期刊
3 BIOTECH
卷 8, 期 7, 页码 -出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s13205-018-1315-y
关键词
Xylanase; Optimization; Co-culture; Submerged fermentation; Bacillus subtilis; Kluyveromyces marxianus
资金
- Scientific Council of Research at METU [BAP-03-14-2011-001]
Co-cultures of Bacillus subtilis and Kluyveromyces marxianus were investigated in submerged fermentation for xylanase production at shake-flask scale. Xylanase production markedly increased when arabinose, xylose, or hazelnut shells were used as the single carbon source. Maximal xylanase of 49.5 IU/mL was achieved with 4% B. subtilis, 4% K. marxianus, 40% solid load of hazelnut shells, and pH 7.0. Overall, xylanase was enhanced by 4.4-fold compared to initial un-optimized monoculture production and 2.8-fold compared to initial un-optimized co-cultured production, after optimization by response surface method.
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