Cancer-specific SNPs originate from low-level heteroplasmic variants in human mitochondrial genomes of a matched cell line pair

Two novel lncRNAs discovered in human mitochondrial DNA using PacBio full-length transcriptome data

(2018) Shan Gao et al.   MITOCHONDRION

Heteroplasmic shifts in tumor mitochondrial genomes reveal tissue-specific signals of relaxed and positive selection

(2017) Sneha Grandhi et al.   HUMAN MOLECULAR GENETICS

Intra-individual purifying selection on mitochondrial DNA variants during human oogenesis

(2017) Sara De Fanti et al.   HUMAN REPRODUCTION

Mutations in mitochondrial DNA causing tubulointerstitial kidney disease

(2017) Thomas M. Connor et al.   PLoS Genetics

Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers

(2016) Laura J. Cobb et al.   Aging-US

Distinct Small RNA Signatures in Extracellular Vesicles Derived from Breast Cancer Cell Lines

(2016) Tonje Fiskaa et al.   PLoS One

Organellar non-coding RNAs: Emerging regulation mechanisms

(2015) André Dietrich et al.   BIOCHIMIE

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

(2015) Changhan Lee et al.   Cell Metabolism

Evidence for frequent and tissue-specific sequence heteroplasmy in human mitochondrial DNA

(2015) Jana Naue et al.   MITOCHONDRION

Extensive tissue-related and allele-related mtDNA heteroplasmy suggests positive selection for somatic mutations

(2015) Mingkun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication-transcription switch in human mitochondria

(2015) K. Agaronyan et al.   SCIENCE

The saga of the many studies wrongly associating mitochondrial DNA with breast cancer

(2014) Antonio Salas et al.   BMC CANCER

An evolutionary preserved intergenic spacer in gadiform mitogenomes generates a long noncoding RNA

(2014) Tor Erik Jørgensen et al.   BMC EVOLUTIONARY BIOLOGY

Circulating Long Noncoding RNA, LIPCAR, Predicts Survival in Patients With Heart Failure

(2014) Regalla Kumarswamy et al.   CIRCULATION RESEARCH

Use of stereotypical mutational motifs to define resolution limits for the ultra-deep resequencing of mitochondrial DNA

(2014) Kristian Gardner et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Down-regulation of the Antisense Mitochondrial Non-coding RNAs (ncRNAs) Is a Unique Vulnerability of Cancer Cells and a Potential Target for Cancer Therapy

(2014) Soledad Vidaurre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sea anemones possess dynamic mitogenome structures

(2014) Åse Emblem et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

Mitochondrial dynamics and inheritance during cell division, development and disease

(2014) Prashant Mishra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of the large ribosomal subunit from human mitochondria

(2014) A. Brown et al.   SCIENCE

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

(2014) Young Seok Ju et al.   eLife

The Warburg effect version 2.0: Metabolic reprogramming of cancer stem cells

(2013) JAVIER MENENDEZ et al.   CELL CYCLE

Functional Recurrent Mutations in the Human Mitochondrial Phylogeny: Dual Roles in Evolution and Disease

(2013) Liron Levin et al.   Genome Biology and Evolution

Correlation between erythropoietin receptor(s) and estrogen and progesterone receptor expression in different breast cancer cell lines

(2013) NINA TROŠT et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Very Low-Level Heteroplasmy mtDNA Variations Are Inherited in Humans

(2013) Yan Guo et al.   Journal of Genetics and Genomics

Performance Comparison of Digital microRNA Profiling Technologies Applied on Human Breast Cancer Cell Lines

(2013) Erik Knutsen et al.   PLoS One

Frequency and Pattern of Heteroplasmy in the Complete Human Mitochondrial Genome

(2013) Amanda Ramos et al.   PLoS One

Humanin: a harbinger of mitochondrial-derived peptides?

(2013) Changhan Lee et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease

(2013) D. C. Wallace et al.   Cold Spring Harbor Perspectives in Biology

Mitochondrial Dysfunction in Cancer

(2013) Michelle L. Boland et al.   Frontiers in Oncology

Mitogenome polymorphism in a single branch sample revealed by SOLiD deep sequencing of the Lophelia pertusa coral genome

(2012) Åse Emblem et al.   GENE

A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop

(2012) P. H. Wanrooij et al.   NUCLEIC ACIDS RESEARCH

Systematic Analysis of Small RNAs Associated with Human Mitochondria by Deep Sequencing: Detailed Analysis of Mitochondrial Associated miRNA

(2012) Lakshmi Sripada et al.   PLoS One

Spectrum of somatic mitochondrial mutations in five cancers

(2012) T. C. Larman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determination of the differential expression of mitochondrial long non-coding RNAs as a noninvasive diagnosis of bladder cancer

(2012) Alexis Rivas et al.   BMC Urology

The awakening of an advanced malignant cancer: An insult to the mitochondrial genome

(2011) Cody C. Cook et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Human Mitochondrial Transcriptome

(2011) Tim R. Mercer et al.   CELL

Comparison of Sequence Reads Obtained from Three Next-Generation Sequencing Platforms

(2011) Shingo Suzuki et al.   PLoS One

Long noncoding RNAs are generated from the mitochondrial genome and regulated by nuclear-encoded proteins

(2011) O. Rackham et al.   RNA

Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins

(2011) Adam Ameur et al.   PLoS Genetics

Dynamics of mitochondrial heteroplasmy in three families investigated via a repeatable re-sequencing study

(2011) Hiroki Goto et al.   GENOME BIOLOGY

Human mitochondrial mRNAs—like members of all families, similar but different

(2010) Richard J. Temperley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Heteroplasmic mitochondrial DNA mutations in normal and tumour cells

(2010) Yiping He et al.   NATURE

G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer formation

(2010) P. H. Wanrooij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mtDNA G10398A variant in African-American women with breast cancer provides resistance to apoptosis and promotes metastasis in mice

(2009) Mariola Kulawiec et al.   JOURNAL OF HUMAN GENETICS

Expression of a family of noncoding mitochondrial RNAs distinguishes normal from cancer cells

(2009) V. A. Burzio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Enhanced glycolysis induced by mtDNA mutations does not regulate metastasis

(2008) Kaori Ishikawa et al.   FEBS LETTERS

An inherited mitochondrial DNA disruptive mutation shifts to homoplasmy in oncocytic tumor cells

(2008) Giuseppe Gasparre et al.   HUMAN MUTATION

Clonal expansion of different mtDNA variants without selective advantage in solid tumors

(2008) Julia Gekeler et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS