Tyrosine kinase inhibitor prodrug-loaded liposomes for controlled release at tumor microenvironment

Synthesis, Characterization and Biological Activity of Novel Cu(II) Complexes of 6-Methyl-2-Oxo-1,2-Dihydroquinoline-3-Carbaldehyde-4n-Substituted Thiosemicarbazones

(2020) Eswaran Ramachandran et al.   MOLECULES

Tyrosine Kinase Inhibitors in Cancer: Breakthrough and Challenges of Targeted Therapy

(2020) Charles Pottier et al.   Cancers

Antiproliferative Homoleptic and Heteroleptic Phosphino Silver(I) Complexes: Effect of Ligand Combination on Their Biological Mechanism of Action

(2020) Khouloud Dammak et al.   MOLECULES

Could 3D models of cancer enhance drug screening?

(2019) Virginia Brancato et al.   BIOMATERIALS

RET-mediated autophagy suppression as targetable co-dependence in acute myeloid leukemia

(2018) S. Rudat et al.   LEUKEMIA

A comprehensive review of protein kinase inhibitors for cancer therapy

(2018) Radhamani Kannaiyan et al.   Expert Review of Anticancer Therapy

Role of Cytochrome P450 Enzymes in the Metabolic Activation of Tyrosine Kinase Inhibitors

(2018) Klarissa Jackson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmaceutical liposomal drug delivery: a review of new delivery systems and a look at the regulatory landscape

(2016) Claudia Zylberberg et al.   DRUG DELIVERY

Remote loading of doxorubicin into liposomes by transmembrane pH gradient to reduce toxicity toward H9c2 cells

(2016) Mohamed Alyane et al.   SAUDI PHARMACEUTICAL JOURNAL

Liposomes as nanomedical devices

(2015) Giuseppina Bozzuto et al.   International Journal of Nanomedicine

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

(2015) Jumin Lee et al.   Journal of Chemical Theory and Computation

Liposome–protein corona in a physiological environment: Challenges and opportunities for targeted delivery of nanomedicines

(2015) Giulio Caracciolo   Nanomedicine-Nanotechnology Biology and Medicine

Targeting kinases with anilinopyrimidines: discovery of N-phenyl-N’-[4-(pyrimidin-4-ylamino)phenyl]urea derivatives as selective inhibitors of class III receptor tyrosine kinase subfamily

(2015) Valentina Gandin et al.   Scientific Reports

Mechanisms of RET signaling in cancer: Current and future implications for targeted therapy

(2014) I. Plaza-Menacho et al.   CELLULAR SIGNALLING

Liposomes as carriers of hydrophilic small molecule drugs: Strategies to enhance encapsulation and delivery

(2014) Josimar Oliveira Eloy et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Microfluidic remote loading for rapid single-step liposomal drug preparation

(2014) R. R. Hood et al.   LAB ON A CHIP

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

Psoralen Derivatives as Inhibitors of NF-κB/DNA Interaction: Synthesis, Molecular Modeling, 3D-QSAR, and Biological Evaluation

(2013) Giovanni Marzaro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nanomaterials in combating cancer: Therapeutic applications and developments

(2013) Samina Nazir et al.   Nanomedicine-Nanotechnology Biology and Medicine

Differential Inducing Effect of Benzo[a]pyrene on Gene Expression and Enzyme Activity of Cytochromes P450 1A1 and 1A2 in Sprague-Dawley and Wistar Rats

(2012) Maura Floreani et al.   Drug Metabolism and Pharmacokinetics

Extension of the CHARMM general force field to sulfonyl-containing compounds and its utility in biomolecular simulations

(2012) Wenbo Yu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Open Babel: An open chemical toolbox

(2011) Noel M O'Boyle et al.   Journal of Cheminformatics

What the Cell “Sees” in Bionanoscience

(2010) Dorota Walczyk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

(2009) Jorg Hartmann et al.   CURRENT DRUG METABOLISM

Radiosensitization Effect of STI-571 on Pancreatic Cancer Cells In Vitro

(2009) Hye Won Chung et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: A comparison with human liver microsomes

(2008) Luigi Quintieri et al.   BIOCHEMICAL PHARMACOLOGY

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY