TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy

The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death

(2020) Wenxian Wu et al.   Cell Reports

Activated MLKL attenuates autophagy following its translocation to intracellular membranes

(2019) Daniel Frank et al.   JOURNAL OF CELL SCIENCE

Systematic analysis of ATG13 domain requirements for autophagy induction

(2018) Nora Wallot-Hieke et al.   Autophagy

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

The WD40 domain of ATG16L1 is required for its non‐canonical role in lipidation of LC3 at single membranes

(2018) Katherine Fletcher et al.   EMBO JOURNAL

AMP-activated protein kinase protects against necroptosis via regulation of Keap1-PGAM5 complex

(2018) Yi-Shu Wang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

A molecular perspective of mammalian autophagosome biogenesis

(2018) Thomas J. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy

(2018) Jakob Mejlvang et al.   JOURNAL OF CELL BIOLOGY

Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17

(2018) Takahide Matsui et al.   JOURNAL OF CELL BIOLOGY

A brief history of autophagy from cell biology to physiology and disease

(2018) Noboru Mizushima   NATURE CELL BIOLOGY

Checkpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer

(2018) Alessandro Annibaldi et al.   TRENDS IN MOLECULAR MEDICINE

Enteroviral Infection Inhibits Autophagic Flux via Disruption of the SNARE Complex to Enhance Viral Replication

(2018) Yasir Mohamud et al.   Cell Reports

Enteroviruses Remodel Autophagic Trafficking through Regulation of Host SNARE Proteins to Promote Virus Replication and Cell Exit

(2018) Abigail K. Corona et al.   Cell Reports

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

(2016) Ji-Man Park et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Autophagy RIPs into cell death

(2016) Megan L. Goodall et al.   CELL CYCLE

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis

(2016) Megan L. Goodall et al.   DEVELOPMENTAL CELL

Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy

(2016) Ying Gao et al.   Cell Death & Disease

A systems study reveals concurrent activation of AMPK and mTOR by amino acids

(2016) Piero Dalle Pezze et al.   Nature Communications

Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells

(2015) Nora Hieke et al.   Autophagy

RIPK3 regulates p62–LC3 complex formation via the caspase-8-dependent cleavage of p62

(2015) Yu Matsuzawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RIP3 Regulates Autophagy and Promotes Coxsackievirus B3 Infection of Intestinal Epithelial Cells

(2015) Katharine G. Harris et al.   Cell Host & Microbe

RIP1 negatively regulates basal autophagic flux through TFEB to control sensitivity to apoptosis

(2015) T. Yonekawa et al.   EMBO REPORTS

Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy

(2015) Weili Tian et al.   FEBS LETTERS

IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense

(2015) Santosh Chauhan et al.   MOLECULAR CELL

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control

(2015) Sravanth K. Hindupur et al.   Cold Spring Harbor Perspectives in Biology

V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation

(2014) Oliver Florey et al.   Autophagy

A Cluster of Thin Tubular Structures Mediates Transformation of the Endoplasmic Reticulum to Autophagic Isolation Membrane

(2014) T. Uemura et al.   MOLECULAR AND CELLULAR BIOLOGY

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

(2014) Pratyusha Mandal et al.   MOLECULAR CELL

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

Diverse Sequence Determinants Control Human and Mouse Receptor Interacting Protein 3 (RIP3) and Mixed Lineage Kinase domain-Like (MLKL) Interaction in Necroptotic Signaling

(2013) Wanze Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Life in the balance – a mechanistic view of the crosstalk between autophagy and apoptosis

(2013) Assaf D. Rubinstein et al.   JOURNAL OF CELL SCIENCE

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization

(2012) Hildegard I.D. Mack et al.   Autophagy

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

Autophagy proteins in macroendocytic engulfment

(2012) Oliver Florey et al.   TRENDS IN CELL BIOLOGY

The serine/threonine kinase ULK1 is a target of multiple phosphorylation events

(2011) Markus Bach et al.   BIOCHEMICAL JOURNAL

AMPK-Dependent Phosphorylation of ULK1 Induces Autophagy

(2011) Mantong Zhao et al.   Cell Metabolism

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

(2011) L. Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ammonia-induced autophagy is independent of ULK1/ULK2 kinases

(2011) H. Cheong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

3D tomography reveals connections between the phagophore and endoplasmic reticulum

(2009) Päivi Ylä-Anttila et al.   Autophagy

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

(2009) Mitsuko Hayashi-Nishino et al.   NATURE CELL BIOLOGY

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY