Article
Cardiac & Cardiovascular Systems
Yin Wang, Wenming Li, Tingrui Zhao, Yao Zou, Tao Deng, Zhangyou Yang, Zhiyi Yuan, Limei Ma, Ruihong Yu, Tingting Wang, Chao Yu
Summary: Th17 cells play important roles in regulating inflammation in hyperlipidemic patients and different stages of atherosclerosis, supporting the potential of IL-17 as a therapeutic target for the treatment of atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Hengcheng Zhang, Cecilia B. Cavazzoni, Manuel A. Podesta, Elsa D. Bechu, Garyfallia Ralli, Pragya Chandrakar, Jeong-Mi Lee, Ismail Sayin, Stefan G. Tullius, Reza Abdi, Anita S. Chong, Bruce R. Blazar, Peter T. Sage
Summary: This study found that a specific subset of effector Tfh cells was activated during allogeneic kidney transplantation, and these cells played a crucial role in transplant rejection by regulating the clonal dynamics of donor-specific germinal center B cells.
Article
Immunology
Wenhao Niu, Yueyue Xu, Xiaoyu Zha, Jiajia Zeng, Sai Qiao, Shuaini Yang, Hong Zhang, Lu Tan, Lida Sun, Gaoju Pang, Tengli Liu, Huili Zhao, Ningbo Zheng, Yongci Zhang, Hong Bai
Summary: The IL-21/IL-21R interaction is involved in host defense against C. muridarum lung infection, with IL-21R(-/-) mice exhibiting a stronger CD4(+) T cell response and higher Th1/Th17 cytokine levels, leading to reduced bacterial burden and milder lung pathology. Conversely, administration of recombinant mouse IL-21 worsens chlamydial lung infection by inhibiting Th1 and Th17 responses.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Enrique Huanosta-Murillo, Marcela Alcantara-Hernandez, Brenda Hernandez-Rico, Georgina Victoria-Acosta, Patricia Miranda-Cruz, Maria Antonieta Dominguez-Gomez, Fermin Jurado-Santacruz, Genaro Patino-Lopez, Vadim Perez-Koldenkova, Alam Palma-Guzman, Paula Licona-Limon, Ezequiel M. Fuentes-Panana, Alicia Lemini-Lopez, Laura C. Bonifaz
Summary: In cutaneous T cell lymphoma (CTCL), a dominant Th2 profile associated with disease progression has been proposed, with TOX+ CD4(+) T cells producing IL-4(+) in early-stage skin lesions. The NLRP3 receptor plays a role in promoting a Th2 response by controlling IL-4 production, which may have significant implications in disease progression. This mechanism of IL-4 regulation mediated by NLRP3 is amplified in late-stage CTCL, indicating its importance in disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Tej Pratap Singh, Augusto M. Carvalho, Lais Amorim Sacramento, Elizabeth A. Grice, Phillip Scott
Summary: This study demonstrates the involvement of IL-17A-producing ILCs in microbiota-driven immunopathology in cutaneous leishmaniasis. Skin microbiota promotes the generation of ROR gamma t(+) IL-17A-producing ILCs, which exacerbate skin inflammation in the disease.
Article
Immunology
Murilo Delgobo, Margarete Heinrichs, Nils Hapke, DiyaaElDin Ashour, Marc Appel, Mugdha Srivastava, Tobias Heckel, Ioakim Spyridopoulos, Ulrich Hofmann, Stefan Frantz, Gustavo Campos Ramos
Summary: The cardiovascular and immune systems undergo significant changes with aging, and an accumulation of CD4(+) T cells in elderly individuals may contribute to myocardial aging and heart disease progression. By studying young mice with expanded CD4(+) T cell compartments, researchers found that these cells can differentiate and impact the heart, suggesting a link between immunological senescence and age-related cardiac deterioration.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Jihee Kim, Ji-Hye Lee, Yunji Song, Ha-Jung Kim
Summary: This study analyzed the correlation between indoor house dust mite (HDM) concentration, canine atopic dermatitis (CAD) severity, and residential environments in 35 CAD dogs and 13 healthy dogs. The results showed that Der f 1 concentration had a negative association with transepidermal water loss (TEWL), but no association with CAD severity index-04 (CADESI-04) and pruritus visual analog scale (PVAS). Der f 1 concentration was significantly higher in the group living near green areas and with indoor relative humidity (RH) ≥40%. The study suggests that living near green areas and maintaining appropriate indoor climate may improve CAD clinical symptoms, and high concentrations of HDM may enhance the skin barrier function.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ming-Zhen Chen, Shao-An Wang, Shih-Chang Hsu, Kleiton Augusto Santos Silva, Feng-Ming Yang
Summary: House dust mite extract stimulates the TLR2/4 signaling pathway involving the sNASP/TRAF6 axis, leading to mucus overproduction and airway inflammation. The PEP-NASP peptide shows potential as a target for asthma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Mariana Farraia, Ines Paciencia, Francisca Castro Mendes, Joao Cavaleiro Rufo, Mohamed H. Shamji, Ioana Agache, Andre Moreira
Summary: This study compared the cost-effectiveness of allergen immunotherapy (AIT) to standard treatment in children with allergic asthma. The results showed that AIT, especially when administered subcutaneously, was cost effective in reducing asthma exacerbations and medication use.
Article
Biochemistry & Molecular Biology
Jose Cristian Vidal-Quist, Jozefien Declercq, Stijn Vanhee, Bart N. Lambrecht, Jose Gomez-Rial, Carmen Vidal, Eylem Aydogdu, Stephane Rombauts, Pedro Hernandez-Crespo
Summary: This study evaluated the impact of viral infection on the physiological characteristics and allergenicity of Dermatophagoides pteronyssinus. Transcriptional changes and allergen accumulation were observed, but the impact on allergic asthma and human IgE binding was not significant. Overall, viral infection did not significantly affect the allergenic performance of extracts or their practical use in allergy diagnosis.
INSECT MOLECULAR BIOLOGY
(2023)
Article
Immunology
Binfeng Chen, Baokui Ye, Mengyuan Li, Shuyi Wang, Jin Li, Yimei Lai, Niansheng Yang, Zunfu Ke, Hui Zhang
Summary: This study identifies the critical role of TIGIT in regulating CD4(+) T-RM cells and demonstrates that TIGIT deficiency can ameliorate gut inflammation and tissue injury caused by colitis. This finding suggests the potential therapeutic value of targeting TIGIT in the treatment of IBDs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Alexandra Berger, Sarah J. Colpitts, Morgan Zych, Christopher J. Paige
Summary: We explored the use of IL-21 cell-based anti-leukemia treatment in a mouse model of acute lymphoblastic leukemia. Injection of IL-21-secreting 70Z/3 leukemia cells induced a strong anti-leukemia response and led to 100% survival rate. IL-21 secretion correlated with improved survival and the expansion of IL-21-secreting cells. The delivery of IL-21 showed the potential to induce a potent immune response and long-term immunity, making it an attractive candidate for cancer immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Dongjie Wang, Wen Li, Natalie Albasha, Lindsey Griffin, Han Chang, Lauren Amaya, Sneha Ganguly, Liping Zeng, Bora Keum, Jose M. Gonzalez-Navajas, Matt Levin, Zohreh AkhavanAghdam, Helen Snyder, David Schwartz, Ailin Tao, Laela M. Boosherhri, Hal M. Hoffman, Michael Rose, Monica Valeria Estrada, Nissi Varki, Scott Herdman, Maripat Corr, Nicholas J. G. Webster, Eyal Raz, Samuel Bertin
Summary: Long-term exposure to house dust mites can accelerate lung tumorigenesis in susceptible hosts, such as individuals exposed to lung carcinogens or genetically predisposed to develop lung cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Environmental Sciences
Ana Sofia Oliveira, Carlos Gaspar, Joana Rolo, Cristiana Costa Pereira, Rita Palmeira-de-Oliveira, Joao Paulo Teixeira, Jose Martinez-de-Oliveira, Ana Palmeira-de-Oliveira
Summary: The study aimed to develop a fast and accessible multiplex PCR technique for detecting and distinguishing two relevant House Dust Mite species in house dust. The results showed high sensitivity of the technique in detecting both species, indicating its potential for practical application.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Oncology
Rosmely Hernandez, Kathryn M. LaPorte, Sunnie Hsiung, Alicia Santos Savio, Thomas R. Malek
Summary: The study demonstrates that amplifying IL-2R signaling in neoantigen-reactive CD4(+) and CD8(+) T cells using high-dose mIL-2/CD25 can enhance tumor clearance and antitumor immunity. The high-dose mIL-2/CD25 supports a tumor microenvironment with increased numbers of effector T cells and robust expansion of neoantigen-specific T cells, leading to more effective antitumor effects than treatment with a similar amount of IL-2.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Seo Woo Kim, Kubra Alci, Femke Van Gaever, Yasmine Driege, Keylla Bicalho, Geert Goeminne, Claude Libert, Alain Goossens, Rudi Beyaert, Jens Staal
Summary: Abscisic acid (ABA) is a signaling molecule found in various organisms. Its pharmacological activities and potential as a biomarker for certain diseases have sparked interest in developing a method to quantify ABA levels in mammalian cells and tissues. Researchers have optimized a biosensor system based on the interaction between plant ABA receptors and co-receptors to detect low concentrations of ABA in HEK293T cells.
Review
Pathology
Helena Aegerter, Bart N. Lambrecht
Summary: Despite the use of new biologics for treating asthma, the disease persists, and patients still experience symptoms even after treatment. Mucus plugs play a significant role in the disease by physically obstructing airways and perpetuating inflammation, acting as an immunogenic stimulus. Changes in mucus biology caused by type 2 inflammation result in sticky and difficult-to-expectorate sputum, which also increases the risk of infections. Therefore, mucus plugs are an overlooked but critical feature of asthma.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Domien Vanneste, Jens Staal, Mira Haegman, Yasmine Driege, Marieke Carels, Elien Van Nuffel, Pieter De Bleser, Yvan Saeys, Rudi Beyaert, Inna S. Afonina
Summary: Prostate cancer is one of the most common cancer types in men, and its increasing prevalence worldwide is attributed to the influence of modern Western lifestyle. Through analysis of cancer databases, it has been found that overexpression of CARD14 is strongly associated with aggressive prostate cancer in human patients. Furthermore, it has been demonstrated that CARD14-induced signaling plays a role in regulating prostate cancer cell survival and gene expression.
Article
Oncology
Olga S. Blomberg, Lorenzo Spagnuolo, Hannah Garner, Leonie Voorwerk, Olga I. Isaeva, Ewald van Dyk, Noor Bakker, Myriam Chalabi, Chris Klaver, Maxime Duijst, Kelly Kersten, Marieke Bruggemann, Dorien Pastoors, Cheei-Sing Hau, Kim Vrijland, Elisabeth A. M. Raeven, Daphne Kaldenbach, Kevin Kos, Inna S. Afonina, Paulien Kaptein, Louisa Hoes, Willemijn S. M. E. Theelen, Paul Baas, Emile E. Voest, Rudi Beyaert, Daniela S. Thommen, Lodewyk F. A. Wessels, Karin E. de Visser, Marleen Kok
Summary: Immune checkpoint blockade (ICB) has revolutionized cancer therapy by promoting effective immune responses through the activation of CD4(+) T cells and the recruitment of eosinophils. This study demonstrates the critical role of eosinophils in ICB response and provides proof-of-principle for enhancing ICB efficacy through eosinophil engagement. Mechanistically, ICB increases IL-5 production, stimulating elevated eosinophil production and systemic eosinophil expansion.
Article
Biochemistry & Molecular Biology
Ioannis Skordos, Yasmine Driege, Mira Haegman, Marja Kreike, Jens Staal, Annelies Demeyer, Rudi Beyaert
Summary: The unique activity of MALT1 protease in controlling immunity in humans has made it an attractive target for autoimmune diseases and lymphoid malignancies. This study investigates the role of MALT1-mediated cleavage of HOIL-1 in T and B cell development and function using knock-in mice, and shows that it has no significant impact on these processes.
Article
Biochemistry & Molecular Biology
Jose Cristian Vidal-Quist, Jozefien Declercq, Stijn Vanhee, Bart N. Lambrecht, Jose Gomez-Rial, Carmen Vidal, Eylem Aydogdu, Stephane Rombauts, Pedro Hernandez-Crespo
Summary: This study evaluated the impact of viral infection on the physiological characteristics and allergenicity of Dermatophagoides pteronyssinus. Transcriptional changes and allergen accumulation were observed, but the impact on allergic asthma and human IgE binding was not significant. Overall, viral infection did not significantly affect the allergenic performance of extracts or their practical use in allergy diagnosis.
INSECT MOLECULAR BIOLOGY
(2023)
Article
Immunology
Leslie Naesens, Santoshi Muppala, Dhiraj Acharya, Josephine Nemegeer, Delfien Bogaert, Jung-Hyun Lee, Katrien Staes, Veronique Debacker, Marieke De Bruyne, Pieter De Bleser, Elfride De Baere, Michiel van Gent, GuanQun Liu, Bart N. Lambrecht, Jens Staal, Tessa Kerre, Rudi Beyaert, Jonathan Maelfait, Simon J. Tavernier, Michaela U. Gack, Filomeen Haerynck
Summary: This study identified compound heterozygous loss-of-function mutations in the gene GTF3A, which encodes for transcription factor IIIA (TFIIIA), leading to impaired innate immune responses against herpes simplex virus 1 (HSV-1) and increased viral replication. It was found that TFIIIA plays a crucial role in the activation of the RNA sensor RIG-I. These findings highlight the association between GTF3A genetic defects and susceptibility to HSV-1-induced encephalitis.
SCIENCE IMMUNOLOGY
(2022)
Article
Allergy
Aurora Holgado, Zhuangzhuang Liu, Aigerim Aidarova, Christina Mueller, Mira Haegman, Yasmine Driege, Marja Kreike, Charlotte L. Scott, Inna S. Afonina, Rudi Beyaert
Summary: IL-33 plays a crucial role in allergic diseases, and A20 is involved in regulating IL-33 signaling. In the absence of A20 in macrophages, IL-33-induced lung immune responses are altered, with reduced type 2 immune response and increased production of IFN-gamma. This study reveals a novel role for A20 in regulating IL-33-induced STAT1 signaling in macrophages.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Bastiaan Maes, Farzaneh Fayazpour, Leen Catrysse, Guillaume Lornet, Evelien van de Velde, Caroline De Wolf, Sofie De Prijck, Justine Van Moorleghem, Manon Vanheerswynghels, Kim Deswarte, Benedicte Descamps, Christian Vanhove, Bart van der Schueren, Roman Vangoitsenhoven, Hamida Hammad, Sophie Janssens, Bart N. Lambrecht
Summary: Healthy adipose tissue contains specific immune cells that are lost in obesity. The kinase TAOK3 has been linked to obesity, but its exact role is unclear. In this study, the authors found that TAOK3 inhibits the presence of regulatory T cells in adipose tissue and regulates metabolic dysfunction in obesity.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Kavita Rawat, Anita Tewari, Xin Li, Arlind B. B. Mara, William T. T. King, Sophie L. L. Gibbings, Chinaza F. F. Nnam, Fred W. W. Kolling, Bart N. N. Lambrecht, Claudia V. V. Jakubzick
Summary: Dendritic cells and monocytes capture, transport, and present antigen to cognate T cells in the draining lymph nodes in a CCR7-dependent manner. It is unclear how monocytes reach the lymph nodes since only migratory dendritic cells express this chemokine receptor.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Tineke Vanderhaeghen, Steven Timmermans, Melanie Eggermont, Deepika Watts, Jolien Vandewalle, Charlotte Wallaeys, Louise Nuyttens, Joyca De Temmerman, Tino Hochepied, Sylviane Dewaele, Joke Vanden Berghe, Niek Sanders, Ben Wielockx, Rudi Beyaert, Claude Libert
Summary: Polymicrobial sepsis leads to anorexia, resulting in lipolysis in white adipose tissue and proteolysis in muscle, leading to the release of FFAs, glycerol, and gluconeogenic amino acids. Dysfunction of PPAR alpha and GR in the liver causes the accumulation of metabolites and the failure to produce ketone bodies and glucose, leading to toxicity. Hypoxia and activation of HIFs were investigated as potential causes for this dysfunction, but the results suggest that HIF1 alpha and HIF2 alpha are activated in hepatocytes in sepsis, but their contribution to lethality is minimal.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Victor Bosteels, Sandra Marechal, Clint De Nolf, Sofie Rennen, Jonathan Maelfait, Simon J. Tavernier, Jessica Vetters, Evelien Van De Velde, Farzaneh Fayazpour, Kim Deswarte, Alexander Lamoot, Julie Van Duyse, Liesbet Martens, Cedric Bosteels, Ria Roelandt, Annelies Emmaneel, Sofie Van Gassen, Louis Boon, Gert Van Isterdael, Isabelle Guillas, Niels Vandamme, Doris Hoeglinger, Bruno G. De Geest, Wilfried Le Goff, Yvan Saeys, Kodi S. Ravichandran, Bart N. Lambrecht, Sophie Janssens
Summary: Dendritic cells mature in different ways depending on the context, either in an immunogenic or tolerogenic manner. Engulfment of apoptotic cells or cholesterol-rich lipid nanoparticles leads to the homeostatic maturation of type 1 conventional DCs (cDC1s) through the activation of the liver X receptor (LXR) pathway. On the other hand, engagement of TLR3 to mimic viral infection represses the LXR pathway, delaying cellular cholesterol efflux and inducing genes associated with T cell-mediated immunity.
SCIENCE IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alessio Borio, Aurora Holgado, Christina Passegger, Herbert Strobl, Rudi Beyaert, Holger Heine, Alla Zamyatina
Summary: The TLR4/MD-2 complex is a crucial receptor in the innate immune system and plays a major role in inflammation, but dysregulation in its signaling can lead to uncontrolled inflammation and disease. Targeting this receptor complex with anti-inflammatory therapies is promising, but the complexity of ligand recognition and species-specificity presents challenges. Researchers have developed glycolipids that mimic lipid A and inhibit TLR4-mediated inflammation, and these glycolipids were evaluated for their activity in human and murine immune cells. A bis-phosphorylated glycolipid was found to have antagonist activity on human TLR4, but acted as a partial agonist on murine TLR4.
Article
Biochemistry & Molecular Biology
Leonie Wittner, Lukas Wagener, Jakob J. Wiese, Iris Stolzer, Susanne M. Krug, Elisabeth Naschberger, Rene Jackstadt, Rudi Beyaert, Raja Atreya, Anja A. Kuehl, Gregor Sturm, Miguel Gonzalez-Acera, Jay V. Patankar, Christoph Becker, Britta Siegmund, Zlatko Trajanoski, Beate Winner, Markus F. Neurath, Michael Schumann, Claudia Guenther
Summary: The paracaspase MALT1 plays a crucial role in mucosal inflammation. It is highly expressed in colonic epithelial cells of UC patients and experimental colitis. Mechanistically, MALT1 protease function inhibits ferroptosis and contributes to NF-kappa B signaling and STAT3 signaling, which are involved in inflammation and tissue healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Xu Jing, Jieyu Wu, Caijuan Dong, Juan Gao, Takahiro Seki, Changil Kim, Egon Urgard, Kayoko Hosaka, Yunlong Yang, Siwen Long, Ping Huang, Junnian Zheng, Laszlo Szekely, Yuanting Zhang, Wei Tao, Jonathan Coquet, Minghua Ge, Yuguo Chen, Mikael Adner, Yihai Cao
Summary: COVID-19 infection enhances adipose browning and non-shivering thermogenesis, leading to adipose atrophy and weight loss. Inhibition of vascular endothelial growth factor (VEGF) signaling may represent an effective approach for preventing and treating COVID-19-associated weight loss.
