期刊
CARCINOGENESIS
卷 36, 期 -, 页码 S38-S60出版社
OXFORD UNIV PRESS
DOI: 10.1093/carcin/bgv030
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资金
- Fondazione Cariplo [2011-0370]
- Kuwait Institute for the Advancement of Sciences [2011-1302-06]
- Grant University Scheme (RUGs) Ministry of Education Malaysia [04-02-12-2099RU]
- Italian Ministry of University and Research [2009FZZ4XM_002]
- University of Florence
- US Public Health Service Grants [RO1 CA92306, RO1 CA92306-S1, RO1 CA113447]
- Department of Science and Technology, Government of India [SR/FT/LS-063/2008]
- National Institute for Health Research [II-ES-0511-21005]
- Nanosilver based catheters
- Medical Research Council UK [MR/L007215/1]
- WEM Consulting
- Getting to know cancer
- Medical Research Council [MR/L007215/1] Funding Source: researchfish
- MRC [MR/L007215/1] Funding Source: UKRI
The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under tight control, i.e. cells respond to a signal to proliferate, and although most cells continue to proliferate into adult life, the multiplication ceases once the stimulatory signal disappears or if the cells are exposed to growth inhibitory signals. Under such circumstances, normal cells remain quiescent until they are stimulated to resume further proliferation. In contrast, tumour cells are unable to halt proliferation, either when subjected to growth inhibitory signals or in the absence of growth stimulatory signals. Environmental chemicals with carcinogenic potential may cause sustained cell proliferation by interfering with some cell proliferation control mechanisms committing cells to an indefinite proliferative span.
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