Article
Nanoscience & Nanotechnology
Zhijuan Sun, Lei Yang, Chenchen Xu, Chenxin Cai, Li Li
Summary: In this study, stable core-shell zwitterionic nanocapsules with dual pH- and thermal-responsiveness were successfully synthesized. These nanocapsules can effectively encapsulate drugs and control drug release. Experimental results showed that the nanocapsules had an average particle size ranging from 178 to 142 nm when the temperature changed from 25°C to 40°C. Sustained release experiments using bovine serum albumin (BSA) as the payload demonstrated the capability of the nanocapsules to achieve controlled drug release, with different release profiles at different temperatures. In vitro cytotoxicity tests also confirmed the feasibility of their biomedical application. These dual pH- and thermal-responsive nanocapsules hold promising potential for drug-controlled release.
Article
Biochemistry & Molecular Biology
Kai Jiang, Xuesong Zhou, Tong He
Summary: The composite hydrogels composed of partially oxidated bacterial cellulose and chitosan showed good mechanical properties and pH responsive performance, making them potential drug carriers for clinical therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Ming Yi, Thi Dao Nguyen, Huan Liu, Yafang Liu, Shu Xiong, Yan Wang
Summary: A smart nanofiltration membrane with rechargeable antibacterial capability was fabricated by interfacial polymerization. The membrane can graft biocides onto its surface under neutral/alkaline conditions and release them under acidic environment, due to the pH-responsive feature of boronate ester complexes. The membrane exhibits fast bacterial inactivating efficiency, rechargeable antibacterial capability, impressive stability, and remarkable separation efficiency to dye/monovalent salt system.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Chemical
Yafang Liu, Ming Yi, Yan Wang
Summary: In this study, a novel method of incorporating antibiotics into membranes with minimal loss of activity was proposed. A boronate ester-based membrane was fabricated using the non-solvent induced phase separation (NIPS) method, followed by cross-linking with trimesoyl chloride (TMC) to form a loose nanofiltration (LNF) membrane. The pH responsive nature of boronate ester complexes allows for the release of boronic acid groups, which act as binding sites for diol-bearing antibiotics. This membrane demonstrated excellent biocidal effect against both Gram-negative and positive bacteria, with high water permeance.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Emily Linnane, Salame Haddad, Francesca Melle, Zihan Mei, David Fairen-Jimenez
Summary: The application of metal-organic frameworks (MOFs) in drug delivery has shown great progress, but their limited biological understanding hinders their translation to clinic. In this review, recent advances regarding the mechanisms of uptake and intracellular trafficking of nano-sized MOFs (nanoMOFs) are discussed, highlighting the importance of biological context in their final fate. The impact of MOF physicochemical properties on intracellular trafficking and cargo delivery are critically examined.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Nanoscience & Nanotechnology
Song Yi Lee, Mingyu Yang, Ji-Hye Seo, Da In Jeong, ChaeRim Hwang, Han-Jun Kim, Junmin Lee, KangJu Lee, JiHye Park, Hyun-Jong Cho
Summary: The pH-modulated hydrogels with optimized viscoelastic properties are designed for peritumoral injection of an anticancer agent. Cross-linking strategies involving boronate ester bonds and self-polymerization of dopamine are introduced, and the final pH of the polymer dispersion is carefully controlled for single syringe injection near physiological pH. The designed injectable hydrogel shows shear-thinning behavior, self-healing property, and convenient application to local cancer therapy with prolonged retention.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Biomaterials
Jae Min Jung, Seong Han Kim, V. H. Giang Phan, Thavasyappan Thambi, Doo Sung Lee
Summary: A thermo-responsive hydrogel was developed for targeted delivery of drugs to tumor tissues, showing stable formation in vivo and potential for suppressing tumor growth. This study suggests that the pH-responsive drug-releasing hydrogel has great promise for localized anticancer therapy.
BIOMATERIALS SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Bagher Kazemi Heragh, Shahrzad Javanshir, Gholam Reza Mahdavinia, Mohammad Reza Naimi Jamal
Summary: A pH-responsive drug carrier was developed for controllable drug release in the gastric environment by grafting hydroxyapatite into a chitosan/nano-clay matrix. The co-precipitation method led to the penetration of hydroxyapatite nanoparticles inside the matrix, reducing drug release rate. The nanocomposite showed high sensitivity to pH and significantly decreased drug release rate in both gastric and intestinal environments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Mingxin Wang, Somia Yassin Hussain Abdalkarim, Ruixin Gong, Haibin Ji, Zhiming Chen, Yunfei Shen, Ying Zhou, Jiayuan Shen, Hou-Yong Yu
Summary: Polymer composite microspheres with excellent biodegradable and controlled long-term release characteristics have gained significant attention. However, producing polymer microspheres with controlled properties and customizable drug release is still a major challenge. In this study, dual-responsive cellulose nanocrystals were engineered and incorporated into polylactide composite microspheres to achieve controlled and sustained drug release behavior. The results demonstrated a temperature and pH dual-responsive controlled drug release capability of the composite microspheres, highlighting their potential as multifunctional drug delivery systems for medical applications.
Article
Chemistry, Multidisciplinary
Stefano Salmaso, Francesca Mastrotto, Marco Roverso, Valentina Gandin, Sara De Martin, Daniela Gabbia, Michele De Franco, Christian Vaccarin, Marco Verona, Adriana Chilin, Paolo Caliceti, Sara Bogialli, Giovanni Marzaro
Summary: Tyrosine kinase inhibitors (TKIs) are a promising class of therapeutics for cancer treatment, but their efficacy and toxicity can be influenced by CYP-mediated metabolism and drug-drug interactions. Developing a liposome formulation of a TKI prodrug (Pro962) specifically designed for tumor pH-controlled release can improve the metabolic stability, intracellular delivery, and release of anticancer drugs.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Haibo Chen, Xuewei Dong, Luping Ou, Chiyun Ma, Bing Yuan, Kai Yang
Summary: In this study, the interaction between irradiated nanoparticles (NPs) and lipid bilayer membranes was investigated using molecular dynamics simulations. The results showed that the wrapping of membranes around NPs is thermally regulated and dependent on NP properties and lipid species. These findings offer valuable insights for understanding cellular internalization of NPs and developing strategies to modulate NP endocytosis.
Article
Chemistry, Physical
Chengbin Guo, Peng Zou, Yu Wang, Rui Song, Zhenyu Chen
Summary: In this study, MOF-5 was used as a nanocarrier to load the corrosion inhibitor of BTA molecules. A novel pH-responsive release system was fabricated by coating a metal-phenolic network (MPN) on MOF-5@BTA through super-assembly. The prepared nanoparticles demonstrated excellent barrier and self-healing protection effects.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Adrian Ges Naranjo, Herlys Viltres Cobas, Nishesh Kumar Gupta, Katy Rodriguez Lopez, Aldo Martinez Pena, Daniel Sacasas, Ruben Alvarez Brito
Summary: Nanogels offer a promising approach for enhancing cancer therapy by increasing the concentration of anti-tumor agents at tumor sites and prolonging their effects on cancer cells without significantly impacting normal tissues.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemistry & Molecular Biology
Chloe Seyrig, Alexandre Poirier, Thomas Bizien, Niki Baccile
Summary: This study demonstrates the development of functional hydrogels with in situ responsivity of their elastic properties by external stimuli, using entirely sustainable materials. The elastic properties of the hydrogels can be modulated by selectively triggering the phase transition of the components.
Article
Chemistry, Multidisciplinary
Pei Zhang, Yingxin Liu, Guobing Feng, Cong Li, Jun Zhou, Chunyang Du, Yuancheng Bai, Shuai Hu, Tianhe Huang, Guan Wang, Peng Quan, Jouni Hirvonen, Jin Fan, Helder A. Santos, Dongfei Liu
Summary: Microparticles with ultrahigh drug loading and zero-order release of protein payloads are successfully engineered through controlled interfacial self-assembly of polymers. Protein molecules are transformed into nanoparticles covered with a polymer layer to improve their miscibility with carrier materials. The resulting microparticles achieve superior encapsulation efficiency and controlled payload release, enabling efficient glycemic control in type 1 diabetes.
ADVANCED MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Chun-Ping Liu, Jian-Xing Liu, Jiangyong Gu, Fang Liu, Jin-Hua Li, Bin-Yang, Yuan-Zheng, Jie-Li, Shou-hai Wu, Qing-he Wu, Xian-Zhang, Long-Mei Li, Hai-Long Yang, Lei Wang, Xiong Li
Summary: Three bioactive components in Sarcandra glabra, Caffeoylquinic acids, coumarins, and dicaffeoyl derivatives, have shown significant anti-inflammatory effects by targeting the MAPK-NF-kappa B pathway. This plant has the potential to be used in the treatment of acute lung injury by suppressing inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Jing Huang, Bin Yang, Yuan Peng, Jinsheng Huang, Siu Hong Dexter Wong, Liming Bian, Kangshun Zhu, Xintao Shuai, Shisong Han
Summary: Immunotherapy has made significant progress in cancer treatment, but faces challenges due to insufficient immunogenicity of tumors and subsequent lack of antitumor immune activation. Nanotechnology plays a crucial role in enhancing the efficacy of immunotherapy and other treatments, by increasing tumor immunogenicity and promoting antitumor immune responses.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Ting Qiu, Yintao Lan, Zuwu Wei, Yanfen Zhang, Yanping Lin, Chenggong Tu, Guangjuan Mao, Lingmin Zhang, Bin Yang, Jian Zhang
Summary: The combination of photoacoustic imaging and photothermal therapy systems with novel PD-FA nanoparticles provides a powerful tool for the early diagnosis and precise treatment of cervical cancer.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Ting Qiu, Yintao Lan, Weijian Gao, Mengyu Zhou, Shiqi Liu, Wenyan Huang, Sujuan Zeng, Janak L. Pathak, Bin Yang, Jian Zhang
Summary: Photoacoustic imaging is an emerging imaging strategy that offers rich optical contrasts, high ultrasound spatial resolution, and deep penetration depth without ionizing radiation. It has diverse applications in various fields, with particular importance in diagnosing brain diseases such as tumors, chemotherapy response, and epileptic activity.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Chemistry, Multidisciplinary
Guodong Zheng, Jiahui Zheng, Le Xiao, Tongyi Shang, Yanjun Cai, Yuwei Li, Yiming Xu, Xiaoming Chen, Yun Liu, Bin Yang
Summary: This study developed a pH-responsive nano-prodrug by conjugating emodin to mPEG-PEI with acid-sensitive boronate ester bonds, showing promising potential for pH-responsive tumor therapy and antibacterial activity. The nano-prodrug exhibited a superior cytotoxic effect against HeLa cells compared to free emodin, and effectively inhibited the growth of both Gram-positive and Gram-negative bacteria.
Article
Engineering, Biomedical
Hao Zhong, Pei-Ying Huang, Ping Yan, Pei-Ling Chen, Qun-Yin Shi, Ze-An Zhao, Jing-Xuan Chen, Xian Shu, Ping Wang, Bin Yang, Zheng-Zheng Zhou, Jian-Jun Chen, Jian-Xin Pang, Ying-Feng Tu, Li-Han Liu, Xian-Zheng Zhang
Summary: The authors developed a versatile nanoparticle (NP)-based drug called PZB NP, which suppresses the innate antioxidant defense system of cancer cells in a two-pronged manner to enhance the efficacy of photodynamic therapy (PDT) for tumor treatment.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Xinying Yu, Tongyi Shang, Guodong Zheng, Hailong Yang, Yuwei Li, Yanjun Cai, Guoxi Xie, Bin Yang
Summary: This study presents a rational design of iron-based nanoparticles for anti-cancer ferroustherapy. The synthesized nanomedicines effectively induce cancer cell ferroptosis through accelerated Fenton reaction and utilize photothermal effect for mild hyperthermia-assisted ferroustherapy. The nanomedicines show promising anti-cancer therapeutic efficacy by inducing ROS production and inhibiting GPX4 expression, and also possess photoacoustic imaging ability.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Ning Guo, Yu Xia, Yuxi Duan, Quanxin Wu, Le Xiao, Yaxin Shi, Bin Yang, Yun Liu
Summary: Cu2-xS nanostructures have been extensively explored as promising agents for chemodynamic therapy (CDT) and photothermal therapy (PTT) due to their efficient Cu(I)-initiated Fenton-like catalytic activity and photothermal conversion property. However, the supply of Cu(I) in the long-term is still limited, and the inherent photothermal conversion efficiency is relatively low. In this study, a self-enhanced synergistic PTT/CDT nanoplatform (Cu1.94S@MPN) was developed by coating Cu1.94S nanoparticles with Fe(III)/tannic acid-based metal-polyphenol networks (MPN). When exposed to the acidic bacterial infection microenvironment, Cu1.94S@MPN can be decomposed to release Cu(II), Fe(III) ions, and tannic acid, enabling Cu(I)/Fe(II)-rich CDT through accelerated Fenton/Fenton-like reactions. Additionally, Cu1.94S@MPN exhibits excellent photothermal antibacterial and photothermal-enhanced CDT properties, making it a potential candidate for future anti-infective therapy.
CHINESE CHEMICAL LETTERS
(2023)
Article
Engineering, Biomedical
Fuan Deng, Mengyi Yan, Yibin Liu, Ruixin Wang, Haiqing He, Ali Chen, Jiajia Wang, Lin Xu, Bin Yang, Hong Cheng, Shiying Li
Summary: In this study, a metal-coordinated mitochondria proto-nophore uncoupler was developed to induce local hypoxia and enhance bioreductive therapy. In vivo experiments demonstrated that this nanomedicine could regulate tumor hypoxia microenvironment and effectively inhibit tumor growth.
Article
Materials Science, Multidisciplinary
Fan Yang, Chenggang Song, Ruixuan Ji, Xiaoyi Song, Bin Yang, Yin Lv, Zhong Wei
Summary: In this study, an amphiphilic copolymer micelle was designed and synthesized, which can form stable micelles in water and effectively load the anticancer drug. The micelle exhibited stimuli-responsive characteristics and showed promising potential for cancer treatment by enhancing antioxidant capacity and synergistic effects on cancer cells.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Peiying He, Qi Lei, Bin Yang, Tongyi Shang, Jianjun Shi, Qing Ouyang, Wei Wang, Liecong Xue, Fanhui Kong, Zeyu Li, Junda Huang, Lihan Liu, Jimin Guo, C. Jeffrey Brinker, Kaisheng Liu, Wei Zhu
Summary: The microenvironment of triple-negative breast cancer (TNBC) reduces the delivery and penetration of therapeutic agents, making it difficult to eliminate cancer cells completely. In this study, a photothermal nanocluster was constructed using a size-shrinkage and ligand modification strategy, allowing for deep penetration and efficient eradication of TNBC cells.
Article
Polymer Science
Yueying Xu, Yanjun Cai, Yu Xia, Quanxin Wu, Mingen Li, Ning Guo, Yingfeng Tu, Bin Yang, Yun Liu
Summary: In this study, a nano-sized photothermal agent (BSA@MPN) was developed by self-assembling Fe3+ and epigallocatechin-3-gallate (EGCG) using BSA as a nanoreactor and colloidal stabilizer. The nanoagent displayed good photothermal and ROS scavenging capabilities, as well as excellent antibacterial and anti-inflammatory effects both in vitro and in vivo. These findings suggest that this nanoagent has great potential for combined antibacterial and anti-inflammatory treatments in future clinical applications.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Nanoscience & Nanotechnology
Fengbing He, Wenzhong Hou, Yintao Lan, Weijian Gao, Mengyu Zhou, Jinghang Li, Shutong Liu, Bin Yang, Jian Zhang
Summary: This study demonstrates the use of photoacoustic imaging and nanomaterials for detecting and diagnosing carotid artery thrombosis. The results show that the nanomaterials have excellent photoacoustic imaging capabilities in the wavelength range of 700 nm to 900 nm.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Zhijian Mai, Nengjie Cao, Erzhuo Cheng, Zhiwen Zeng, Yancong Feng, Yao Wang, Paddy J. French, Yi-Kuen Lee, Haihong Yang, Bin Yang, Hao Li, Guofu Zhou
Summary: In this study, a multifunctional self-assembled nanobomb was designed and developed, which can be used for tumor imaging and cancer therapy. The nanobomb releases a fluorescence probe and an anticancer drug simultaneously upon acidolysis, achieving high-efficiency effects.
ACS APPLIED NANO MATERIALS
(2023)
Article
Materials Science, Biomaterials
Qingye Liu, Du Yang, Tongyi Shang, Lixiao Guo, Bin Yang, Xiaojuan Xu
BIOMATERIALS SCIENCE
(2020)
