期刊
JOURNAL OF ADVANCED RESEARCH
卷 13, 期 -, 页码 113-126出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jare.2018.03.007
关键词
Schiff base; Metal complex; Urea; Urease; Urease inhibitor; Helicobacter pylori; Canavalia ensiformis
资金
- Brazilian agency Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Brazilian agency Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Brazilian agency Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
- CNPq
Schiff bases, an aldehyde-or ketone-like compounds in which the carbonyl group is replaced by an imine or azomethine, are some of the most widely used organic compounds. Indeed, they are widely used for industrial purposes and also exhibit a broad range of biological activities, including anti-urease activity. Ureases, enzymes that catalyze urea hydrolysis, have received considerable attention for their impact on living organisms' health, since the persistence of urease activity in human and animal cells can be the cause of some diseases and pathogen infections. This short review compiles examples of the most anti-urease Schiff bases (0.23 mu M < IC50 < 37.00 mu M) and their metal complexes (0.03 mu M < IC50 < 100 mu M). Emphasis is given to ureases of Helicobacter pylori and Canavalia ensiformis, although the active site of this class of hydrolases is conserved among living organisms. (C) 2018 Production and hosting by Elsevier B.V. on behalf of Cairo University.
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