Review
Medicine, Research & Experimental
M. K. Chaitanya Mannava, Abhijit Garai, Ashwini K. Nangia
Summary: Improving drug solubility and permeability through cocrystallization is a significant topic in crystal engineering with practical applications in developing high bioavailability medicines. The review article explores the fundamentals of drug permeability mechanisms and presents examples of pharmaceutical cocrystals and salts designed to enhance drug diffusion and permeability by modulating various structural factors. The findings suggest that hydrogen-bonded drug-coformer aggregates and coformers/cocrystals can increase drug flux and facilitate drug passage by affecting tight junctions and reducing electrical resistance. The study highlights the potential of de novo design of high permeability coformers for improved-performance pharmaceutical cocrystals.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Fabio Sonvico, Veronica Chierici, Giada Varacca, Eride Quarta, Davide D'Angelo, Ben Forbes, Francesca Buttini
Summary: The newly developed RespiCell (TM) dissolution apparatus is suitable for testing the dissolution of active pharmaceutical ingredients in pulmonary products, aiding in the study of particle dissolution rate and providing significant data for product quality and efficacy.
Article
Chemistry, Multidisciplinary
Konrad Ehelebe, Julius Knoeppel, Markus Bierling, Britta Mayerhoefer, Thomas Boehm, Nadiia Kulyk, Simon Thiele, Karl J. J. Mayrhofer, Serhiy Cherevko
Summary: Research has shown that specific Pt dissolution increases significantly with decreasing Pt loading; compared to experiments in aqueous model systems with flow cells, the measured dissolution in GDE experiments is considerably lower; further reduction in Pt dissolution is observed by adding a membrane onto the catalyst layer.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Pharmacology & Pharmacy
Ville A. Vartiainen, Federico Lavorini, Anna C. Murphy, Klaus F. Rabe
Summary: This review article discusses the sustainability of inhaler therapy in respiratory diseases, particularly the concern over the use of propellant-based inhalers with high global warming potential. It examines the airflow resistance of dry powder inhalers (DPIs) and their effectiveness in different respiratory conditions, including exacerbations.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Energy & Fuels
Jianping Yang, Xiangying Lu, Fanyue Meng, Hailong Li
Summary: This study investigates the dissolution behavior of overhaul slag in a molten salt system through thermodynamic calculation and experiments, and proposes a synergistic disposal strategy by utilizing the waste as a raw material in the aluminum electrolysis process.
Review
Materials Science, Multidisciplinary
Ze Liu, Naijia Liu, Jan Schroers
Summary: Nanomolding is a versatile top-down fabrication method suitable for a wide range of materials and states of matter. It offers solutions for the fabrication of various nanomaterials for diverse applications and improvements in lithography techniques. Recent advances in nanomolding have transformed nanofabrication by allowing designs to be selected from a wide palette of materials.
PROGRESS IN MATERIALS SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Niloofar Moazami Goudarzi, Aseel Samaro, Chris Vervaet, Matthieu N. Boone
Summary: Visualization and analysis of the dynamic behavior of pharmaceutical dosage forms during the dissolution process using X-ray tomography can provide insights into drug release mechanisms and facilitate the design of customized dosage forms. In this study, a flow-through cell dissolution apparatus was developed for mimicking the standard in vitro dissolution process and an X-ray tomography-based method was utilized to monitor and analyze the structure at the pore scale level. The proposed approach allowed real-time tracking of solution ingress into the product and visualization of the internal structure of the sample.
Article
Thermodynamics
Jiawei Xu, Yuhua Wu, Shude Luo, Caizhi Zhang, Xinhai Xu
Summary: It is found that the high-temperature proton exchange membrane fuel cell with phosphoric acid-doped polybenzimidazole membrane is commonly used with a methanol steam reformer due to its high CO tolerance. However, the effect of water in the methanol reformate on the fuel cell is unclear. A comprehensive model considering the water influence mechanism shows that increasing water content can improve cell performance and reduce platinum loading.
APPLIED THERMAL ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Beatriz Noriega-Fernandes, Maria Malmlof, Mattias Nowenwik, Per Gerde, M. Luisa Corvo, Eunice Costa
Summary: The study aims to evaluate the structure and dissolution characteristics of inhaled drug particles, finding that particles with different surface properties significantly impact the dissolution and deposition mechanisms of the drug, which helps to further understand the aerosolization and deposition mechanisms of dry powder inhalers.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Energy & Fuels
Kai Wang, Yanhai Wang, Haijun Guo, Jianquan Zhang, Guodong Zhang
Summary: This study investigated multiple gas diffusion mechanisms in the nanopores of coal particles and their contributions to the total gas diffusion quantity under different pressure and pore radius conditions. It was found that Knudsen diffusion dominates in the low-pressure region, slip flow dominates in the high-pressure region with large pore radius, and surface diffusion dominates with small pore radius. Additionally, the gas diffusion velocity and total diffusion quantity were lower under adiabatic conditions compared to isothermal conditions.
Article
Thermodynamics
Sheng-Yen Hsu, Ching-Wei Wu
Summary: The study found that different particle shapes can affect dissolution time in mass-diffusion-controlled processes, mainly influenced by the Reynolds number. Particle shape affects dissolution time through three aspects: surface area, convective intensity, and intensity of flow recirculation, with the latter becoming more significant at higher Reynolds numbers.
INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER
(2021)
Article
Engineering, Marine
Longqing Xin, Peng Liu, Siqi Wang, Heng Zhuo, Zhaopeng Zhang
Summary: This paper proposes a new tandem paddle propulsion method for drift-cleaning vessels in shallow-draft waters. Numerical simulations and experimental tests are conducted to validate its propulsion performance. The results show that the tandem paddles can generate a large thrust under suitable submerged depth and paddle design conditions.
Article
Pharmacology & Pharmacy
Shotaro Ikuta, Hidetoshi Nakagawa, Toshiya Kai, Kiyohiko Sugano
Summary: The purpose of this study was to develop a bicarbonate buffer flow-through cell (FTC) dissolution test for predicting the in vivo performance of colon targeting tablets. The results showed that the developed FTC method was consistent with the clinical study in predicting the dissolution characteristics of colon targeting tablets.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Zongming Gao, Anjanette Smith
Summary: In vitro dissolution tests are important quality control tools for drug products. Variability in dissolution testing can occur due to factors such as the size and setting of the sampling cannula used to withdraw aliquots from the dissolution medium. This study evaluated the effects of different cannula sizes and settings on dissolution results using the USP 2 apparatus. The results showed that both cannula size and setting can cause significant systematic errors, and the degree of interference depends on the cannula's outer diameter.
Article
Pharmacology & Pharmacy
Yiwang Guo, Changquan Calvin Sun
Summary: This study examined two formulation strategies to mitigate the negative effect of sodium lauryl sulfate (SLS) on the dissolution of p-aminobenzoic acid (PABA), which are increasing the microenvironment pH and reducing the critical micelle concentration (CMC) of SLS.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)