel Lera, Sheila Unger, Andrea Superti-Furga, Matteo Dal Peraro, Marcos Gonzalez Gaitan, Francoise Gisou van der Goot
DEVELOPMENTAL CELL
(2020)
Article
Allergy
Bahia Bekhouche, Aurore Tourville, Yamini Ravichandran, Rachida Tacine, Laurence Abrami, Michael Dussiot, Andrea Khau-Dancasius, Olivia Boccara, Meriem Khirat, Marianne Mangeney, Florent Dingli, Damarys Loew, Batiste Boeda, Penelope Jordan, Thierry Jo Molina, Nathalia Bellon, Sylvie Fraitag, Smail Hadj-Rabia, Stephane Blanche, Anne Puel, Sandrine Etienne-Manneville, F. Gisou van der Goot, Jacqueline Cherfils, Olivier Hermine, Jean-Laurent Casanova, Christine Bodemer, Asma Smahi, Jerome Delon
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
I. Castanon, J. T. Hannich, L. Abrami, F. Huber, M. Dubois, M. Mueller, F. G. van der Goot, M. Gonzalez-Gaitan
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Laurence Abrami, Martina Audagnotto, Sylvia Ho, Maria Jose Marcaida, Francisco S. Mesquita, Muhammad U. Anwar, Patrick A. Sandoz, Giulia Fonti, Florence Pojer, Matteo Dal Peraro, F. Gisou van der Goot
Summary: Acyl protein thioesterase APT2 interacts with membranes via its charged beta-tongue, becomes palmitoylated by ZDHHC3/7, and deforms the bilayer to extract substrate acyl chains. APT2 deacylation leads to its membrane release and degradation.
NATURE CHEMICAL BIOLOGY
(2021)
Article
Cell Biology
Matias Blaustein, Estefania Piegari, Camila Martinez Calejman, Antonella Vila, Analia Amante, Maria Victoria Manese, Ari Zeida, Laurence Abrami, Mariela Veggetti, David A. Guertin, F. Gisou van der Goot, Maria Martha Corvi, Alejandro Colman-Lerner
Summary: The study reveals that Akt protein undergoes S-palmitoylation modification, affecting its localization and function. Lack of palmitoylation leads to increased recruitment of Akt to cytoplasmic structures co-localizing with lysosomes during autophagy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Francisco S. Mesquita, Laurence Abrami, Oksana Sergeeva, Priscilla Turelli, Enya Qing, Beatrice Kunz, Charlene Raclot, Jonathan Paz Montoya, Luciano A. Abriata, Tom Gallagher, Matteo Dal Peraro, Didier Trono, Giovanni D'Angelo, F. Gisou van der Goot
Summary: During SARS-CoV-2 infection, spike protein undergoes lipid modification which controls its biosynthesis and degradation, promoting viral budding. This lipidation leads to the formation of cholesterol and sphingolipid-rich lipid nanodomains in the early Golgi, enhancing virus fusion capacity.
DEVELOPMENTAL CELL
(2021)
Article
Biology
Amado Carreras-Sureda, Laurence Abrami, Kim Ji-Hee, Wen-An Wang, Christopher Henry, Maud Frieden, Monica Didier, F. Gisou van der Goot, Nicolas Demaurex
Summary: This study reveals the critical role of ORAI1 channels in the immune synapse, with S-acylation playing a key regulatory role in channel trafficking and function at the synapse. Additionally, ORAI1 S-acylation is found to enhance TCR recruitment to the synapse.
Article
Multidisciplinary Sciences
Gonzalo P. Solis, Arghavan Kazemzadeh, Laurence Abrami, Jana Valnohova, Cecilia Alvarez, F. Gisou van der Goot, Vladimir L. Katanaev
Summary: This study describes the inherent partitioning of G alpha oα subunit between the plasma membrane and Golgi and establishes the SwissKASH assay to probe the substrate specificity of PATs. The findings uncover the remarkable substrate selectivity of PATs in different membrane compartments, which is the basis for PMP compartmentalization.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Francisco S. Mesquita, Laurence Abrami, Arthur Samurkas, F. Gisou van Der Goot
Summary: S-acylation is a covalent modification of proteins with fatty acids, allowing dynamic control of protein properties and functions in association with cell membranes. It regulates a substantial portion of the human proteome and has increasingly recognized roles in protein lifespan. Recent advancements have provided new insights into its mechanisms and implications. This review focuses on the importance of S-acylation in the homeostasis, function, and coordination of integral membrane proteins.
Review
Cell Biology
Muhammad U. Anwar, F. Gisou van der Goot
Summary: S-acylation is an important posttranslational modification that regulates cellular processes. This reversible lipid modification affects cellular pathways and physiological processes, and the enzymes and proteins involved in S-acylation are still being discovered and studied.
JOURNAL OF CELL BIOLOGY
(2023)
