Article
Biotechnology & Applied Microbiology
Xiang Zhang, Zhenxing Wang, Yu Shrike Zhang, Shujie Yan, Chuanyu Hou, Youping Gong, Jingjiang Qiu, Mo Chen, Qian Li
Summary: This study demonstrated that endothelialized tissue-engineered blood vessels cultured statically may experience endothelial cell shedding under arterial blood flow conditions, which was effectively addressed by regulating the flow field in a vascular chip platform. The adaptation of endothelial cells to artery-like microenvironment and improved cellular orientations were observed, providing a promising strategy for various applications in vascular engineering and drug analysis.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Biology
E. E. Van Haaften, S. Quicken, W. Huberts, C. V. C. Bouten, N. A. Kurniawan
Summary: Researchers demonstrate a numerical-experimental approach to reconstruct the graft-host response and investigate mechanoregulation in dialysis grafts. They find that oscillatory shear stress, in the presence of cyclic strain, promotes neotissue development by influencing vascular cell secretion and collagen network formation, providing a potential method to inhibit neointimal hyperplasia in grafts.
COMMUNICATIONS BIOLOGY
(2021)
Review
Engineering, Biomedical
Leanne de Silva, Paulina N. Bernal, A. J. W. Rosenberg, Jos Malda, Riccardo Levato, Debby Gawlitta
Summary: The development of tissue engineering strategies for treatment of large bone defects is crucial, and creating a vascular network is vital for tissue engineered bone constructs.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Sangil Min, David Cleveland, In Kap Ko, Ji Hyun Kim, Hee Jo Yang, Anthony Atala, James J. Yoo
Summary: By incorporating vascular endothelial growth factor (VEGF) into the vascular scaffold, improved angiogenic capability was achieved, promoting vascularization, reducing apoptosis of implanted cells, and forming hybrid renal tubule-like structures.
ACTA BIOMATERIALIA
(2021)
Review
Chemistry, Medicinal
Jonathan Ardhianto Panggabean, Sya'ban Putra Adiguna, Mutia Hardhiyuna, Siti Irma Rahmawati, Nina Hermayani Sadi, Gunawan Pratama Yoga, Eva Nafisyah, Asep Bayu, Masteria Yunovilsa Putra
Summary: Aquatic-based collagens have great potential in biomedical applications, especially in tissue engineering, due to their superior characteristics compared to mammalian-based collagen. They are biocompatible, biodegradable, easy to extract, and pose a low immunological risk. The utilization of aquatic-based collagen also offers advantages such as fewer religious restrictions and lower production costs, while promoting environmental sustainability through aquatic waste utilization.
Article
Polymer Science
Thi My Do, Yang Yang, Aipeng Deng
Summary: The newly developed bilayer vascular grafts have appropriate mechanical properties and biocompatibility, reducing mortality from cardiovascular diseases. The inner layer was constructed using a polymer blend, while nanoscale fibers enhanced endothelial cell adhesion and increased porosity facilitated smooth muscle cell proliferation and infiltration.
Article
Engineering, Biomedical
Tatsuto Kageyama, Hikaru Akieda, Yukie Sonoyama, Ken Sato, Hiroshi Yoshikawa, Hitoshi Isono, Makoto Hirota, Hiroaki Kitajima, Yang-Sook Chun, Shoji Maruo, Junji Fukuda
Summary: This study proposes a hydrogel microbead-based approach for preparing vascularized and high-density tissue grafts, demonstrating the significant effects of endothelialization on in vivo bone regeneration. The spontaneous constriction of mesenchymal stem cell-encapsulated collagen microgels improves the density and osteogenic differentiation of the cells, enhancing the efficacy of engraftment and bone regeneration.
ACTA BIOMATERIALIA
(2023)
Review
Biotechnology & Applied Microbiology
Britani N. Blackstone, Summer C. Gallentine, Heather M. Powell
Summary: This systematic review examines the use of electrospun collagen in tissue engineering applications, finding that different crosslinking methods can affect degradation resistance and strength of the scaffolds, which are capable of forming engineered tissues with high similarity to native structures.
BIOENGINEERING-BASEL
(2021)
Article
Engineering, Biomedical
Kaveh Roshanbinfar, Maria Kolesnik-Gray, Miriam Angeloni, Stefan Schruefer, Maren Fiedler, Dirk W. Schubert, Fulvia Ferrazzi, Vojislav Krstic, Felix B. Engel
Summary: Cardiac tissue engineering is a promising strategy to prevent heart failure, but several issues remain unsolved. This study develops a biohybrid hydrogel that enhances the beating properties of engineered cardiac tissues and allows for concurrent drug release.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Seyedeh Sara Ashraf, Kazem Parivar, Nasim Hayati Roodbari, Shohre Mashayekhan, Naser Amini
Summary: This study aimed to fabricate and characterize a nanofiber skin substitute with enhanced mechanical properties and cellular compatibility. The scaffold consisted of collagen, sodium alginate, and exopolysaccharides produced by Rhodotorula mucilaginosa sp. GUMS16. The cross-linked nanofibers were characterized and tested for cell viability and proliferation. The results showed that the incorporation of GUMS16-produced exopolysaccharides increased cell viability and proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Multidisciplinary Sciences
Majd Machour, Ariel A. Szklanny, Shulamit Levenberg
Summary: 3D bioprinting is a promising technology for creating artificial vascular networks by adding printable biomaterials and cells layer by layer. In this study, a combined 3D bioprinting and sacrificial mold-based 3D printing approach was used to fabricate engineered vascularized tissue flaps. The method involves printing endothelial and support cells using a special bioink and then assembling them around a mesoscale vessel-like scaffold. This approach enables the establishment of a hierarchical vascular network within the engineered tissue flap.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Polymer Science
Kiran M. Ali, Yihan Huang, Alaowei Y. Amanah, Nasif Mahmood, Taylor C. Suh, Jessica M. Gluck
Summary: This study evaluates the potential use of traditional textile methods in the tissue engineering industry and proves the safety and efficacy of the material and fabrication method by creating collagen yarns using the traditional ring spinning method. The process is not only simple and efficient but also results in standardized products.
Review
Polymer Science
Lei Wang, Wenjun Li, Song Qin
Summary: With the rise in wounds and body damage, the clinical demand for antibacterial, hemostatic, and repairable biomaterials is growing. Research on various biomedical materials, including marine-derived alginate, chitosan, and collagen, has increased, focusing on improving mechanics, antibacterial ability, and degradation speed.
Article
Biochemistry & Molecular Biology
Hsu-Hsiang Lin, Pen-Hsiu Grace Chao, Wei-Chiu Tai, Po-Chun Chang
Summary: This study successfully developed a biomimetic microfibrous system to assist PDL regeneration and withstand functional load. Collagen-based microfibers were fabricated and PDL cells seeded on waveform microfibers showed enhanced growth and gene expression levels, indicating potential for promoting healing and regeneration under shear stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Le Yu, Mei Wei
Summary: This review discusses the mineralization of collagen fibrils into hydroxyapatite, dividing it into intrafibrillar and extrafibrillar mineralization. Various mechanisms and strategies for inducing biomimetic intrafibrillar mineralization are examined, along with applications for bone regeneration and dentin repair using mineralized collagen fibers. Potential future trends in collagen-based materials for bone and tooth repair are also speculated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Sally A. N. Gowers, Vincenzo F. Curto, Carlo A. Seneci, Chu Wang, Salzitsa Anastasova, Pankaj Vadgama, Guang-Zhong Yang, Martyn G. Boutelle
ANALYTICAL CHEMISTRY
(2015)
Review
Oncology
Wilhelm Engstrom, Philippa Darbre, Staffan Eriksson, Linda Gulliver, Tove Hultman, Michalis V. Karamouzis, James E. Klaunig, Rekha Mehta, Kim Moorwood, Thomas Sanderson, Hideko Sone, Pankaj Vadgama, Gerard Wagemaker, Andrew Ward, Neetu Singh, Fahd Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Anna Maria Colacci, Monica Vaccari, Chiara Mondello, A. Ivana Scovassi, Jayadev Raju, Roslida A. Hamid, Lorenzo Memeo, Stefano Forte, Rabindra Roy, Jordan Woodrick, Hosni K. Salem, Elizabeth Ryan, Dustin G. Brown, William H. Bisson
Review
Oncology
William H. Goodson, Leroy Lowe, David O. Carpenter, Michael Gilbertson, Abdul Manaf Ali, Adela Lopez de Cerain Salsamendi, Ahmed Lasfar, Amancio Carnero, Amaya Azqueta, Amedeo Amedei, Amelia K. Charles, Andrew R. Collins, Andrew Ward, Anna C. Salzberg, Annamaria Colacci, Ann-Karin Olsen, Arthur Berg, Barry J. Barclay, Binhua P. Zhou, Carmen Blanco-Aparicio, Carolyn J. Baglole, Chenfang Dong, Chiara Mondello, Chia-Wen Hsu, Christian C. Naus, Clement Yedjou, Colleen S. Curran, Dale W. Laird, Daniel C. Koch, Danielle J. Carlin, Dean W. Felsher, Debasish Roy, Dustin G. Brown, Edward Ratovitski, Elizabeth P. Ryan, Emanuela Corsini, Emilio Rojas, Eun-Yi Moon, Ezio Laconi, Fabio Marongiu, Fahd Al-Mulla, Ferdinando Chiaradonna, Firouz Darroudi, Francis L. Martin, Frederik J. Van Schooten, Gary S. Goldberg, Gerard Wagemaker, Gladys Nangami, Gloria M. Calaf, Graeme Williams, Gregory T. Wolf, Gudrun Koppen, Gunnar Brunborg, H. Kim Lyerly, Harini Krishnan, Hasiah Ab Hamid, Hemad Yasaei, Hideko Sone, Hiroshi Kondoh, Hosni K. Salem, Hsue-Yin Hsu, Hyun Ho Park, Igor Koturbash, Isabelle R. Miousse, A. Ivana Scovassi, James E. Klaunig, Jan Vondracek, Jayadev Raju, Jesse Roman, John Pierce Wise, Jonathan R. Whitfield, Jordan Woodrick, Joseph A. Christopher, Josiah Ochieng, Juan Fernando Martinez-Leal, Judith Weisz, Julia Kravchenko, Jun Sun, Kalan R. Prudhomme, Kannan Badri Narayanan, Karine A. Cohen-Solal, Kim Moorwood, Laetitia Gonzalez, Laura Soucek, Le Jian, Leandro S. D'Abronzo, Liang-Tzung Lin, Lin Li, Linda Gulliver, Lisa J. McCawley, Lorenzo Memeo, Louis Vermeulen, Luc Leyns, Luoping Zhang, Mahara Valverde, Mahin Khatami, Maria Fiammetta Romano, Marion Chapellier, Marc A. Williams, Mark Wade, Masoud H. Manjili, Matilde Lleonart, Menghang Xia, Michael J. Gonzalez, Michalis V. Karamouzis, Micheline Kirsch-Volders, Monica Vaccari, Nancy B. Kuemmerle, Neetu Singh, Nichola Cruickshanks, Nicole Kleinstreuer, Nik van Larebeke, Nuzhat Ahmed, Olugbemiga Ogunkua, P. K. Krishnakumar, Pankaj Vadgama, Paola A. Marignani, Paramita M. Ghosh, Patricia Ostrosky-Wegman, Patricia Thompson, Paul Dent, Petr Heneberg, Philippa Darbre, Po Sing Leung, Pratima Nangia-Makker, Qiang (Shawn) Cheng, R. Brooks Robey, Rabeah Al-Temaimi, Rabindra Roy, Rafaela Andrade-Vieira, Ranjeet K. Sinha, Rekha Mehta, Renza Vento, Riccardo Di Fiore, Richard Ponce-Cusi, Rita Dornetshuber-Fleiss, Rita Nahta, Robert C. Castellino, Roberta Palorini, Roslida Abd Hamid, Sabine A. S. Langie, Sakina Eltom, Samira A. Brooks, Sandra Ryeom, Sandra S. Wise, Sarah N. Bay, Shelley A. Harris, Silvana Papagerakis, Simona Romano, Sofia Pavanello, Staffan Eriksson, Stefano Forte, Stephanie C. Casey, Sudjit Luanpitpong, Tae-Jin Lee, Takemi Otsuki, Tao Chen, Thierry Massfelder, Thomas Sanderson, Tiziana Guarnieri, Tove Hultman, Valerian Dormoy, Valerie Odero-Marah, Venkata Sabbisetti, Veronique Maguer-Satta, W. Kimryn Rathmell, Wilhelm Engstrom, William K. Decker, William H. Bisson, Yon Rojanasakul, Yunus Luqmani, Zhenbang Chen, Zhiwei Hu
Article
Biophysics
Wen Ma, Bo Situ, Weifeng Lv, Bo Li, Xiaomao Yin, Pankaj Vadgama, Lei Zheng, Wen Wang
BIOSENSORS & BIOELECTRONICS
(2016)
Article
Chemistry, Analytical
S. A. N. Gowers, K. Hamaoui, P. Cunnea, S. Anastasova, V. F. Curto, P. Vadgama, G. -Z. Yang, V. Papalois, E. M. Drakakis, C. Fotopoulou, S. G. Weber, M. G. Boutelle
Article
Engineering, Biomedical
Maryam Eslami, Nihal Engin Vrana, Pinar Zorlutuna, Shilpa Sant, Sungmi Jung, Nafiseh Masoumi, Ramazan Ali Khavari-Nejad, Gholamreza Javadi, Ali Khademhosseini
JOURNAL OF BIOMATERIALS APPLICATIONS
(2014)
Article
Engineering, Biomedical
Luiz E. Bertassoni, Juliana C. Cardoso, Vijayan Manoharan, Ana L. Cristino, Nupura S. Bhise, Wesleyan A. Araujo, Pinar Zorlutuna, Nihal E. Vrana, Amir M. Ghaemmaghami, Mehmet R. Dokmeci, Ali Khademhosseini
Article
Biochemistry & Molecular Biology
Nystha Baishya, Mohammad Mamouei, Karthik Budidha, Meha Qassem, Pankaj Vadgama, Panayiotis A. Kyriacou
Review
Chemistry, Analytical
Pankaj Vadgama
Article
Chemistry, Analytical
Karthik Budidha, Mohammad Mamouei, Nystha Baishya, Meha Qassem, Pankaj Vadgama, Panayiotis A. Kyriacou
Article
Chemistry, Analytical
Nystha Baishya, Mohammad Mamouei, Karthik Budidha, Meha Qassem, Pankaj Vadgama, Panayiotis A. Kyriacou
Summary: This study compared the performance of different types of NIR spectrometers in predicting lactate concentrations in whole blood for biomedical applications. Results indicated a significant improvement in predictive capability when analyzing full range spectral data compared to limited spectral regions or lactate signature peaks. Additionally, FTNIR demonstrated 10% better predictive capability than the dual beam dispersive NIR spectrometer for the same wavelength region.
Article
Chemistry, Analytical
Pankaj Vadgama
Summary: The article provides a comprehensive overview of the highly reactive nature of oxygen and nitrogen free radicals within eukaryote cells and their impact on tissue damage and diseases, with a focus on cardiovascular disease. It highlights the common issue of inflammation-driven damage across different tissues, as well as emphasizing the importance of RONS in biological signaling.
Article
Chemistry, Analytical
Anna-Maria Spehar-Deleze, Salzitsa Anastasova, Pankaj Vadgama
Summary: Lactate electrochemical biosensors were successfully fabricated using Pediococcus sp lactate oxidase, enabling detection of lactate in subcutaneous tissue, saliva, and sweat. The study revealed significant differences between blood lactate and salivary lactate, suggesting limitations in using lactate sensors for extravascular monitoring.
Article
Chemistry, Analytical
Thomas Soranzo, Awatef Ben Tahar, Ayman Chmayssem, Marc Zelsmann, Pankaj Vadgama, Jean-Luc Lenormand, Phillipe Cinquin, Donald K. Martin, Abdelkader Zebda
Summary: In this study, the enzyme aldehyde reductase was synthesized and cloned from a human gene. Spectrophotometric and electrochemical measurements demonstrated that aldehyde reductase can catalyze the reduction of glucose to sorbitol and significantly decrease the electrocatalytic oxidation current of NADPH after glucose addition. This work provides insights into the construction of an efficient electrochemical glucose biosensor.
Article
Biophysics
K. Adatia, M. Raja, P. Vadgama
COLLOIDS AND SURFACES B-BIOINTERFACES
(2017)