Article
Nutrition & Dietetics
Xiao Han, Bing Han, Yue Zhao, Gang Li, Tian Wang, Jie He, Wenxiao Du, Xiaolin Cao, Jing Gan, Zhenhua Wang, Wei Zheng
Summary: This study aimed to evaluate the neuroprotective role of rosmarinic acid (RA) and investigate its mechanism of action in Parkinson's disease. The results showed that RA had a dose-dependent neuroprotective effect in a rotenone-induced SH-SY5Y cell model of Parkinson's disease. It reduced cell apoptosis, restored normal cell morphology, decreased protein phosphorylation levels, and increased the phosphorylation levels of AMPK and Akt, while inhibiting ROS overproduction. Furthermore, it was found that the neuroprotective effect of RA was partially attributed to the inhibition of Abl tyrosine kinase.
Article
Biochemistry & Molecular Biology
Shunichi Hatamiya, Masatsugu Miyara, Yaichiro Kotake
Summary: Tributyltin (TBT), an environmental pollutant, has been found to be toxic to mammals. This study investigated the mechanism by which TBT inhibits autophagic degradation in SH-SY5Y cells. The results showed that TBT reduced the acidity of lysosomes without affecting lysosomal membrane integrity, leading to the impairment of autophagy. This finding suggests that autophagy impairment may be involved in TBT-induced neuronal death and T-cell-dependent thymus atrophy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Wei Zheng, Xiao Han, Bing Han, Gang Li, Jing Gan, Tian Wang, Bo Xu, Jie He, Wenxiao Du, Xiaolin Cao, Zhenhua Wang
Summary: The study investigates the role of leukocyte common antigen-related protein tyrosine phosphatase (LAR) in a cell-based model of Parkinson's disease (PD). LAR downregulation has a protective effect on U251 cells, increasing cell viability, reducing cell mortality, and restoring appropriate cellular morphology. LAR downregulation also enhances IGF-1R phosphorylation and downstream signaling, contributing to reduced apoptosis and improved mitochondrial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lucie Valek, Irmgard Tegeder
Summary: Knockdown of nucleoredoxin (NXN) in neuronal cells leads to increased proliferation, elevated basal respiratory rates, and a similar relative change in oxygen consumption compared to control cells under mitochondrial stressors. Moreover, NXN-deficient cells show increased expression of redox-sensitive heat shock proteins and autophagy markers, indicating higher levels of self-renewal and autophagy.
Article
Biochemistry & Molecular Biology
Mahesh Ramalingam, Han-Seong Jeong, Jinsu Hwang, Hyong-Ho Cho, Byeong C. Kim, Eungpil Kim, Sujeong Jang
Summary: In this study, it was found that Rotenone inhibits mitochondrial complex I, leading to neurodegeneration and aggregation of α-syn, resulting in Parkinson's disease. Our previous research has shown that neurogenic differentiated human adipose tissue-derived stem cell-conditioned medium (NI-hADSC-CM) has a protective effect against Rotenone-induced toxicity. This study further discovered that NI-hADSC-CM can modulate autophagy signaling pathways, alleviating α-syn aggregation in Parkinson's disease and other neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Lou-Yan Ma, Song -fang Liu, Ya-gang Guo, Zheng-quan Ma, Ya Li, Shu-jin Wang, Yu Niu, Mo Li, Jia-jia Zhai, Su-hang Shang, Ya-Li Lv, Qiu-Min Qu
Summary: Diabetes activates autophagy but impairs lysosome function, leading to accumulation of amyloid-beta in diabetic cognitive impairment. High glucose treatment downregulates lysosome function, interferes with autophagosome-lysosome fusion, and partially blocks amyloid-beta clearance.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Kewal Kumar Mahapatra, Soumya Ranjan Mishra, Bishnu Prasad Behera, Shankargouda Patil, David A. Gewirtz, Sujit Kumar Bhutia
Summary: Lysosomes are crucial organelles responsible for degrading cellular cargo and maintaining cellular homeostasis, playing a critical role in the connection between autophagy and endocytosis. Damage to the lysosomal membrane can lead to selective lysosomal degradation pathway and trigger lysophagy in severe cases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Environmental Sciences
Carlos Villaorduna, Mariano Mendoza-Carlos, Manuel Chuyma, Jhon Aviles, Ayda Avalos-Diaz, Ronald Lozano-Reategui, Juan Garcia-Ruiz, Nadia Panduro-Tenazoa, Jessy Vargas, Ysabel Moran-Quintanilla, Jose-Luis Rodriguez
Summary: Ipconazole, an antifungal agrochemical, poses a hazard to human, animal, and environmental health due to its widespread use in agriculture and easy accumulation in the environment. Our study investigated the cytotoxic effects of ipconazole on SH-SY5Y neuroblastoma cells, revealing a dose-dependent reduction in cell viability, increased ROS production, and induction of cell death. These findings suggest that ipconazole exposure may contribute to neurotoxicity or neurodegeneration.
Article
Neurosciences
Xin Liu, Le Qu, Na Zhang, Xiaoqi Yu, Zhixin Xiao, Limei Song, Junxia Xie, Huamin Xu
Summary: Our study demonstrated that Ndfip1 could protect against rotenone-induced neurotoxicity by antagonizing the increase in alpha-syn protein levels and inhibiting the upregulation of caspase-3 and decrease in tyrosine hydroxylase caused by rotenone. Ndfip1 may serve as a potential new drug target for the prevention and treatment of Parkinson's disease.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Biology
Jason C. Sang, Eric Hidari, Georg Meisl, Rohan T. Ranasinghe, Maria Grazia Spillantini, David Klenerman
Summary: Researchers found that cells respond to disruption of protein homeostasis by alpha-synuclein seeds primarily by secreting nanoscopic aggregates. This mechanism may represent an important protective response by cells to protein aggregation.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mahesh Ramalingam, Sujeong Jang, Han-Seong Jeong
Summary: The study assessed the neuroregenerative effects of stem cell-conditioned medium in a Parkinson's disease-related cell model, and found that this treatment method had significant protective effects against cell toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Peizheng Li, Hongbo Lv, Bohan Zhang, Ruonan Duan, Xiufang Zhang, Pengfei Lin, Chengyuan Song, Yiming Liu
Summary: This study found that GDF15 can protect mitochondrial function and reduce apoptosis in PD cell models by upregulating PGC1 alpha. Additionally, GDF15 overexpression can improve cell protection by activating the PI3K/Akt/mTOR signaling pathway.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Yanjun Zhou, Nanqu Huang, Yuanyuan Li, Zhisheng Ba, Yong Luo
Summary: This study investigated the protective effect of icaritin (ICT) in SH-SY5Y cells infected with TAR DNA-binding domain protein 43 (TDP-43) and its underlying mechanism by examining the expression of autophagy-related proteins. The results showed that ICT intervention increased cell viability, decreased TDP-43 expression, and reduced the expression of cleaved Caspase-3, Beclin-1, and LC3-II/I, while increasing the expression of p62. This suggests that ICT has a protective effect on TDP-43-induced neuronal cell injury by reducing TDP-43 protein expression and inhibiting autophagy.
Review
Neurosciences
Fan Zhang, Zhiwei Wu, Fei Long, Jieqiong Tan, Ni Gong, Xiaorong Li, Changwei Lin
Summary: This article summarizes the effects of ATP13A2 gene mutations on PD, discusses the molecular mechanism of lysosomal autophagy inhibition and abnormal alpha-synuclein accumulation, and provides a new direction for future research on the pathogenesis and therapeutic targets of ATP13A2 gene-related PD.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Remi Kinet, Benjamin Dehay
Summary: The aging population and lack of curative treatment for Parkinson's disease pose essential challenges in the coming years, making research crucial for therapeutic developments. Advances in understanding this neurodegenerative disorder have led to the discovery of new pathogenesis-related genes through genome-wide association analysis. Additionally, recent insights into the connection between Parkinson's disease and disrupted autophagy mechanisms have allowed the development of animal models mimicking autophagic dysregulation, providing opportunities to explore potential therapeutic strategies for restoring autophagy activity.
Editorial Material
Pathology
Kevin A. Roth, Audra E. Cox
AMERICAN JOURNAL OF PATHOLOGY
(2015)
Editorial Material
Pathology
Kevin A. Roth, Jonas S. Almeida
AMERICAN JOURNAL OF PATHOLOGY
(2015)
Article
Neurosciences
Eun Ran Kim, Zhaofei Wu, Hao Sun, Yuanzhong Xu, Leandra R. Mangieri, Yong Xu, Qingchun Tong
JOURNAL OF NEUROSCIENCE
(2015)
Article
Neurosciences
Zhaofei Wu, Eun Ran Kim, Hao Sun, Yuanzhong Xu, Leandra R. Mangieri, De-Pei Li, Hui-Lin Pan, Yong Xu, Benjamin R. Arenkiel, Qingchun Tong
JOURNAL OF NEUROSCIENCE
(2015)
Correction
Multidisciplinary Sciences
Niroop Kaza, Latika Kohli, Christopher D. Graham, Barbara J. Klocke, Steven L. Carroll, Kevin A. Roth
Editorial Material
Pathology
Chhavi Chauhan, Kevin A. Roth
AMERICAN JOURNAL OF PATHOLOGY
(2016)
Editorial Material
Pathology
Kevin A. Roth, Audra E. Cox
AMERICAN JOURNAL OF PATHOLOGY
(2016)
Editorial Material
Pathology
Kevin A. Roth
AMERICAN JOURNAL OF PATHOLOGY
(2016)
Article
Clinical Neurology
Christopher D. Graham, Niroop Kaza, Barbara J. Klocke, G. Yancey Gillespie, Lalita A. Shevde, Steven L. Carroll, Kevin A. Roth
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2016)
Article
Multidisciplinary Sciences
Leandra R. Mangieri, Yungang Lu, Yuanzhong Xu, Ryan M. Cassidy, Yong Xu, Benjamin R. Arenkiel, Qingchun Tong
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Leandra R. Mangieri, Burton J. Mader, Cailin E. Thomas, Charles A. Taylor, Austin M. Luker, Tonia E. Tse, Carrie Huisingh, John J. Shacka
Article
Multidisciplinary Sciences
E. Bianchetti, S. J. Bates, S. L. Carroll, M. D. Siegelin, K. A. Roth
SCIENTIFIC REPORTS
(2018)
Article
Cell Biology
Elena Bianchetti, Sierra J. Bates, Trang T. T. Nguyen, Markus D. Siegelin, Kevin A. Roth
Summary: The study revealed that RAB38 plays a role in regulating glioblastoma growth by affecting cell proliferation and death, showing potential as a therapeutic target for glioblastoma treatment.
Article
Medicine, Research & Experimental
Eun Ran Kim, Shengjie Fan, Dmitry Akhmedov, Kaiqi Sun, Hoyong Lim, William O'Brien, Yuanzhong Xu, Leandra R. Mangieri, Yaming Zhu, Cheng-Chi Lee, Yeonseok Chung, Yang Xia, Yong Xu, Feng Li, Kai Sun, Rebecca Berdeaux, Qingchun Tong
Article
Neurosciences
Yuanzhong Xu, Yungang Lu, Pingwen Xu, Leandra R. Mangieri, Elsa Isingrini, Yong Xu, Bruno Giros, Qingchun Tong